专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4379922A Cepham compounds 失效
标题翻译： Cepham化合物
公开(公告)号：US4379922A
公开(公告)日：1983-04-12
申请号：US213217
申请日：1980-12-05
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14
CPC分类号： C07D317/30 , C07D319/06
摘要： This invention relates to new compounds comprising alkoxyimino dioxy butyric acid cepham derivatives, useful as intermediates in the production of antimicrobial agents.
摘要翻译：本发明涉及包含烷氧基亚氨基二氧基丁酸头孢类衍生物的新化合物，其可用作生产抗微生物剂的中间体。

2. 发明授权

US4729991A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4729991A
公开(公告)日：1988-03-08
申请号：US423183
申请日：1982-09-24
申请人： Ikuo Ueda , Masakazu Kobayashi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Masakazu Kobayashi , Tadashi Kitaguchi
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D277/20 , C07D501/04 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36
CPC分类号： C07D277/587
摘要： The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is halogen,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, lower alkyl or lower alkoxy,R.sup.5 is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxymethyl or unsaturated heterocyclicthiomethyl in which the heterocyclic moiety may be substituted with lower alkyl or lower alkenyl, andR.sup.6 is carboxy or functionally modified carboxy, and its pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有下式的高抗微生物活性的新型头孢烯化合物：其中R1是氨基或被保护的氨基，R2是卤素，R3是氢或低级烷基，R4是氢，低级烷基或低级烷氧基，R5是氢卤素，低级烷基，低级烷氧基，羟甲基或不饱和杂环硫甲基，其中杂环部分可被低级烷基或低级链烯基取代，R6为羧基或官能改性羧基，及其药学上可接受的盐。

3. 发明授权

US4518774A 3-Cephem intermediates 失效
标题翻译： 3-Cephem中间体
公开(公告)号：US4518774A
公开(公告)日：1985-05-21
申请号：US411312
申请日：1982-08-25
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14 , C07D501/20 , A61K31/545
CPC分类号： C07D317/30 , C07D319/06
摘要： The invention relates to new compounds comprising alkoxyimino dioxy butyric acid cephem derivatives of high antimicrobial activity.

4. 发明授权

US4594446A 2-alkoxyimino-3,3-dialkoxy-butyrates and derivatives 失效
标题翻译： 2-烷氧基亚氨基-3,3-二烷氧基 - 丁酸酯及其衍生物
公开(公告)号：US4594446A
公开(公告)日：1986-06-10
申请号：US690989
申请日：1985-01-14
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14 , C07D501/20 , C07C131/00 , C07D317/14 , C07D321/00 , C07F7/04
CPC分类号： C07D317/30 , C07D319/06
摘要： The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.

5. 发明授权

US4703046A Cephem compounds and processes for preparation thereof 失效
标题翻译：头孢烯化合物及其制备方法
公开(公告)号：US4703046A
公开(公告)日：1987-10-27
申请号：US72990
申请日：1979-09-06
申请人： Ikuo Ueda , Masakazu Kobayashi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Masakazu Kobayashi , Tadashi Kitaguchi
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D277/20 , C07D501/04 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36
CPC分类号： C07D277/587
摘要： This invention concerns antibiotic cephalosporins of the formula ##STR1## wherein R.sup.1 is amino or protected amino; R.sup.2 is halogen; R.sup.3 is alkyl; and R.sup.6 is carboxy or protected carboxy.
摘要翻译：本发明涉及式IMA的抗生素头孢菌素，其中R1是氨基或被保护的氨基; R2是卤素; R3是烷基; 并且R 6是羧基或被保护的羧基。

6. 发明授权

US4298529A Alkoxyimino dioxy butyric acid derivatives 失效
标题翻译：烷氧基亚氨基二氧代丁酸衍生物
公开(公告)号：US4298529A
公开(公告)日：1981-11-03
申请号：US101527
申请日：1979-12-10
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14 , C07D501/20 , C07D317/28
CPC分类号： C07D317/30 , C07D319/06
摘要： The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.
摘要翻译：本发明涉及新的抗微生物活性3-头孢烯化合物，制备这种化合物的方法，包括可用于所述方法的烷氧基亚氨基二氧基丁酸衍生物的新中间体化合物，以及所述中间体的制备方法。

7. 发明授权

US4327093A 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
标题翻译： 3,7-二取代-2或3-头孢烯-4-羧酸化合物
公开(公告)号：US4327093A
公开(公告)日：1982-04-27
申请号：US85684
申请日：1979-10-17
申请人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
发明人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/30 , C07D501/34 , C07D501/38 , C07D501/60
CPC分类号： C07D501/14
摘要： 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is acylamino or ar(lower)alkylamino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; --N--R.sup.3, R.sup.4 is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower) alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S-- or ##STR2## and pharmaceutically acceptable salts thereof. The present compounds are useful for the treatment of infectious diseases in animals and human beings.
摘要翻译： 3,7-二取代的2-或3-头孢烯-4-羧酸化合物，其结构式如下：其中R 1是酰氨基或芳（低级）烷基氨基; R2是被药学上可接受的基团保护的羧基或羧基; -N-R3，R4是二（低级）烷基氨基（低级）烷基氨基，含有1-4个氮原子的不饱和或饱和的3至8元杂单环（低级）烷基氨基，不饱和或饱和的3至8元杂单环（低级）由低级烷基或羟基（低级）烷基取代的含有1至4个氮原子的烷基氨基，含2-4个氮原子的不饱和或饱和5至6元杂单环基团，含有2至4个不饱和或饱和的5至6元杂单环基团被低级烷基或羟基（低级）烷基或羟基哌啶子基取代的氮原子，X是-S-或其药学上可接受的盐。本发明化合物可用于治疗动物和人类的感染性疾病。

8. 发明授权

US5102985A Process for the formation of intramolecular disulfide bridge in a polypeptide 失效
标题翻译：在多糖中形成分子间桥的方法
公开(公告)号：US5102985A
公开(公告)日：1992-04-07
申请号：US417323
申请日：1989-10-04
申请人： Mineo Niwa , Masakazu Kobayashi , Yoshinori Ishii , Ikuo Ueda
发明人： Mineo Niwa , Masakazu Kobayashi , Yoshinori Ishii , Ikuo Ueda
IPC分类号： C07K1/02 , C07K1/00 , C07K1/113 , C07K1/12 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/54 , C07K14/55 , C07K14/575 , C07K14/58 , C07K14/655
CPC分类号： C07K1/12
摘要： The cysteine-containing polypeptide is oxidized with hydrogen peroxide to produce the biologically active polypeptide having the intramolecular disulfide bridge.

9. 发明授权

US4399278A 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
标题翻译： 3,7-二取代-2或3-头孢烯-4-羧酸化合物
公开(公告)号：US4399278A
公开(公告)日：1983-08-16
申请号：US353000
申请日：1982-02-26
申请人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
发明人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/30 , C07D501/34 , C07D501/38 , C07D501/60
CPC分类号： C07D501/14
摘要： 7-Amino-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is amino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; ##STR2## is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic(lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic(lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl orhydroxy(lower)alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S or ##STR3## and pharmaceutically acceptable salts thereof.

10. 发明授权

US4354022A Process for preparing 3-methylenecepham compounds or a salt thereof 失效
标题翻译：制备3-亚甲基头孢烯化合物或其盐的方法
公开(公告)号：US4354022A
公开(公告)日：1982-10-12
申请号：US270876
申请日：1981-06-05
申请人： Takao Takaya , Takashi Masugi , Toshiyuki Chiba , Akiteru Yoshioka , Masayuki Kato , Ikuo Ueda , Masakazu Kobayashi
发明人： Takao Takaya , Takashi Masugi , Toshiyuki Chiba , Akiteru Yoshioka , Masayuki Kato , Ikuo Ueda , Masakazu Kobayashi
IPC分类号： C07D501/04
CPC分类号： C07D501/04
摘要： A new process for preparing 3-methylenecepham compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group, andR.sup.2 is a carboxy or a protected carboxy group,or a salt thereof,which comprises reducing a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, andR.sup.3 is halogen or heterocyclicthio which may have suitable sutstituent, or a salt thereof, with a combination of a metal selected from the group consisting of zinc, tin and iron, and an ammonium salt of an acid selected from the group consisting of ammonium halide, ammonium carbonate and ammonium acetate, said 3-methylenecepham compounds being useful as intermediates for preparing antimicrobially active 3-cephem compounds.
摘要翻译：一种制备下式的3-亚甲基头孢烯化合物的新方法：其中R1为氨基或被保护的氨基，R2为羧基或被保护的羧基，或其盐，其包括将式：其中R 1和R 2各自如上所定义，并且R 3是可以具有合适取代基的卤素或杂环硫基，或其盐与选自锌，锡和铁的金属的组合，和选自卤化铵，碳酸铵和乙酸铵的酸的铵盐，所述3-亚甲基头孢烯化合物可用作制备抗微生物活性3-头孢烯化合物的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式