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1. 发明公开

EP2844774A1 DNA SEQUENCING 有权转让
标题翻译： DNA测序
公开(公告)号：EP2844774A1
公开(公告)日：2015-03-11
申请号：EP13785056.6
申请日：2013-05-02
申请人： Ibis Biosciences, Inc. , Eshoo, Mark W.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2537/165 , C12Q2563/107
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, and systems for sequencing a nucleic acid using two or more labels and signal ratios to distinguish bases.
摘要翻译：本文提供了与核酸测序相关的技术，并且具体地但不排他地涉及用于使用两个或更多个标记和信号比率来区分碱基来测序核酸的方法，组合物和系统。

2. 发明申请

WO2013101935A1 BIOAGENT DETECTION OLIGONUCLEOTIDES 审中-公开
标题翻译：生物检测寡核苷酸
公开(公告)号：WO2013101935A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/071830
申请日：2012-12-27
申请人： IBIS BIOSCIENCES, INC. , ECKER, David J. , HOFSTADLER, Steven A. , SAMPATH, Rangarajan , BLYN, Lawrence B. , HALL, Thomas A. , ESHOO, Mark W.
发明人： ECKER, David J. , HOFSTADLER, Steven A. , SAMPATH, Rangarajan , BLYN, Lawrence B. , HALL, Thomas A. , ESHOO, Mark W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6853 , C12Q1/686 , C12Q2600/158
摘要： The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
摘要翻译：在污染性非细菌DNA存在下鉴定，检测和/或定量细菌DNA的本发明组合物，方法和系统。特别地，本发明提供了在绝大多数污染的人DNA存在的情况下检测相对少量的细菌DNA的寡核苷酸。

3. 发明申请

WO2012100194A1 MICROFLUIDIC TRANSDUCER 审中-公开
标题翻译：微流量传感器
公开(公告)号：WO2012100194A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/022077
申请日：2012-01-20
申请人： IBIS BIOSCIENCES, INC. , ESHOO, Mark W. , GUTIERREZ, Jose R. , DRADER, Jared J. , PICURI, John , CABRERA, Karl M. , MOTLEY, Stanley
发明人： ESHOO, Mark W. , GUTIERREZ, Jose R. , DRADER, Jared J. , PICURI, John , CABRERA, Karl M. , MOTLEY, Stanley
IPC分类号： C12N13/00 , C12M1/33
CPC分类号： G01N1/31 , B01L3/502715 , B01L2200/027 , B01L2300/06 , B01L2300/0816 , C12M47/06 , C12N1/066 , C12N13/00 , C12Q1/6806 , G01N1/30 , Y10T436/25
摘要： Methods and apparatus for fragmenting nucleic acids or disrupting cells in a disposable microfluidic device are disclosed. The apparatus is designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells.
摘要翻译：公开了在一次性微流体装置中分裂核酸或破坏细胞的方法和装置。该设备被设计成将样品定位成与向发射超声波频率的高频振动元件直接接触，使得转换到样品中的振动能量导致碎裂的核酸或破坏细胞。

4. 发明申请

WO2008151023A2 METHODS AND COMPOSITIONS FOR MULTIPLE DISPLACEMENT AMPLIFICATION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于多重位移放大核酸的方法和组合物
公开(公告)号：WO2008151023A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065332
申请日：2008-05-30
申请人： IBIS BIOSCIENCES, INC. , DUNCAN, David A. , ESHOO, Mark W.
发明人： DUNCAN, David A. , ESHOO, Mark W.
IPC分类号： C12Q1/68 , C12N15/09 , C07H21/00
CPC分类号： C12Q1/6846 , C12Q2531/119 , C12Q2527/125 , C12Q2525/101
摘要： Disclosed are methods for multiple displacement amplification of a nucleic acid sequence in a sample. The nucleic acid is contacted with a reaction mixture that includes a set of oligonucleotide primers and a plurality of polymerase enzymes. The reaction mixture is subjected to conditions under which the nucleic acid sequence is amplified to produce an amplification product in a multiple displacement amplification reaction. Also disclosed are kits containing a set of oligonucleotide primers with random sequences having lengths of 6 to 8 nucleobases. At least some of the individual members of the primers have one or more ribose modifications that stabilize or lock the ribose ring in a 3' -endo conformation. At least some of the primers have one or more universal nucleobases.
摘要翻译：公开了用于样品中核酸序列的多重位移扩增的方法。核酸与包含一组寡核苷酸引物和多个聚合酶的反应混合物接触。使反应混合物经受在多位置扩增反应中扩增核酸序列产生扩增产物的条件。还公开了包含一组具有长度为6至8个核碱基的随机序列的寡核苷酸引物的试剂盒。引物的至少一些单独成员具有一个或多个核糖修饰，其稳定或锁定3'内质网构型中的核糖环。至少一些引物具有一个或多个通用核碱基。

5. 发明申请

WO2014159631A1 SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS 审中-公开
标题翻译：用于分离核酸的系统和方法
公开(公告)号：WO2014159631A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/024504
申请日：2014-03-12
申请人： IBIS BIOSCIENCES, INC. , ESHOO, Mark W.
发明人： ESHOO, Mark W.
IPC分类号： A61K48/00 , C12Q1/68
CPC分类号： C12N15/1006 , C12Q1/6806
摘要： The present disclosure relates to systems and methods for nucleic acid isolation. In particular, the present disclosure provides systems and methods for purifying nucleic acids for downstream applications.
摘要翻译：本公开涉及用于核酸分离的系统和方法。特别地，本公开提供用于纯化用于下游应用的核酸的系统和方法。

6. 发明申请

WO2013166303A1 DNA SEQUENCING 审中-公开
标题翻译： DNA序列
公开(公告)号：WO2013166303A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039295
申请日：2013-05-02
申请人： IBIS BIOSCIENCES, INC. , ESHOO, Mark W.
发明人： ESHOO, Mark W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2525/101 , C12Q2525/185 , C12Q2563/107
摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, systems, and kits for sequencing a nucleic acid using a degenerate two-base code. Particular embodiments provide: 1) that the two-base degenerate code relates a first element to a base comprising adenine (A) or guanine (G) and a second element to a base comprising cytosine (C) or thymine (T); 2) that the two-base degenerate code relates a first element to a base comprising A or C and a second element to a base comprising G or T; and 3) that the two-base degenerate code relates a first element to a base comprising G or C and a second element to a base comprising A or T.
摘要翻译：本文提供了与测序核酸有关的技术，特别但并非排他地涉及使用简并二碱基编码对核酸进行测序的方法，组合物，系统和试剂盒。具体实施方案提供：1）所述双碱基简并代码将第一元件与包含腺嘌呤（A）或鸟嘌呤（G）的碱和第二元素连接至包含胞嘧啶（C）或胸腺嘧啶（T）的碱; 2）两碱性简并代码将第一元素与包含A或C的碱和第二元素相关联到包含G或T的碱; 和3）两碱性简并代码将第一元素与包含G或C的碱和第二元素相关联到包含A或T的碱。

7. 发明申请

WO2013102091A1 NUCLEIC ACID LIGATION SYSTEMS AND METHODS 审中-公开
标题翻译：核酸配位体系及方法
公开(公告)号：WO2013102091A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/072089
申请日：2012-12-28
申请人： IBIS BIOSCIENCES, INC. , ESHOO, Mark W. , PICURI, John , MOTLEY, Stanley , PHILLIPSON, Curtis
发明人： ESHOO, Mark W. , PICURI, John , MOTLEY, Stanley , PHILLIPSON, Curtis
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6855 , C12N15/10 , C12N15/11 , C12N15/66 , C12P19/34 , C12Q1/6869 , C12Q2525/191 , C12Q2525/301 , C12Q2537/143
摘要： The present disclosure relates to systems and methods for nucleic acid ligation. In particular, the present disclosure provides oligonucleotide adaptors for use in nucleic acid ligation reactions.
摘要翻译：本公开涉及用于核酸连接的系统和方法。特别地，本公开提供用于核酸连接反应的寡核苷酸衔接子。

8. 发明申请

WO2013096798A2 AMPLIFICATION OF A SEQUENCE FROM A RIBONUCLEIC ACID 审中-公开
标题翻译：核糖核酸序列的扩增
公开(公告)号：WO2013096798A2
公开(公告)日：2013-06-27
申请号：PCT/US2012/071303
申请日：2012-12-21
申请人： IBIS BIOSCIENCES, INC. , MOTLEY, Stanley , ESHOO, Mark W.
发明人： MOTLEY, Stanley , ESHOO, Mark W.
IPC分类号： C12Q1/70
CPC分类号： C12Q1/70 , C12N15/1096 , C12Q1/6869 , C12Q2531/143 , C12Q2535/122
摘要： The present invention relates to methods and compositions for tagging, amplifying, purifying, and or characterizing of ribonucleic acid (RNA) in a sample. In particular, methods are provided for preparing RNA from a sample for subsequent analysis.
摘要翻译：本发明涉及用于在样品中标记，扩增，纯化和/或表征核糖核酸（RNA）的方法和组合物。特别地，提供了用于从样品制备RNA以进行后续分析的方法。

9. 发明申请

WO2012092433A1 RAPID WHOLE GENOME AMPLIFICATION 审中-公开
标题翻译：快速全基因扩增
公开(公告)号：WO2012092433A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/067739
申请日：2011-12-29
申请人： IBIS BIOSCIENCES, INC. , ESHOO, Mark W. , MOTLEY, Stanley , PICURI, John
发明人： ESHOO, Mark W. , MOTLEY, Stanley , PICURI, John
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , C12P19/34 , C12Q1/6846 , C12Q2521/525 , C12Q2525/179 , C12Q2527/125
摘要： The present invention provides compositions and methods for rapidly amplifying target nucleic acid (e.g., using whole genome amplification) that allows small amounts of starting nucleic acid to be employed. In certain embodiments, the methods employ compositions that comprise: phi29 polymerase, exo- Klenow polymerase and/or Klenow polymerase, dNTPs, primers, and a buffering agent. In some embodiments, the target nucleic acid is amplified at a rate that would result in at least 1000-fold amplification in thirty minutes.
摘要翻译：本发明提供用于快速扩增允许使用少量起始核酸的靶核酸（例如，使用全基因组扩增）的组合物和方法。在某些实施方案中，所述方法使用包含以下的组合物：phi29聚合酶，ex-Klenow聚合酶和/或Klenow聚合酶，dNTP，引物和缓冲剂。在一些实施方案中，以在30分钟内至少产生1000倍扩增的速率扩增靶核酸。

10. 发明申请

WO2013102093A1 MULTIPLE- ANALYTE ASSAY DEVICE AND SYSTEM 审中-公开
标题翻译：多分析仪器和系统
公开(公告)号：WO2013102093A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/072091
申请日：2012-12-28
申请人： IBIS BIOSCIENCES, INC. , ESHOO, Mark W. , PICURI, John
发明人： ESHOO, Mark W. , PICURI, John
IPC分类号： C12M1/34 , C12Q1/00 , G01N33/487
CPC分类号： B01L3/502769 , B01L7/00 , B01L2200/06 , B01L2200/10 , G01N33/54366 , G01N2035/00158
摘要： Provided herein are systems and methods for performing complex chemical, physical and biological assays. In particular, provided herein are systems and methods for performing microfluidic assays.
摘要翻译：本文提供了用于进行复杂化学，物理和生物测定的系统和方法。特别地，本文提供了用于进行微流体测定的系统和方法。

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