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1. 发明专利

IL265236D0 Therapeutic multi-targeting constructs and uses thereof 未知
公开(公告)号：IL265236D0
公开(公告)日：2019-05-30
申请号：IL26523619
申请日：2019-03-07
申请人： ILAN MORAD , HANAN ITZHAKI , AEBI LTD
发明人： ILAN MORAD , HANAN ITZHAKI
IPC分类号： A61P20060101

2. 发明授权

US06551793B1 Carotenoid-associated proteins useful for high carotenoid accumulation and production in plants and other organisms 失效
标题翻译：类胡萝卜素相关蛋白可用于植物和其他生物体中高类胡萝卜素积累和产生
公开(公告)号：US06551793B1
公开(公告)日：2003-04-22
申请号：US09326806
申请日：1999-06-04
申请人： Alexander Vainstein , Michael Vishnevetsky , Marianna Ovadis , Hanan Itzhaki
发明人： Alexander Vainstein , Michael Vishnevetsky , Marianna Ovadis , Hanan Itzhaki
IPC分类号： C12P2300
CPC分类号： C12N15/8237 , C07K14/415 , C12N15/823 , C12N15/8238 , C12N15/825
摘要： A method for production of high amounts of carotenoids in plants, bacteria or cells. Carotenoid-associated proteins CHRC and CHRD isolated from corollas of Cucumis sativus, chrc gene, CHRC deduced sequence, the molecular cloning, cDNA and RNA. A new CHRC promoter able to direct expression for foreign genes. The cloned promoter comprising approximately 3.5 Kb of the CHRC upstream region.
摘要翻译：用于在植物，细菌或细胞中产生大量类胡萝卜素的方法。从Cucumis sativus，chrc基因，CHRC推导序列，分子克隆，cDNA和RNA的花冠分离的类胡萝卜素相关蛋白CHRC和CHRD。一个能够引导外源基因表达的新型CHRC启动子。克隆的启动子包含约3.5Kb的CHRC上游区。

3. 发明授权

US07101706B1 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase 失效
标题翻译：编码的多核苷酸和多肽与乙酰肝素酶远距离同源
公开(公告)号：US07101706B1
公开(公告)日：2006-09-05
申请号：US09959643
申请日：2000-06-19
申请人： Iris Pecker , Israel Michal , Hanan Itzhaki
发明人： Iris Pecker , Israel Michal , Hanan Itzhaki
IPC分类号： C12N5/00 , C12N15/63 , C70H21/02 , C07H21/04
CPC分类号： C12Y302/01166 , C12N9/2402
摘要： The present invention relates to novel polynucleotides encoding polypeptides homologous to heparanase, nucleic acid constructs including these novel polynucleotides, genetically modified cells expressing the same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotides, analogs thereof and ribozymes derived from these polynucleotides.
摘要翻译：本发明涉及编码与乙酰肝素酶同源的多肽的新型多核苷酸，包含这些新型多核苷酸的核酸构建体，表达该多核苷酸的经遗传修饰的细胞，由此编码的重组蛋白质，其可具有乙酰肝素酶或其他糖基水解酶活性，识别重组蛋白的抗体，寡核苷酸，其类似物和衍生自这些多核苷酸的核酶。

4. 发明申请

US20090305898A1 Methods and Compositions for Identifying a Peptide Having an Intermolecular Interaction With a Target of Interest 审中-公开
标题翻译：用于识别与感兴趣的目标具有分子间相互作用的肽的方法和组合物
公开(公告)号：US20090305898A1
公开(公告)日：2009-12-10
申请号：US11989203
申请日：2006-07-12
申请人： Ilan Morad , Hanan Itzhaki
发明人： Ilan Morad , Hanan Itzhaki
IPC分类号： C40B20/00 , C40B40/10 , C40B40/06 , C40B40/02 , C12N7/00 , C12N15/63 , C12N1/00 , C12N9/48
CPC分类号： C12N15/1037 , C07K2319/50 , C07K2319/70 , C12N15/1058 , C40B10/00 , C40B40/02 , G01N33/5023 , G01N33/56983 , G01N2333/95
摘要： This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest. The invention further provides uses thereof, including a method for identifying a peptide which has an intermolecular interaction with a target of interest or identifying the agonistic or antagonistic feature of a peptide that has an intermolecular reaction with a target of interest.
摘要翻译：本发明在一个实施方案中提供了重组病毒或重组病毒文库，其中每个病毒包含参与病毒附着或感染的蛋白质，多肽与文库中的另一个肽或多肽至少单个氨基酸不同，以及与肽和蛋白质接近的修饰的切割位点，其中修饰切割位点使得介导切割的化合物与未修饰的切割位点相比具有降低的结合亲和力。本发明进一步提供了包含蛋白酶，涉及分子间相互作用的目标靶标的蛋白酶，以及附着蛋白酶和感兴趣靶标的柔性连接物的目标复合物。本发明进一步提供其用途，包括鉴定与感兴趣的靶标具有分子间相互作用的肽或识别与感兴趣的靶标具有分子间反应的肽的激动或拮抗特征的方法。

5. 发明申请

US20050070000A1 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase 审中-公开
标题翻译：编码的多核苷酸和多肽与乙酰肝素酶远距离同源
公开(公告)号：US20050070000A1
公开(公告)日：2005-03-31
申请号：US10938661
申请日：2004-09-13
申请人： Iris Pecker , Israel Michal , Hanan Itzhaki
发明人： Iris Pecker , Israel Michal , Hanan Itzhaki
IPC分类号： C12N9/24 , C07H21/04 , C12N9/02
CPC分类号： C12Y302/01166 , C12N9/2402
摘要： Novel polynucleotides encoding polypeptides distantly homologous to heparanase, nucleic acid constructs including the polynucleotides, genetically modified cells expressing same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotide's and oligonucleotide analogs derived from the polynucleotides and ribozymes including same.
摘要翻译：编码与乙酰肝素酶远距离同源的多肽的新型多核苷酸，包含多核苷酸的核酸构建体，表达其的经遗传修饰的细胞，由此编码的重组蛋白，可能具有乙酰肝素酶或其他糖基水解酶活性的抗体，识别重组蛋白的抗体，衍生自多核苷酸和包含其的核酶。

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