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1. 发明申请

US20140370520A1 METHODS AND COMPOUNDS FOR DETECTING CANCER 审中-公开
标题翻译：检测癌症的方法和化合物
公开(公告)号：US20140370520A1
公开(公告)日：2014-12-18
申请号：US13993554
申请日：2011-12-08
申请人： Ian Weeks , Mohammad Jaffar , Richard Knox
发明人： Ian Weeks , Mohammad Jaffar , Richard Knox
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A61K31/04 , A61K31/122 , A61K31/135 , A61K31/366 , A61K31/404 , C12Q1/32 , G01N33/57407 , G01N33/57484 , G01N33/57496 , G01N2333/90209
摘要： The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): wherein R1, R2, R3, R4, R5 X, Y and z are as defined herein.
摘要翻译：本发明涉及使用通式（I）的化合物诊断癌症，特别是膀胱或前列腺癌的方法：其中R1，R2，R3，R4，R5，X，Y和z如本文所定义。

2. 发明申请

US20070166759A1 Chemiluminescent compounds 审中-公开
公开(公告)号：US20070166759A1
公开(公告)日：2007-07-19
申请号：US10570175
申请日：2004-08-26
申请人： Ian Weeks , Andrew Rutter , Zhaoqiang Li , Keith Smith
发明人： Ian Weeks , Andrew Rutter , Zhaoqiang Li , Keith Smith
IPC分类号： G01N33/53 , C07D219/02
CPC分类号： C07D401/12 , C04B35/632 , C09B15/00 , C09K11/07 , C09K2211/1011 , C09K2211/1029 , G01N33/582
摘要： The invention relates to chemiluminescent compounds of general formula: (I) wherein: either: R1 is a reactive group capable of reacting with an amine or thiol moiety; L1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aryl, fused aryl, C1-C4 alkoxy, C1-C4acyl, halide, hydroxy or nitro; or, alternatively: the combination R1-L1- comprises a C1-C4 alkyl group optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2 comprises a group R4-L1-, where R4 is a reactive group capable of reacting with an amine or thiol moiety; and L1 is as defined above; L2 is —C(═O)O—, —C(═O)—S— or —C(═O)N(SO2R5)—, wherein, in each case, the —C(═O) is linked to the ring carbon atom, and R5 is C1-C8 alkyl, aryl, C1-C8 alkoxy or C1-C8 acyl; R3 a substituted C1-C8 alkyl, C2-C8 alkenyl, C1-C8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R3 and the —O, —S or —N(SO2R5) of the L2 group is ≦ about 9.5; and X− is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R2 moieties on either or both outer rings, provided that only one of said R2 moieties may comprise an R4-L1-group.

3. 发明授权

US07169554B2 Monitoring oligonucleotide binding processes using chemiluminescence quenching 失效
标题翻译：使用化学发光猝灭监测寡核苷酸结合过程
公开(公告)号：US07169554B2
公开(公告)日：2007-01-30
申请号：US10149146
申请日：2000-12-11
申请人： Andrew James Rutter , Ian Weeks , Zhaoqiang Li , Keith Smith
发明人： Andrew James Rutter , Ian Weeks , Zhaoqiang Li , Keith Smith
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6818 , C12Q2565/101
摘要： Oligonucleotide building processes are monitored by means of an oligonucleotide probe which in one embodiment is labelled at one end with a chemiluminescent label and at the other end with a quencher molecule. The conformation of the oligonucleotide probe changes according to whether the probe hybridises with a substantially complementary nucleic acid sequence. In the non-hybridised state the chemiluminescent label is sufficiently close proximity to the quencher that the chemiluminescent emission is substantially attenuated, but in the hybridised state the separation is such that there is little or no attenuation. Particular probes and emitter/quencher pairs are disclosed.
摘要翻译：通过寡核苷酸探针监测寡核苷酸构建过程，寡核苷酸探针在一个实施方案中在一端用化学发光标记物标记，另一端用猝灭剂分子标记。寡核苷酸探针的构象根据探针是否与基本互补的核酸序列杂交而变化。在非杂交状态下，化学发光标记与猝灭剂充分接近，化学发光发射基本上被衰减，但在杂交状态下，分离使得几乎没有或没有衰减。公开了特定的探针和发射/猝灭剂对。

4. 发明授权

US06344331B1 Water immiscible solvent based binding systems 有权
标题翻译：与水不混溶的溶剂型结合体系
公开(公告)号：US06344331B1
公开(公告)日：2002-02-05
申请号：US09147174
申请日：1998-10-23
申请人： Raymond Lathan Ball , Jeremy Paul Aston , Jennifer Cryer , Ian Weeks
发明人： Raymond Lathan Ball , Jeremy Paul Aston , Jennifer Cryer , Ian Weeks
IPC分类号： G01N3353
CPC分类号： G01N33/5308 , G01N33/5375 , Y10S435/968 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10T436/13
摘要： A biphase immunoassay method is provided in which a water immiscible liquid is qualitatively or quantitatively measured by mixing a sample of the water immiscible liquid with an aqueous solution containing a specific binding partner of the analyte. Binding occurs at or across the interface between the respective liquids and the degree of association of the analyte with its binding partner is dependent upon the concentration ratio rather than absolute quantities. The degree of association may be determined and used to determine the presence and/or concentration of analyte in the sample.
摘要翻译：提供了一种双相免疫测定方法，其中通过将水不混溶液体的样品与含有分析物的特异性结合配偶体的水溶液混合而定性或定量测量水不混溶液体。结合发生在相应液体之间或之间的界面处，并且分析物与其结合配偶体的缔合程度取决于浓度比而不是绝对量。可以确定缔合程度并用于确定样品中分析物的存在和/或浓度。

5. 发明授权

US5840873A Labeled hybridization assay probes useful for the detection and quantification of multiple nucleic acid sequences 失效
标题翻译：用于检测和定量多个核酸序列的标记杂交测定探针
公开(公告)号：US5840873A
公开(公告)日：1998-11-24
申请号：US858803
申请日：1997-05-19
申请人： Norman Charles Nelson , James Stuart Woodhead , Ian Weeks , Azzouz Ben Cheikh
发明人： Norman Charles Nelson , James Stuart Woodhead , Ian Weeks , Azzouz Ben Cheikh
IPC分类号： C12N15/09 , C07D219/04 , C07H21/00 , C12Q1/68 , C07H21/02 , C09K3/00 , C12N15/00 , G01N33/00
CPC分类号： C12Q1/6813 , C07D219/04 , C07H21/00 , C12Q1/6816 , Y10S436/805 , Y10S436/826 , Y10T436/143333 , Y10T436/25
摘要： The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The methods may be used in a heterogeneous, homogeneous or non-homogeneous assay system. The invention also relates to specific combinations of chemiluminescent labeling reagents suitable, when coupled to an oligonucleotide probe, for use together in methods for the detection of multiple nucleic acid analytes. The invention also concerns kits useful in these methods.
摘要翻译：本发明涉及使用与不同化学发光标记试剂偶联的寡核苷酸杂交探针在单个培养基中同时或依次检测多种核酸分析物的方法。该方法可以用于异质，均相或非均一的测定系统中。本发明还涉及化学发光标记试剂在与寡核苷酸探针偶联时适用于检测多种核酸分析物的方法中的特定组合。本发明还涉及在这些方法中有用的试剂盒。

6. 发明授权

US5827656A Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences 失效
标题翻译：用于同时检测和定量多种特异性核酸序列的组合物和方法
公开(公告)号：US5827656A
公开(公告)日：1998-10-27
申请号：US683124
申请日：1996-07-16
申请人： Norman Charles Nelson , James Stuart Woodhead , Ian Weeks , Azzouz Ben Cheikh
发明人： Norman Charles Nelson , James Stuart Woodhead , Ian Weeks , Azzouz Ben Cheikh
IPC分类号： C12N15/09 , C07D219/04 , C07H21/00 , C12Q1/68 , C07H21/04 , C09K3/00 , C12N15/00
CPC分类号： C12Q1/6813 , C07D219/04 , C07H21/00 , C12Q1/6816 , Y10S436/805 , Y10S436/826 , Y10T436/143333 , Y10T436/25
摘要： The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The methods may be used in a heterogeneous, homogeneous or non-homogeneous assay system. The invention also relates to specific combinations of chemiluminescent labeling reagents suitable, when coupled to an oligonucleotide probe, for use together in methods for the detection of multiple nucleic acid analytes. The invention also concerns kits useful in these methods.
摘要翻译：本发明涉及使用与不同化学发光标记试剂偶联的寡核苷酸杂交探针在单个培养基中同时或依次检测多种核酸分析物的方法。该方法可以用于异质，均相或非均一的测定系统中。本发明还涉及化学发光标记试剂在与寡核苷酸探针偶联时适用于检测多种核酸分析物的方法中的特定组合。本发明还涉及在这些方法中有用的试剂盒。

7. 发明授权

US5656207A Detecting or quantifying multiple analytes using labelling techniques 失效
标题翻译：使用标签技术检测或定量多种分析物
公开(公告)号：US5656207A
公开(公告)日：1997-08-12
申请号：US439311
申请日：1995-05-11
申请人： James Stuart Woodhead , Ian Weeks , Shariar Batmanghelich
发明人： James Stuart Woodhead , Ian Weeks , Shariar Batmanghelich
IPC分类号： C12Q1/68 , G01N21/76 , G01N33/58 , G01N33/53 , C09K3/00
CPC分类号： G01N33/582 , C12Q1/6816 , G01N21/76 , Y10S435/968 , Y10S435/973
摘要： A method for the assay, detection etc. of each of a plurality of substances of interest in a sample comprises labelling each of the substances with one or more components each capable of taking part in a respective distinguishable chemiluminescent reaction. Luminescent reagents for use in the method are also disclosed.
摘要翻译：用于样本中的多个感兴趣物质中的每一个的测定，检测等的方法包括用能够参与各自可区分的化学发光反应的一种或多种成分标记每种物质。还公开了用于该方法的发光试剂。

8. 发明申请

US20110082279A1 Chemiluminescent Compounds 审中-公开
标题翻译：化学发光化合物
公开(公告)号：US20110082279A1
公开(公告)日：2011-04-07
申请号：US12965623
申请日：2010-12-10
申请人： Ian WEEKS , Andrew J. RUTTER , Zhaoqiang LI , Keith Smith
发明人： Ian WEEKS , Andrew J. RUTTER , Zhaoqiang LI , Keith Smith
IPC分类号： C07D401/12 , C07H21/00 , C07K2/00 , C07K14/00
CPC分类号： C07D401/12 , C04B35/632 , C09B15/00 , C09K11/07 , C09K2211/1011 , C09K2211/1029 , G01N33/582
摘要： The invention relates to chemiluminescent compounds of general formula (I) wherein: either: R1 is a reactive group capable of reacting with an amine or thiol moiety; L1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aryl, fused aryl, C1-C4 alkoxy, C1-C4 acyl, halide, hydroxy or nitro; or, alternatively: the combination R1-L1- comprises a C1-C4 alkyl group optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2 comprises a group R4-L1-, where R4 is a reactive group capable of reacting with an amine or thiol moiety; and L1 is as defined above; L2 is —C(═O)O—, —C(═O)—S— or —C(═O)N(SO2R5)—, wherein, in each case, the —C(═O) is linked to the ring carbon atom, and R5 is C1-C8 alkyl, aryl, C1-C8 alkoxy or C1-C8 acyl; R3 is a substituted C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R3 and the —O, —S or —N(SO2R5) of the L2 group is ≦about 9.5; and X−is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R2 moieties on either or both outer rings, provided that only one of said R2 moieties may comprise an R4-L1-group.
摘要翻译：本发明涉及通式（I）的化学发光化合物，其中：或者：R 1是能够与胺或硫醇部分反应的反应性基团; L1是包含2-12个碳原子的烃连接体部分，任选被羟基，卤素，硝基或C 1 -C 4烷氧基取代; R 2是氢，C 1 -C 4烷基，C 1 -C 4卤代烷基，芳基，稠合芳基，C 1 -C 4烷氧基，C 1 -C 4酰基，卤素，羟基或硝基; 或者，组合R1-L1-包括任选被羟基，卤素，硝基或C 1 -C 4烷氧基取代的C 1 -C 4烷基; 并且R 2包含基团R 4 -L 1 - ，其中R 4是能够与胺或硫醇部分反应的反应性基团; 且L1如上所定义; L 2是-C（= O）O-，-C（= O）-S-或-C（= O）N（SO 2 R 5） - ，其中，在每种情况下，-C（= O）环碳原子，R5为C1-C8烷基，芳基，C1-C8烷氧基或C1-C8酰基; R3是取代的C1-C8烷基，C2-C8链烯基，C2-C8炔基或芳基，其中至少一个所述取代基是吸电子的，使得由R3形成的离去基团的共轭酸的pKa和 -O，-S或-N（SO2R5）为大约9.5; 并且X是由于分子的合成和加工而形成的阴离子; 其中所述化合物可以在一个或两个外环上含有一个或多个另外的R 2部分，条件是所述R 2部分中只有一个可以包含R4-L1-基团。

9. 发明申请

US20050084861A1 Methods of detecting modification of genetic material and monitoring processes thereof 审中-公开
标题翻译：检测遗传物质修饰及其监测过程的方法
公开(公告)号：US20050084861A1
公开(公告)日：2005-04-21
申请号：US10499223
申请日：2002-12-17
申请人： Ian Weeks , Richard Brown , Andrew Morby , Colin Berry
发明人： Ian Weeks , Richard Brown , Andrew Morby , Colin Berry
IPC分类号： G01N33/50 , A61K45/00 , A61P31/04 , A61P31/12 , A61P43/00 , C12N15/09 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/533 , C12Q1/68 , G01N21/77 , G01N21/78 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/58
CPC分类号： G01N33/582 , C12Q1/25
摘要： The invention relates to a method for determining the activity of an enzyme or enediyne capable of altering the structure of a “substrate” nucleic acid from a first to a second state wherein the activity of the enzyme or enedyine is monitored using a chemiluminescent label that is either attached to the “substrate” nucleic acid or an oligonucleotide which is complementary thereto or the enzyme or enediyne product thereof.
摘要翻译：本发明涉及一种用于测定能够将“底物”核酸的结构从第一状态改变为第二状态的酶或烯二炔的活性的方法，其中酶或烯碱基的活性使用化学发光标记或者与“底物”核酸或其互补的寡核苷酸或其酶或烯二炔产物连接。

10. 发明授权

US06414152B1 Luminescent labelling material and procedures 失效
标题翻译：发光标签材料和程序
公开(公告)号：US06414152B1
公开(公告)日：2002-07-02
申请号：US08328563
申请日：1994-10-24
申请人： Anthony Keith Campbell , James Stuart Woodhead , Ian Weeks
发明人： Anthony Keith Campbell , James Stuart Woodhead , Ian Weeks
IPC分类号： C07D21904
CPC分类号： C07D401/12 , G01N33/533 , G03G15/0898 , G03G15/09
摘要： A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitation of an antigen of interest, by initiation of the luminescent reaction and subsequent measurement of the photonic emission of the immune complex formed during the immunological reaction.
摘要翻译：在免疫测定中用作化学发光标记的化合物包括与N-琥珀酰亚胺基部分连接的芳基吖啶酯。该化合物方便地与单克隆抗体或其它蛋白质连接，并用于双位点免疫测定中，用于定量感兴趣的抗原，通过引发发光反应和随后测量在期间形成的免疫复合物的光子发射免疫反应。

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