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1. 发明申请

WO2008097370A2 METHOD FOR HIGH THROUGHPUT, HIGH VOLUME MANUFACTURING OF BIOMOLECULE MICRO ARRAYS 审中-公开
标题翻译：生物分子微阵列的高通量，高容量制造方法
公开(公告)号：WO2008097370A2
公开(公告)日：2008-08-14
申请号：PCT/US2007/079748
申请日：2007-09-27
申请人： INTEL CORPORATION , SUNDARARAJAN, Narayan , RAJASEKARAN, John J. , XU, Guangyu , TIWARI, Gunjan , CABEZAS, Edelmira
发明人： SUNDARARAJAN, Narayan , RAJASEKARAN, John J. , XU, Guangyu , TIWARI, Gunjan , CABEZAS, Edelmira
CPC分类号： C40B50/18 , B01J19/0046 , B01J2219/00432 , B01J2219/00495 , B01J2219/00527 , B01J2219/00612 , B01J2219/00617 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C40B40/06
摘要： The embodiments of the invention relate to a system and method for making a biomolecule microarray comprising a spacer attachment module adapted to attach a linker to a substrate surface of the biomolecule microarray, a coupling module adapted to couple a molecule to the linker, the molecule being capable of forming a peptide bond and containing a protecting group that prevents the formation of the peptide bond, and a deprotection module adapted to create deprotection of the protecting group with a radiation exposure of about 1 - 50 mJ/cm 2 .
摘要翻译：本发明的实施方案涉及用于制备生物分子微阵列的系统和方法，其包括适于将接头连接到生物分子微阵列的底物表面的间隔物附着模块，适于将分子连接到接头的耦合模块，所述分子是能够形成肽键并含有防止肽键形成的保护基团，以及脱保护模块，其适于在约1-50mJ / cm 2的辐射照射下产生保护基团的脱保护， SUP>。

2. 发明申请

WO2008051454A1 SOLID-PHASE MEDIATED SYNTHESIS OF MOLECULAR MICROARRAYS 审中-公开
标题翻译：分子微阵列的固相合成
公开(公告)号：WO2008051454A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/022287
申请日：2007-10-18
申请人： INTEL CORPORATION , SUNDARARAJAN, Narayan , RAJASEKARAN, John, J. , XU, Guangyu
发明人： SUNDARARAJAN, Narayan , RAJASEKARAN, John, J. , XU, Guangyu
IPC分类号： C07H21/00 , H01L21/00 , G01N33/53
CPC分类号： C07H21/00 , C40B50/14
摘要： Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived methods and electrochemically generated reagents. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides, polymers joined by peptide bonds, nucleic acids, and polymers joined by phosphodiester bonds may be fabricated in a highly multiplexed manner.
摘要翻译：使用半导体加工衍生的方法和电化学产生的试剂提供以高度复用的方式制备聚合物分子的致密阵列的方法。有利地，该方法适用于各种聚合物的合成。例如，通过肽键连接的肽的阵列，通过磷酸二酯键连接的核酸和聚合物可以以高度复用的方式制造。

3. 发明申请

WO2007078635A2 METHOD TO DETECT SMALL MOLECULES BINDING TO PROTEINS USING SURFACE ENHANCED RAMAN SCATTERING (SERS) 审中-公开
标题翻译：使用表面增强拉曼散射（SERS）检测与蛋白质结合的小分子的方法
公开(公告)号：WO2007078635A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/047093
申请日：2006-12-07
申请人： INTEL CORPORATION , SUNG, Kung-bin , SUNDARARAJAN, Narayan , CHAN, Selena
发明人： SUNG, Kung-bin , SUNDARARAJAN, Narayan , CHAN, Selena
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , G01N33/483
摘要： Embodiments of the invention relate to detecting binding of a first analyte to a second analyte by Raman spectroscopy. An embodiment includes attaching one analyte to a substrate and then detecting the binding of another analyte to the analyte on the substrate by Raman spectroscopy. Another embodiment includes contacting analytes in a fluid and then detecting the binding of one analyte to another analyte by Raman spectroscopy.
摘要翻译：本发明的实施例涉及通过拉曼光谱检测第一分析物与第二分析物的结合。一个实施方案包括将一种分析物附着到基底上，然后通过拉曼光谱检测另一分析物与基底上的分析物的结合。另一个实施方案包括使分析物接触流体，然后通过拉曼光谱检测一种分析物与另一种分析物的结合。

4. 发明申请

WO2006023458A1 DETECTION AND IDENTIFICATION OF PEPTIDE AND PROTEIN MODIFICATIONS 审中-公开
标题翻译：多肽和蛋白质修饰的检测和鉴定
公开(公告)号：WO2006023458A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/029019
申请日：2005-08-13
申请人： INTEL CORPORATION , SUNDARARAJAN, Narayan , SUN, Lei , SU, Xing , YAMAKAWA, Mineo , JINGWU, Zhang , CHAN, Selena , BERLIN, Andrew , KOO, Tae-Woong , ROTH, Mark , GAFEN, Phil
发明人： SUNDARARAJAN, Narayan , SUN, Lei , SU, Xing , YAMAKAWA, Mineo , JINGWU, Zhang , CHAN, Selena , BERLIN, Andrew , KOO, Tae-Woong , ROTH, Mark , GAFEN, Phil
IPC分类号： G01N33/68 , G01N21/65
CPC分类号： G01N33/6851 , G01N21/658 , G01N33/54373 , G01N33/68 , G01N33/6842 , G01N33/6848 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diognosis, prognosis and drug efficacy studies, emzymatic activity profiling and assays.
摘要翻译：本发明的实施例提供了用于使用表面增强拉曼（SERS）和拉曼光谱来检测，鉴定，区分和量化蛋白质和肽的修饰状态的装置和方法。本发明实施方案的应用包括例如蛋白质组广泛的修饰分析和应用于疾病预后，预后和药物功效研究，酶活性分析和测定的分析。

5. 发明申请

WO2008016375A2 MODIFICATION OF METAL NANOPARTICLES FOR IMPROVED ANALYTE DETECTION BY SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) 审中-公开
标题翻译：通过表面增强拉曼光谱（SERS）改进分析仪检测金属纳米颗粒的改性
公开(公告)号：WO2008016375A2
公开(公告)日：2008-02-07
申请号：PCT/US2006/048009
申请日：2006-12-14
申请人： INTEL CORPORATION , ZHANG, Jingwu , SUNDARARAJAN, Narayan , NGOLA, Sarah, M. , LI, Handong
发明人： ZHANG, Jingwu , SUNDARARAJAN, Narayan , NGOLA, Sarah, M. , LI, Handong
CPC分类号： G01N33/54373 , B82Y30/00 , G01N21/658 , G01N33/54346 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： A SERS active particle having a metal-containing particle and a cationic coating on the metal-containing particle, wherein the SERS active particle carries a positive charge is disclosed. Also, a SERS active particle having a metal-containing particle and a non-metallic molecule, wherein the metal-containing particle is derivatized with the non-metallic molecule is disclosed. In addition, several methods of modifying the nanoparticles surfaces of a SERS active particle and of improving the interaction between the SERS active particle and an analyte are disclosed.
摘要翻译：公开了一种SERS活性颗粒，其具有含金属颗粒和阳离子涂层在含金属颗粒上，其中SERS活性颗粒携带正电荷。另外，公开了含有金属的粒子和非金属分子的SERS活性粒子，其中含金属的粒子被非金属分子衍生化。另外，公开了改进SERS活性颗粒的纳米颗粒表面和改善SERS活性颗粒与分析物之间的相互作用的几种方法。

6. 发明申请

WO2005066369A2 NUCLEIC ACID SEQUENCING BY RAMAN MONITORING OF UPTAKE OF NUCLEOTIDES DURING MOLECULAR REPLICATION 审中-公开
标题翻译：在分子复制期间通过拉曼监测核酸摄取的核酸序列
公开(公告)号：WO2005066369A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043633
申请日：2004-12-28
申请人： INTEL CORPORATION , BERLIN, Andrew , SU, Xing , CHAN, Selena , KOO, Tae-Woong , SUN, Lei , SUNDARARAJAN, Narayan
发明人： BERLIN, Andrew , SU, Xing , CHAN, Selena , KOO, Tae-Woong , SUN, Lei , SUNDARARAJAN, Narayan
IPC分类号： C12Q1/68
CPC分类号： G01N21/658 , C12Q1/6869 , C12Q2565/632 , C12Q2533/101
摘要： The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS) or surface enhanced coherent anti-Stokes Raman spectroscopy (SECARS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction. Methods for enhancing the SERS signal of a nucleotide or nucleoside by cleaving the base from a sugar moiety are provided. Furthermore, methods for detecting single base repeats are provided.
摘要翻译：本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。该方法涉及使用表面增强拉曼光谱（SERS）或表面增强相干抗斯托克斯拉曼光谱（SECARS）检测核苷酸，核苷或碱基。检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。提供了通过从糖部分切割碱来增强核苷酸或核苷的SERS信号的方法。此外，提供了用于检测单碱基重复的方法。

7. 发明申请

WO2005066367A2 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043364
申请日：2004-12-24
申请人： INTEL CORPORATION , SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
发明人： SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
IPC分类号： C12Q1/68
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成纳米管阵列，将聚合物（120,210）分子连接到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列的装置以及包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

8. 发明申请

WO2008085538A2 NEW ASSAY PLATFORMS AND DETECTION METHODOLOGY USING SURFACE ENHANCED RAMAN SCATTERING (SERS) UPON SPECIFIC BIOCHEMICAL INTERACTIONS 审中-公开
标题翻译：使用特定生物化学相互作用的表面增强拉曼散射（SERS）的新测定平台和检测方法
公开(公告)号：WO2008085538A2
公开(公告)日：2008-07-17
申请号：PCT/US2007/072298
申请日：2007-06-27
申请人： INTEL CORPORATION , ZHANG, Jingwu , LI, Handong , SUNDARARAJAN, Narayan , SU, Xing , SUN, Lei
发明人： ZHANG, Jingwu , LI, Handong , SUNDARARAJAN, Narayan , SU, Xing , SUN, Lei
CPC分类号： G01N33/585 , C12Q1/6816 , G01N21/658 , G01N33/54373 , C12Q2563/155 , C12Q2565/632
摘要： The embodiments of the invention are directed to a SERS cluster comprising a capture particle that is at least partially surrounded by analyte molecules, wherein both the capture particle and the analyte molecules surrounding the capture particle are at least partially surrounded by enhancer particles, wherein a majority of the analyte molecules are either sandwiched between capture and enhancer particles or located between junctions of the enhancer particles. The embodiments of the invention also relate to methods of manufacturing and detecting the SERS cluster. The embodiments of the invention also relate to a SERS active particle comprising a tag molecule comprising a Raman active compound and a probe or a linker having a specific biochemical binding capability and to a method for detecting of a target molecule using a SERS active particle having a tag molecule comprising a Raman active compound and a probe or a linker.
摘要翻译：本发明的实施方案涉及包含被分析物分子至少部分包围的捕获颗粒的SERS簇，其中捕获颗粒和捕获颗粒周围的分析物分子至少部分地被增强子颗粒包围，其中多数分析物分子被夹在捕获和增强剂颗粒之间或位于增强剂颗粒的结之间。本发明的实施例还涉及制造和检测SERS簇的方法。本发明的实施方案还涉及包含包含拉曼活性化合物的标签分子和具有特定生物化学结合能力的探针或接头的SERS活性颗粒以及使用具有下列化合物的SERS活性颗粒检测靶分子的方法：标签分子，其包含拉曼活性化合物和探针或接头。

9. 发明申请

WO2005065541A3 METHODS FOR USING RAMAN SPECTROSCOPY TO OBTAIN A PROTEIN PROFILE OF A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：WO2005065541A3
公开(公告)日：2005-07-21
申请号：PCT/US2004/043769
申请日：2004-12-29
申请人： INTEL CORPORATION , BERLIN, Andrew , SU, Xing , CHAN, Selena , KOO, Tae-Woong , SUN, Lei , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo
发明人： BERLIN, Andrew , SU, Xing , CHAN, Selena , KOO, Tae-Woong , SUN, Lei , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo
IPC分类号： G01N33/58
摘要： The invention provides methods for analyzing the protein content of a biological sample, for example to obtain a protein profile of a sample provided by a particular individual. The proteins and protein fragments in the sample are separated on the basis of chemical and/or physical properties and maintained in a separated state at discrete locations on a solid substrate or within a stream of flowing liquid. Raman spectra are then detected as produced by the separated proteins or fragments at the discrete locations such that a spectrum from a discrete location provides information about the structure or identity of one or more particular proteins or fragments at the discrete location. The proteins or fragments at discrete locations can be coated with a metal, such as gold or silver, and/or the separated proteins can be contacted with a chemical enhancer to provide SERS spectra. Method and kits for practicing the invention are also provided.

10. 发明申请

WO2007051032A2 CHEMICAL DERIVATIZATION, DETECTION, AND IDENTIFICATION OF PEPTIDE AND PROTEIN MODIFICATIONS 审中-公开
标题翻译：化学衍生物，检测和肽及蛋白质修饰的鉴定
公开(公告)号：WO2007051032A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042334
申请日：2006-10-26
申请人： INTEL CORPORATION , SUNDARARAJAN, Narayan , LI, Handong
发明人： SUNDARARAJAN, Narayan , LI, Handong
IPC分类号： G01N33/68
CPC分类号： G01N33/6842 , G01N33/6848 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of peptides using Surface Enhanced Raman Spectroscopy (SERS) and Raman spectroscopy. Additional embodiments provide strategies for chemically derivatizing post-translational modifications and detecting the chemically derivatized products using SERS. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供了使用表面增强拉曼光谱学（SERS）和拉曼光谱术来检测，鉴定，区分和量化肽的修饰状态的装置和方法。另外的实施方案提供了用于化学衍生翻译后修饰并使用SERS检测化学衍生产物的策略。本发明实施方案的应用包括蛋白质组广泛修饰分析和分析，其应用于疾病诊断，预后和药物功效研究，酶活性分析和测定。

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