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1. 发明申请

WO0116150A3 NUCLEOSIDE ANALOGUES 审中-公开
标题翻译：核苷类似物
公开(公告)号：WO0116150A3
公开(公告)日：2001-11-15
申请号：PCT/GB0003301
申请日：2000-08-30
申请人： NYCOMED AMERSHAM PLC , SMITH CLIFFORD , CUMMINS WILLIAM JONATHAN , NAIRNE ROBERT JAMES DOMETT
发明人： SMITH CLIFFORD , CUMMINS WILLIAM JONATHAN , NAIRNE ROBERT JAMES DOMETT
IPC分类号： G01N33/53 , C07D233/66 , C07D249/12 , C07D249/14 , C07H19/052 , C07H19/056 , C07H21/00 , C07H21/04 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/58
CPC分类号： C07H21/00 , C07D249/12 , C07D249/14 , C07H19/052
摘要： Compounds having structure (I) where X is CH or N, Y is -CO-, -CONW-, -O-, -S-, -SO-, -SO2-, -NWCO-, -NW-, or -OCO-, W is the same or different at different places in the molecule and each is H or alkyl or aryl or Rp or -Ln-Rp, Ln is a linker group, Rp is a reporter moiety, and Q is a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue, provided that at least one reporter moiety Rp is present, provide nucleoside triphosphates which are good enzyme substrates.
摘要翻译：具有结构式（I）的化合物其中X是CH或N，Y是-CO - ， - CONW - ， - O - ， - S - ， - SO - ， - SO2 - ， - NCOCO-，-NW-或-OCO - ，W在分子的不同位置相同或不同，各自为H或烷基或芳基或Rp或-Ln-Rp，Ln为接头基团，Rp为报道部分，Q为糖或糖类似物或核酸主链或主链类似物，条件是存在至少一个报道分子部分Rp，提供核苷三磷酸酯，其是良好的酶底物。

2. 发明申请

WO1995004160A1 TAG REAGENT AND ASSAY METHOD 审中-公开
标题翻译：标签试剂和测定方法
公开(公告)号：WO1995004160A1
公开(公告)日：1995-02-09
申请号：PCT/GB1994001675
申请日：1994-08-01
申请人： ISIS INNOVATION LIMITED , SOUTHERN, Edwin , CUMMINS, William, Jonathan
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6874 , C07F7/1804 , C07H21/00 , C12N15/1075 , C12Q1/6816 , C12Q1/6837 , C12Q1/6872 , Y10S435/912 , C12Q2563/167 , C12Q2565/627
摘要： A reagent comprises: a) an analyte moiety comprising at least two analyte residues, and linked to; b) a tag moiety comprising one or more reporter groups adapted for detection by mass spectrometry, wherein a reporter group designates an analyte residue, and the reporter group at each position of the tag moiety is chosen to designate an analyte residue at a defined position of the analyte moiety. A plurality of such reagents, each comprising a different analyte moiety, provides a library of reagents which may be used in assay methods involving a target substance. Analysis of the tag moieties indicates the nature of the analyte moieties bound to the target substance. A method of sequencing nucleic acid employs a library of the reagents to determine the sequence of a target nucleic acid.
摘要翻译：试剂包括：a）分析物部分，其包含至少两个分析物残基，并连接到; b）包含一个或多个适于通过质谱检测的报告基团的标签部分，其中报道基团指定分析物残基，并且标签部分的每个位置处的报告基团被选择为在分析物部分。多个这样的试剂，各自包含不同的分析物部分，提供可用于涉及靶物质的测定方法的试剂文库。标签部分的分析表明结合到目标物质的分析物部分的性质。测序核酸的方法使用试剂文库来确定靶核酸的序列。

3. 发明申请

WO1998015829A1 ANALYSIS OF CARBOHYDRATES 审中-公开
标题翻译：碳水化合物的分析
公开(公告)号：WO1998015829A1
公开(公告)日：1998-04-16
申请号：PCT/GB1997002727
申请日：1997-10-03
申请人： AMERSHAM INTERNATIONAL PLC , JACKSON, Peter , CUMMINS, William, Jonathan , WEST, Richard , SMITH, John, Anthony , BRIGGS, Mark, Samuel, Jonathan
发明人： AMERSHAM INTERNATIONAL PLC
IPC分类号： G01N33/52
CPC分类号： G01N27/44795 , G01N27/44726 , G01N33/52 , G01N33/533
摘要： A method of separating or distinguishing carbohydrate substances, by the use of a fluorescent labelling reagent which has a positive charge when bound to a carbohydrate, involves separating or distinguishing labelled carbohydrate substances, e.g. by performing electrophoresis to cause differential migration of different labelled carbohydrate substances, or by isoelectric focusing in a pH gradient. Preferably the fluorescent labelling reagent is a cyanine dye.
摘要翻译：通过使用与碳水化合物结合时具有正电荷的荧光标记试剂来分离或区分碳水化合物物质的方法涉及分离或区分标记的碳水化合物物质，例如，通过进行电泳以引起不同标记的碳水化合物物质的差异迁移，或通过在pH梯度中的等电聚焦。优选地，荧光标记试剂是花青染料。

4. 发明申请

WO1997040104A1 SQUARATE DYES AND THEIR USE IN FLUORESCENT SEQUENCING METHOD 审中-公开
标题翻译：大容量染料及其在荧光测序方法中的应用
公开(公告)号：WO1997040104A1
公开(公告)日：1997-10-30
申请号：PCT/GB1997001105
申请日：1997-04-21
申请人： AMERSHAM INTERNATIONAL PLC , HAMILTON, Alan, Lewis , WEST, Richard, Martin , BRIGGS, Mark, Samuel, Jonathan , CUMMINS, William, Jonathan , BRUCE, Ian, Edward
发明人： AMERSHAM INTERNATIONAL PLC
IPC分类号： C09B57/00
CPC分类号： C09B57/007 , C07H21/00
摘要： Novel squarate dyes are described, and adducts of these dyes with biologically significant chemical species such as nucleosides or nucleotides. The adducts have useful properties for fluorescent nucleic acid sequencing methods.
摘要翻译：描述了新型方酸盐染料，以及这些染料与生物学重要化学物质如核苷或核苷酸的加合物。加合物对于荧光核酸测序方法具有有用的性质。

5. 发明申请

WO0058405A3 SQUARAINE DYES 审中-公开
公开(公告)号：WO0058405A3
公开(公告)日：2001-02-01
申请号：PCT/GB0001223
申请日：2000-03-30
申请人： AMERSHAM PHARM BIOTECH UK LTD , WEST RICHARD MARTIN , CUMMINS WILLIAM JONATHAN , NAIRNE ROBERT JAMES DOMETT , BULL MATTHEW GRAHAM
发明人： WEST RICHARD MARTIN , CUMMINS WILLIAM JONATHAN , NAIRNE ROBERT JAMES DOMETT , BULL MATTHEW GRAHAM
IPC分类号： C07D209/14 , C07D209/60 , C07D215/12 , C07D215/14 , C07D277/64 , C07D401/08 , C07D401/14 , C07D413/08 , C07H19/10 , C07K2/00 , C09B1/00 , C09B23/00 , C09B26/02 , C09B57/00 , C09K11/06 , G01N33/58 , G01N33/68
CPC分类号： C09B57/007 , G01N33/583
摘要： Compounds having the structure: W = Sq - A where A has the formula: -NR R , where R and R are the same or different and each is H or C1-C20 hydrocarbon or a group -L-G, or one of R and R is -OR or -NR R or -COR or -NR COR or -N =R or R and R together form a single ring or fused ring system, saturated or unsaturated and unsubstituted or substituted, or an azacrown or a metal-binding group, Sq represents formula (A) or formula (B) where m is 1, 2 or 3, W represents a wing moiety having structure (C), L' is a linker of 0-3 moieties selected from carbon atoms and arylene groups, the dotted line represents a single ring or fused ring system, aromatic or heterocyclic, unsubstituted or substituted, containing or joined to a tertiary or quaternary N atom, and having unsaturation co-ordinated with that of L' = Sq, each of R , R , R and R is H or C1-C20 hydrocarbon or a group -L-G, R is a negative charge or a group -L-G, L is a linker chain of 0 to 30 moieties, branched or unbranched which optionally contains one or more arylene groups, or O or N or N or S or S or P or P or Se atoms, and G is a functional or a reactive group by means of which the compound may be covalently linked to a biomolecule, or a group which enhances or reduces water solubility or provides electron donating or withdrawing properties to modify the spectral characteristics of the compound, and homo-dimers and -oligomers and hetero-dimers and -oligomers of the compounds.
摘要翻译：具有以下结构的化合物：W = Sq-A其中A具有下式：-NR 1 R 2，其中R 1和R 2相同或不同，并且各自为H或C 1 -C 20烃或基团-LG，或R 1和R 2中的一个为-OR 5或-NR 6 R 7或-COR 7或-NR 6 COR 7。或-N = R 8或R 1和R 2一起形成饱和或不饱和的且未取代或取代的单环或稠环体系，或偶氮染料或金属结合基团，Sq表示式（ A）或式（B）其中m为1,2或3，W表示具有结构（C）的翼部分，L'为选自碳原子和亚芳基的0-3个部分的连接体，虚线表示单环或稠环系，未取代或取代的，含有或连接至叔或季N原子，并且具有与L'= Sq的不饱和键相互独立的R 5，R 6， >，R 7和R 8是H或C 1 -C 20烃或基团-LG，R 9是负电荷或基团-LG，L是连接基团 0至30个部分，任选含有一个或多个亚芳基，或O或N或N +或S或S +或P或P +或Se原子的支链或非支链，并且G是官能团或反应性基团，通过其可以将化合物共价连接到生物分子，或提高或降低水溶性或提供给电子或取出性质以改变化合物的光谱特征的基团，以及同型二聚体和低聚物和化合物的异二聚体和低聚物。

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