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1. 发明申请

WO2003077851A2 COMPOUNDS AND METHODS FOR ANALYZING THE PROTEOME 审中-公开
标题翻译：用于分析保护物的化合物和方法
公开(公告)号：WO2003077851A2
公开(公告)日：2003-09-25
申请号：PCT/US2003/007479
申请日：2003-03-11
申请人： HK PHARMACEUTICALS, INC. , KÖSTER, Hubert , SHCHEPINOV, Mikhail, S. , LITTLE, Daniel, P.
发明人： KÖSTER, Hubert , SHCHEPINOV, Mikhail, S. , LITTLE, Daniel, P.
IPC分类号： A61K
CPC分类号： G01N33/6848 , C12Q1/6834 , G01N33/54353 , G01N33/6842 , G01N33/6851 , C12Q2565/627 , C12Q2565/518
摘要： Gradient arrays for the analysis of biomolecules are provided. In particular, arrays and methods are provided for analyzing complex protein mixtures, such as the proteome. The arrays provide bifunctional reagents that allow for the separation and isolation of complex protein mixtures. Automated instruments for performing the methods are also provided.
摘要翻译：提供了用于分析生物分子的梯度阵列。特别地，提供阵列和方法用于分析复合蛋白质混合物，例如蛋白质组。阵列提供双功能试剂，允许分离和分离复杂的蛋白质混合物。还提供了用于执行方法的自动仪器。

2. 发明申请

WO2005040425A3 NUCLEIC ACID SEQUENCING METHODS 审中-公开
标题翻译：核酸序列测序方法
公开(公告)号：WO2005040425A3
公开(公告)日：2005-07-28
申请号：PCT/GB2004004432
申请日：2004-10-20
申请人： ISIS INNOVATION , SHCHEPINOV MIKHAIL S , MIR KALIM
发明人： SHCHEPINOV MIKHAIL S , MIR KALIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6818 , C12Q1/6869 , G01N21/6428 , G01N2021/6432 , G01N2021/6441 , C12Q2565/501 , C12Q2565/101 , C12Q2563/155 , C12Q2565/518 , C12Q2533/107 , C12Q2535/122 , C12Q2533/101 , C12Q2563/173 , C12Q2565/301 , C12Q2561/113
摘要： The present invention relates to a method of sequencing a target polynucleotide by enzymatic and/or chemical means. The sequencing method includes a method for characterizing multiple alleles in a sample, a method for comparing polynucleotide sequence. The method involves analysing molecules as members of an array, Many target polynucleotides or many segments of a singe target polynucleotide can be sequenced simultaneously. In a preferred embodiment the method involves analysing individual molecules within an array and base calls are based on the signals from two or more molecules. A method to prevent non-specific signal in sequencing is also provided. The invention is readily automated, both for small-scale and large-scale operation and relevant algorithms and the composition of kits and systems are provided.
摘要翻译：本发明涉及通过酶和/或化学方法测序靶多核苷酸的方法。测序方法包括用于表征样品中多个等位基因的方法，用于比较多核苷酸序列的方法。该方法包括将分子分析为阵列成员，许多靶多核苷酸或单个靶多核苷酸的许多片段可以同时测序。在优选实施方案中，该方法包括分析阵列内的各个分子，并且基于来自两个或更多个分子的信号进行碱基呼叫。还提供了一种在排序中防止非特异性信号的方法。本发明容易地自动化，用于小规模和大规模操作以及相关算法，并提供了套件和系统的组成。

3. 发明申请

WO2005040425A2 PARALLEL POLYMER SEQUENCING METHODS 审中-公开
标题翻译：并行聚合物测序方法
公开(公告)号：WO2005040425A2
公开(公告)日：2005-05-06
申请号：PCT/GB2004/004432
申请日：2004-10-20
申请人： ISIS INNOVATION LTD , SHCHEPINOV, Mikhail, S. , MIR, Kalim
发明人： SHCHEPINOV, Mikhail, S. , MIR, Kalim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6818 , C12Q1/6869 , G01N21/6428 , G01N2021/6432 , G01N2021/6441 , C12Q2565/501 , C12Q2565/101 , C12Q2563/155 , C12Q2565/518 , C12Q2533/107 , C12Q2535/122 , C12Q2533/101 , C12Q2563/173 , C12Q2565/301 , C12Q2561/113
摘要： The present invention relates to a method of sequencing a target polynucleotide by enzymatic and/or chemical means. The sequencing method includes a method for characterizing multiple alleles in a sample, a method of calculating confidence levels in ascertained sequences, a method for comparing polynucleotide sequences and a method of resolving ambiguities in a polynucleotide sequence. It also provides methods for appropriately preparing samples, for immobilising template molecules, for organising the template molecules and to conduct the sequencing of many molecules in parallel. The method involves analysing molecules as members of an array. Many target polynucleotides or many segments of a single target polynucleotide can be sequenced simultaneously. In a preferred embodiment the method involves analysing individual molecules within an array and base calls are based on the signals from two or more molecules. A method to prevent non-specific signal in sequencing is also provided. The invention is readily automated, both for small-scale and large-scale operation and relevant algorithms and the composition of kits and systems are provided.
摘要翻译：本发明涉及通过酶和/或化学方法测序靶多核苷酸的方法。测序方法包括用于表征样品中多个等位基因的方法，计算确定序列中的置信水平的方法，用于比较多核苷酸序列的方法和解决多核苷酸序列中的模糊度的方法。它还提供了适当制备样品，固定模板分子，组织模板分子和并行进行许多分子测序的方法。该方法包括分析分子作为阵列的成员。单个靶多核苷酸的许多靶多核苷酸或许多片段可以同时测序。在优选实施方案中，该方法包括分析阵列内的各个分子，并且基于来自两个或更多个分子的信号进行碱基呼叫。还提供了一种在排序中防止非特异性信号的方法。本发明容易地自动化，用于小规模和大规模操作以及相关算法，并提供了套件和系统的组成。

4. 发明申请

WO2003077851A3 COMPOUNDS AND METHODS FOR ANALYZING THE PROTEOME 审中-公开
公开(公告)号：WO2003077851A3
公开(公告)日：2003-09-25
申请号：PCT/US2003/007479
申请日：2003-03-11
申请人： HK PHARMACEUTICALS, INC. , KÖSTER, Hubert , SHCHEPINOV, Mikhail, S. , LITTLE, Daniel, P.
发明人： KÖSTER, Hubert , SHCHEPINOV, Mikhail, S. , LITTLE, Daniel, P.
IPC分类号： G01N31/00
摘要： Gradient arrays for the analysis of biomolecules are provided. In particular, arrays and methods are provided for analyzing complex protein mixtures, such as the proteome. The arrays provide bifunctional reagents that allow for the separation and isolation of complex protein mixtures. Automated instruments for performing the methods are also provided.

5. 发明申请

WO2009114814A3 THERAPEUTIC SUBSTANCES THAT MODULATE GENOME METHYLATION 审中-公开
公开(公告)号：WO2009114814A3
公开(公告)日：2009-09-17
申请号：PCT/US2009/037173
申请日：2009-03-13
申请人： RETROTOPE, INC. , SHCHEPINOV, Mikhail, S.
发明人： SHCHEPINOV, Mikhail, S.
IPC分类号： C07H19/06 , A61K31/7068 , A61P29/00 , A61P35/00 , A61P37/00 , C07B59/00 , C07D239/47 , C12P19/38
摘要： Compounds containing nucleic acid bases or their precursors modified by enrichment at specific sites with heavy stable isotopes of elements naturally present at those sites in minute amount are useful for the treatment of diseases characterized by altered gene expression and altered pattern of epigenomic control. These compounds, when used as nutrients or in other medicinal application methods, can alter the DNA methylation pattern in a simple way through the well-understood mechanism of kinetic isotope effect (KIE). This effect could also be useful for modifying methylation kinetics in stem cell technology, cloning and as disease therapeutics.

6. 发明申请

WO2009114809A1 THERAPIES FOR CANCER USING ISOTOPICALLY SUBSTITUTED LYSINE 审中-公开
标题翻译：使用同位素替代的LYSINE治疗癌症
公开(公告)号：WO2009114809A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/037161
申请日：2009-03-13
申请人： RETROTOPE, INC. , SHCHEPINOV, Mikhail, S.
发明人： SHCHEPINOV, Mikhail, S.
IPC分类号： C07C229/26 , A61P35/00 , A61K31/195 , C07B59/00
CPC分类号： C07B59/001 , A61K31/195 , C07B2200/05 , C07C229/26
摘要： Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.
摘要翻译：治疗方法和治疗癌症的物质可能会使用或导致以不会天然存在的水平产生同位素修饰的赖氨酸。

7. 发明申请

WO2011053870A1 ALLEVIATING OXIDATIVE STRESS DISORDERS WITH PUFA DERIVATIVES 审中-公开
标题翻译：用PUFA衍生物去除氧化应激障碍
公开(公告)号：WO2011053870A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/054866
申请日：2010-10-29
申请人： RETROTOPE, INC. , SHCHEPINOV, Mikhail, S.
发明人： SHCHEPINOV, Mikhail, S.
IPC分类号： A01N37/00 , A61K31/20
CPC分类号： A61K31/20 , A61K31/201 , A61K31/202 , C07B59/001
摘要： Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).
摘要翻译：本发明的一些方面提供了在特定位置被取代以减缓活性氧物质（ROS）的氧化损伤的必需脂肪酸，并且为了防止或减少损伤的目的，抑制随后形成反应产物的速率与氧化应激相关疾病如神经系统疾病和年龄相关性黄斑变性（AMD）相关。

8. 发明申请

WO2009114814A2 THERAPEUTIC SUBSTANCES THAT MODULATE GENOME METHYLATION 审中-公开
标题翻译：调节基因组甲基化的治疗药物
公开(公告)号：WO2009114814A2
公开(公告)日：2009-09-17
申请号：PCT/US2009037173
申请日：2009-03-13
申请人： RETROTOPE INC , SHCHEPINOV MIKHAIL S
发明人： SHCHEPINOV MIKHAIL S
CPC分类号： C07H19/06 , C07D405/04 , C07H19/073
摘要： Compounds containing nucleic acid bases or their precursors modified by enrichment at specific sites with heavy stable isotopes of elements naturally present at those sites in minute amount are useful for the treatment of diseases characterized by altered gene expression and altered pattern of epigenomic control. These compounds, when used as nutrients or in other medicinal application methods, can alter the DNA methylation pattern in a simple way through the well-understood mechanism of kinetic isotope effect (KIE). This effect could also be useful for modifying methylation kinetics in stem cell technology, cloning and as disease therapeutics.
摘要翻译：含有核酸碱基或其前体的化合物可用于治疗以基因表达改变和表观遗传调控模式改变为特征的疾病的特异性位点，在特定部位通过富集天然存在于元件天然存在的重要的稳定同位素进行富集而修饰。这些化合物在用作营养物质或其他药物施用方法时，可以通过了解动力学同位素效应（KIE）的机理，以简单的方式改变DNA甲基化模式。这种作用还可用于修饰干细胞技术中的甲基化动力学，克隆和疾病治疗。

9. 发明申请

WO03077851A9 COMPOUNDS AND METHODS FOR ANALYZING THE PROTEOME 审中-公开
标题翻译：用于分析蛋白质的化合物和方法
公开(公告)号：WO03077851A9
公开(公告)日：2004-05-21
申请号：PCT/US0307479
申请日：2003-03-11
申请人： HK PHARMACEUTICALS INC , KOESTER HUBERT , SHCHEPINOV MIKHAIL S , LITTLE DANIEL P
发明人： KOESTER HUBERT , SHCHEPINOV MIKHAIL S , LITTLE DANIEL P
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543 , G01N33/68 , A61K
CPC分类号： G01N33/6848 , C12Q1/6834 , G01N33/54353 , G01N33/6842 , G01N33/6851 , C12Q2565/627 , C12Q2565/518
摘要： Gradient arrays for the analysis of biomolecules are provided. In particular, arrays and methods are provided for analyzing complex protein mixtures, such as the proteome. The arrays provide bifunctional reagents that allow for the separation and isolation of complex protein mixtures. Automated instruments for performing the methods are also provided.
摘要翻译：提供了用于分析生物分子的梯度阵列。具体而言，提供用于分析复杂蛋白质混合物（例如蛋白质组）的阵列和方法。阵列提供了双功能试剂，可以分离和分离复杂的蛋白质混合物。还提供了用于执行该方法的自动化仪器。

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