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1. 发明申请

US20060280724A1 Identification of ligands that enable endocytosis, using in vivo manipulation of neuronal fibers 审中-公开
标题翻译：鉴定能够内吞作用的配体，使用神经元纤维的体内操作
公开(公告)号：US20060280724A1
公开(公告)日：2006-12-14
申请号：US10423683
申请日：2003-04-26
申请人： Ian Ferguson , Hiroaki Tani
发明人： Ian Ferguson , Hiroaki Tani
IPC分类号： C40B30/06 , C40B50/06
CPC分类号： C12N15/1037
摘要： In vivo screening is used to identify and isolate ligands that drive endocytosis (internalisation) of molecules into animal cells. These ligands can transport passenger molecules (drug or diagnostic compounds, genetic vectors, etc.) into targeted classes of cells. A population of candidate ligands, such as a phage display or combinatorial library, is placed in a rat leg, in contact with a sciatic nerve bundle, and a ligature is tightened around the same nerve bundle at the hip. After a delay, to enable ligands that bind to endocytotic receptors on the nerve fibers to be internalised and transported within the fibers, fiber segments are harvested from the ligature site in the hip. Ligands that entered the harvested nerve segments can be isolated, sequenced, reproduced, etc. If desired, rats can be transformed to express human endocytotic receptors, to allow selection of ligands that will be transported into targeted human cells.
摘要翻译：体内筛选用于鉴定和分离驱动分子进入动物细胞的内吞作用（内在化）的配体。这些配体可以将乘客分子（药物或诊断化合物，遗传载体等）运输到目标类别的细胞中。将候选配体群体，例如噬菌体展示或组合文库放置在与坐骨神经束接触的大鼠腿中，并且在髋关节周围的相同神经束周围将结扎紧固。延迟后，为了使与神经纤维上的内吞受体结合的配体在纤维内被内化和转运，从臀部的结扎部位收获纤维段。进入收获的神经节段的配体可以被分离，测序，复制等。如果需要，可以转化大鼠以表达人内吞受体，以允许选择将被转运到靶向人细胞中的配体。

2. 发明授权

US5726643A Radio paging receiver capable of displaying a predetermined message 失效
标题翻译：能够显示预定消息的无线寻呼接收机
公开(公告)号：US5726643A
公开(公告)日：1998-03-10
申请号：US368399
申请日：1995-01-03
申请人： Hiroaki Tani
发明人： Hiroaki Tani
IPC分类号： H04Q7/16 , G08B5/22
CPC分类号： G08B5/227
摘要： In a radio paging receiver, a CPU selects (SA3) from call signals a specific call signal specific to the receiver and from message signals a specific message signal that follows the specific call signal and represents a specific message, which is displayed (SA23) on a display. The CPU judges (SA20) whether or not the specific message is identical with a predetermined message. An EEPROM memorizes (SA21) an inhibit signal when the specific message is identical with the predetermined message. The CPU puts (SA23-SA25) the receiver out of operation when the EEPROM memorizes the inhibit signal. The CPU makes (SA23) the display display the predetermined message when the EEPROM memorizes the inhibit signal.
摘要翻译：在无线寻呼接收机中，CPU从呼叫信号中选择特定于接收机的特定呼叫信号（SA3），并从消息信号中选择跟随特定呼叫信号的特定消息信号，并表示特定消息（SA23）一个显示。 CPU判断（SA20）特定消息是否与预定消息相同。当特定消息与预定消息相同时，EEPROM存储（SA21）禁止信号。当EEPROM存储禁止信号时，CPU将（SA23-SA25）接收器放弃运行。当EEPROM存储禁止信号时，CPU使（SA23）显示器显示预定的消息。

3. 发明授权

US07557907B2 Object-detection device for vehicle 有权
标题翻译：车辆物体检测装置
公开(公告)号：US07557907B2
公开(公告)日：2009-07-07
申请号：US12187903
申请日：2008-08-07
申请人： Yuko Matsuo , Kenichi Sawada , Hiroyuki Koike , Katsuya Mizutani , Hiroaki Tani
发明人： Yuko Matsuo , Kenichi Sawada , Hiroyuki Koike , Katsuya Mizutani , Hiroaki Tani
IPC分类号： G01P3/36
CPC分类号： G01S7/415 , G01S7/411 , G01S7/4802 , G01S13/424 , G01S13/52 , G01S13/931 , G01S17/936 , G01S2013/9321 , G01S2013/9342 , G01S2013/9346 , G01S2013/9353
摘要： The object-detection device for vehicle provides a transmission-and-reception device; a reflection point calculation device; a segment setting device; a median point calculation device; and a relative speed calculation device, wherein the relative speed calculation device eliminates a calculation result of the relative speed in the car width direction, with respect to the reflection points calculated based on the electromagnetic waves which are irradiated to the most downward direction in the specified angle in the vertical direction, in case that the number of difference between the reflection points in the current processing and the reflection points in the previous processing is equal to or greater than a predetermined number.
摘要翻译：车辆物体检测装置提供发送和接收装置; 反射点计算装置; 段设定装置; 中点计算装置; 以及相对速度计算装置，其中，相对速度计算装置相对于基于在规定的照射到最下方的电磁波计算出的反射点，消除车宽方向的相对速度的计算结果在当前处理中的反射点与先前处理中的反射点之间的差的数量等于或大于预定数量的情况下，垂直方向上的角度。

4. 发明授权

US09170329B2 Object detection apparatus for vehicle 有权
标题翻译：车辆物体检测装置
公开(公告)号：US09170329B2
公开(公告)日：2015-10-27
申请号：US14004206
申请日：2012-04-16
申请人： Akihito Kimata , Hiroaki Tani , Yoji Sasabuchi , Hiroyuki Koike
发明人： Akihito Kimata , Hiroaki Tani , Yoji Sasabuchi , Hiroyuki Koike
IPC分类号： G01S13/93 , G08G1/16 , G01S17/93
CPC分类号： G01S13/931 , G01S17/936 , G08G1/165 , G08G1/166
摘要： A roadside object present at the side of a subject vehicle travel path and a preceding vehicle at a speed equal to or greater than a predetermined speed are detected based on points derived by transmitting an electromagnetic beam forward of the subject vehicle and projecting reflection points obtained onto a two-dimensional plane, a determination is made when the preceding vehicle passes near the roadside object as to whether it moved toward the travel path within a predetermined time before and after the passage, and the roadside object is not determined to be the obstacle when it is determined to have moved toward the travel path, thereby preventing the roadside object from being misidentified as the obstacle owing to erroneous recognition of it having intruded into the travel path of the subject vehicle when detecting the object using an electromagnetic beam.
摘要翻译：基于通过向目标车辆的前方发送电磁波而得到的点，并将获得的反射点投射到上述目标车辆行驶路径和前方车辆侧的路边物体，以等于或大于预定速度的速度被检测到二维平面时，当前方车辆经过路边物体附近时，判断是否在通过前后的预定时间内朝向行驶路径移动，并且路边物体未被确定为障碍物确定已经朝向行进路径移动，从而当检测到使用电磁波的物体时，由于其被侵入到本车辆的行进路径中的错误识别，从而防止路边物体被误认为是障碍物。

5. 发明授权

US07215166B2 DLL circuit with delay equal to one clock cycle 有权
标题翻译： DLL电路的延迟等于一个时钟周期
公开(公告)号：US07215166B2
公开(公告)日：2007-05-08
申请号：US10942129
申请日：2004-09-16
申请人： Hiroaki Tani
发明人： Hiroaki Tani
IPC分类号： H03L7/06
CPC分类号： H03L7/0812 , H03L7/0805 , H03L7/0891 , H03L7/10
摘要： A DLL circuit includes a phase comparator configured to compare timing between a first clock signal and a second clock signal, a delay circuit configured to delay the first clock signal for output as the second clock signal by a delay length responsive to a result of comparison by the phase comparator, and a control circuit configured to suspend supply of the first clock signal to the phase comparator temporarily while the second clock signal is supplied to the phase comparator.
摘要翻译： DLL电路包括：相位比较器，被配置为比较第一时钟信号和第二时钟信号之间的定时;延迟电路，被配置为将第一时钟信号作为第二时钟信号延迟延迟响应于比较结果的延迟长度所述相位比较器以及控制电路被配置为在所述第二时钟信号被提供给所述相位比较器时暂停向所述相位比较器暂停所述第一时钟信号的供给。

6. 发明申请

US20050231249A1 DLL circuit with delay equal to one clock cycle 有权
标题翻译： DLL电路的延迟等于一个时钟周期
公开(公告)号：US20050231249A1
公开(公告)日：2005-10-20
申请号：US10942129
申请日：2004-09-16
申请人： Hiroaki Tani
发明人： Hiroaki Tani
IPC分类号： H03K5/135 , H03L7/06 , H03L7/081 , H03L7/089 , H03L7/10
CPC分类号： H03L7/0812 , H03L7/0805 , H03L7/0891 , H03L7/10
摘要： A DLL circuit includes a phase comparator configured to compare timing between a first clock signal and a second clock signal, a delay circuit configured to delay the first clock signal for output as the second clock signal by a delay length responsive to a result of comparison by the phase comparator, and a control circuit configured to suspend supply of the first clock signal to the phase comparator temporarily while the second clock signal is supplied to the phase comparator.
摘要翻译： DLL电路包括：相位比较器，被配置为比较第一时钟信号和第二时钟信号之间的定时;延迟电路，被配置为将第一时钟信号作为第二时钟信号延迟延迟响应于比较结果的延迟长度所述相位比较器以及控制电路被配置为在所述第二时钟信号被提供给所述相位比较器时暂停向所述相位比较器暂停所述第一时钟信号的供给。

7. 发明申请

US20140002295A1 OBJECT DETECTION APPARATUS FOR VEHICLE 有权
标题翻译：车辆对象检测装置
公开(公告)号：US20140002295A1
公开(公告)日：2014-01-02
申请号：US14004206
申请日：2012-04-16
申请人： Akihito Kimata , Hiroaki Tani , Yoji Sasabuchi , Hiroyuki Koike
发明人： Akihito Kimata , Hiroaki Tani , Yoji Sasabuchi , Hiroyuki Koike
IPC分类号： G01S13/93
CPC分类号： G01S13/931 , G01S17/936 , G08G1/165 , G08G1/166
摘要： A roadside object present at the side of a subject vehicle travel path and a preceding vehicle at a speed equal to or greater than a predetermined speed are detected based on points derived by transmitting an electromagnetic beam forward of the subject vehicle and projecting reflection points obtained onto a two-dimensional plane, a determination is made when the preceding vehicle passes near the roadside object as to whether it moved toward the travel path within a predetermined time before and after the passage, and the roadside object is not determined to be the obstacle when it is determined to have moved toward the travel path, thereby preventing the roadside object from being misidentified as the obstacle owing to erroneous recognition of it having intruded into the travel path of the subject vehicle when detecting the object using an electromagnetic beam.
摘要翻译：基于通过向目标车辆的前方发送电磁波而得到的点，并将获得的反射点投射到上述目标车辆行驶路径和前方车辆侧的路边物体，以等于或大于预定速度的速度被检测到二维平面时，当前方车辆经过路边物体附近时，判断是否在通过前后的预定时间内朝向行驶路径移动，并且路边物体未被确定为障碍物确定已经朝向行进路径移动，从而当检测到使用电磁波的物体时，由于其被侵入到本车辆的行进路径中的错误识别，从而防止路边物体被误认为是障碍物。

8. 发明申请

US20080233049A1 Agents And Methods For Early Diagnosis And Monitoring Of Alzheimer's Disease And Other Neurological Disorders 审中-公开
标题翻译：早期诊断和监测阿尔茨海默病和其他神经系统疾病的代理和方法
公开(公告)号：US20080233049A1
公开(公告)日：2008-09-25
申请号：US11571241
申请日：2005-06-23
申请人： Hiroaki Tani , Ian Andrew Ferguson
发明人： Hiroaki Tani , Ian Andrew Ferguson
IPC分类号： A61K49/00 , A61K49/04
CPC分类号： A61K38/03 , A61K49/0043 , A61K49/0097 , C07K2319/735 , C12N2795/14043 , C12N2795/14045 , C12N2810/40 , C12N2810/859
摘要： This invention is in the fields of medicine and neurology, and relates to methods and agents for early diagnosis and monitoring of Alzheimer's disease and other neurological disorders. More particularly, the present invention provides the method for evaluating the health of central nervous system neurons in a human patient, comprising the steps of: a) administering to said patient a population of molecular complexes comprising (i) a polypeptide capable of activating neuronal endocytosis, axonal transport, and synaptic transfer; and (ii) an imaging agent suited for determining location and evaluating neuronal transport of said molecular complexes within said patient; and b) using at least one imaging method to determine location and evaluate neuronal transport of said molecular complexes within said patient.
摘要翻译：本发明涉及医学和神经学领域，涉及用于早期诊断和监测阿尔茨海默病和其他神经障碍的方法和试剂。更具体地，本发明提供了评估人类患者中枢神经系统神经元健康的方法，包括以下步骤：a）向所述患者施用一组分子复合物，其包含（i）能够激活神经元内吞的多肽，轴突运输和突触转移; 和（ii）适于确定所述患者内所述分子复合物的位置和评估神经元运输的成像剂; 以及b）使用至少一种成像方法来确定所述患者内所述分子复合物的位置和评估神经元运输。

9. 发明授权

US06504439B1 Voltage controlled oscillation circuit having oscillation frequency variable control units inserted between inversion circuit elements 失效
标题翻译：具有插入反相电路元件之间的振荡频率可变控制单元的压控振荡电路
公开(公告)号：US06504439B1
公开(公告)日：2003-01-07
申请号：US09025735
申请日：1998-02-18
申请人： Naoki Ozawa , Hiroaki Tani , Kenichi Nomura
发明人： Naoki Ozawa , Hiroaki Tani , Kenichi Nomura
IPC分类号： H03B524
CPC分类号： H03K3/0315 , H03K3/014
摘要： A voltage controlled oscillation circuit with an oscillation frequency thereof controlled in accordance with an external voltage is disclosed. An odd number of inversion circuit elements such as inverters for inverting output signals thereof with respect to input signals thereto are connected in series with each other. An output side of the last-stage one of the odd number of the inversion circuit elements is connected to an input side of the first-stage one of the inversion circuit elements to thereby cause an oscillation. A plurality of oscillation frequency variable control units such as variable resistor circuit elements for changing an oscillation frequency in accordance with an external voltage are each inserted between each set of adjacent inversion circuit elements. A plurality of fixed resistor circuit elements each having a fixed resistance value are connected in parallel with a plurality of the oscillation frequency variable control units, respectively. The functions of both the variable resistor circuit elements and the fixed resistor circuit elements can be carried out at the same time by the use of a depletion type transistor or a transistor of a short channel type.
摘要翻译：公开了根据外部电压控制其振荡频率的压控振荡电路。奇数个反相电路元件，例如用于使输出信号相对于其输入信号反相的反相器彼此串联连接。奇数个反转电路元件的最后一级的输出侧连接到第一级反转电路元件的输入侧，从而引起振荡。多个振荡频率可变控制单元，例如用于根据外部电压改变振荡频率的可变电阻器电路元件各自插入在每组相邻的反转电路元件之间。分别具有固定电阻值的多个固定电阻电路元件与多个振荡频率可变控制单元并联连接。可变电阻电路元件和固定电阻电路元件的功能可以通过使用耗尽型晶体管或短沟道型晶体管同时进行。

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