专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明公开

EP3932482A1 CHARGED PARTICLE TREATMENT PLANNING SYSTEM WITH PBS BEAMLETS SEQUENCE OPTIMIZED FOR HIGH DOSE DEPOSITION RATE 有权
公开(公告)号：EP3932482A1
公开(公告)日：2022-01-05
申请号：EP20194440.2
申请日：2020-09-03
申请人： Ion Beam Applications S.A.
发明人： LABARBE, Rudi , HOTOIU, Lucian , PIN, Arnaud
IPC分类号： A61N5/10
摘要： The present invention concerns a treatment planning system (TPS) for generating a plan for treatment by radiation with charged particles beams, preferably with proton beams, applied by pencil beam scanning (PBS) onto a target tissue (3t) comprising tumoral cells enclosed within a peripheral surface, wherein the TPS comprises,
• a dose definition stage defining the doses to be deposited within the peripheral surface
• a beam definition stage defining positions and dimensions of the beamlets of the PBS during the at least one high rate fraction, the beams definition stage comprising
• a dose rate definition stage comprising at least one high rate fraction j, wherein specific volumes (Vs) comprising healthy cells are irradiated at a ultra-high dose deposition rate (HDR), wherein HDR = Dj / t ≥ 1 Gy / s, j, and
• a beamlets scanning sequence stage defining a scanning sequence of irradiation of the beamlets.
The beamlets scanning sequence stage aims at optimizing a time sequence of beamlets emission such that at the end of a fraction j, a dose is deposited onto at least a predefined fraction of each specific volume at a mean deposition rate (DRa) superior or equal to a predefined value (DRa0) of a mean ultra-high dose deposition rate boundary (DRa ≥ DRa0), wherein DRa is defined as, DRa = ∑Dj/Δt ≥ DRa0 ≥ 1 Gy / s, wherein ∑Dj is a sum of a percentile of at least 95%, preferably at least 98% of all the doses deposited by one or more beamlets onto a given volume and Δt is the time between the first and last doses deposited onto the given volume.

IPRDB

热门服务

关于我们

友情链接

联系方式