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1. 发明申请

WO2007068066A2 DEVICE AND METHOD FOR POSITIONING A TARGET VOLUME IN A RADIATION THERAPY APPARATUS 审中-公开
标题翻译：用于定位辐射治疗装置中目标体积的装置和方法
公开(公告)号：WO2007068066A2
公开(公告)日：2007-06-21
申请号：PCT/BE2006/000133
申请日：2006-12-12
申请人： ION BEAM APPLICATIONS S.A. , JONGEN, Yves , LABARBE, Rudi
发明人： JONGEN, Yves , LABARBE, Rudi
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/0421 , A61N5/1065 , A61N5/1069 , A61N2005/1087
摘要： Device for positioning a target volume (112) such, as a phantom or a patient in a radiation therapy apparatus, said apparatus directing a radiation beam (405) towards said target (112), characterized in that it comprises: - a target support (100) whereon the target is immobilized; a two dimensional radiation detector (103) fixed with fixations means (101,102, 104, 106 107; 301, 302, 304, 305, 306; 208, 209) in a known geometric relationship to said target support (100), said radiation detector (103) being capable of detecting the position of intersection of said radiation beam (105) with said detector (103) ; correcting means for correcting the relative position of said beam (105) and said target support 100) , based on said detected intersection position.
摘要翻译：用于定位目标体积（112）的装置，例如放射治疗装置中的体模或患者，所述装置将辐射束（405）引向所述目标（112），其特征在于，其包括：目标支撑 100）目标是固定的; 以与已知几何关系的固定装置（101,102,104,106,107; 301,302,304,305,306,208,209）固定的二维辐射探测器（103），所述辐射探测器（103）能够检测所述辐射束（105）与所述检测器（103）的相交的位置; 校正装置，用于基于所述检测到的交叉位置校正所述光束（105）和所述目标支撑件100的相对位置。

2. 发明公开

EP1960051A2 DEVICE AND METHOD FOR POSITIONING A TARGET VOLUME IN A RADIATION THERAPY APPARATUS 有权
标题翻译：设备和方法具有目标容积在放射治疗装置定位
公开(公告)号：EP1960051A2
公开(公告)日：2008-08-27
申请号：EP06828086.6
申请日：2006-12-12
申请人： ION BEAM APPLICATIONS S.A.
发明人： JONGEN, Yves , LABARBE, Rudi
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/0421 , A61N5/1065 , A61N5/1069 , A61N2005/1087
摘要： Device for positioning a target volume (112) such, as a phantom or a patient in a radiation therapy apparatus, said apparatus directing a radiation beam (405) towards said target (112), characterized in that it comprises: - a target support (100) whereon the target is immobilized; a two dimensional radiation detector (103) fixed with fixations means (101,102, 104, 106 107; 301, 302, 304, 305, 306; 208, 209) in a known geometric relationship to said target support (100), said radiation detector (103) being capable of detecting the position of intersection of said radiation beam (105) with said detector (103) ; correcting means for correcting the relative position of said beam (105) and said target support 100) , based on said detected intersection position.

3. 发明公开

EP4175709A1 CONFORMAL PARTICLE THERAPY SYSTEM 审中-实审
公开(公告)号：EP4175709A1
公开(公告)日：2023-05-10
申请号：EP21734017.3
申请日：2021-06-24
申请人： Ion Beam Applications S.A.
发明人： LABARBE, Rudi , HOTOIU, Lucian , DE NEUTER, Sebastien , COLLIGNON, Laurent , PIN, Arnaud
IPC分类号： A61N5/10

4. 发明公开

EP3932482A1 CHARGED PARTICLE TREATMENT PLANNING SYSTEM WITH PBS BEAMLETS SEQUENCE OPTIMIZED FOR HIGH DOSE DEPOSITION RATE 有权
公开(公告)号：EP3932482A1
公开(公告)日：2022-01-05
申请号：EP20194440.2
申请日：2020-09-03
申请人： Ion Beam Applications S.A.
发明人： LABARBE, Rudi , HOTOIU, Lucian , PIN, Arnaud
IPC分类号： A61N5/10
摘要： The present invention concerns a treatment planning system (TPS) for generating a plan for treatment by radiation with charged particles beams, preferably with proton beams, applied by pencil beam scanning (PBS) onto a target tissue (3t) comprising tumoral cells enclosed within a peripheral surface, wherein the TPS comprises,
• a dose definition stage defining the doses to be deposited within the peripheral surface
• a beam definition stage defining positions and dimensions of the beamlets of the PBS during the at least one high rate fraction, the beams definition stage comprising
• a dose rate definition stage comprising at least one high rate fraction j, wherein specific volumes (Vs) comprising healthy cells are irradiated at a ultra-high dose deposition rate (HDR), wherein HDR = Dj / t ≥ 1 Gy / s, j, and
• a beamlets scanning sequence stage defining a scanning sequence of irradiation of the beamlets.
The beamlets scanning sequence stage aims at optimizing a time sequence of beamlets emission such that at the end of a fraction j, a dose is deposited onto at least a predefined fraction of each specific volume at a mean deposition rate (DRa) superior or equal to a predefined value (DRa0) of a mean ultra-high dose deposition rate boundary (DRa ≥ DRa0), wherein DRa is defined as, DRa = ∑Dj/Δt ≥ DRa0 ≥ 1 Gy / s, wherein ∑Dj is a sum of a percentile of at least 95%, preferably at least 98% of all the doses deposited by one or more beamlets onto a given volume and Δt is the time between the first and last doses deposited onto the given volume.

5. 发明授权

EP1960051B1 DEVICE AND METHOD FOR POSITIONING A TARGET VOLUME IN A RADIATION THERAPY APPARATUS 有权
标题翻译：设备和方法具有目标容积在放射治疗装置定位
公开(公告)号：EP1960051B1
公开(公告)日：2010-07-07
申请号：EP06828086.6
申请日：2006-12-12
申请人： ION BEAM APPLICATIONS S.A.
发明人： JONGEN, Yves , LABARBE, Rudi
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/0421 , A61N5/1065 , A61N5/1069 , A61N2005/1087
摘要： Device for positioning a target volume (112) such, as a phantom or a patient in a radiation therapy apparatus, said apparatus directing a radiation beam (405) towards said target (112), characterized in that it comprises: - a target support (100) whereon the target is immobilized; a two dimensional radiation detector (103) fixed with fixations means (101,102, 104, 106 107; 301, 302, 304, 305, 306; 208, 209) in a known geometric relationship to said target support (100), said radiation detector (103) being capable of detecting the position of intersection of said radiation beam (105) with said detector (103) ; correcting means for correcting the relative position of said beam (105) and said target support 100) , based on said detected intersection position.

6. 发明申请

WO2003050518A2 SYSTEM AND METHOD FOR TIME CORRELATED MULTI-PHOTON COUNTING MEASUREMENTS 审中-公开
标题翻译：用于时间相关的多光子计数测量的系统和方法
公开(公告)号：WO2003050518A2
公开(公告)日：2003-06-19
申请号：PCT/GB2002/005543
申请日：2002-12-06
申请人： AMERSHAM BIOSCIENCES UK LIMITED , LABARBE, Rudi , SEWELL, Roger , PUMPHERY, Sam
发明人： LABARBE, Rudi , SEWELL, Roger , PUMPHERY, Sam
IPC分类号： G01N21/64
CPC分类号： G01N21/6408
摘要： The invention provides a method and a measurement system for characterisation of luminescence properties, the method comprises irradiating the luminescent material with a pulse of excitation light, providing a triggering signal correlated to the pulse of excitation light; detecting with a photodetector such as a photomultiplier tube (PMT) a plurality of photons emitted from the luminescent material as result of the pulse of excitation light, the photodetector providing an output signal upon the event of detection of a photon; determining for each detected photon a photon arrival time and providing an output suitable for inputting to an analysing module wherein an output comprises zero, one, or more photon arrival time for each excitation, receiving said outputs in an analysing module; and determining in the analysing module, characteristics properties of the luminescent material by performing a statistical analysis based on Bayesian inference.
摘要翻译：本发明提供了用于表征发光特性的方法和测量系统，该方法包括用激发光脉冲照射发光材料，提供与激发光脉冲相关的触发信号; 利用诸如光电倍增管（PMT）的光电检测器检测作为激发光脉冲的结果从发光材料发射的多个光子，光检测器在检测到光子事件时提供输出信号; 针对每个检测到的光子确定光子到达时间并且提供适合于输入到分析模块的输出，其中输出包括针对每个激励的零个，一个或多个光子到达时间，在分析模块中接收所述输出; 以及通过基于贝叶斯推断进行统计分析，在分析模块中确定发光材料的特性。

7. 发明申请

WO2007068919A2 SPECTROPHOTOMETER 审中-公开
标题翻译：分光光度计
公开(公告)号：WO2007068919A2
公开(公告)日：2007-06-21
申请号：PCT/GB2006/004657
申请日：2006-12-13
申请人： ZINIR LIMITED , GOODYER, Ian , NUTALL, Tracy, Ann , LABARBE, Rudi , ARINI, Nicholas, Salvatore , SEDDON, Andrew , STOCK, Nick , ROSS, Gary , PATZ, Ralf
发明人： GOODYER, Ian , NUTALL, Tracy, Ann , LABARBE, Rudi , ARINI, Nicholas, Salvatore , SEDDON, Andrew , STOCK, Nick , ROSS, Gary , PATZ, Ralf
IPC分类号： G01J3/36
CPC分类号： G01J3/02 , G01J3/0202 , G01J3/0218 , G01J3/0237 , G01J3/024 , G01J3/0262 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0286 , G01J3/0291 , G01J3/06 , G01J3/10 , G01J3/28 , G01N21/274 , G01N21/3563 , G01N21/359 , G01N2201/12707 , G01N2201/128 , G01N2201/129
摘要： A spectrophotometer has a first photodetector (24) and a second photodetector (25) which is displaced spatially from the first photodetector in the direction of increasing wavelength in the spectrum. At any given time the second photodetector receives light at a wavelength which is substantially greater than that being received simultaneously by the first photodetector at that time. The first photodetector has a first range of wavelengths over which it is operable and a first upper operating limit, and the second photodetector has a second range of wavelengths over which it is operable and a second upper operating limit, the second range overlapping the first range and the second upper operating limit being greater than the first upper operating limit. Thus the range of operation is extended, and data in two different ranges is processed simultaneously. The spectrophotometer comprises a housing (1) containing a light source (11), a monochromator (15, 16, 18) and the photodetectors, there being a fibre optic connected to a probe (2) for transmitting light from the light source to a sample to be analysed and receiving light from the sample. Optical components are mounted to a chassis (26) of the housing rigidly, the chassis being connected to the housing by shock absorbing mounts (28, 29). The light source is mounted to the housing by means of an adjuster (24) providing for adjustment laterally with respect to the optical axis of the light source.
摘要翻译：分光光度计具有第一光电检测器（24）和第二光电检测器（25），所述第一光电检测器（25）在光谱中沿着波长增加的方向从第一光电检测器空间位移。在任何给定时间，第二光电探测器接收的光的波长明显大于当时由第一光电探测器同时接收的波长。第一光电检测器具有可操作的第一波长范围和第一上限操作极限，并且第二光电检测器具有可操作的第二波长范围和第二上限操作极限，第二范围与第一范围重叠并且第二上限运行极限大于第一上限运行极限。因此扩展了操作范围，同时处理两个不同范围的数据。分光光度计包括容纳光源（11），单色仪（15,16,18）和光电检测器的壳体（1），其中连接有探针（2）的光纤，用于将光从光源传输到样品进行分析并从样品中接收光。光学元件刚性地安装到外壳的底盘（26）上，底盘通过减震座（28,29）连接到外壳。光源通过调节器（24）安装到壳体，该调节器提供相对于光源的光轴横向调节。

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