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1. 发明申请

WO2009118524A3 EFFICIENT INSERTION OF DNA INTO EMBRYONIC STEM CELLS 审中-公开
标题翻译：有效插入DNA在胚胎干细胞中的表达
公开(公告)号：WO2009118524A3
公开(公告)日：2009-11-26
申请号：PCT/GB2009000790
申请日：2009-03-25
申请人： ITI SCOTLAND LTD , SEIBLER JOST , SCHEER NICO
发明人： SEIBLER JOST , SCHEER NICO
IPC分类号： A01K67/027 , C12N15/90
CPC分类号： A61K49/0008 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/07 , A01K2217/072 , A01K2217/15 , A01K2217/206 , A01K2227/105 , C12N9/0077 , C12N15/86 , C12N15/907 , C12N2710/14143
摘要： The present invention relates, in general, to a method for introducing a heterologous replacement gene sequence into a host embryonic stem cell to replace an endogenous host gene target sequence. In particular, the invention relates to a method for inserting large pieces of DNA into embryonic stem cells with improved efficiency, by first deleting the endogenous host gene target sequence, and subsequently utilising two proximally positioned site-specific recombinase target (RT) sites to insert a heterologous replacement gene sequence into the host chromosome.
摘要翻译：本发明一般涉及将异源取代基因序列引入宿主胚胎干细胞以取代内源宿主基因靶序列的方法。具体而言，本发明涉及通过首先删除内源宿主基因靶序列并随后利用两个位于近侧的定点位点特异性重组酶靶（RT）位点来插入具有提高的效率的大块DNA到胚胎干细胞中的方法以插入将异源替换基因序列导入宿主染色体。

2. 发明申请

WO2009118524A2 EFFICIENT INSERTION OF DNA INTO EMBRYONIC STEM CELLS 审中-公开
标题翻译： DNA有效插入胚胎干细胞
公开(公告)号：WO2009118524A2
公开(公告)日：2009-10-01
申请号：PCT/GB2009/000790
申请日：2009-03-25
申请人： ITI SCOTLAND LIMITED , SEIBLER, Jost , SCHEER, Nico
发明人： SEIBLER, Jost , SCHEER, Nico
IPC分类号： C12N5/00
CPC分类号： A61K49/0008 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/07 , A01K2217/072 , A01K2217/15 , A01K2217/206 , A01K2227/105 , C12N9/0077 , C12N15/86 , C12N15/907 , C12N2710/14143
摘要： The present invention relates, in general, to a method for introducing a heterologous replacement gene sequence into a host embryonic stem cell to replace an endogenous host gene target sequence. In particular, the invention relates to a method for inserting large pieces of DNA into embryonic stem cells with improved efficiency, by first deleting the endogenous host gene target sequence, and subsequently utilising two proximally positioned site-specific recombinase target (RT) sites to insert a heterologous replacement gene sequence into the host chromosome.
摘要翻译：本发明一般涉及将异源替代基因序列引入宿主胚胎干细胞以替代内源宿主基因靶序列的方法。特别地，本发明涉及通过首先缺失内源宿主基因靶序列，随后利用两个近端位置的位点特异性重组酶靶（RT）位点来插入大块DNA，从而提高效率，将其插入到胚胎干细胞中异源替代基因序列进入宿主染色体。

3. 发明申请

WO2008149080A1 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
标题翻译：用于评估药物代谢和毒性的转基因动物
公开(公告)号：WO2008149080A1
公开(公告)日：2008-12-11
申请号：PCT/GB2008/001897
申请日：2008-06-04
申请人： ITI SCOTLAND LIMITED , WOLF, Charles, Roland , SCHEER, Nico
发明人： WOLF, Charles, Roland , SCHEER, Nico
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/721 , C07K14/80 , C12N15/8509
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
摘要翻译：本发明涉及转基因非人动物，由其衍生的组织或细胞及其生产方法。从其衍生的转基因非人动物或组织或细胞提供能够表达负责药物代谢的人蛋白来代替同源的内源性非人动物蛋白的系统，以及引入动物的人基因的受控表达，使得人类基因的表达以与人类体内更为类似的方式调节。本发明的一个方面涉及包含人PXR基因的至少部分内含子6和/或7的人DNA序列的用途。

4. 发明申请

WO2006064197A2 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
标题翻译：用于评估药物代谢和毒性的转基因动物
公开(公告)号：WO2006064197A2
公开(公告)日：2006-06-22
申请号：PCT/GB2005/004772
申请日：2005-12-13
申请人： ITI SCOTLAND LIMITED , WOLF, Charles, Roland , SCHEER, Nico , FAUST, Nicole
发明人： WOLF, Charles, Roland , SCHEER, Nico , FAUST, Nicole
IPC分类号： A01K67/027 , C12N15/09 , G01N33/50
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0393 , C07K14/721 , C07K14/80 , C12N15/8509
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
摘要翻译：本发明涉及转基因非人动物，从其衍生的组织或细胞及其生产方法。从其衍生的转基因非人动物或组织或细胞提供能够表达负责药物代谢的人类蛋白来代替同源的内源性非人动物蛋白质的系统，以及引入动物的人类基因的受控表达，人类基因的表达以与人类体内更为接近的方式进行调节。

5. 发明申请

WO2009034328A3 TWO STEP CLUSTER DELETION AND HUMANISATION 审中-公开
标题翻译：两步骤删除和人性化
公开(公告)号：WO2009034328A3
公开(公告)日：2009-04-30
申请号：PCT/GB2008003084
申请日：2008-09-12
申请人： ITI SCOTLAND LTD , SCHEER NICO
发明人： SCHEER NICO
IPC分类号： C12N15/90 , A01K67/027 , C12N9/02
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/0071
摘要： This invention relates to a method for humanising a mouse. In particular, the invention relates to a method for replacing a cluster of mouse genes with single or multiple genes from the corresponding human cluster using a combination of homologous recombination and site-specific recombination.
摘要翻译：本发明涉及一种用于人性化小鼠的方法。特别地，本发明涉及使用同源重组和位点特异性重组的组合从相应的人群中用单个或多个基因替换小鼠基因簇的方法。

6. 发明申请

WO2009034328A2 TWO STEP CLUSTER DELETION AND HUMANISATION 审中-公开
标题翻译：两步骤集群删除与人性化
公开(公告)号：WO2009034328A2
公开(公告)日：2009-03-19
申请号：PCT/GB2008/003084
申请日：2008-09-12
申请人： ITI SCOTLAND LIMITED , SCHEER, Nico
发明人： SCHEER, Nico
IPC分类号： C12N15/85 , C12N15/90 , A01K67/027 , C12N9/02
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/0071
摘要： This invention relates to a method for humanising a mouse. In particular, the invention relates to a method for replacing a cluster of mouse genes with single or multiple genes from the corresponding human cluster using a combination of homologous recombination and site-specific recombination.
摘要翻译：本发明涉及一种人性化小鼠的方法。具体而言，本发明涉及用同源重组和位点特异性重组的组合从相应的人簇中用单个或多个基因置换小鼠基因簇的方法。

7. 发明申请

WO2009050484A1 KNOCKOUT MICE FOR A P450 GENE CLUSTER 审中-公开
标题翻译： P450基因座的KNOCKOUT MICE
公开(公告)号：WO2009050484A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/003531
申请日：2008-10-17
申请人： ITI SCOTLAND LIMITED , SCHEER, Nico , WOLF, Charles, Roland
发明人： SCHEER, Nico , WOLF, Charles, Roland
IPC分类号： C12N15/85 , A01K67/027 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03
摘要： The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation. One example of this complexity is reflected in the mammalian cytochrome P450 system, where the sizes of multigene families of proteins which carry out particular metabolic functions vary enormously between species.
摘要翻译：本发明涉及药物代谢小鼠模型的产生，其中参与药物代谢的基因簇已被淘汰。用于治疗用途或用于其他目的的新药和化学品的开发是非常复杂的。特别重要的是了解这些化学试剂如何在体内被处理，是否具有适当的药代动力学，以及作为新陈代谢的结果，是否出现任何安全问题。涉及药物的代谢，处置和消除的许多蛋白质是多基因家族的成员，其在基因数目，功能和调控上表现出非常明显的物种差异。由于这些原因，在实验动物中进行的实验动物建立新陈代谢或毒性的路线可能会受到严重的损害，因此不能忠实地代表人的情况。这种复杂性的一个例子反映在哺乳动物细胞色素P450系统中，其中进行特定代谢功能的多基因家族蛋白质的大小在物种之间变化很大。

8. 发明申请

WO2006064197A3 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
标题翻译：用于评估药物代谢和毒性的转基因动物
公开(公告)号：WO2006064197A3
公开(公告)日：2006-09-28
申请号：PCT/GB2005004772
申请日：2005-12-13
申请人： ITI SCOTLAND LTD , WOLF CHARLES ROLAND , SCHEER NICO , FAUST NICOLE
发明人： WOLF CHARLES ROLAND , SCHEER NICO , FAUST NICOLE
IPC分类号： A01K67/027 , C12N15/09 , G01N33/50
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0393 , C07K14/721 , C07K14/80 , C12N15/8509
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
摘要翻译：本发明涉及转基因非人动物，由其衍生的组织或细胞及其制备方法。转基因非人动物或组织或由其衍生的细胞提供了能够表达负责药物代谢的人蛋白质代替同源内源性非人动物蛋白质和用于引入动物的人基因的受控表达的系统，人类基因的表达以与人体内所见相似的方式进行调节。

9. 发明专利

IL202127D0 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 未知
公开(公告)号：IL202127D0
公开(公告)日：2010-06-16
申请号：IL20212709
申请日：2009-11-15
申请人： ITI SCOTLAND LTD , WOLF CHARLES ROLAND , SCHEER NICO
IPC分类号： A01K20100101
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.

10. 发明专利

IL183885D0 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 未知
公开(公告)号：IL183885D0
公开(公告)日：2007-10-31
申请号：IL18388507
申请日：2007-06-12
申请人： ITI SCOTLAND LTD , WOLF CHARLES ROLAND , SCHEER NICO , FAUST NICOLA
IPC分类号： A01K20100101

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