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1. 发明申请

WO2012148540A1 COMBINATION OF KANASE INHIBITORS AND USES THREOF 审中-公开
标题翻译：消费者抑制剂和使用用途的组合
公开(公告)号：WO2012148540A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/026399
申请日：2012-02-23
申请人： INTELLIKINE, LLC , REN, Pingda , LIU, Yi , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian , WILSON, Troy, Edward
发明人： REN, Pingda , LIU, Yi , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian , WILSON, Troy, Edward
IPC分类号： A61K31/535
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/4439 , A61K31/4745 , A61K31/498 , A61K31/501 , A61K31/517 , A61K31/519 , A61K31/527 , A61K31/53 , A61K31/541 , A61K31/551 , A61K45/06 , A61K31/4709 , A61K2300/00
摘要： The present invention provides for a method for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.
摘要翻译：本发明提供了治疗与受试者中PI3激酶a和/或mTOR相关的疾病状况的方法。在另一方面，本发明提供了治疗与受试者中PI3激酶a和/或mTOR相关的疾病状况的方法。另一方面，阐述了抑制细胞中Akt（S473）和Akt（T308）的磷酸化的方法。

2. 发明申请

WO2012151562A1 COMBINATION PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：组合药物组合物及其用途
公开(公告)号：WO2012151562A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036688
申请日：2012-05-04
申请人： INTELLIKINE, LLC , LIU, Yi , REN, Pingda , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian
发明人： LIU, Yi , REN, Pingda , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian
IPC分类号： C40B30/06 , A61K31/535 , C07D487/00 , C07D413/00
CPC分类号： A61K31/519 , A61K31/337 , A61K31/436 , A61K31/52 , C07D473/34 , A61K2300/00
摘要： The present invention provides for methods and pharmaceutical compositions for treating proliferative disorders. In one aspect, the method comprises administration of two cell-cycle suppressors having a synergistic effect. In another aspect, two cell-cycle suppressors having a synergistic effect are provided in a pharmaceutical composition.
摘要翻译：本发明提供了治疗增殖性疾病的方法和药物组合物。一方面，该方法包括施用具有协同作用的两种细胞周期抑制剂。另一方面，在药物组合物中提供具有协同作用的两种细胞周期抑制剂。

3. 发明申请

WO2013071264A1 COMBINATION OF KINASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译：激酶抑制剂的组合及其用途
公开(公告)号：WO2013071264A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064719
申请日：2012-11-12
申请人： INTELLIKINE, LLC , JESSEN, Katayoun , GUO, Xin , REN, Pingda , ROMMEL, Christian , LIU, Yi
发明人： JESSEN, Katayoun , GUO, Xin , REN, Pingda , ROMMEL, Christian , LIU, Yi
IPC分类号： G01N33/574
CPC分类号： A61K39/39533 , A61K31/423 , A61K31/428 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/4738 , A61K31/496 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , A61K2039/505 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12Q1/485 , G01N33/5011
摘要： The present invention provides for a method for treating a disease condition associated with PI3- kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3 -kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.
摘要翻译：本发明提供了治疗与受试者中PI3-激酶a和/或受体酪氨酸激酶（RTK）相关的疾病状况的方法。另一方面，本发明提供了治疗与受试者中PI3激酶α和/或RTK相关的疾病状况的方法。另一方面，阐述了抑制细胞中Akt（S473）磷酸化的方法。

4. 发明申请

WO2022011075A1 NOVEL ROR1 ANTIBODY IMMUNOCONJUGATES 审中-公开
公开(公告)号：WO2022011075A1
公开(公告)日：2022-01-13
申请号：PCT/US2021/040778
申请日：2021-07-08
申请人： VELOSBIO INC. , LANNUTTI, Brian , JESSEN, Katti , GUO, Xin , KO, Mira , WATKINS, Jeffry, D. , JOHNSON, Stephanie Louise , MCKEE, Colin Martin
发明人： LANNUTTI, Brian , JESSEN, Katti , GUO, Xin , KO, Mira , WATKINS, Jeffry, D. , JOHNSON, Stephanie Louise , MCKEE, Colin Martin
IPC分类号： A61K31/165 , A61K31/4015 , A61K31/4745 , A61K31/48
摘要： Provided herein are immunoconjugates comprising an anti-ROR1 antibody or an antigen-binding fragment thereof and an exatecan moiety or an analog thereof. These immunoconjugates are useful for treating ROR1-expressing cancers.

5. 发明申请

WO2014179186A1 ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
公开(公告)号：WO2014179186A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/035596
申请日：2014-04-28
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
发明人： BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
IPC分类号： C07D471/04 , A61K31/444 , C07D498/04 , A61P9/00
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): I and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R3, R4, R5, R 6 , R 7 , W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of a variety of diseases that are mediated or sustained by aldosterone activity, including renal disease, diabetic nephropathy, cardiovascular diseases and fibrotic disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物：I及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，W，Y，本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗由醛固酮活性介导或维持的各种疾病的方法，包括肾脏疾病，糖尿病性肾病，心血管疾病和纤维化疾病，制备这些化合物的方法在这些方法中有用的化合物和中间体。

6. 发明申请

WO2007035474A2 TRANSDERMAL DELIVERY PEPTIDES AND METHOD OF USE THEREOF 审中-公开
标题翻译：超导递送肽及其使用方法
公开(公告)号：WO2007035474A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036012
申请日：2006-09-14
申请人： NOVOMED TECHNOLOGIES, INC. (Shanghai) , UNIVERSITY OF SCIENCE & TECHNOLOGY OF CHINA , WEN, Long-ping , CHEN, Yongping , SHEN, Yuanyuan , GUO, Xin , WANG, Weiping , ZHANG, Brian, M.
发明人： WEN, Long-ping , CHEN, Yongping , SHEN, Yuanyuan , GUO, Xin , WANG, Weiping , ZHANG, Brian, M.
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61K9/0014 , A61K9/06 , A61K38/27 , C07K1/20 , Y02A50/406
摘要： Transdermal delivery peptides for the treatment of skin diseases and/or facilitation or enhancement of transdermal delivery of pharmaceutically active agents are provided. Compositions comprising the transdermal delivery peptides and methods of therapeutic use, including the improvement of transdermal delivery of drugs or other pharmaceutically active agents, are also disclosed. Nucleic acids, expression vectors, and methods of their use, which encode the transdermal delivery peptides are disclosed. Methods are also provided for in vivo phage display for identifying further peptides with enhanced transdermal delivery capability.
摘要翻译：提供了用于治疗皮肤疾病和/或促进或增强药物活性剂透皮递送的透皮递送肽。还公开了包含透皮递送肽的组合物和治疗用途的方法，包括改善药物或其它药物活性剂的透皮递送。公开了编码透皮递送肽的核酸，表达载体及其使用方法。还提供了用于体内噬菌体展示以鉴定具有增强的透皮递送能力的其它肽的方法。

7. 发明申请

WO2014190941A1 A SYSTEM AND METHOD FOR MANAGING UTILIZATION OF UN-LICENSED FREQUENCY SPECTRUM RESOURCES FOR SECONDARY SYSTEMS, AND A NON-TRANSITORY COMPUTER-READABLE MEDIUM 审中-公开
标题翻译：用于管理用于二次系统的不被许可的频谱资源的系统和方法以及非中继计算机可读介质
公开(公告)号：WO2014190941A1
公开(公告)日：2014-12-04
申请号：PCT/CN2014/078963
申请日：2014-05-30
申请人： SONY CORPORATION , GUO, Xin , SUN, Chen
发明人： GUO, Xin , SUN, Chen
IPC分类号： H04W16/10
CPC分类号： H04W16/14 , H04W28/16
摘要： The present disclosure provides a system and method for managing utilization of un-licensed frequency spectrum resources for secondary systems, a system and a method for the system, and a non-transitory computer-readable medium including computer-readable instructions. The system for managing utilization of un-licensed frequency spectrum resources for secondary systems comprises: circuitry, configured to assign a first un-licensed frequency spectrum resource in an availability time period to a first secondary system and reassign at least part of the first un-licensed frequency spectrum resource during the availability time period based on current resource utilization, wherein the circuitry is configured to assign and reassign the first un-licensed frequency spectrum resource under protection of a primary system which is licensed with the un-licensed frequency spectrum resources.
摘要翻译：本公开提供了一种用于管理二次系统的未授权频谱资源的利用的系统和方法，系统和系统的方法以及包括计算机可读指令的非暂时计算机可读介质。用于管理用于辅助系统的未经授权的频谱资源的利用的系统包括：电路，被配置为在可用性时间段内将第一未授权的频谱资源分配给第一次要系统，并且重新分配所述第一未授权的频谱资源的至少一部分，基于当前的资源利用率，可用时间段内的授权频谱资源，其中该电路被配置为在被许可的未许可的频谱资源的主系统的保护下分配和重新分配第一个未许可的频谱资源。

8. 发明申请

WO2011071716A1 HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE 审中-公开
标题翻译：含有核心的杂环化合物
公开(公告)号：WO2011071716A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/058271
申请日：2010-11-30
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOYER, Stephen, James , GAO, Donghong, Amy , GUO, Xin , KIRRANE, Thomas, Martin, Jr. , SARKO, Christopher, Ronald , SNOW, Roger, John , SOLEYMANZADEH, Fariba , ZHANG, Yunlong
发明人： BOYER, Stephen, James , GAO, Donghong, Amy , GUO, Xin , KIRRANE, Thomas, Martin, Jr. , SARKO, Christopher, Ronald , SNOW, Roger, John , SOLEYMANZADEH, Fariba , ZHANG, Yunlong
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/551 , A61P9/00 , A61P29/00
CPC分类号： C07D487/04 , C07D487/20 , C07D491/20
摘要： Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.
摘要翻译：公开了抑制RSK的新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。还公开了使用本发明化合物治疗RSK2调节性疾病的方法。

9. 发明申请

WO2013147818A1 NONVOLATILE MEMORY ERASURE TECHNIQUES 审中-公开
标题翻译：非易失性存储器擦除技术
公开(公告)号：WO2013147818A1
公开(公告)日：2013-10-03
申请号：PCT/US2012/031312
申请日：2012-03-29
申请人： INTEL CORPORATION , SANDA, Hiroyuki , PANGAL, Kiran , GUO, Xin , NAGANUMA, Kaoru
发明人： SANDA, Hiroyuki , PANGAL, Kiran , GUO, Xin , NAGANUMA, Kaoru
IPC分类号： G11C16/34 , G11C16/14
CPC分类号： G11C16/16 , G06F12/0246 , G11C11/5635 , G11C16/3445
摘要： Embodiments of the present disclosure describe methods, apparatus, and system configurations for conditional pre-programming of nonvolatile memory before erasure. In one instance, the method includes receiving a request to erase information in a portion of the nonvolatile memory device, in which the portion includes a plurality of storage units, determining whether one or more storage units of the plurality of storage units included in the portion of the non-volatile memory device are programmed, pre-programming the portion of the non-volatile memory device if the one or more storage units are determined to be programmed, and erasing the pre-programmed portion of the non-volatile memory device. A number of determined programmed storage units may not exceed a predetermined value. Other embodiments may be described and/or claimed.
摘要翻译：本公开的实施例描述了在擦除之前非易失性存储器的条件预编程的方法，装置和系统配置。在一种情况下，该方法包括接收擦除非易失性存储器件的一部分中的信息的请求，其中该部分包括多个存储单元，确定包括在该部分中的多个存储单元中的一个或多个存储单元对所述非易失性存储器件进行编程，如果所述一个或多个存储单元被确定为被编程，并且擦除所述非易失性存储器件的预编程部分，则对所述非易失性存储器件的所述部分进行预编程。多个确定的编程存储单元可能不超过预定值。可以描述和/或要求保护其他实施例。

10. 发明申请

WO2013147803A1 ADAPTIVE MOVING READ REFERENCES FOR MEMORY CELLS 审中-公开
标题翻译：自适应移动读存储器的参考
公开(公告)号：WO2013147803A1
公开(公告)日：2013-10-03
申请号：PCT/US2012/031261
申请日：2012-03-29
申请人： INTEL CORPORATION , LEEM, Lark-Hoon , PANGAL, Kiran , GUO, Xin
发明人： LEEM, Lark-Hoon , PANGAL, Kiran , GUO, Xin
IPC分类号： G11C16/34
CPC分类号： G06F11/08 , G06F11/1048 , G11C11/5628 , G11C16/3418
摘要： Examples are disclosed for generating or providing a moving read reference (MRR) table for recovering from a read error of one or more memory cells of a non-volatile memory included in a storage device. Priorities may be adaptively assigned to entries included in the MRR table and the entries may be ordered for use based on the assigned priorities. Other examples are described and claimed.
摘要翻译：公开了用于生成或提供用于从包括在存储设备中的非易失性存储器的一个或多个存储器单元的读取错误中恢复的移动读取参考（MRR）表的示例。可以将优先级自适应地分配给包括在MRR表中的条目，并且可以基于分配的优先级对条目进行排序使用。其他的例子被描述和要求保护。

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