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1. 发明申请

WO1989010977A1 ANALYSING POLYNUCLEOTIDE SEQUENCES 审中-公开
标题翻译：分析多核苷酸序列
公开(公告)号：WO1989010977A1
公开(公告)日：1989-11-16
申请号：PCT/GB1989000460
申请日：1989-05-02
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6876 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/00385 , B01J2219/0043 , B01J2219/00527 , B01J2219/00529 , B01J2219/00574 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C40B40/06 , C40B60/14 , C12Q2565/513 , C12Q2565/507 , C12Q2525/204 , C12Q2565/501
摘要： This invention provides apparatus and method for analysing a polynucleotide sequence, either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pairs of oligonucleotides. The polynuclotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analysis of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.
摘要翻译：本发明提供用于分析未知序列或已知序列的多核苷酸序列的装置和方法。支持，例如玻璃板载有能够参与杂交反应的完整的寡核苷酸组的全部阵列或选定部分的阵列。阵列可以包含一对或多对寡核苷酸。多核苷酸序列或其片段在杂交条件下被标记并应用于阵列。应用包括已知点突变的分析，基因组指纹图谱，连锁分析，mRNAs表征，mRNA群体和序列测定。

2. 发明申请

WO1996031622A1 DETECTING DNA SEQUENCE VARIATIONS 审中-公开
标题翻译：检测DNA序列变异
公开(公告)号：WO1996031622A1
公开(公告)日：1996-10-10
申请号：PCT/GB1996000848
申请日：1996-04-09
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin, Mellor , PRITCHARD, Clare, Elizabeth , CASE-GREEN, Stephen, Charles
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6858 , B01J19/0046 , B01J2219/00608 , B01J2219/0061 , B01J2219/00626 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6862 , C12Q1/6869 , C12Q1/6876 , C12Q2563/179 , C12Q2600/156 , C12Q2521/501 , C12Q2565/501 , C12Q2535/125 , C12Q2537/125 , C12Q2533/107 , C12Q2525/151 , C12Q2565/518 , C12Q2521/101 , C12Q2565/537 , C12Q2561/125
摘要： A method of analysing a polynucleotide target involves incubating the target with an oligonucleotide probe, generally an array of immobilised oligonucleotide probes, to form a duplex, and using ligase or polymerase to extend one chain of the duplex. A point mutation or variable number tandem repeat section may be analysed. Arrays of immobilised oligonucleotides are provided for use in the method.
摘要翻译：分析多核苷酸靶的方法包括用寡核苷酸探针（通常是固定的寡核苷酸探针的阵列）孵育靶，以形成双链体，并使用连接酶或聚合酶延伸双链体的一条链。可以分析点突变或可变数串联重复部分。提供固定化寡核苷酸的阵列用于该方法。

3. 发明申请

WO1995021265A1 METHODS FOR DISCOVERING LIGANDS 审中-公开
标题翻译：发现配偶的方法
公开(公告)号：WO1995021265A1
公开(公告)日：1995-08-10
申请号：PCT/GB1995000209
申请日：1995-02-01
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin, Mellor , MIR, Kalim, Ullah , CASE-GREEN, Stephen, Charles
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6811 , B01J19/0046 , B01J2219/0043 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C07H21/00 , C12N15/1048 , C12Q1/6837 , C40B40/06 , C40B50/06 , C40B60/14 , Y10T436/143333
摘要： A method of identifying one or a combination of ligands, e.g. oligonucleotides or analogues, that interact specifically with a target, e.g. a DNA or an RNA molecule having a secondary or tertiary structure. One ligand may be pre-reacted to open up the target for interaction with other ligands forming an array on a solid surface.
摘要翻译：鉴定一种或多种配体组合的方法，例如与靶特异性相互作用的寡核苷酸或类似物。具有二级或三级结构的DNA或RNA分子。一个配体可以被预反应以开放靶，以与在固体表面上形成阵列的其它配体相互作用。

4. 发明申请

WO1995004160A1 TAG REAGENT AND ASSAY METHOD 审中-公开
标题翻译：标签试剂和测定方法
公开(公告)号：WO1995004160A1
公开(公告)日：1995-02-09
申请号：PCT/GB1994001675
申请日：1994-08-01
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin , CUMMINS, William, Jonathan
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6874 , C07F7/1804 , C07H21/00 , C12N15/1075 , C12Q1/6816 , C12Q1/6837 , C12Q1/6872 , Y10S435/912 , C12Q2563/167 , C12Q2565/627
摘要： A reagent comprises: a) an analyte moiety comprising at least two analyte residues, and linked to; b) a tag moiety comprising one or more reporter groups adapted for detection by mass spectrometry, wherein a reporter group designates an analyte residue, and the reporter group at each position of the tag moiety is chosen to designate an analyte residue at a defined position of the analyte moiety. A plurality of such reagents, each comprising a different analyte moiety, provides a library of reagents which may be used in assay methods involving a target substance. Analysis of the tag moieties indicates the nature of the analyte moieties bound to the target substance. A method of sequencing nucleic acid employs a library of the reagents to determine the sequence of a target nucleic acid.
摘要翻译：试剂包括：a）分析物部分，其包含至少两个分析物残基，并连接到; b）包含一个或多个适于通过质谱检测的报告基团的标签部分，其中报道基团指定分析物残基，并且标签部分的每个位置处的报告基团被选择为在分析物部分。多个这样的试剂，各自包含不同的分析物部分，提供可用于涉及靶物质的测定方法的试剂文库。标签部分的分析表明结合到目标物质的分析物部分的性质。测序核酸的方法使用试剂文库来确定靶核酸的序列。

5. 发明申请

WO1990003382A1 SUPPORT-BOUND OLIGONUCLEOTIDES 审中-公开
标题翻译：支持边界寡核苷酸
公开(公告)号：WO1990003382A1
公开(公告)日：1990-04-05
申请号：PCT/GB1989001114
申请日：1989-09-21
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin, M. , MASKOS, Uwe
发明人： ISIS INNOVATION LIMITED
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , C40B40/00 , Y02P20/55
摘要： A method of preparing an oligonucleotide bound to a support, such as porous glass or glass beads, involves attaching a nucleoside 3'-reagent through the phosphate group by a covalent phosphodiester link to aliphatic hydroxyl groups carried by the support. The oligonucleotide is then synthesised on the supported nucleoside, and protecting groups removed from the synthetic oligonucleotide chain under standard conditions which do not cleave the oligonucleotide from the support. Suitable reagents include nucleoside phosphoramidite and nucleoside hydrogen phosphonate.
摘要翻译：制备与载体如多孔玻璃或玻璃珠结合的寡核苷酸的方法涉及通过与载体携带的脂族羟基的共价磷酸二酯键连接核苷3'-试剂通过磷酸酯基团。然后在不从载体上切割寡核苷酸的标准条件下，在负载的核苷上合成寡核苷酸，以及从合成寡核苷酸链中除去的保护基。合适的试剂包括核苷亚磷酰胺和核苷氢膦酸盐。

6. 发明申请

WO1993022480A1 ELECTROCHEMICAL TREATMENT OF SURFACES 审中-公开
标题翻译：电化学处理表面
公开(公告)号：WO1993022480A1
公开(公告)日：1993-11-11
申请号：PCT/GB1993000857
申请日：1993-04-23
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin
发明人： ISIS INNOVATION LIMITED
IPC分类号： C25D05/02
CPC分类号： B01J19/0046 , B01J2219/0043 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00628 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , C07H21/00 , C40B40/06 , C40B60/14
摘要： A method of electrochemically patterning a surface comprises providing an electrolyte overlying the surface and an array of electrodes adjacent the surface and in contact with the electrolyte, and altering the potential of one or more electrodes of the array so as to deposit or remove or chemically modify a substance on the surface adjacent the electrode. Several such treatments can be performed in sequence, using different electrodes of the array. The method is particularly suitable for step-wise chemical synthesis e.g. of oligonucleotides or other oligomers tethered to the surface. Electrode arrays for use in the method are also claimed.
摘要翻译：电化学图案化表面的方法包括提供覆盖表面的电解质和邻近表面并与电解质接触的电极阵列，并且改变阵列的一个或多个电极的电位以便沉积或去除或化学修饰在邻近电极的表面上的物质。可以使用阵列的不同电极来顺序地执行几种这样的处理。该方法特别适用于逐步化学合成，例如的寡核苷酸或其他低聚物连接到表面。还要求用于该方法的电极阵列。

7. 发明公开

EP0656949A1 VACCINIA VIRUS B15R USED IN INTERLEUKIN B1-INVOLVING CONDITION 失效
标题翻译：白细胞介素中引起B1使用的疫苗病毒B15R条件。
公开(公告)号：EP0656949A1
公开(公告)日：1995-06-14
申请号：EP93905517.0
申请日：1993-03-05
申请人： ISIS INNOVATION LIMITED
发明人： ISIS INNOVATION LIMITED
IPC分类号： C07K14 , C12N15 , A61K38
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70503 , C12N2710/24122
摘要： This invention relates to proteins encoded by vaccinia virus and which function to interfere with the host's immune system. In particular, the invention provides for use of the nucleotide sequence designated herein as B15R or of a nucleotide sequence coding for an allele of, or functionally equivalent fragment, derivative or variant of the polypeptide encoded by the B15R nucleotide sequence in a process relating to the manufacture of a medicament for the treatment of a condition in which interleukin-1β is involved in the mediation of one or more symptoms associated with the condition. The invention also provides an anti-fever medicament which comprises a polypeptide which is encoded by the B15R gene product or an allele of, or functionally equivalent fragment, derivative or variant of that product.

8. 发明申请

WO1998026087A1 BACILLUS STRAIN AND ANTIBIOTIC SCREENING METHOD 审中-公开
标题翻译：贝类菌株和抗生素筛选方法
公开(公告)号：WO1998026087A1
公开(公告)日：1998-06-18
申请号：PCT/GB1997003401
申请日：1997-12-10
申请人： ISIS INNOVATION LIMITED , ERRINGTON, Jeffery , WU, Ling, Juan
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/18
CPC分类号： C12R1/07 , C07K14/32 , C12Q1/18
摘要： A Bacillus strain has a chromosome with the following modifications: a mutation of a spolllE gene which blocks transfer of the prespore chromosome; a mutation which prevents loss of SpoOJ function from blocking sporulation; a first reporter gene dependent on sigma factor and placed at a location where impaired SpoOJ function leads to increased trapping in the prespore; and a second reporter gene having a promoter which is dependent on sigma factor and where impaired SpoOJ function leads to reduced trapping in the prespore. The strain is useful in a method of screening for putative antibiotics.
摘要翻译：芽孢杆菌菌株具有染色体，其具有以下修饰：阻断前体染色体转移的spolllE基因的突变; 防止SpoOJ功能丧失阻止孢子形成的突变; 一个依赖于西格玛因子的第一个报告基因，并被置于受损的SpoOJ功能导致在前体中增加捕获的位置; 和具有依赖于σ因子的启动子的第二报告基因，并且其中受损的SpoOJ功能导致在前体中的捕获减少。该菌株可用于筛选推定抗生素的方法。

9. 发明申请

WO1998016550A1 CHIRAL PEPTIDE NUCLEIC ACIDS 审中-公开
公开(公告)号：WO1998016550A1
公开(公告)日：1998-04-23
申请号：PCT/GB1997002820
申请日：1997-10-13
申请人： ISIS INNOVATION LIMITED , LOWE, Gordon
发明人： ISIS INNOVATION LIMITED
IPC分类号： C07K14/00
CPC分类号： C07D403/04 , C07D207/16 , C07D403/12 , C07D473/18 , C07K14/003
摘要： Chiral peptide nucleic acids are provided which hybridise strongly with complementary nucleic acids and have potential as antigene and antisense agents and as tools in molecular biology. Compounds with cis-stereochemistry and based on proline and a spacer amino acid have structures (II), (III), where n is 1 or 2 - 200, B is a protected or unprotected base, R is H or alkyl, aralkyl or heteroaryl and may be substituted, X may be OH, and Y may be H.
摘要翻译：提供手性肽核酸，其与互补核酸强烈杂交，并且具有作为分子生物学的反义和反义试剂的潜力。具有顺式立体化学和基于脯氨酸和间隔氨基酸的化合物具有结构（II），（III），其中n为1或2〜200，B为受保护或未保护的碱，R为H或烷基，芳烷基或杂芳基并且可以被取代，X可以是OH，Y可以是H.

10. 发明申请

WO1997041606A1 SPIN TRANSISTOR 审中-公开
标题翻译：旋转晶体管
公开(公告)号：WO1997041606A1
公开(公告)日：1997-11-06
申请号：PCT/GB1997001167
申请日：1997-04-28
申请人： ISIS INNOVATION LIMITED , GREGG, John, Francis , SPARKS, Patricia, Dresel
发明人： ISIS INNOVATION LIMITED
IPC分类号： H01L43/00
CPC分类号： H01L29/66984
摘要： The spin transistor is a hybrid magnetic/semiconductor transistor in which a magnetically controllable barrier (5) is provided between a semiconductor base (4) and collector (3) to control the diffusion of charge carriers to the collector (3). With the spin transistor the charge carrier populations are distinguished by the direction of the spin or magnetic moment of the carriers instead of the electronic charge. A spin injector (1) is used to spin polarise the charge carrier population so that the population has a selected magnetic moment which population may or may not be enabled to flow to the collector via the magnetic barrier. The spin transistor utilises the electronic characteristics of a conventional semiconductor transistor in combination with a carrier flow controlled by magnetic moment to maximise gain.
摘要翻译：自旋晶体管是混合磁/半导体晶体管，其中在半导体基底（4）和集电极（3）之间设置有可控制的屏障（5），以控制载流子到集电极（3）的扩散。对于自旋晶体管，载流子群体通过载流子的自旋或磁矩的方向而不是电子电荷来区分。自旋注入器（1）用于使电荷载体群旋转极化，使得群体具有选定的磁矩，其中群体可能或可能不能通过磁屏障流向收集器。旋转晶体管利用常规半导体晶体管的电子特性与由磁矩控制的载流相结合，以使增益最大化。

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