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1. 发明申请

US20090305898A1 Methods and Compositions for Identifying a Peptide Having an Intermolecular Interaction With a Target of Interest 审中-公开
标题翻译：用于识别与感兴趣的目标具有分子间相互作用的肽的方法和组合物
公开(公告)号：US20090305898A1
公开(公告)日：2009-12-10
申请号：US11989203
申请日：2006-07-12
申请人： Ilan Morad , Hanan Itzhaki
发明人： Ilan Morad , Hanan Itzhaki
IPC分类号： C40B20/00 , C40B40/10 , C40B40/06 , C40B40/02 , C12N7/00 , C12N15/63 , C12N1/00 , C12N9/48
CPC分类号： C12N15/1037 , C07K2319/50 , C07K2319/70 , C12N15/1058 , C40B10/00 , C40B40/02 , G01N33/5023 , G01N33/56983 , G01N2333/95
摘要： This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest. The invention further provides uses thereof, including a method for identifying a peptide which has an intermolecular interaction with a target of interest or identifying the agonistic or antagonistic feature of a peptide that has an intermolecular reaction with a target of interest.
摘要翻译：本发明在一个实施方案中提供了重组病毒或重组病毒文库，其中每个病毒包含参与病毒附着或感染的蛋白质，多肽与文库中的另一个肽或多肽至少单个氨基酸不同，以及与肽和蛋白质接近的修饰的切割位点，其中修饰切割位点使得介导切割的化合物与未修饰的切割位点相比具有降低的结合亲和力。本发明进一步提供了包含蛋白酶，涉及分子间相互作用的目标靶标的蛋白酶，以及附着蛋白酶和感兴趣靶标的柔性连接物的目标复合物。本发明进一步提供其用途，包括鉴定与感兴趣的靶标具有分子间相互作用的肽或识别与感兴趣的靶标具有分子间反应的肽的激动或拮抗特征的方法。

2. 发明申请

US20060239469A1 Story-telling doll 审中-公开
标题翻译：讲故事的娃娃
公开(公告)号：US20060239469A1
公开(公告)日：2006-10-26
申请号：US10560166
申请日：2004-06-09
申请人： Assaf Gil , Ilan Morad , Eitan Morad , Arie Litbak , Yaniv Petel
发明人： Assaf Gil , Ilan Morad , Eitan Morad , Arie Litbak , Yaniv Petel
IPC分类号： H04B3/00
CPC分类号： A63H3/28 , A63H2200/00
摘要： A story-telling doll includes a doll body (10) which contains a processing system (12) including at least one digital processor, a programmable data storage device (14) and an audio output device (16). At least one user-operable switch (SW1, SW2, SW3) is manually operable by manipulation of at least one region (18, 20, 22) of body (10) to provide an input signal to processing system (12). A communications unit (24), also contained within body (10), is configured to operate under control of processing unit (12) in response to the input signal to: (a) initiate a data communications link via a general purpose communications network with a remote content provider source, (b) transmit to the remote content provider a request for download of at least one data file including audio content, and (c) receive the at least one data file including audio content from the remote content provider. Processor system (12) is further configured to save the at least one data file in storage device (14) and subsequently to play the audio content read from the at least one data file via audio output device (16).
摘要翻译：一个讲故事的娃娃包括一个包含至少一个数字处理器，可编程数据存储装置（14）和音频输出装置（16）的处理系统（12）的娃娃体（10）。至少一个用户可操作的开关（SW 1，SW 2，SW 3）可通过操纵主体（10）的至少一个区域（18,20,22）来手动操作，以向处理系统（12）提供输入信号，。还包含在主体（10）内的通信单元（24）被配置为响应于输入信号在处理单元（12）的控制下操作：（a）经由通用通信网络发起数据通信链路，远程内容提供者源，（b）向远程内容提供商发送下载包括音频内容的至少一个数据文件的请求，以及（c）从远程内容提供商接收包括音频内容的至少一个数据文件。处理器系统（12）还被配置为将至少一个数据文件保存在存储设备（14）中，并且随后经由音频输出设备（16）播放从至少一个数据文件读取的音频内容。

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