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1. 发明申请

WO2009109769A3 SCREENING FOR NON-GENOTOXIC CARCINOGENS 审中-公开
公开(公告)号：WO2009109769A3
公开(公告)日：2009-09-11
申请号：PCT/GB2009/000642
申请日：2009-03-09
申请人： ITI SCOTLAND LIMITED , WOLF, Charles, Roland , ELCOMBE, Clifford, Roy
发明人： WOLF, Charles, Roland , ELCOMBE, Clifford, Roy
IPC分类号： A01K67/027
摘要： The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARα, and in which the endogenous equivalent genes have been rendered inoperable.

2. 发明申请

WO2002066028A3 PHARMACEUTICAL COMPOSITIONS CONTAINING FLUORINATED OR PERFLUORINATED CARBOXYLIC ACIDS 审中-公开
公开(公告)号：WO2002066028A3
公开(公告)日：2002-08-29
申请号：PCT/GB2002/000726
申请日：2002-02-18
申请人： CXR BIOSCIENCES LIMITED , ELCOMBE, Clifford, Roy , WOLF, Charles, Roland
发明人： ELCOMBE, Clifford, Roy , WOLF, Charles, Roland
IPC分类号： A61K31/19
摘要： Fluorinated or perfluorinated carboxylic acids are useful in treating diabetes, obesity, hypercholesterolaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable.

3. 发明申请

WO2011101643A1 COMPOSITIONS COMPRISING PERFLUOROOCTANOIC ACID 审中-公开
标题翻译：包含全氟代酸的组合物
公开(公告)号：WO2011101643A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000232
申请日：2011-02-18
申请人： CXR BIOSCIENCES LIMITED , ELCOMBE, Clifford, Roy , WOLF, Charles, Roland , WESTWOOD, Anna, Louise
发明人： ELCOMBE, Clifford, Roy , WOLF, Charles, Roland , WESTWOOD, Anna, Louise
IPC分类号： A61K31/19 , A61P35/00
CPC分类号： A61K31/19 , A61K45/06 , A61K2300/00
摘要： There is provided compositions comprising perfluorooctanoic acid (PFOA) or a salt, derivative or variant thereof. There is also provided uses, methods therapeutic systems and combination therapies relating to PFOA.
摘要翻译：提供了包含全氟辛酸（PFOA）或其盐，衍生物或变体的组合物。还提供了与PFOA相关的用途，方法治疗系统和联合疗法。

4. 发明申请

WO2004019927A2 METHODS 审中-公开
标题翻译：方法
公开(公告)号：WO2004019927A2
公开(公告)日：2004-03-11
申请号：PCT/GB2003/003789
申请日：2003-08-29
申请人： CXR BIOSCIENCES LIMITED (SC 211745) , ELCOMBE, Clifford, Roy , WOLF, Charles, Roland
发明人： ELCOMBE, Clifford, Roy , WOLF, Charles, Roland
IPC分类号： A61K31/19
CPC分类号： A61K31/23 , A61K31/02 , A61K31/19 , A61K31/194 , A61K31/20 , A61K31/205 , G01N2333/90245 , G01N2333/918 , Y10T436/144444
摘要： A perfluoroctanoic acid or a salt or an ester thereof, perfluorosuberic acid, perfluoroheptanoic acid, perfluorohexanoic acid, perfluoropentanoic acid, perfluorobutanoic acid or perfluoropropionic acid or a salt or an ester any thereof, or perfluoroctane are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable.
摘要翻译：全氟辛酸或其盐或其酯，全氟辛酸，全氟庚酸，全氟己酸，全氟戊酸，全氟丁酸或全氟丙酸或其任意的盐或酯，或全氟辛烷可用于治疗糖尿病，肥胖，高胆固醇血症，高脂血症，癌症，炎症或其中可能需要调节脂质或类花生酸状态或功能的其它条件。

5. 发明申请

WO2006008484A3 DETECTION OF CELLULAR STRESS 审中-公开
公开(公告)号：WO2006008484A3
公开(公告)日：2006-01-26
申请号：PCT/GB2005/002779
申请日：2005-07-15
申请人： CXR BIOSCIENCES LIMITED , ROSLIN INSTITUTE (EDINBURGH) , CLARK, Helen, Elizabeth , WOLF, Charles, Roland , WHITELAW, Christopher, Bruce, Alexander , ELCOMBE, Clifford, Roy , BROWN, Kenneth
发明人： WOLF, Charles, Roland , WHITELAW, Christopher, Bruce, Alexander , ELCOMBE, Clifford, Roy , BROWN, Kenneth
IPC分类号： C12Q1/68 , C12N15/09 , C12N5/10 , A01K67/027
摘要： We provide reporter gene constructs incorporating nucleic acid sequences from a promoter region of a gene or set of genes whose expression is modified in response to external or internal changes in the cellular environment such as biochemical stress or toxic conditions. The promoters are operatively linked to nucleic acid sequences chosen on the basis of the ease with which their transcription and/or translation products may be assayed so that the reporter gene constructs can provide a system capable of detecting intracellular conditions. Also described are transfected cell lines including the constructs and transgenic non-human animal models including the constructs.

6. 发明申请

WO2008149080A1 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
标题翻译：用于评估药物代谢和毒性的转基因动物
公开(公告)号：WO2008149080A1
公开(公告)日：2008-12-11
申请号：PCT/GB2008/001897
申请日：2008-06-04
申请人： ITI SCOTLAND LIMITED , WOLF, Charles, Roland , SCHEER, Nico
发明人： WOLF, Charles, Roland , SCHEER, Nico
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/721 , C07K14/80 , C12N15/8509
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
摘要翻译：本发明涉及转基因非人动物，由其衍生的组织或细胞及其生产方法。从其衍生的转基因非人动物或组织或细胞提供能够表达负责药物代谢的人蛋白来代替同源的内源性非人动物蛋白的系统，以及引入动物的人基因的受控表达，使得人类基因的表达以与人类体内更为类似的方式调节。本发明的一个方面涉及包含人PXR基因的至少部分内含子6和/或7的人DNA序列的用途。

7. 发明申请

WO2009050484A1 KNOCKOUT MICE FOR A P450 GENE CLUSTER 审中-公开
标题翻译： P450基因座的KNOCKOUT MICE
公开(公告)号：WO2009050484A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/003531
申请日：2008-10-17
申请人： ITI SCOTLAND LIMITED , SCHEER, Nico , WOLF, Charles, Roland
发明人： SCHEER, Nico , WOLF, Charles, Roland
IPC分类号： C12N15/85 , A01K67/027 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03
摘要： The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation. One example of this complexity is reflected in the mammalian cytochrome P450 system, where the sizes of multigene families of proteins which carry out particular metabolic functions vary enormously between species.
摘要翻译：本发明涉及药物代谢小鼠模型的产生，其中参与药物代谢的基因簇已被淘汰。用于治疗用途或用于其他目的的新药和化学品的开发是非常复杂的。特别重要的是了解这些化学试剂如何在体内被处理，是否具有适当的药代动力学，以及作为新陈代谢的结果，是否出现任何安全问题。涉及药物的代谢，处置和消除的许多蛋白质是多基因家族的成员，其在基因数目，功能和调控上表现出非常明显的物种差异。由于这些原因，在实验动物中进行的实验动物建立新陈代谢或毒性的路线可能会受到严重的损害，因此不能忠实地代表人的情况。这种复杂性的一个例子反映在哺乳动物细胞色素P450系统中，其中进行特定代谢功能的多基因家族蛋白质的大小在物种之间变化很大。

8. 发明申请

WO2006064197A2 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
标题翻译：用于评估药物代谢和毒性的转基因动物
公开(公告)号：WO2006064197A2
公开(公告)日：2006-06-22
申请号：PCT/GB2005/004772
申请日：2005-12-13
申请人： ITI SCOTLAND LIMITED , WOLF, Charles, Roland , SCHEER, Nico , FAUST, Nicole
发明人： WOLF, Charles, Roland , SCHEER, Nico , FAUST, Nicole
IPC分类号： A01K67/027 , C12N15/09 , G01N33/50
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0393 , C07K14/721 , C07K14/80 , C12N15/8509
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
摘要翻译：本发明涉及转基因非人动物，从其衍生的组织或细胞及其生产方法。从其衍生的转基因非人动物或组织或细胞提供能够表达负责药物代谢的人类蛋白来代替同源的内源性非人动物蛋白质的系统，以及引入动物的人类基因的受控表达，人类基因的表达以与人类体内更为接近的方式进行调节。

9. 发明授权

EP2215240B1 KNOCKOUT MICE FOR A P450 GENE CLUSTER 有权
标题翻译：基因敲除小鼠FOR A P450基因簇
公开(公告)号：EP2215240B1
公开(公告)日：2016-11-23
申请号：EP08806623.8
申请日：2008-10-17
申请人： ITI Scotland Limited
发明人： SCHEER, Nico , WOLF, Charles, Roland
IPC分类号： C12N15/85 , A01K67/027 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03

10. 发明公开

EP2268135A2 SCREENING FOR NON-GENOTOXIC CARCINOGENS 审中-公开
标题翻译：的筛选非遗传毒性致癌物
公开(公告)号：EP2268135A2
公开(公告)日：2011-01-05
申请号：EP09717169.8
申请日：2009-03-09
申请人： ITI Scotland Limited
发明人： WOLF, Charles, Roland , ELCOMBE, Clifford, Roy
IPC分类号： A01K67/027
CPC分类号： G01N33/5014 , A01K67/0278 , A01K2207/15 , A01K2217/07 , A01K2227/105 , A01K2267/03 , C07K14/47 , C07K14/70567 , C12N15/8509
摘要： The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARα, and in which the endogenous equivalent genes have been rendered inoperable.

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