专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997011177A1 NEUTRALIZING MONOCLONAL ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：将单克隆抗体中和到呼吸道感染病毒
公开(公告)号：WO1997011177A1
公开(公告)日：1997-03-27
申请号：PCT/US1996014944
申请日：1996-09-18
申请人： INTRACEL CORPORATION , PILKINGTON, Glenn, R. , GILMOUR, Page, S.
发明人： INTRACEL CORPORATION
IPC分类号： C12N15/13
CPC分类号： C07K16/1027 , A61K38/00 , A61K39/00 , A61K48/00 , A61K51/1006 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/565 , G01N33/56983
摘要： The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.
摘要翻译：本发明涉及鉴定和克隆呼吸道合胞病毒的新型中和人单克隆抗体。本发明提供了这样的抗体，保留RSV结合能力的这些抗体片段，保留RSV结合能力的嵌合抗体以及包含这种抗体的药物组合物。本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。最后，本发明提供了使用本发明的抗体和核酸的诊断和治疗方法。

2. 发明申请

WO1997010846A1 NEUTRALIZING MONOCLONAL ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：将单克隆抗体中和到呼吸道感染病毒
公开(公告)号：WO1997010846A1
公开(公告)日：1997-03-27
申请号：PCT/US1996014937
申请日：1996-09-18
申请人： INTRACEL CORPORATION , THE GOVERNMENT OF THE UNITED STATES, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , PILKINGTON, Glenn, R. , GILMOUR, Page, S. , CHANOCK, Robert, M. , CROWE, James, E., Jr. , MURPHY, Brian, R.
发明人： INTRACEL CORPORATION , THE GOVERNMENT OF THE UNITED STATES, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： A61K39/42
CPC分类号： C07K16/1027 , A61K38/00 , A61K39/00 , A61K48/00 , A61K51/1006 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/565 , G01N33/56983
摘要： The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratoy Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.
摘要翻译：本发明涉及鉴定和克隆抗呼吸综合征病毒的新型中和人单克隆抗体。本发明提供了这样的抗体，保留RSV结合能力的这些抗体片段，保留RSV结合能力的嵌合抗体以及包含这种抗体的药物组合物。本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。最后，本发明提供了使用本发明的抗体和核酸的诊断和治疗方法。

3. 发明申请

WO1995018970A1 RADIAL FLOW ASSAY 审中-公开
标题翻译：径向流量测定
公开(公告)号：WO1995018970A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000110
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： INTRACEL CORPORATION , DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KLIBANOV, Alexander, M.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/805 , Y10S436/81
摘要： A delivering member for filtering and delivering a sample to a test assay surface includes a prefilter having a sample receiving surface and a surface for delivering a sample to a test assay surface. The prefilter includes a diffusing material on its receiving surface for rapidly and evenly diffusing a sample across the prefilter receiving surface. In this way, a sample may be rapidly and evenly delivered to a test assay surface. A test assay solid phase has a surface including an area carrying an immobilized species and an area free of immobilized species. When a sample is applied to the surface, followed by application of a labeled species, the evenness of distribution of the labeled species is indicative of the evenness of application of the sample. A kit includes a delivering member and an assay surface.
摘要翻译：用于过滤和将样品递送到测试测定表面的递送构件包括具有样品接收表面的预过滤器和用于将样品递送到测试测定表面的表面。预过滤器在其接收表面上包括扩散材料，用于使样品快速均匀地扩散穿过预过滤器接收表面。以这种方式，样品可以快速均匀地输送到测试测定表面。测试测定固相具有包括携带固定化物质的区域和没有固定化物种的区域的表面。当将样品施加到表面上，随后施加标记物质时，标记物质的分布均匀性表示样品的均匀度。试剂盒包括递送成分和测定表面。

4. 发明申请

WO1995018973A1 ASSAY EMPLOYING BOTH PROTEIN AND ANTIBODY 审中-公开
标题翻译：测定使用两种蛋白质和抗体
公开(公告)号：WO1995018973A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000048
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： INTRACEL CORPORATION , DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KEIL, Walter , KLIBANOV, Alexander, M.
IPC分类号： G01N33/566
CPC分类号： G01N33/54306 , G01N33/56988 , G01N33/6854 , Y10S435/805 , Y10S435/971 , Y10S435/973 , Y10S436/828
摘要： The binding site on an immunoglobulin for a protein is blocked by hydrophobically coupling the immunoglobulin to a blocking agent such as a label. This results in a detection reagent useful in a variety of test assays in which a protein and an immunoglobulin are advantageously used together, but separately. The reagent is useful in the simultaneous determination of IgG and one of IgA or IgM. Anti-IgA-IgG or anti-IgM-IgG is coupled to a hydrophobic label, particularly a pigment or dye, which label blocks the binding site on IgG for Protein A, and labeled Protein A is added.
摘要翻译：蛋白质免疫球蛋白上的结合位点通过将免疫球蛋白疏水性偶合到封闭剂如标记物来阻断。这导致检测试剂可用于各种测试测定，其中蛋白质和免疫球蛋白有利地一起使用，但分开。该试剂可用于同时测定IgG和IgA或IgM中的一种。抗IgA-IgG或抗IgM-IgG与疏水标记物，特别是颜料或染料偶联，该标记阻断蛋白A的IgG上的结合位点，并加入标记的蛋白A.

5. 发明申请

WO1990001543A1 METHOD FOR THE GENETIC EXPRESSION OF HETEROLOGOUS PROTEINS BY CELLS TRANSFECTED IN VIVO 审中-公开
标题翻译：用VIVO转染的细胞对异位蛋白进行遗传表达的方法
公开(公告)号：WO1990001543A1
公开(公告)日：1990-02-22
申请号：PCT/CH1989000141
申请日：1989-07-28
申请人： INTRACEL CORPORATION , FISCHBACH, Michel , DIEZ IBANEZ, Miguel , CAO, Hanwei , DREANO, Michel , TSACONAS, Christos , MONTANDON, Frederic , BROMLEY, Peter , PADIEU, Prudent
发明人： INTRACEL CORPORATION
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2267/01 , C07K14/61 , C07K16/26 , C12N15/85 , C12N15/88
摘要： The method disclosed is used for the genetic expression in vivo of heterologous proteins such as the c-ras oncogene of Harvey, the human growth hormone gene (hGH) and the gene resisting to neomycine by means of cells transfected with liposome that is injected as a suspension in the blood circulating in an animal (rat or rabbit). The expression vector encapsulated in the liposomes injected may contain for example the gene coding for an oncogene. In this case, a member containing transfected differentiated cells is taken from the animal and they are then cultivated in vitro in order to select the cells which express the oncogene and which, consequently, may proliferate in vitro. When the animal is injected with liposomes encapsulating the gene of hGH and the neomycine resistant gene, the cells selected in culture media containing the antibiotic produce hGH. On the other hand, when the expression vector contains the gene of hGH controlled by the human promotor of the 70 kd, thermal shock protein gene, and it is injected to animals, the latter secrete in the circulating blood hGH after thermal induction. Furthermore the repetition of these steps induces the synthesis of anti-hGH antibodies by the animal. The main fields of application of the invention are either the production of differentiated cells capable of proliferating in vitro or the production in vivo of biologically active or antigenic heterologous proteins.
摘要翻译：所公开的方法用于异源蛋白质如Harvey的c-ras致癌基因，人生长激素基因（hGH）和通过以脂质体转染的细胞抗新世代基因的基因的遗传表达，其被注射为悬浮在动物（大鼠或兔子）中循环的血液中。封装在注射的脂质体中的表达载体可以包含例如编码癌基因的基因。在这种情况下，从动物中取出含有转染的分化细胞的成员，然后在体外培养它们，以便选择表达致癌基因的细胞，并因此在体外可能增殖。当注射包裹hGH基因的脂质体和新霉素抗性基因时，在含有抗生素的培养基中选择的细胞产生hGH。另一方面，当表达载体含有由70kd的人类启动子控制的hGH基因的热休克蛋白基因时，其被注射到动物中，后者在热诱导后分泌在循环血液中。此外，这些步骤的重复诱导动物对抗hGH抗体的合成。本发明的主要应用领域是生产能够在体外增殖或体内生物活性或抗原异源蛋白质生产的分化细胞。

6. 发明申请

WO1989009822A1 METHOD FOR THE IN-VIVO PRODUCTION AND TESTING OF PROTEINS BY RECOMBINANT GENE EXPRESSION IN SELECTED HOST-CELLS 审中-公开
标题翻译：通过重组基因表达在选择的宿主细胞中生产和测试蛋白质的方法
公开(公告)号：WO1989009822A1
公开(公告)日：1989-10-19
申请号：PCT/EP1989000416
申请日：1989-04-06
申请人： INTRACEL CORPORATION , DREANO, Michel , BROMLEY, Peter , VOELLMY, Richard
发明人： INTRACEL CORPORATION
IPC分类号： C12N15/00
CPC分类号： A01K67/0271 , A01K2217/05 , C07K14/61 , C07K16/26
摘要： Eukaryotic host-cells transformed with stress-inducible gene constructs are inoculated into selected warm-blooded recipient animals multiplied either neat or as tumor fragments. Upon application of stress, either locally (tumor site) or as a whole, under harmless conditions, gene expression occurs and the gene products can be isolated from the body fluids of the animals. The response of the animals to the newly synthesized products can be observed directly, which eliminates all purification problems inherent to first isolating the substance before making physiological tests. Moreover the antibodies raised by the animal against the new product can be isolated by usual means or produced in-vitro from hybridoma strains involving cells taken from immunoorgans of the animals.

7. 发明申请

WO1989000603A1 A METHOD FOR THE EXPRESSION OF RECOMBINANT GENES UNDER STIMULATION FROM AN INDUCIVELY EXPRESSED ACTIVATOR PROTEIN 审中-公开
标题翻译：用于表达来自诱导表达的激活蛋白的重组基因的表达方法
公开(公告)号：WO1989000603A1
公开(公告)日：1989-01-26
申请号：PCT/EP1988000640
申请日：1988-07-15
申请人： INTRACEL CORPORATION , BROMLEY, Peter , DREANO, Michel , VOELLMY, Richard
发明人： INTRACEL CORPORATION
IPC分类号： C12N15/00
CPC分类号： C12N15/85 , C07K14/61
摘要： A DNA system for the stimulated expression of genes of interest. Said genes are placed under the control of an activator stimulated promoter and the gene coding for this activator is driven by an inducible promoter. The hybrid DNA constructions are incorporated in suitable host cells which, after multiplication and optional gene amplification, are stressed, whereby the activator produced continues to bring about expression of said genes of interest for a long period of time after the inducible promoter has returned to rest.

8. 发明授权

EP0853487B1 NEUTRALIZING MONOCLONAL ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS 失效转让
标题翻译：中和抗呼吸道合胞病毒单克隆抗体
公开(公告)号：EP0853487B1
公开(公告)日：2000-07-05
申请号：EP96933810.2
申请日：1996-09-18
申请人： INTRACEL CORPORATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： PILKINGTON, Glenn, R. , GILMOUR, Page, S. , CHANOCK, Robert, M. , CROWE, James, E., Jr. , MURPHY, Brian, R.
IPC分类号： A61K39/42 , A61K48/00 , A61K51/00 , C07K16/10 , G01N33/569 , G01N33/577
CPC分类号： C07K16/1027 , A61K38/00 , A61K39/00 , A61K48/00 , A61K51/1006 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/565 , G01N33/56983
摘要： The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratoy Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.

9. 发明公开

EP0853487A1 NEUTRALIZING MONOCLONAL ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS 失效转让
标题翻译：中和单克隆抗体杰伦呼吸道合胞病毒
公开(公告)号：EP0853487A1
公开(公告)日：1998-07-22
申请号：EP96933810.0
申请日：1996-09-18
申请人： INTRACEL CORPORATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： PILKINGTON, Glenn, R. , GILMOUR, Page, S. , CHANOCK, Robert, M. , CROWE, James, E., Jr. , MURPHY, Brian, R.
IPC分类号： A61K51 , C07K16 , C12N1 , C12N15 , G01N33 , A61K38 , A61K39 , A61K48
CPC分类号： C07K16/1027 , A61K38/00 , A61K39/00 , A61K48/00 , A61K51/1006 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/565 , G01N33/56983
摘要： The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratoy Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.

10. 发明公开

EP0738393A1 ASSAY EMPLOYING BOTH PROTEIN AND ANTIBODY 失效
标题翻译： BOTH蛋白以及抗体，将测定
公开(公告)号：EP0738393A1
公开(公告)日：1996-10-23
申请号：EP95906156.0
申请日：1995-01-04
申请人： INTRACEL CORPORATION
发明人： DORVAL, Brent, L. , DENHAM, Lilibeth, K. , KEIL, Walter , KLIBANOV, Alexander, M.
IPC分类号： G01N33
CPC分类号： G01N33/54306 , G01N33/56988 , G01N33/6854 , Y10S435/805 , Y10S435/971 , Y10S435/973 , Y10S436/828
摘要： The binding site on an immunoglobulin for a protein is blocked by hydrophobically coupling the immunoglobulin to a blocking agent such as a label. This results in a detection reagent useful in a variety of test assays in which a protein and an immunoglobulin are advantageously used together, but separately. The reagent is useful in the simultaneous determination of IgG and one of IgA or IgM. Anti-IgA-IgG or anti-IgM-IgG is coupled to a hydrophobic label, particularly a pigment or dye, which label blocks the binding site on IgG for Protein A, and labeled Protein A is added.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式