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1. 发明申请

US20070077639A1 Estimation of activity or inhibition of processes involved in nucleic acid modification using chemiluminescence quenching 审中-公开
标题翻译：使用化学发光淬灭估计涉及核酸修饰的过程的活性或抑制
公开(公告)号：US20070077639A1
公开(公告)日：2007-04-05
申请号：US10570176
申请日：2004-08-26
申请人： Ian Weeks , Richard Brown , Andrew Morby , Colin Berry
发明人： Ian Weeks , Richard Brown , Andrew Morby , Colin Berry
IPC分类号： C12N9/94
CPC分类号： C12Q1/44 , C12Q1/25 , C12Q1/6818 , G01N33/542 , G01N2333/9015 , G01N2333/922 , C12Q2537/143 , C12Q2525/301
摘要： A method for determining the activity of a substance capable of altering the structure of a nucleic acid molecule from a first to a second state which is based upon the use of labelled nucleic acid molecules and/or complementary oligonucleotides. The label is a chemiluminescent molecule and a corresponding quencher molecule whose optical properties are different depending upon whether the nucleic acid molecule exist in said first or second state.
摘要翻译：一种基于使用标记的核酸分子和/或互补寡核苷酸来确定能够将核酸分子的结构从第一状态改变为第二状态的物质的活性的方法。该标记是化学发光分子和相应的淬灭剂分子，其光学性质根据核酸分子是否存在于所述第一或第二状态而不同。

2. 发明申请

US20050084861A1 Methods of detecting modification of genetic material and monitoring processes thereof 审中-公开
标题翻译：检测遗传物质修饰及其监测过程的方法
公开(公告)号：US20050084861A1
公开(公告)日：2005-04-21
申请号：US10499223
申请日：2002-12-17
申请人： Ian Weeks , Richard Brown , Andrew Morby , Colin Berry
发明人： Ian Weeks , Richard Brown , Andrew Morby , Colin Berry
IPC分类号： G01N33/50 , A61K45/00 , A61P31/04 , A61P31/12 , A61P43/00 , C12N15/09 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/533 , C12Q1/68 , G01N21/77 , G01N21/78 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/58
CPC分类号： G01N33/582 , C12Q1/25
摘要： The invention relates to a method for determining the activity of an enzyme or enediyne capable of altering the structure of a “substrate” nucleic acid from a first to a second state wherein the activity of the enzyme or enedyine is monitored using a chemiluminescent label that is either attached to the “substrate” nucleic acid or an oligonucleotide which is complementary thereto or the enzyme or enediyne product thereof.
摘要翻译：本发明涉及一种用于测定能够将“底物”核酸的结构从第一状态改变为第二状态的酶或烯二炔的活性的方法，其中酶或烯碱基的活性使用化学发光标记或者与“底物”核酸或其互补的寡核苷酸或其酶或烯二炔产物连接。

3. 发明申请

US20140370520A1 METHODS AND COMPOUNDS FOR DETECTING CANCER 审中-公开
标题翻译：检测癌症的方法和化合物
公开(公告)号：US20140370520A1
公开(公告)日：2014-12-18
申请号：US13993554
申请日：2011-12-08
申请人： Ian Weeks , Mohammad Jaffar , Richard Knox
发明人： Ian Weeks , Mohammad Jaffar , Richard Knox
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A61K31/04 , A61K31/122 , A61K31/135 , A61K31/366 , A61K31/404 , C12Q1/32 , G01N33/57407 , G01N33/57484 , G01N33/57496 , G01N2333/90209
摘要： The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): wherein R1, R2, R3, R4, R5 X, Y and z are as defined herein.
摘要翻译：本发明涉及使用通式（I）的化合物诊断癌症，特别是膀胱或前列腺癌的方法：其中R1，R2，R3，R4，R5，X，Y和z如本文所定义。

4. 发明授权

US5756709A Compositions for the simultaneous detection and quantification of multiple specific nucleic acid sequences 失效
标题翻译：用于同时检测和定量多种特异性核酸序列的组合物
公开(公告)号：US5756709A
公开(公告)日：1998-05-26
申请号：US683122
申请日：1996-07-16
申请人： Norman Charles Nelson , James Stuart Woodhead , Ian Weeks , Azzouz Ben Cheikh
发明人： Norman Charles Nelson , James Stuart Woodhead , Ian Weeks , Azzouz Ben Cheikh
IPC分类号： C12N15/09 , C07D219/04 , C07H21/00 , C12Q1/68 , C07H21/04 , C09K3/00 , C12N15/00 , C01N33/00
CPC分类号： C12Q1/6813 , C07D219/04 , C07H21/00 , C12Q1/6816 , Y10S436/805 , Y10S436/826 , Y10T436/143333 , Y10T436/25
摘要： The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The methods may be used in a heterogeneous, homogeneous or non-homogeneous assay system. The invention also relates to specific combinations of chemiluminescent labeling reagents suitable, when coupled to an oligonucleotide probe, for use together in methods for the detection of multiple nucleic acid analytes. The invention also concerns kits useful in these methods.
摘要翻译：本发明涉及使用与不同化学发光标记试剂偶联的寡核苷酸杂交探针在单个培养基中同时或依次检测多种核酸分析物的方法。该方法可以用于异质，均相或非均一的测定系统中。本发明还涉及化学发光标记试剂在与寡核苷酸探针偶联时适用于检测多种核酸分析物的方法中的特定组合。本发明还涉及在这些方法中有用的试剂盒。

5. 发明授权

US06414152B1 Luminescent labelling material and procedures 失效
标题翻译：发光标签材料和程序
公开(公告)号：US06414152B1
公开(公告)日：2002-07-02
申请号：US08328563
申请日：1994-10-24
申请人： Anthony Keith Campbell , James Stuart Woodhead , Ian Weeks
发明人： Anthony Keith Campbell , James Stuart Woodhead , Ian Weeks
IPC分类号： C07D21904
CPC分类号： C07D401/12 , G01N33/533 , G03G15/0898 , G03G15/09
摘要： A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitation of an antigen of interest, by initiation of the luminescent reaction and subsequent measurement of the photonic emission of the immune complex formed during the immunological reaction.
摘要翻译：在免疫测定中用作化学发光标记的化合物包括与N-琥珀酰亚胺基部分连接的芳基吖啶酯。该化合物方便地与单克隆抗体或其它蛋白质连接，并用于双位点免疫测定中，用于定量感兴趣的抗原，通过引发发光反应和随后测量在期间形成的免疫复合物的光子发射免疫反应。

6. 发明授权

US6094865A Shutter handle latch 失效
标题翻译：快门把手锁
公开(公告)号：US6094865A
公开(公告)日：2000-08-01
申请号：US201665
申请日：1998-12-01
申请人： Ian Weeks
发明人： Ian Weeks
IPC分类号： E05B65/00 , E05B65/08 , E05C3/14 , E06B9/17 , E06B9/80 , E06B7/086 , E06B9/56
CPC分类号： E06B9/80 , E05C3/14 , E06B9/17046 , E05B65/0021 , E05B65/0835 , Y10S292/36
摘要： A shutter, as used on fire engines, consists of a number of laths (13), which are hingedly connected together and can be drawn across an opening by handle and can be latched in the closed condition by a latch. The handle, which extends across the shutter, being formed by the mounting bracket (12), which is mounted on a lath (13), and the latch member (11) which is hingedly connected to the mounting bracket (12), thereby reducing the number of parts required and the need for separate opening and closing handles. The latch member (11) co-operates with a keeper (18) which is mounted on the structure (10) which surrounds the opening thereby latching the shutter in position.
摘要翻译：在消防车上使用的快门由许多板条（13）组成，它们铰接连接在一起，并且可以通过手柄拉过开口，并且可以通过闩锁在闭合状态下锁定。延伸穿过闸门的手柄由安装在板条（13）上的安装支架（12）和铰链地连接到安装支架（12）上的闩锁构件（11）形成，从而减少需要的零件数量和需要独立的开关手柄。闩锁构件（11）与安装在围绕开口的结构（10）上的保持器（18）配合，从而将闸板锁定就位。

7. 发明授权

US5756011A Detecting or quantifying multiple analytes using labelling techniques 失效
标题翻译：使用标签技术检测或定量多种分析物
公开(公告)号：US5756011A
公开(公告)日：1998-05-26
申请号：US810099
申请日：1997-03-03
申请人： James Stuart Woodhead , Ian Weeks , Shariar Batmanghelich
发明人： James Stuart Woodhead , Ian Weeks , Shariar Batmanghelich
IPC分类号： C12Q1/68 , G01N21/76 , G01N33/58 , C09K3/00 , G01N33/53
CPC分类号： G01N33/582 , C12Q1/6816 , G01N21/76 , Y10S435/968 , Y10S435/973
摘要： A composition for use in a specific binding assay comprising each of a plurality of substances with one or more components each capable of taking part in a respective distinguishable chemiluminescent reaction.
摘要翻译：用于特异性结合测定的组合物，其包含具有一种或多种各自能够参与相应的可区分化学发光反应的多种物质中的每一种。

8. 发明授权

US4761382A Immunological procedure for detecting or quantifying substances 失效
标题翻译：检测或定量物质的免疫程序
公开(公告)号：US4761382A
公开(公告)日：1988-08-02
申请号：US13215
申请日：1987-02-05
申请人： James S. Woodhead , Ian Weeks
发明人： James S. Woodhead , Ian Weeks
IPC分类号： G01N33/542 , G01N33/536
CPC分类号： G01N33/542 , Y10S436/80 , Y10S436/805
摘要： This invention relates to a method of detecting, analyzing, quantifying, or locating a substance of biological interest by an immunoassay in which a first component of an immune reaction in the form of an antigen, hapten, or antibody, is linked with one or more components of a chemiluminescent reaction, and the other component of the immune reaction, the analyte, is complexed therewith to cause entropic and/or ethalpic changes in a subsequent light emitting action as compared with the reaction of uncomplexed labelled component, the reaction being observed and compared to provide information on the immune complex formation. Preferably the intensity of light emission of the rate of photonic emission or the rate of change of intensity of emission are observed compared with the equivalent properties of the uncomplexed component.
摘要翻译：本发明涉及通过免疫测定来检测，分析，定量或定位生物学上的物质的方法，其中抗原，半抗原或抗体形式的免疫反应的第一组分与一种或多种化学发光反应的组分和免疫反应的另一个成分（分析物）与其结合，导致随后的发光作用中的熵和/或乙醛变化，与未络合的标记组分的反应相比，观察到的反应和比较提供免疫复合物形成的信息。优选地，与未复合组分的等效特性相比，观察到光子发射速率的发光强度或发射强度变化率。

9. 发明申请

US20070166759A1 Chemiluminescent compounds 审中-公开
公开(公告)号：US20070166759A1
公开(公告)日：2007-07-19
申请号：US10570175
申请日：2004-08-26
申请人： Ian Weeks , Andrew Rutter , Zhaoqiang Li , Keith Smith
发明人： Ian Weeks , Andrew Rutter , Zhaoqiang Li , Keith Smith
IPC分类号： G01N33/53 , C07D219/02
CPC分类号： C07D401/12 , C04B35/632 , C09B15/00 , C09K11/07 , C09K2211/1011 , C09K2211/1029 , G01N33/582
摘要： The invention relates to chemiluminescent compounds of general formula: (I) wherein: either: R1 is a reactive group capable of reacting with an amine or thiol moiety; L1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aryl, fused aryl, C1-C4 alkoxy, C1-C4acyl, halide, hydroxy or nitro; or, alternatively: the combination R1-L1- comprises a C1-C4 alkyl group optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2 comprises a group R4-L1-, where R4 is a reactive group capable of reacting with an amine or thiol moiety; and L1 is as defined above; L2 is —C(═O)O—, —C(═O)—S— or —C(═O)N(SO2R5)—, wherein, in each case, the —C(═O) is linked to the ring carbon atom, and R5 is C1-C8 alkyl, aryl, C1-C8 alkoxy or C1-C8 acyl; R3 a substituted C1-C8 alkyl, C2-C8 alkenyl, C1-C8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R3 and the —O, —S or —N(SO2R5) of the L2 group is ≦ about 9.5; and X− is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R2 moieties on either or both outer rings, provided that only one of said R2 moieties may comprise an R4-L1-group.

10. 发明授权

US07169554B2 Monitoring oligonucleotide binding processes using chemiluminescence quenching 失效
标题翻译：使用化学发光猝灭监测寡核苷酸结合过程
公开(公告)号：US07169554B2
公开(公告)日：2007-01-30
申请号：US10149146
申请日：2000-12-11
申请人： Andrew James Rutter , Ian Weeks , Zhaoqiang Li , Keith Smith
发明人： Andrew James Rutter , Ian Weeks , Zhaoqiang Li , Keith Smith
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6818 , C12Q2565/101
摘要： Oligonucleotide building processes are monitored by means of an oligonucleotide probe which in one embodiment is labelled at one end with a chemiluminescent label and at the other end with a quencher molecule. The conformation of the oligonucleotide probe changes according to whether the probe hybridises with a substantially complementary nucleic acid sequence. In the non-hybridised state the chemiluminescent label is sufficiently close proximity to the quencher that the chemiluminescent emission is substantially attenuated, but in the hybridised state the separation is such that there is little or no attenuation. Particular probes and emitter/quencher pairs are disclosed.
摘要翻译：通过寡核苷酸探针监测寡核苷酸构建过程，寡核苷酸探针在一个实施方案中在一端用化学发光标记物标记，另一端用猝灭剂分子标记。寡核苷酸探针的构象根据探针是否与基本互补的核酸序列杂交而变化。在非杂交状态下，化学发光标记与猝灭剂充分接近，化学发光发射基本上被衰减，但在杂交状态下，分离使得几乎没有或没有衰减。公开了特定的探针和发射/猝灭剂对。

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