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1. 发明申请

WO1995018970A1 RADIAL FLOW ASSAY 审中-公开
标题翻译：径向流量测定
公开(公告)号：WO1995018970A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000110
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： INTRACEL CORPORATION , DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KLIBANOV, Alexander, M.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/805 , Y10S436/81
摘要： A delivering member for filtering and delivering a sample to a test assay surface includes a prefilter having a sample receiving surface and a surface for delivering a sample to a test assay surface. The prefilter includes a diffusing material on its receiving surface for rapidly and evenly diffusing a sample across the prefilter receiving surface. In this way, a sample may be rapidly and evenly delivered to a test assay surface. A test assay solid phase has a surface including an area carrying an immobilized species and an area free of immobilized species. When a sample is applied to the surface, followed by application of a labeled species, the evenness of distribution of the labeled species is indicative of the evenness of application of the sample. A kit includes a delivering member and an assay surface.
摘要翻译：用于过滤和将样品递送到测试测定表面的递送构件包括具有样品接收表面的预过滤器和用于将样品递送到测试测定表面的表面。预过滤器在其接收表面上包括扩散材料，用于使样品快速均匀地扩散穿过预过滤器接收表面。以这种方式，样品可以快速均匀地输送到测试测定表面。测试测定固相具有包括携带固定化物质的区域和没有固定化物种的区域的表面。当将样品施加到表面上，随后施加标记物质时，标记物质的分布均匀性表示样品的均匀度。试剂盒包括递送成分和测定表面。

2. 发明申请

WO1995018973A1 ASSAY EMPLOYING BOTH PROTEIN AND ANTIBODY 审中-公开
标题翻译：测定使用两种蛋白质和抗体
公开(公告)号：WO1995018973A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000048
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： INTRACEL CORPORATION , DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KEIL, Walter , KLIBANOV, Alexander, M.
IPC分类号： G01N33/566
CPC分类号： G01N33/54306 , G01N33/56988 , G01N33/6854 , Y10S435/805 , Y10S435/971 , Y10S435/973 , Y10S436/828
摘要： The binding site on an immunoglobulin for a protein is blocked by hydrophobically coupling the immunoglobulin to a blocking agent such as a label. This results in a detection reagent useful in a variety of test assays in which a protein and an immunoglobulin are advantageously used together, but separately. The reagent is useful in the simultaneous determination of IgG and one of IgA or IgM. Anti-IgA-IgG or anti-IgM-IgG is coupled to a hydrophobic label, particularly a pigment or dye, which label blocks the binding site on IgG for Protein A, and labeled Protein A is added.
摘要翻译：蛋白质免疫球蛋白上的结合位点通过将免疫球蛋白疏水性偶合到封闭剂如标记物来阻断。这导致检测试剂可用于各种测试测定，其中蛋白质和免疫球蛋白有利地一起使用，但分开。该试剂可用于同时测定IgG和IgA或IgM中的一种。抗IgA-IgG或抗IgM-IgG与疏水标记物，特别是颜料或染料偶联，该标记阻断蛋白A的IgG上的结合位点，并加入标记的蛋白A.

3. 发明公开

EP0738393A1 ASSAY EMPLOYING BOTH PROTEIN AND ANTIBODY 失效
标题翻译： BOTH蛋白以及抗体，将测定
公开(公告)号：EP0738393A1
公开(公告)日：1996-10-23
申请号：EP95906156.0
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KEIL, Walter , KLIBANOV, Alexander, M.
IPC分类号： G01N33
CPC分类号： G01N33/54306 , G01N33/56988 , G01N33/6854 , Y10S435/805 , Y10S435/971 , Y10S435/973 , Y10S436/828
摘要： The binding site on an immunoglobulin for a protein is blocked by hydrophobically coupling the immunoglobulin to a blocking agent such as a label. This results in a detection reagent useful in a variety of test assays in which a protein and an immunoglobulin are advantageously used together, but separately. The reagent is useful in the simultaneous determination of IgG and one of IgA or IgM. Anti-IgA-IgG or anti-IgM-IgG is coupled to a hydrophobic label, particularly a pigment or dye, which label blocks the binding site on IgG for Protein A, and labeled Protein A is added.

4. 发明公开

EP0738391A1 RADIAL FLOW ASSAY 失效
标题翻译： RADIALSTROMTEST
公开(公告)号：EP0738391A1
公开(公告)日：1996-10-23
申请号：EP95906758.0
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KLIBANOV, Alexander, M.
IPC分类号： G01N33
CPC分类号： G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/805 , Y10S436/81
摘要： A delivering member for filtering and delivering a sample to a test assay surface includes a prefilter having a sample receiving surface and a surface for delivering a sample to a test assay surface. The prefilter includes a diffusing material on its receiving surface for rapidly and evenly diffusing a sample across the prefilter receiving surface. In this way, a sample may be rapidly and evenly delivered to a test assay surface. A test assay solid phase has a surface including an area carrying an immobilized species and an area free of immobilized species. When a sample is applied to the surface, followed by application of a labeled species, the evenness of distribution of the labeled species is indicative of the evenness of application of the sample. A kit includes a delivering member and an assay surface.

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