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1. 发明公开

EP3121292A1 AUTOMATED METHOD FOR DETECTING CANCERS AND HIGH GRADE HYPERPLASIAS 无效
标题翻译： VERFAHREN ZUR ERKENNUNG VON KREBSEN UND HOCHGRADIGER HYPERPLASIE
公开(公告)号：EP3121292A1
公开(公告)日：2017-01-25
申请号：EP16163237.7
申请日：2009-11-03
申请人： Ikonisys, Inc.
发明人： TAFAS, Triantafyllos , TSIPOURAS, Petros , KILPATRICK, Michael , SARKIS, Gary
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6841
摘要： An automated method of screening for cervical cancer cells, comprising the steps of:
(a) obtaining a slide containing a fluid biological sample comprising nuclei from a subject, said biological sample having been contacted with a first nuclear centromeric probe bearing a first detectable label directed either to chromosome 3 or chromosome 7, and a second nuclear non-centromeric probe bearing a second detectable label directed to single copy sequences on the q arm of chromosome 3 wherein said single copy sequences comprise a contiguous sequence of four overlapping BAC clones containing at least a portion of the TERC gene at chromosomal location 3q26, and counterstained with DAPI, wherein said first and second probes are contacted under conditions that promote hybridization of each said first and second probe to the respective chromosomal loci;
(b) searching said slide for DAPI stained areas within said biological sample;
(c) searching said DAPI stained areas for the presence of label of said first nuclear centromeric probe and label of said second nuclear non-centromeric probe;
(d) quantitatively determining the number of said first nuclear centromeric probe and second nuclear non-centromeric probe per nucleus in each DAPI stained area within said biological sample;
(e) designating the biological sample as comprising a potential for progression to high hyperplasia and invasive cervical cancer when the number of said first probe per nucleus within the DAPI is about 2 per nucleus and the number of said second nuclear non-centromeric probe per nucleus within the DAPI stained area is equal to or greater than 4.
摘要翻译：一种筛选宫颈癌细胞的自动化方法，包括以下步骤：（a）获得包含含有来自受试者的核的流体生物样品的载玻片，所述生物样品已经与带有第一可检测标记的第一核着丝粒探针接触或者染色体3或染色体7，以及携带针对染色体3的q臂上的单拷贝序列的第二可检测标记的第二核非着丝粒探针，其中所述单拷贝序列包含至少含有四个重叠BAC克隆的连续序列在染色体位置3q26处的TERC基因的一部分，并用DAPI复染色，其中所述第一和第二探针在促进每个所述第一和第二探针与相应染色体基因座杂交的条件下接触; （b）在所述生物样品中搜索所述载玻片上的DAPI染色区域; （c）搜索所述DAPI染色区域存在所述第一核着丝粒探针的标记和所述第二核非着丝粒探针的标记; （d）定量测定所述生物样品中每个DAPI染色区域中每个核的所述第一核着丝粒探针和第二核无着丝粒探针的数目; （e）当DAPI内的每个核上的所述第一个探针的数量为每个细胞核约2个，每个细胞核的所述第二个核非着丝粒探针的数目为多个时，指定生物样品包括进展为高增生和侵袭性宫颈癌的可能性在DAPI染色区域内等于或大于4。

2. 发明公开

EP2078030A2 AUTOMATED DETECTION OF CANCER AND HIGH GRADE HYPERPLASIAS 审中-公开
标题翻译：自动化检测癌症和高档增生
公开(公告)号：EP2078030A2
公开(公告)日：2009-07-15
申请号：EP07871241.1
申请日：2007-10-25
申请人： Ikonisys, Inc.
发明人： TAFAS, Triantafyllos P. , TSIPOURAS, Petros , KILPATRICK, Michael , SARKIS, Gary
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6841 , G01N21/6428 , G01N21/6458 , G01N33/57496 , G01N2021/6421 , G01N2021/6439 , G02B21/0004 , G02B21/16
摘要： Automated methods for detecting cancer and related hyperplasias in biological samples.

3. 发明申请

WO2008070333A2 AUTOMATED DETECTION OF CANCER AND HIGH GRADE HYPERPLASIAS 审中-公开
标题翻译：自动检测癌症和高级别超级乳腺癌
公开(公告)号：WO2008070333A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/082540
申请日：2007-10-25
申请人： IKONISYS, INC. , TAFAS, Triantafyllos, P. , TSIPOURAS, Petros , KILPATRICK, Michael , SARKIS, Gary
发明人： TAFAS, Triantafyllos, P. , TSIPOURAS, Petros , KILPATRICK, Michael , SARKIS, Gary
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , G01N21/6428 , G01N21/6458 , G01N33/57496 , G01N2021/6421 , G01N2021/6439 , G02B21/0004 , G02B21/16
摘要： Automated methods for detecting cancer and related hyperplasias in biological samples.
摘要翻译：用于检测生物样品中癌症和相关增生的自动化方法。

4. 发明申请

WO2002074055A2 SYSTEM AND METHOD FOR INCREASING THE CONTRAST OF AN IMAGE PRODUCED BY AN EPIFLUORESCENCE MICROSCOPE 审中-公开
标题翻译：用于增加由差异显微镜产生的图像的对比度的系统和方法
公开(公告)号：WO2002074055A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/008646
申请日：2002-03-19
申请人： IKONISYS, INC.
发明人： TAFAS, Triantafyllos , TSIPOURAS, Petros
IPC分类号： G02B21/16 , G02B21/34
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.
摘要翻译：通过在荧光显微镜下产生的图像的对比可以通过在样品后面放置高通二向色反射膜来增加。反射膜通过物镜反射由样品中的荧光标签发出的发射光，同时允许较短波长的激发光通过样品保持器。

5. 发明公开

EP2047408A2 METHOD FOR DETECTING FLUORESCENT SIGNALS IN A BIOLOGICAL SAMPLE 审中-公开
标题翻译： VERFAHREN ZUR ERKENNUNG VON FLUORESZENZSIGNALEN IN BIOLOGISCHEN PROBEN
公开(公告)号：EP2047408A2
公开(公告)日：2009-04-15
申请号：EP07813777.5
申请日：2007-08-03
申请人： Ikonisys, Inc.
发明人： KIM, Young Min , ZHU, Yanning , AGARWAL, Yash , WANG, Xiuzhong , ARMSTRONG, Aaron , BORGERDING, Robert , MACGINITIE, Andrew , SEPPO, Antti , ICHETOVKIN, Ilia , KILPATRICK, Michael , TSIPOURAS, Petros , TAFAS, Triantafyllos
IPC分类号： G06K9/00 , G01N33/20 , G01N23/00 , C12Q1/64 , G01N33/48 , G21K7/00
CPC分类号： G01N35/00732 , G01J3/2803 , G01J3/4406 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00851 , G01N2201/06113 , G01N2201/12
摘要： Optical means for automatic microscopic (15) detection and analysis (30) of fluorescent signals (29) from a treated biological sample.
摘要翻译：一种用于自动显微镜分析的方法，其中从每个显微镜载片上的可询问数据获得测试方案。该方法还包括实现测试协议的算法。

6. 发明公开

EP1240535A1 COMPOSING MICROSCOPE 审中-公开
标题翻译：汇编显微镜的
公开(公告)号：EP1240535A1
公开(公告)日：2002-09-18
申请号：EP00979183.1
申请日：2000-11-16
申请人： Ikonisys, Inc.
发明人： TSIPOURAS, Petros , TAFAS, Triantafyllos
IPC分类号： G02B6/06 , G02B27/00
CPC分类号： G02B26/105 , G02B6/06 , G02B21/002 , G02B21/361 , G02B21/364
摘要： A composing microscope for scanning a large area of a specimen (240) in a minimal amount of time comprises an optical sensor (230) and a plurality of optical projecting systems (210) arranged adjacent to each other in rows. Each of the optical projecting systems (210) has a first end for acquiring an image at one location of the specimen (240) and a second end. An optical reflector (220) moveable with respect to the second ends of the optical projecting systems (210) receives the images from a row of the optical projecting systems (210) at the second ends and projects the images on the optical sensor (230). The optical sensor (230) simultaneously digitizes the images. An image acquisition device simultaneously receives and stores the digitized images with information about their locations on the specimen (240).

7. 发明申请

WO2007106838A2 A NON-INVASIVE METHOD FOR DIAGNOSING FETAL CELLS AND CANCER CELLS 审中-公开
标题翻译：用于诊断子宫细胞和癌细胞的非侵入性方法
公开(公告)号：WO2007106838A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/063928
申请日：2007-03-13
申请人： IKONISYS, INC. , TAFAS, Triantafyllos, P. , KILPATRICK, Michael , TSIPOURAS, Petros
发明人： TAFAS, Triantafyllos, P. , KILPATRICK, Michael , TSIPOURAS, Petros
IPC分类号： C12Q1/68 , G01N33/567 , G06T7/40 , G06F19/00
CPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q1/6886 , G06T7/0012 , G06T2207/30024 , C12Q2563/107
摘要： A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.
摘要翻译：提供了用于确定胎儿的发育年龄或检测样品中的癌细胞的非侵入性方法。该方法使用例如来自孕妇和端粒核酸探针的血液样品。

8. 发明申请

WO2002098280A2 METHOD FOR DETECTING INFECTIOUS AGENTS USING COMPUTER CONTROLLED AUTOMATED IMAGE ANALYSIS 审中-公开
标题翻译：使用计算机控制自动图像分析检测感染性代理的方法
公开(公告)号：WO2002098280A2
公开(公告)日：2002-12-12
申请号：PCT/US2002/017586
申请日：2002-06-04
申请人： IKONISYS INC. , TAFAS, Triantafyllos , KILPATRICK, Michael , TSIPOURAS, Petros
发明人： TAFAS, Triantafyllos , KILPATRICK, Michael , TSIPOURAS, Petros
IPC分类号： A61B
CPC分类号： G06K9/00147 , C12Q1/04 , G01N15/1475 , G06K9/00127 , G06T7/0012 , G06T2207/30024
摘要： Computer controlled methods, systems and apparatus for detecting an infectious agent in a host cell, an animal cell, or plant cell, a body fluid or tissue sample to provide information useful to diagnose a disease or prognosticate disease susceptibility, extent or outcome are provided. In one illustrative embodiment, the infected animal cell is a Chlamydia infected mononuclear phagocyte in a blood sample. In another illustrative embodiment, the infected body fluid is a blood sample infected with "fee floating" Chlamydia . Detection and preferably, quantification of such an infected mononuclear phagocyte(s) or blood sample provides information useful in diagnosing or prognosticating susceptibility, extent or outcome of patients suspected of suffering from vascular, coronary or central nervous disease(s) or disorder(s).
摘要翻译：提供了用于检测宿主细胞，动物细胞或植物细胞，体液或组织样本中的感染剂的计算机控制方法，系统和装置，以提供用于诊断疾病或预测疾病易感性，程度或结果的信息。在一个说明性实施方案中，感染的动物细胞是血液样品中衣原体感染的单核吞噬细胞。在另一个说明性实施例中，感染的体液是感染“费用漂浮”衣原体的血液样本。检测并优选地定量这种受感染的单核吞噬细胞或血液样品提供了可用于诊断或预测怀疑患有血管，冠状动脉或中枢神经疾病或病症的患者的易感性，程度或结果的信息，。

9. 发明申请

WO2008019324A2 METHOD FOR DETECTING FLUORESCENT SIGNALS IN A BIOLOGICAL SAMPLE 审中-公开
标题翻译：在生物样品中检测荧光信号的方法
公开(公告)号：WO2008019324A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/075210
申请日：2007-08-03
申请人： IKONISYS, INC. , KIM, Young Min , ZHU, Yanning , AGARWAL, Yash , WANG, Xiuzhong , ARMSTRONG, Aaron , BORGERDING, Robert , MACGINITIE, Andrew , SEPPO, Antti , ICHETOVKIN, Ilia , KILPATRICK, Michael , TSIPOURAS, Petros , TAFAS, Triantafyllos
发明人： KIM, Young Min , ZHU, Yanning , AGARWAL, Yash , WANG, Xiuzhong , ARMSTRONG, Aaron , BORGERDING, Robert , MACGINITIE, Andrew , SEPPO, Antti , ICHETOVKIN, Ilia , KILPATRICK, Michael , TSIPOURAS, Petros , TAFAS, Triantafyllos
IPC分类号： G01N21/00
CPC分类号： G01N35/00732 , G01J3/2803 , G01J3/4406 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00851 , G01N2201/06113 , G01N2201/12
摘要： Optical means for automatic microscopic detection and analysis of fluorescent signals from a treated biological sample.
摘要翻译：用于自动显微检测和分析来自经处理的生物样品的荧光信号的光学装置。

10. 发明申请

WO2008019311A2 AUTOMATED CASSETTE AND SLIDE HANDLING SYSTEM FOR AN AUTOMATIC MICROSCOPE 审中-公开
标题翻译：用于自动显微镜的自动暗盒和幻灯片处理系统
公开(公告)号：WO2008019311A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/075170
申请日：2007-08-03
申请人： IKONISYS, INC. , VIRAG, Tibor , AGARWAL, Yash , GUO, Wei , EBERLE, Richard , KIM, Young Min , KILPATRICK, Michael , TSIPOURAS, Petros , TAFAS, Triantafyllos
发明人： VIRAG, Tibor , AGARWAL, Yash , GUO, Wei , EBERLE, Richard , KIM, Young Min , KILPATRICK, Michael , TSIPOURAS, Petros , TAFAS, Triantafyllos
IPC分类号： G02B21/34
CPC分类号： G02B21/34 , G01N35/026 , G01N35/04 , G01N2035/0425 , G01N2035/0427 , Y10S359/90
摘要： An automated cassette and slide handling system is disclosed which organizes microscope slides in cassettes, automatically and sequentially removes individual slides from their respective cassesttes, positioned each slide under the microscope as provided by the protocol, and after examination returns the slide to its proper cassette.
摘要翻译：公开了一种自动化的盒和载玻片处理系统，其组织盒中的显微镜载玻片，从其相应的盒中自动并顺序地移除单个载玻片，将每个载玻片定位在方案提供的显微镜下，并在检查后将幻灯片放回正确的卡带。

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