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1. 发明申请

WO2009121850A1 DEVICE AND METHOD FOR MEASURING CHARACTERISTICS OF AN ION BEAM 审中-公开
标题翻译：用于测量离子束特性的装置和方法
公开(公告)号：WO2009121850A1
公开(公告)日：2009-10-08
申请号：PCT/EP2009/053761
申请日：2009-03-30
申请人： ION BEAM APPLICATIONS S.A. , JONGEN, Yves , ARNOLD, Martin , CLAEREBOUDT, Yves , PRIEELS, Damien
发明人： JONGEN, Yves , ARNOLD, Martin , CLAEREBOUDT, Yves , PRIEELS, Damien
IPC分类号： G01T1/29
CPC分类号： G01T1/2935
摘要： The present invention relates to a detector (600, 800) for measuring characteristics of an energetic particle beam (1000) generated by a radiation source, the detector (600, 800) comprising: • means to vary the incoming particle beam energy; • a plurality of sensors (602, 602a, 602b, 802) arranged in parallel; • processing means capable of processing signals coming from said sensors (602, 602a, 602b, 802) in correlation with said energy variation.
摘要翻译：本发明涉及一种用于测量由辐射源产生的能量粒子束（1000）的特性的检测器（600,800），该检测器（600,800）包括：改变进入的粒子束能量的装置; 多个并联布置的传感器（602,602a，602b，802）; 处理装置能够处理来自所述传感器（602,602a，602b，802）的信号与所述能量变化相关。

2. 发明申请

WO2011009953A1 DISPOSITIF ET MÉTHODE POUR LA MESURE D'UN FAISCEAU ENERGETIQUE DE PARTICULES 审中-公开
标题翻译：用于测量能量粒子束的装置和方法
公开(公告)号：WO2011009953A1
公开(公告)日：2011-01-27
申请号：PCT/EP2010/060747
申请日：2010-07-23
申请人： ION BEAM APPLICATIONS S.A. , PRIEELS, Damien
发明人： PRIEELS, Damien
IPC分类号： H01J47/02
CPC分类号： H01J47/02 , G01N27/66 , G01T1/185
摘要： La présente invention concerne un dispositif de dosimétrie d'un faisceau énergétique de particules provenant d'une source et comprenant au moins deux chambres d' ionisation comprenant chacune une électrode collectrice et une électrode de polarisation, lesdites électrodes de chaque chambre d' ionisation étant séparées par un gap comprenant un fluide, lesdites chambres d' ionisation étant traversées par un faisceau énergétique provenant d'une même source, le dispositif étant caractérisé en ce que lesdites chambres d'ionisation présentent des facteurs d'efficacité de collection de charges différents. Ledit algorithme de calcul du débit de dose déposé par ledit faisceau se base sur la mesure d'un signal de sortie dans chaque chambre d' ionisation du dispositif et sur un facteur « gain » relatif à une première chambre d' ionisation, ledit facteur « gain » étant déterminé théoriquement en fonction desdits paramètres intrinsèques et/ou extrinsèques desdites chambres d'ionisation.
摘要翻译：本发明涉及一种用于来自源的能量粒子束的剂量测定装置，其包括至少两个电离室，每个离子化室包括集电极和极化电极，每个电离室中的所述电极被包括流体来自通过所述电离室的单个源的能量束，其特征在于，所述电离室具有不同的电荷收集效率因子。所述用于由所述光束沉积的剂量率的所述计算算法基于所述器件的每个电离室中的输出信号的测量和Δε增益Δθ。与第一电离室有关的因子，理论上根据所述电离室的所述固有和/或非固有参数来预定因子。

3. 发明申请

WO2012152938A2 A METHOD AND APPARATUS FOR PARTICLE BEAM RANGE VERIFICATION 审中-公开
标题翻译：用于粒子束范围验证的方法和装置
公开(公告)号：WO2012152938A2
公开(公告)日：2012-11-15
申请号：PCT/EP2012/058836
申请日：2012-05-11
申请人： ION BEAM APPLICATIONS S.A. , PRIEELS, Damien , DEBATTY, Alexandre
发明人： PRIEELS, Damien , DEBATTY, Alexandre
IPC分类号： A61N5/10
CPC分类号： A61N5/1065 , A61N5/1048 , A61N2005/1052 , A61N2005/1087 , G01T1/2914
摘要： The invention is related to a method and apparatus for verifying the beam range in a target irradiated with a charged hadron beam, such as a proton beam. The beam range is the location of the Bragg peak in the target, being the location where the largest portion of the dose is delivered. The method utilizes a prompt gamma camera provided with a slit-shaped opening, so as to be able to produced a 1-dimensional profile of the dose distribution along the beam line. The camera is mounted with the slit oriented perpendicularly to the beam line. The method comprises the steps of calculating a position of the camera with respect to a target, for a plurality of beam energies and spots to be irradiated. The method further comprises the steps of verifying the beam range for said plurality of spots, and delivering a value representative of the difference between the estimated beam range and the actual beam range. The apparatus of the invention is provided with a positioning module for positioning the camera.
摘要翻译：本发明涉及一种用于验证用充电的强子束（例如质子束）照射的目标中的光束范围的方法和装置。光束范围是目标中的布拉格峰的位置，其是递送最大部分剂量的位置。该方法利用提供有狭缝形开口的快速γ相机，以便能够沿着束线产生剂量分布的一维轮廓。相机安装成狭缝定向成垂直于光束线。该方法包括以下步骤：针对多个光束能量和要照射的斑点，计算相机相对于目标的位置。所述方法还包括以下步骤：验证所述多个光点的光束范围，以及传递代表所估计的光束范围和实际光束范围之间的差的值。本发明的装置设置有用于定位相机的定位模块。

4. 发明申请

WO2008119777A1 DEVICE AND METHOD FOR ONLINE QUALITY ASSURANCE IN HADRON THERAPY 审中-公开
标题翻译： HADRON治疗中在线质量保证的设备和方法
公开(公告)号：WO2008119777A1
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053774
申请日：2008-03-29
申请人： ION BEAM APPLICATIONS S.A. , PRIEELS, Damien , BREEV, Victor
发明人： PRIEELS, Damien , BREEV, Victor
IPC分类号： A61N5/10 , H01J47/02
CPC分类号： H01J47/02 , A61N5/1075 , A61N2005/1076 , A61N2005/1087
摘要： A device and method for on line dosimetry monitoring of a hadron beam generated from a source of radiation and delivered to a target, the device comprising a plurality of support plates arranged in parallel in a face-to-face relation, separated from each other by gas filled gaps and perpendicularly to the central axis of said hadron beam, and forming a plurality of ionization chambers, each support plate having on a first side one or more collecting electrodes and on a second side one or more high voltage electrode, arranged in such a way that each support plate has said first side substantially opposed to said second side of another support plate. Each support plate has an opening so as to form an inner cavity for allowing the undisturbed passage of a central portion of the hadron beam delivered to said target and a peripheral region for intercepting and measuring, by means of said plurality of ionization chambers, a peripheral portion of said hadron beam.
摘要翻译：一种用于在线辐射源产生的强子束的线上剂量测量监测装置和方法，该装置和方法被输送到目标物，所述装置包括以面对面关系平行排列的多个支撑板，气体填充的间隙并垂直于所述强子束的中心轴线，并且形成多个电离室，每个支撑板在第一侧上具有一个或多个集电极，并且在第二侧上具有一个或多个高压电极，每个支撑板具有基本上与另一个支撑板的所述第二侧相对的第一侧的方式。每个支撑板具有开口以形成内腔，用于允许输送到所述靶的强子束的中心部分的不受干扰的通道和用于通过所述多个电离室截取和测量周边区域的周边所述强子束的一部分。

5. 发明申请

WO2012104416A1 AN APPARATUS FOR PARTICLE THERAPY VERIFICATION 审中-公开
标题翻译：用于颗粒治疗验证的装置
公开(公告)号：WO2012104416A1
公开(公告)日：2012-08-09
申请号：PCT/EP2012/051866
申请日：2012-02-03
申请人： ION BEAM APPLICATIONS S.A. , UNIVERSITE LIBRE DE BRUXELLES , PRIEELS, Damien , STICHELBAUT, Frédéric , SMEETS, Julien , DUBUS, Alain , DEHAES, Jean-Claude
发明人： PRIEELS, Damien , STICHELBAUT, Frédéric , SMEETS, Julien , DUBUS, Alain , DEHAES, Jean-Claude
IPC分类号： A61N5/10 , G01T1/164 , A61N5/00
CPC分类号： A61N5/1071 , A61N5/1048 , A61N5/1075 , A61N2005/1052 , A61N2005/1087 , F04C2270/041 , G01T1/2914
摘要： The invention is related to an apparatus and method for charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating a target (6) with a charged hadron beam. The apparatus comprises a collimator (1) provided with a slit-shaped portion (2) configured to be arranged perpendicularly to the beam line and facing the target, a detection means (3,4) suitable for detecting said prompt gammas and a calculation and representation means. In the apparatus and method of the invention, the slit is configured to allow the passage of prompt gammas emitted from a range of depths in said target (6), said depths being measured in the direction of the charged hadron beam. Furthermore, said detection means is configured to detect prompt gammas emitted from each location within said range, and said calculation and representation means is configured to derive from a detected prompt gamma a value representative of the dose at the location from where said prompt gamma is emitted, and to represent a dose-related distribution for a plurality of locations within said range.
摘要翻译：本发明涉及一种用于通过检测和/或量化利用带电荷的强子束照射目标（6）时产生的提示性伽马的充电强子治疗验证的装置和方法。该装置包括准直器（1），该准直器（1）具有被配置为垂直于射束线且面向目标的狭缝状部分（2），适于检测所述快速伽马的检测装置（3,4）表示手段。在本发明的装置和方法中，狭缝被配置为允许从所述目标（6）中的深度范围发射的提示伽马射线的通过，所述深度在被充电的强子波束的方向上被测量。此外，所述检测装置被配置为检测从所述范围内的每个位置发出的迅速伽马值，并且所述计算和表示装置被配置为从检测到的提示gamma导出表示在所述快速伽马发射的位置处的剂量的值并且表示在所述范围内的多个位置的剂量相关分布。

6. 发明申请

WO2003101538A1 APPARATUS FOR IRRADIATING A TARGET VOLUME 审中-公开
标题翻译：用于减少目标音量的装置
公开(公告)号：WO2003101538A1
公开(公告)日：2003-12-11
申请号：PCT/BE2002/000180
申请日：2002-11-29
申请人： ION BEAM APPLICATIONS S.A. , BRUSASCO, Caterina , MARCHAND, Bruno , DE LE HOYE, Jean-François , PRIEELS, Damien
发明人： BRUSASCO, Caterina , MARCHAND, Bruno , DE LE HOYE, Jean-François , PRIEELS, Damien
IPC分类号： A61N5/10
CPC分类号： G21K1/087 , A61N5/10 , A61N5/1043 , A61N5/1048 , A61N2005/1087
摘要： An irradiation apparatus for irradiating by scanning a target volume according to a predetermined dose profile with a scanning beam of charged particles forming an irradiation spot on said target volume, said apparatus comprising: a beam generating device; a reference generator for computing, from said predetermined dose profile, through a dynamic inverse control strategy, the time evolution of commanded variables, these variables being the beam current I(t), the spot position settings x(t), y(t) and the scanning speed settings v x (t), v y (t); a monitor device having means for detecting at each time (t), the actual spot position as a measured position defined by the values x m (t), y m (t) on the target volume, characterised in that said irradiation apparatus further comprises means for determining the differences e x (t), e y (t) between the measured values x m (t), y m (t) and the spot position settings x(t) and y(t), and means for applying a correction to the scanning speed settings v x (t) and v y (t) depending on said differences e x (t), e y (t). The present invention is also related to a monitor for determining beam position in real-time.
摘要翻译：一种照射装置，用于通过在所述目标体积上形成照射点的带电粒子的扫描光束根据预定剂量分布扫描目标体积进行照射，所述装置包括：光束产生装置; 参考发生器，用于根据所述预定剂量分布图，通过动态反向控制策略，指令变量的时间演化，这些变量是射束电流I（t），光点位置设置x（t），y（t）和扫描速度设置vx（t），vy（t）; 监视器装置，具有用于在每个时间（t）检测作为由目标体积上的值xm（t），ym（t）定义的测量位置的实际光斑位置的装置，其特征在于，所述照射装置还包括：确定测量值xm（t），ym（t）和光点位置设置x（t）和y（t）之间的差异ex（t），ey（t）以及对扫描速度进行校正的装置根据所述差异ex（t），ey（t），设定vx（t）和vy（t）。本发明还涉及实时确定波束位置的监视器。

7. 发明申请

WO2015040225A1 METHOD AND APPARATUS FOR THE RANGE CONTROL OF PARTICLE RADIATION OF A RADIATION DEVICE FOR RADIATION THERAPY 审中-公开
标题翻译：用于辐射治疗的辐射装置的颗粒辐射范围控制的方法和装置
公开(公告)号：WO2015040225A1
公开(公告)日：2015-03-26
申请号：PCT/EP2014/070159
申请日：2014-09-22
申请人： TECHNISCHE UNIVERSITÄT DRESDEN , HELMHOLTZ-ZENTRUM DRESDEN - ROSSENDORF E.V. , ION BEAM APPLICATIONS S.A.
发明人： PAUSCH, Guntram , ENGHARDT, Wolfgang , GOLNIK, Christian , JANSSENS, Guillaume , PRIEELS, Damien , SMEETS, Julien , VANDER STAPPEN, Francois , HUESO-GONZALEZ, Fernando
IPC分类号： G01T1/29
CPC分类号： A61N5/1067 , A61N2005/1052 , A61N2005/1074 , A61N2005/1087 , G01T1/24 , G01T1/29
摘要： The invention relates to a device and a method for the monitoring of the range of a particle radiation (3) of a radiation device (1) for radiation therapy with at least one detector (2) being able to detect single gamma particles (4) and at least one analyzer (7), characterized in that when detecting a gamma particle (4), furthermore denominated as event, a signal is created in the detector (2), whereby the signal is correlated in time with the arrival of the gamma particle (4) in detector (2), the analyzer (7), analyzing the signal of the detector (2), does assign either every event or selected events a time of detection, the radiation device (1) or a separate particle detector (8) does provide a reference signal, which is correlated to the emersion of single particles or particle bunches from the radiation device (1) out of the radiation device (1) with an uncertainty in time of equal or smaller than 10 ns, a time is obtained from the reference signal for each event or each of the selected events in the analyzer (7), at which the particle or the particle bunch, which has produced the gamma particle (4) detected by the detector (2), further described as event triggering particle or particle bunch, has passed a reference plane perpendicular to the direction of the beam of the radiation device (1), the time difference between the time of the detection of the gamma particle (4) in the detector (2) and the time of the passing of the reference plane by the event triggering particle or particle bunch is calculated for each event or the selected events within the analyzer (7), at least one statistic distribution (6) of the time differences is obtained in the analyzer (7), furthermore described as time distribution (6), and that the time distribution (6) is analyzed and information about the range of the particle beam (3) is derived therefrom, so that a statement with respect to the conformity of the therapy to be monitored with the apparatus with the therapy plan can be obtained mainly from that time distribution (6).
摘要翻译：本发明涉及一种用于监测放射治疗用辐射装置（1）的粒子辐射（3）的范围的装置和方法，其中至少一个检测器（2）能够检测单个γ粒子（4）和至少一个分析器（7），其特征在于，当检测到另外被称为事件的伽马粒子（4）时，在所述检测器（2）中产生信号，由此所述信号在伽马粒子检测器（2）中的粒子（4），分析器（7）分析检测器（2）的信号，分配每个事件或所选事件一次检测时间，辐射装置（1）或单独的粒子检测器（8）确实提供参考信号，该参考信号与来自辐射装置（1）的单个颗粒或粒子束从辐射装置（1）的散射相关，具有等于或小于10ns的时间不确定度，a 从每个事件的参考信号或每个事件的每一个获得时间在分析器（7）中的选定的事件，其中产生由检测器（2）检测到的伽马粒子（4）的粒子或粒子束进一步描述为事件触发粒子或粒子束，已经通过参考平面垂直于辐射装置（1）的光束的方向，检测器（2）中的伽马粒子（4）的检测时间与事件通过参考平面的时间之间的时间差针对每个事件或分析仪（7）内的所选事件计算触发粒子或粒子束，在分析器（7）中获得时间差异的至少一个统计分布（6），进一步描述为时间分布（6），并且分析时间分布（6），并且从其导出关于粒子束（3）的范围的信息，从而关于待监视的治疗与用于治疗计划的装置的一致性的声明可以是o 主要从那个时间分配（6）。

8. 发明公开

EP2457248A1 DISPOSITIF ET MÉTHODE POUR LA MESURE D'UN FAISCEAU ENERGETIQUE DE PARTICULES 有权
标题翻译： VORRICHTUNG UND VERFAHREN ZUR MESSUNG EINES ENERGIEPARTIKELSTRAHLS
公开(公告)号：EP2457248A1
公开(公告)日：2012-05-30
申请号：EP10741930.1
申请日：2010-07-23
申请人： Ion Beam Applications S.A.
发明人： PRIEELS, Damien
IPC分类号： H01J47/02
CPC分类号： H01J47/02 , G01N27/66 , G01T1/185
摘要： The present invention relates to a dosimetry device for an energy particle beam from a source and including at least two ionization chambers, each of which includes a collector electrode and a polarization electrode, said electrodes in each ionization chamber being separated by a gap including a fluid, an energy beam from a single source passing through said ionization chambers, the device being characterized in that said ionization chambers have different charge collection efficiency factors. Said calculation algorithm for the dose rate deposited by said beam is based on the measurement of an output signal in each ionization chamber of the device and on a gain factor related to a first ionization chamber, said gain factor being theoretically predetermined on the basis of said intrinsic and/or extrinsic parameters of said ionization chambers.
摘要翻译：本发明涉及一种用于来自源的能量粒子束的剂量测定装置，其包括至少两个电离室，每个离子化室包括集电极和极化电极，每个电离室中的所述电极被包括流体来自穿过所述电离室的单个源的能量束，其特征在于，所述电离室具有不同的电荷收集效率因子。用于由所述光束沉积的剂量率的所述计算算法基于对器件的每个电离室中的输出信号的测量以及与第一电离室相关的□增益□因子，所述□增益□因子在理论上预定在所述电离室的所述固有和/或外部参数的基础。

9. 发明授权

EP2977083B1 AN APPARATUS FOR PARTICLE THERAPY VERIFICATION 有权
标题翻译：一种用于颗粒治疗验证的装置
公开(公告)号：EP2977083B1
公开(公告)日：2017-12-27
申请号：EP15181468.8
申请日：2012-02-03
申请人： ION BEAM APPLICATIONS S.A. , Université Libre de Bruxelles
发明人： PRIEELS, Damien , STICHELBAUT, Frédéric , SMEETS, Julien , DUBUS, Alain , DEHAES, Jean-Claude
IPC分类号： A61N5/10 , G01T1/164 , A61N5/00
CPC分类号： A61N5/1071 , A61N5/1048 , A61N5/1075 , A61N2005/1052 , A61N2005/1087 , F04C2270/041 , G01T1/2914
摘要： The invention is related to an apparatus and method for charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating a target (6) with a charged hadron beam. The apparatus comprises a collimator (1) provided with a slit-shaped portion (2) configured to be arranged perpendicularly to the beam line and facing the target, a detection means (3,4) suitable for detecting said prompt gammas and a calculation and representation means. In the apparatus and method of the invention, the slit is configured to allow the passage of prompt gammas emitted from a range of depths in said target (6), said depths being measured in the direction of the charged hadron beam. Furthermore, said detection means is configured to detect prompt gammas emitted from each location within said range, and said calculation and representation means is configured to derive from a detected prompt gamma a value representative of the dose at the location from where said prompt gamma is emitted, and to represent a dose-related distribution for a plurality of locations within said range.

10. 发明授权

EP2670485B1 AN APPARATUS FOR PARTICLE THERAPY VERIFICATION 有权
标题翻译：设备技术粒子治疗回顾
公开(公告)号：EP2670485B1
公开(公告)日：2015-09-02
申请号：EP12702533.6
申请日：2012-02-03
申请人： ION BEAM APPLICATIONS S.A. , Université Libre de Bruxelles
发明人： PRIEELS, Damien , STICHELBAUT, Frédéric , SMEETS, Julien , DUBUS, Alain , DEHAES, Jean-Claude
IPC分类号： A61N5/10 , G01T1/164 , A61N5/00
CPC分类号： A61N5/1071 , A61N5/1048 , A61N5/1075 , A61N2005/1052 , A61N2005/1087 , F04C2270/041 , G01T1/2914

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