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1. 发明授权

US09212385B2 Fluorinated resorufin compounds and their application 有权
标题翻译：氟化合物及其应用
公开(公告)号：US09212385B2
公开(公告)日：2015-12-15
申请号：US13612681
申请日：2012-09-12
申请人： Robert H. Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
发明人： Robert H. Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
IPC分类号： A61B10/00 , A61B8/00 , A61B5/00 , C12Q1/28 , C07D265/38 , C07D413/12 , C07D495/04 , C09B19/00
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

2. 发明申请

US20110086341A1 FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION 审中-公开
标题翻译：氟化修饰化合物及其应用
公开(公告)号：US20110086341A1
公开(公告)日：2011-04-14
申请号：US12971279
申请日：2010-12-17
申请人： Robert Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
发明人： Robert Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
IPC分类号： C12Q1/28 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/53 , C12Q1/26
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

3. 发明申请

US20050214807A1 Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection 审中-公开
标题翻译：环境敏感性荧光化合物及其应用于单线态氧和蛋白质检测
公开(公告)号：US20050214807A1
公开(公告)日：2005-09-29
申请号：US10993908
申请日：2004-11-19
申请人： Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch
发明人： Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch
IPC分类号： C07D209/54 , C07D491/02 , C09B11/08 , C09B19/00 , C12Q1/68
CPC分类号： C09B19/00 , C09B1/00 , C09B11/08 , C09B11/24 , C09B57/02 , Y10S436/80 , Y10T436/20
摘要： The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.
摘要翻译：本发明提供荧光探针和相应的荧光化合物，使用探针的方法，包括探针的化合物和试剂盒。

4. 发明授权

US07875261B2 Fluorinated resorufin compounds and their application 有权
标题翻译：氟化合物及其应用
公开(公告)号：US07875261B2
公开(公告)日：2011-01-25
申请号：US12015476
申请日：2008-01-16
申请人： Robert Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
发明人： Robert Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
IPC分类号： A61B10/00 , A61B5/00
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

5. 发明申请

US20050096315A1 Fluorinated resorufin compounds and their application 有权
标题翻译：氟化合物及其应用
公开(公告)号：US20050096315A1
公开(公告)日：2005-05-05
申请号：US10980139
申请日：2004-11-01
申请人： Robert Batchelor , Yue Ge , Kyle Gee , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg
发明人： Robert Batchelor , Yue Ge , Kyle Gee , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg
IPC分类号： A61K31/498 , A61K31/538 , A61K31/5415 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

6. 发明授权

US08173698B2 Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection 有权
标题翻译：环境敏感性荧光化合物及其应用于单线态氧和蛋白质检测
公开(公告)号：US08173698B2
公开(公告)日：2012-05-08
申请号：US12040850
申请日：2008-02-29
申请人： Iain Johnson , Jixiang Liu , Brian Patch , Wai-Yee Leung
发明人： Iain Johnson , Jixiang Liu , Brian Patch , Wai-Yee Leung
IPC分类号： A61K31/352 , C07D311/82
CPC分类号： C09B19/00 , C09B1/00 , C09B11/08 , C09B11/24 , C09B57/02 , Y10S436/80 , Y10T436/20
摘要： The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.
摘要翻译：本发明提供荧光探针和相应的荧光化合物，使用探针的方法，包括探针的化合物和试剂盒。

7. 发明申请

US20130090470A1 OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE 有权
标题翻译：光学检测酶基质及其使用方法
公开(公告)号：US20130090470A1
公开(公告)日：2013-04-11
申请号：US13614948
申请日：2012-09-13
申请人： Schuyler CORRY , William Downey , Brian Filanoski , Kyle Gee , Lawrence Greenfield , James Hirsch , Iain Johnson , Aleksey Rukavishnikov
发明人： Schuyler CORRY , William Downey , Brian Filanoski , Kyle Gee , Lawrence Greenfield , James Hirsch , Iain Johnson , Aleksey Rukavishnikov
IPC分类号： C07D503/00 , C07F5/02 , C07D501/58
CPC分类号： C07F5/022 , C07D499/00 , C07D501/00 , C07D501/58 , C07D501/60 , C07D503/00 , C07D519/00 , C12Q1/34 , C12Q2334/00 , G01N33/581 , G01N2333/986
摘要： The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.
摘要翻译：本发明涉及作为酶的底物的化合物，并且在与酶反应时提供可检测的反应，例如可光学检测的反应。特别地，这些化合物可用于检测样品中β-内酰胺酶的存在。除了化合物之外，还公开了分析样品中存在β-乳糖酶的方法，例如，作为包括编码β-乳糖酶的序列的核酸序列的表达的指示剂。公开了包括所公开的化合物和另外的组分的试剂盒，例如细胞，抗体，β-乳酸酶或在测定中使用组分的说明书。

8. 发明授权

US08981100B2 Use of novel coumarins as glutathione and thiol labels 有权
标题翻译：使用新型香豆素作为谷胱甘肽和硫醇标记
公开(公告)号：US08981100B2
公开(公告)日：2015-03-17
申请号：US12666256
申请日：2008-07-24
申请人： Hee Chol Kang , Kyle Gee , Iain Johnson , Michael Janes
发明人： Hee Chol Kang , Kyle Gee , Iain Johnson , Michael Janes
IPC分类号： C07D491/16 , C07D491/00 , G01N33/52
CPC分类号： G01N33/52 , C07D491/06 , C07D491/16 , C07F9/5442 , C07K5/0215 , G01N33/582 , G01N2333/4701 , Y10T436/17 , Y10T436/182
摘要： Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.
摘要翻译：描述了与结合硫醇化合物的亲电子反应性基团取代的荧光喹诺酮香豆素化合物。该化合物可用于检测活细胞中氧化应激和相关过程。

9. 发明授权

US08865891B2 Optically-detectable enzyme substrates and their method of use 有权
标题翻译：光学上可检测的酶底物及其使用方法
公开(公告)号：US08865891B2
公开(公告)日：2014-10-21
申请号：US13614948
申请日：2012-09-13
申请人： Schuyler Corry , William Downey , Brian Filanoski , Kyle Gee , Lawrence Greenfield , James Hirsch , Iain Johnson , Aleksey Rukavishnikov
发明人： Schuyler Corry , William Downey , Brian Filanoski , Kyle Gee , Lawrence Greenfield , James Hirsch , Iain Johnson , Aleksey Rukavishnikov
IPC分类号： C07D501/36 , C07D501/58 , C07D501/00 , C07F5/02 , C07D503/00 , C07D499/00 , C12Q1/34
CPC分类号： C07F5/022 , C07D499/00 , C07D501/00 , C07D501/58 , C07D501/60 , C07D503/00 , C07D519/00 , C12Q1/34 , C12Q2334/00 , G01N33/581 , G01N2333/986
摘要： The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactamase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactamase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactamase or instructions for using the components in an assay.
摘要翻译：本发明涉及作为酶的底物的化合物，并且在与酶反应时提供可检测的反应，例如可光学检测的反应。特别地，这些化合物可用于检测样品中β-内酰胺酶的存在。除了化合物之外，公开了用于分析样品中β-内酰胺酶的存在的方法，例如，作为包括编码β-内酰胺酶的序列的核酸序列的表达的指示剂。公开了包括所公开的化合物和另外的组分的试剂盒，例如细胞，抗体，β-内酰胺酶或在测定中使用组分的说明书。

10. 发明申请

US20070269902A1 Antibody complexes and methods for immunolabeling 审中-公开
标题翻译：抗体复合物和免疫标记方法
公开(公告)号：US20070269902A1
公开(公告)日：2007-11-22
申请号：US10666291
申请日：2003-09-17
申请人： Joseph Beechem , David Hagen , Iain Johnson
发明人： Joseph Beechem , David Hagen , Iain Johnson
IPC分类号： G01N33/00 , C12Q1/68
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y10/00 , G01N33/53 , G01N33/58 , G01N33/6857
摘要： The present invention provides labeling reagents and methods for labeling primary antibodies and for detecting a target in a sample using an immuno-labeled complex that comprises a target-binding antibody and one or more labeling reagents. The labeling reagents comprise monovalent antibody fragments or non-antibody monomeric proteins whereby the labeling reagents have affinity for a specific region of the target-binding antibody and are covalently attached to a label. Typically, the labeling reagent is an anti-Fc Fab or Fab′ fragment that was generated by immunizing a goat or rabbit with the Fc fragment of an antibody. The present invention provides for discrete subsets of labeling reagent and immuno-labeled complexes that facilitate the simultaneous detection of multiple targets in a sample wherein the immuno-labeled complexes are distinguished by i) a ratio of label to labeling reagent, or ii) a physical property of said label, or iii) a ratio of labeling reagent to said target-binding antibody, or iv) by said target-binding antibody. This is particularly useful for fluorophore labels that can be attached to labeling reagents and subsequently immuno-labeled complexes in ratios for the detection of multiple targets.
摘要翻译：本发明提供标记试剂和用于标记一抗的标记试剂和使用包含靶结合抗体和一种或多种标记试剂的免疫标记复合物检测样品中靶标的方法。标记试剂包含单价抗体片段或非抗体单体蛋白质，由此标记试剂对靶结合抗体的特定区域具有亲和力，并且共价连接到标记物上。通常，标记试剂是通过用抗体的Fc片段免疫山羊或兔而产生的抗Fc Fab或Fab'片段。本发明提供标记试剂和免疫标记的复合物的离散子集，其有助于同时检测样品中的多个靶标，其中通过i）标记物与标记试剂的比率来区分免疫标记的复合物，或ii）物理或iii）标记试剂与所述靶结合抗体的比例，或iv）所述靶结合抗体。这对于可以连接到标记试剂和随后的用于检测多个靶的比例的免疫标记的复合物的荧光团标记物特别有用。

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