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1. 发明申请

WO2019126040A1 FLOW CELLS WITH HYDROGEL COATING 审中-公开
公开(公告)号：WO2019126040A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066011
申请日：2018-12-17
申请人： ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
发明人： REN, Hongji , BOUTELL, Jonathan Mark , MOON, John A. , BOWEN, M. Shane , NEMIROSKI, Alex , SKINNER, Gary Mark , CHEN, Kenny
IPC分类号： B01J19/00 , C12Q1/6874 , C08F220/58 , C09D105/12 , C09D133/26 , C09D171/02
摘要： In an example of the method, a functionalized coating layer is applied in depressions of a patterned flow cell substrate. The depressions are separated by interstitial regions. A primer is grafted to the functionalized coating layer to form a grafted functionalized coating layer in the depressions. A hydrogel is applied on at least the grafted functionalized coating layer.

2. 发明公开

EP3727674A1 FLOW CELLS WITH HYDROGEL COATING 审中-公开
公开(公告)号：EP3727674A1
公开(公告)日：2020-10-28
申请号：EP18892345.2
申请日：2018-12-17
申请人： Illumina Inc. , Illumina Cambridge Limited
发明人： REN, Hongji , BOUTELL, Jonathan Mark , MOON, John A. , BOWEN, M. Shane , NEMIROSKI, Alex , SKINNER, Gary Mark , CHEN, Kenny
IPC分类号： B01J19/00 , C12Q1/6874 , C08F220/58 , C09D105/12 , C09D133/26 , C09D171/02

3. 发明授权

EP3241913B1 SYSTEM FOR SEQUENCING BY ORTHOGONAL SYNTHESIS 有权
公开(公告)号：EP3241913B1
公开(公告)日：2019-02-20
申请号：EP17164818.1
申请日：2014-06-25
申请人： Illumina, Inc.
发明人： FABANI, Martin Maria , MOON, John A. , ROGERT BACIGALUPO, Maria Candelaria
IPC分类号： C12Q1/6874

4. 发明申请

WO2017172798A1 MULTI-PLANE MICROARRAYS 审中-公开
标题翻译：多平面微型阵列
公开(公告)号：WO2017172798A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024578
申请日：2017-03-28
申请人： ILLUMINA, INC. , BOWEN, M. Shane
发明人： BOWEN, M. Shane , GRAIGE, Michael , HONG, Stanley S. , MOON, John A. , SIU, Merek
IPC分类号： B01L3/00 , G01N33/543 , G01N33/53 , C12Q1/68
摘要： An array including a solid support having a plurality of contours along its exterior surface. A first subset of contours is positioned along the exterior surface of the solid support to form a first pattern of features and a second subset of contours is positioned along the exterior surface to form a second pattern of features. The contours of the first subset are juxtaposed with the second subset along the exterior surface, whereby the first and second patterns form an interleaved pattern. The features of the first pattern occur at a first elevation z1 and the features of the second pattern occur at a second elevation z2. The features of the first pattern are configured to attach analytes at a different elevation relative to analytes attached to the features of the second pattern.
摘要翻译：包括具有沿其外表面的多个轮廓的固体支撑件的阵列。轮廓的第一子集沿固体支撑件的外表面定位以形成特征的第一图案，轮廓的第二子集沿着外表面定位以形成特征的第二图案。第一子集的轮廓沿着外表面与第二子集并置，由此第一和第二图案形成交错图案。第一图案的特征出现在第一高程z1处，并且第二图案的特征出现在第二高度z2处。第一种图案的特征被配置为以与附着于第二图案的特征的分析物不同的高度附着分析物。

5. 发明申请

WO2013151622A1 INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 审中-公开
标题翻译：用于核酸序列的集成光电读头和流体盒
公开(公告)号：WO2013151622A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/025963
申请日：2013-02-13
申请人： ILLUMINA, INC.
发明人： BUERMANN, Dale , MOON, John A. , CRANE, Bryan , WANG, Mark , HONG, Stanley S. , HARRIS, Jason , HAGE, Matthew , NIBBE, Mark J.
IPC分类号： G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
摘要翻译：一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。检测装置和盒可以一起使用或彼此独立使用。

6. 发明申请

WO2012170936A3 PATTERNED FLOW-CELLS USEFUL FOR NUCLEIC ACID ANALYSIS 审中-公开
公开(公告)号：WO2012170936A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/041732
申请日：2012-06-08
申请人： ILLUMINA, INC. , LIN, Shengrong , WU, Yir-Shyuan , GUNDERSON, Kevin , MOON, John A.
发明人： LIN, Shengrong , WU, Yir-Shyuan , GUNDERSON, Kevin , MOON, John A.
IPC分类号： C12Q1/68 , G01N21/25
摘要： Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal regions and the interstitial regions. Nucleic acids or other analytes can be attached to the continuous gel layer such that a greater amount is attached over the metal regions than over the interstitial region. Also provided are methods for making such surfaces. Methods are also provided for making an array of nucleic acids or other analytes using such surfaces.

7. 发明公开

EP2718465A2 PATTERNED FLOW-CELLS USEFUL FOR NUCLEIC ACID ANALYSIS 有权
标题翻译： EYED FLOW细胞核酸分析
公开(公告)号：EP2718465A2
公开(公告)日：2014-04-16
申请号：EP12797526.6
申请日：2012-06-08
申请人： Illumina, Inc.
发明人： LIN, Shengrong , WU, Yir-Shyuan , GUNDERSON, Kevin , MOON, John A.
IPC分类号： C12Q1/68 , G01N21/25
CPC分类号： C12Q1/6806 , C12Q1/6837 , G01N27/447
摘要： Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal regions and the interstitial regions. Nucleic acids or other analytes can be attached to the continuous gel layer such that a greater amount is attached over the metal regions than over the interstitial region. Also provided are methods for making such surfaces. Methods are also provided for making an array of nucleic acids or other analytes using such surfaces.

8. 发明公开

EP2834622A1 INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 有权
标题翻译：集成光电阅读器和流体筒用于核酸测序
公开(公告)号：EP2834622A1
公开(公告)日：2015-02-11
申请号：EP13710114.3
申请日：2013-02-13
申请人： Illumina, Inc.
发明人： BUERMANN, Dale , MOON, John A. , CRANE, Bryan , WANG, Mark , HONG, Stanley S. , HARRIS, Jason , HAGE, Matthew , NIBBE, Mark J.
IPC分类号： G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

9. 发明公开

EP4219012A1 METHOD OF IMAGING A SUBSTRATE COMPRISING FLUORESCENT FEATURES AND USE OF THE METHOD IN NUCLEIC ACID SEQUENCING 审中-实审
公开(公告)号：EP4219012A1
公开(公告)日：2023-08-02
申请号：EP23167200.7
申请日：2013-02-13
申请人： Illumina, Inc.
发明人： BUERMANN, Dale , CRANE, Bryan , HAGE, Matthew , HARRIS, Jason , HONG, Stanley S. , MOON, John A. , NIBBE, Mark J. , WANG, Mark
IPC分类号： B01L3/00 , G01N21/64 , C12Q1/6874 , G01N21/03 , G01N21/05
摘要： A method of imaging a substrate comprising fluorescent features on a surface is described. The surface is imaged using a read head (150) including a plurality of microfluorometers positioned to simultaneously acquire a plurality of wide-field images of a first portion of the surface, wherein each microfluorometer acquires a wide-field image from a different location of the surface and wherein the field diameter of an individual microfluorometer is at least 1 mm. The microfluorometers are affixed to a carriage which is translated in a direction parallel to the surface to acquire a further plurality of wide-field images of a second portion of the surface. The method may be applied as a detection operation in the context of a nucleic acid sequencing procedure, wherein fluidic operations of the nucleic acid sequencing procedure are performed in a fluidic cartridge.

10. 发明公开

EP3377226A1 MULTI-PLANE MICROARRAYS 有权
公开(公告)号：EP3377226A1
公开(公告)日：2018-09-26
申请号：EP17776477.6
申请日：2017-03-28
申请人： Illumina, Inc.
发明人： BOWEN, M. Shane , GRAIGE, Michael , HONG, Stanley S. , MOON, John A. , SIU, Merek
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/6837 , C12Q1/6844 , C12Q1/6874
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00509 , B01J2219/00621 , B01J2219/00662 , B01J2219/00668 , B01J2219/00722 , B01L2300/0636 , B01L2300/0819 , B01L2300/0848 , B01L2300/0851 , C12Q1/6837 , C12Q1/6844 , C12Q1/6874 , C12Q2565/537
摘要： An array including a solid support having a plurality of contours along its exterior surface. A first subset of contours is positioned along the exterior surface of the solid support to form a first pattern of features and a second subset of contours is positioned along the exterior surface to form a second pattern of features. The contours of the first subset are juxtaposed with the second subset along the exterior surface, whereby the first and second patterns form an interleaved pattern. The features of the first pattern occur at a first elevation z1 and the features of the second pattern occur at a second elevation z2. The features of the first pattern are configured to attach analytes at a different elevation relative to analytes attached to the features of the second pattern.

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