专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO2009018092A1 SUPRAMOLECULAR FUNCTIONALIZATION OF GRAPHITIC NANOPARTICLES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的糖皮质纳米颗粒的分子功能化
公开(公告)号：WO2009018092A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071032
申请日：2008-07-24
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , DAI, Hongjie , LIU, Zhuang , LIN, Xiao , SUN, Xiaoming
发明人： DAI, Hongjie , LIU, Zhuang , LIN, Xiao , SUN, Xiaoming
IPC分类号： A01N25/28 , A01N25/26 , C01B31/04 , D01F9/12
CPC分类号： A61K47/48215 , A61K9/0092 , A61K31/337 , A61K31/704 , A61K38/16 , A61K39/395 , A61K47/62 , A61K47/68 , A61K47/6925 , A61K47/6929 , A61K47/6949 , B82Y5/00 , Y10T428/2982
摘要： Disclosed are nanoparticles, such as carbon nanotubes or other materials having extended aromatic surfaces (e.g., graphene sheet or nanotube), which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a "drug") to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer to render them stable in suspension. This molecule may be covalently attached to the nanoparticle, or may be adsorbed thereto as an amphiphilic molecule. The nanoparticles are coupled to the drug through supramolecular bonding i.e., binding to the exterior of the nanoparticle through π - stacking. The drug may also be covalently bonded to the hydrophilic polymer, which is coupled to the nanoparticle through supramolecular bonding. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug-coupled, functionalized nanoparticles may also be targeted to specific cells through modification of the hydrophilic polymer, e.g., by adding an RGD peptide, or an antibody, which is targeted to cells expressing integrins, or an antibody directed to a cell surface marker. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.
摘要翻译：公开了纳米颗粒，例如碳纳米管或具有延伸芳族表面的其它材料（例如，石墨烯片或纳米管），其用于将活性剂如药物，标记或染料（为方便起见称为“药物”）递送到内部的细胞。纳米颗粒由亲水性聚合物官能化，使其在悬浮液中稳定。该分子可以共价连接到纳米颗粒上，或者可以作为两亲分子被吸附。纳米颗粒通过超分子键合与药物偶联，即通过p-堆叠与纳米颗粒的外部结合。该药物也可以与亲水性聚合物共价键合，亲水性聚合物通过超分子键合与纳米颗粒偶联。因此，该药物能够在细胞外释放。药物在较低的pH下更快速释放，例如在肿瘤细胞中发现。药物偶联的官能化纳米颗粒也可以通过改性亲水性聚合物来靶向特定细胞，例如通过添加靶向表达整联蛋白的细胞的RGD肽或抗体或针对细胞表面标记的抗体。药物也可以连接到支链亲水性聚合物，使得每个聚合物分子携带多于一种可切割接头结合的药物。

IPRDB

热门服务

关于我们

友情链接

联系方式