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1. 发明申请

WO2005040425A2 PARALLEL POLYMER SEQUENCING METHODS 审中-公开
标题翻译：并行聚合物测序方法
公开(公告)号：WO2005040425A2
公开(公告)日：2005-05-06
申请号：PCT/GB2004/004432
申请日：2004-10-20
申请人： ISIS INNOVATION LTD , SHCHEPINOV, Mikhail, S. , MIR, Kalim
发明人： SHCHEPINOV, Mikhail, S. , MIR, Kalim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6818 , C12Q1/6869 , G01N21/6428 , G01N2021/6432 , G01N2021/6441 , C12Q2565/501 , C12Q2565/101 , C12Q2563/155 , C12Q2565/518 , C12Q2533/107 , C12Q2535/122 , C12Q2533/101 , C12Q2563/173 , C12Q2565/301 , C12Q2561/113
摘要： The present invention relates to a method of sequencing a target polynucleotide by enzymatic and/or chemical means. The sequencing method includes a method for characterizing multiple alleles in a sample, a method of calculating confidence levels in ascertained sequences, a method for comparing polynucleotide sequences and a method of resolving ambiguities in a polynucleotide sequence. It also provides methods for appropriately preparing samples, for immobilising template molecules, for organising the template molecules and to conduct the sequencing of many molecules in parallel. The method involves analysing molecules as members of an array. Many target polynucleotides or many segments of a single target polynucleotide can be sequenced simultaneously. In a preferred embodiment the method involves analysing individual molecules within an array and base calls are based on the signals from two or more molecules. A method to prevent non-specific signal in sequencing is also provided. The invention is readily automated, both for small-scale and large-scale operation and relevant algorithms and the composition of kits and systems are provided.
摘要翻译：本发明涉及通过酶和/或化学方法测序靶多核苷酸的方法。测序方法包括用于表征样品中多个等位基因的方法，计算确定序列中的置信水平的方法，用于比较多核苷酸序列的方法和解决多核苷酸序列中的模糊度的方法。它还提供了适当制备样品，固定模板分子，组织模板分子和并行进行许多分子测序的方法。该方法包括分析分子作为阵列的成员。单个靶多核苷酸的许多靶多核苷酸或许多片段可以同时测序。在优选实施方案中，该方法包括分析阵列内的各个分子，并且基于来自两个或更多个分子的信号进行碱基呼叫。还提供了一种在排序中防止非特异性信号的方法。本发明容易地自动化，用于小规模和大规模操作以及相关算法，并提供了套件和系统的组成。

2. 发明申请

WO2012056192A1 PREPARATION AND ANALYSIS OF SAMPLES IN MICRO-/NANO-FLUIDIC DEVICES 审中-公开
标题翻译：微型/纳米流体装置中样品的制备和分析
公开(公告)号：WO2012056192A1
公开(公告)日：2012-05-03
申请号：PCT/GB2011/001522
申请日：2011-10-24
申请人： MIR, Kalim , MARIE, Rodolphe , KRISTENSEN, Anders , RASMUSSEN, Kristian
发明人： MIR, Kalim , MARIE, Rodolphe , KRISTENSEN, Anders , RASMUSSEN, Kristian
IPC分类号： B01L3/00 , C12Q1/68 , G01N33/487
CPC分类号： C12P19/34 , B01L3/502746 , B01L3/502761 , B01L2200/06 , B01L2300/0877 , B01L2400/086 , C12Q1/6806 , G01N33/48721 , C12Q2525/204 , C12Q2543/10 , C12Q2565/629
摘要： The invention comprises a system for the preparation, manipulation and analysis of genomes and selection and further analysis or manipulation of parts thereof. The invention particularly relates to single cell, analysis single chromosome analysis and polynucleotide sequencing. The system comprise micro-/nanofluidic devices, compositions, methods, kits, apparatus/instrumentation and algorithms. The invention also comprises uses of the methods and system.
摘要翻译：本发明包括用于基因组的制备，操作和分析以及其部分的选择和进一步分析或操作的系统。本发明特别涉及单细胞，分析单染色体分析和多核苷酸测序。该系统包括微/纳流体装置，组合物，方法，试剂盒，装置/仪器和算法。本发明还包括方法和系统的使用。

3. 发明公开

EP4320268A2 SYSTEMS, METHODS, AND COMPOSITIONS FOR DETECTING EPIGENETIC MODIFICATIONS OF NUCLEIC ACIDS 审中-实审
公开(公告)号：EP4320268A2
公开(公告)日：2024-02-14
申请号：EP22796935.9
申请日：2022-06-02
申请人： XGenomes Corp. , Mir, Kalim
发明人： MIR, Kalim
IPC分类号： C12Q1/6823 , C12Q1/6827 , C12Q1/6874 , C12Q1/6883

4. 发明申请

WO2023028270A1 RANDOM EPIGENOMIC SAMPLING 审中-公开
公开(公告)号：WO2023028270A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/041594
申请日：2022-08-25
申请人： XGENOMES CORP. , HEALY, John , MIR, Kalim
发明人： HEALY, John , MIR, Kalim
IPC分类号： G01N33/574 , C12N15/10 , C12Q1/68 , C04B40/06 , G16B35/00
摘要： Methods and systems for determining the presence of disease in a subject by determining the state of modification (e.g. methylation) of a random subset of loci across the genome by sequencing and/or methylation detection is provided, where the composition of the random subset may differ from one sample to another.

5. 发明公开

EP4392781A1 RANDOM EPIGENOMIC SAMPLING 审中-公开
公开(公告)号：EP4392781A1
公开(公告)日：2024-07-03
申请号：EP22862109.0
申请日：2022-08-25
申请人： XGenomes Corp. , Healy, John , Mir, Kalim
发明人： HEALY, John , MIR, Kalim
IPC分类号： G01N33/574 , C12N15/10 , C12Q1/68 , C04B40/06 , G16B35/00
CPC分类号： C40B40/06 , C12Q1/6886 , C12Q2600/15420130101 , C12Q2600/11220130101 , G16B20/00 , G16H50/20

6. 发明申请

WO2016015018A1 NANOPIPETTE ANALYSIS OF POLYMERS 审中-公开
标题翻译：聚合物纳米材料分析
公开(公告)号：WO2016015018A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/042123
申请日：2015-07-24
申请人： MIR, Kalim
发明人： MIR, Kalim
IPC分类号： G01Q60/44 , C12Q1/02 , C12Q1/68 , B01L3/02 , B82Y5/00
CPC分类号： C12Q1/6825 , B01L3/021 , B01L2200/0663 , B01L2200/143 , B01L2300/0896 , B01L2400/0415 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B82Y5/00 , G01N33/48721 , G01N33/5438 , G01Q60/44 , C12Q2563/116 , C12Q2565/631
摘要： The disclosure relates to devices and instruments for detecting and individually analyzing biomolecules, biomolecular complexes and biomolecules with ligands attached thereon.
摘要翻译：本公开涉及用于检测和分别分析附着于其上的配体的生物分子，生物分子复合物和生物分子的装置和仪器。

7. 发明申请

WO2004027093A1 MOLECULAR ARRAYS AND SINGLE MOLECULE DETECTION 审中-公开
标题翻译：分子阵列和单分子检测
公开(公告)号：WO2004027093A1
公开(公告)日：2004-04-01
申请号：PCT/GB2003/004041
申请日：2003-09-19
申请人： THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD , MIR, Kalim
发明人： MIR, Kalim
IPC分类号： C12Q1/68
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00317 , B01J2219/00367 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00592 , B01J2219/00596 , B01J2219/00599 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00691 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y5/00 , B82Y10/00 , B82Y30/00
摘要： Methods are provided for producing a molecular array comprising a plurality of molecules immobilised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilisation. The use of spatially addressable low density molecular arrays in single molecule detection techniques is also provided.
摘要翻译：提供了用于产生包含固定在固体底物上的多个分子的分子阵列，其密度以允许各个固定化分子单独分辨的密度，其中阵列中的每个单独的分子是空间可寻址的，并且每个分子的身份是已知的，或者在固定前确定。还提供了在单分子检测技术中使用空间可寻址的低密度分子阵列。

8. 发明申请

WO2022232709A2 SYSTEMS, METHODS, AND COMPOSITIONS FOR DETECTING EPIGENETIC MODIFICATIONS OF NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2022232709A2
公开(公告)日：2022-11-03
申请号：PCT/US2022/032012
申请日：2022-06-02
申请人： XGENOMES CORP. , MIR, Kalim
发明人： MIR, Kalim
IPC分类号： C12Q1/6823 , C12Q1/6827 , C12Q1/6874 , C12Q1/6883
摘要： Systems, methods, and compositions for detecting epigenetic modifications in nucleic acids are provided. The invention comprises methods, compositions, and systems for determining the modification status of a nucleic acid molecule by using probes to detect a difference in signal when the nucleic acid is modified compared to when it is not. The modification may comprise a covalent modification such as methylation on a nucleobase.

9. 发明申请

WO2002074988A2 ARRAYS AND METHODS OF USE 审中-公开
标题翻译：阵列和使用方法
公开(公告)号：WO2002074988A2
公开(公告)日：2002-09-26
申请号：PCT/GB2002/001245
申请日：2002-03-18
申请人： THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD , MIR, Kalim
发明人： MIR, Kalim
IPC分类号： C12Q1/68
CPC分类号： C12N15/1065 , B01J2219/00497 , B01J2219/005 , B01J2219/00513 , B01J2219/0052 , B01J2219/00524 , B01J2219/00554 , B01J2219/00572 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/0072 , B82Y10/00 , B82Y30/00 , C12Q1/6818 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , G01N33/582 , C12Q2523/303 , C12Q2565/507 , C12Q2565/629
摘要： Methods are provided for producing a molecular array comprising a plurality of molecules immobilised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilisation. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.
摘要翻译：提供了用于产生包含固定在固体底物上的多个分子的分子阵列，其密度以允许各个固定化分子单独分辨的密度，其中阵列中的每个单独的分子是空间可寻址的，并且每个分子的身份是已知的，或者在固定前确定。还提供了在单分子检测和分析技术中使用空间可寻址的低密度分子阵列。还提供了新的测定和方法。

10. 发明申请

WO2016015022A1 SINGLE MOLECULE PROTEOMICS 审中-公开
标题翻译：单分子保护
公开(公告)号：WO2016015022A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/042127
申请日：2015-07-24
申请人： MIR, Kalim , SHCHEPINOV, Mikhail
发明人： MIR, Kalim
IPC分类号： G01N33/68 , G01N33/58 , G06F19/18
CPC分类号： G01N33/58 , G01N33/6803 , G06F19/18
摘要： This disclosure comprises devices and methods for determining the identity of individual protein molecules in a complex mixture.
摘要翻译：该公开内容包括用于确定复合混合物中单个蛋白质分子的身份的装置和方法。

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