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1. 发明申请

WO2006023458A1 DETECTION AND IDENTIFICATION OF PEPTIDE AND PROTEIN MODIFICATIONS 审中-公开
标题翻译：多肽和蛋白质修饰的检测和鉴定
公开(公告)号：WO2006023458A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/029019
申请日：2005-08-13
申请人： INTEL CORPORATION , SUNDARARAJAN, Narayan , SUN, Lei , SU, Xing , YAMAKAWA, Mineo , JINGWU, Zhang , CHAN, Selena , BERLIN, Andrew , KOO, Tae-Woong , ROTH, Mark , GAFEN, Phil
发明人： SUNDARARAJAN, Narayan , SUN, Lei , SU, Xing , YAMAKAWA, Mineo , JINGWU, Zhang , CHAN, Selena , BERLIN, Andrew , KOO, Tae-Woong , ROTH, Mark , GAFEN, Phil
IPC分类号： G01N33/68 , G01N21/65
CPC分类号： G01N33/6851 , G01N21/658 , G01N33/54373 , G01N33/68 , G01N33/6842 , G01N33/6848 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diognosis, prognosis and drug efficacy studies, emzymatic activity profiling and assays.
摘要翻译：本发明的实施例提供了用于使用表面增强拉曼（SERS）和拉曼光谱来检测，鉴定，区分和量化蛋白质和肽的修饰状态的装置和方法。本发明实施方案的应用包括例如蛋白质组广泛的修饰分析和应用于疾病预后，预后和药物功效研究，酶活性分析和测定的分析。

2. 发明申请

WO2005065541A3 METHODS FOR USING RAMAN SPECTROSCOPY TO OBTAIN A PROTEIN PROFILE OF A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：WO2005065541A3
公开(公告)日：2005-07-21
申请号：PCT/US2004/043769
申请日：2004-12-29
申请人： INTEL CORPORATION , BERLIN, Andrew , SU, Xing , CHAN, Selena , KOO, Tae-Woong , SUN, Lei , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo
发明人： BERLIN, Andrew , SU, Xing , CHAN, Selena , KOO, Tae-Woong , SUN, Lei , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo
IPC分类号： G01N33/58
摘要： The invention provides methods for analyzing the protein content of a biological sample, for example to obtain a protein profile of a sample provided by a particular individual. The proteins and protein fragments in the sample are separated on the basis of chemical and/or physical properties and maintained in a separated state at discrete locations on a solid substrate or within a stream of flowing liquid. Raman spectra are then detected as produced by the separated proteins or fragments at the discrete locations such that a spectrum from a discrete location provides information about the structure or identity of one or more particular proteins or fragments at the discrete location. The proteins or fragments at discrete locations can be coated with a metal, such as gold or silver, and/or the separated proteins can be contacted with a chemical enhancer to provide SERS spectra. Method and kits for practicing the invention are also provided.

3. 发明申请

WO2005066367A2 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043364
申请日：2004-12-24
申请人： INTEL CORPORATION , SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
发明人： SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
IPC分类号： C12Q1/68
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成纳米管阵列，将聚合物（120,210）分子连接到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列的装置以及包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

4. 发明申请

WO2005066368A2 METHODS AND COMPOSITIONS FOR DETECTING NUCLEIC ACIDS USING SCANNING PROBE MICROSCOPY AND NANOCODES 审中-公开
标题翻译：使用扫描探针显微镜和纳米级检测核酸的方法和组合物
公开(公告)号：WO2005066368A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043632
申请日：2004-12-28
申请人： INTEL CORPORATION , BERLIN, Andrew , YAMAKAWA, Mineo
发明人： BERLIN, Andrew , YAMAKAWA, Mineo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B82Y5/00 , B82Y10/00 , C12Q2565/601 , C12Q2563/155 , C12Q2525/179
摘要： A method for determining a nucleotide sequence of a nucleic acid is provided that includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, wherein each labeled oligonucleotide includes a known nucleotide sequence and a molecular nanocode. The nanocode of an isolated labeled oligonucleotides that binds to the nucleic acid is then detected using SPM. Nanocodes of the present invention in certain aspects include detectable features beyond the arrangement of tags that encode information about the barcoded object, which assist in detecting the tags that encode information about the barcoded object. The detectable features include structures of a nanocode or associated with a nanocode, referred to herein as detectable feature tags, for error checking/error-correction, encryption, and data reduction/compression.
摘要翻译：提供了用于确定核酸的核苷酸序列的方法，其包括使核酸与一系列用于结合核酸的标记的寡核苷酸接触，其中每个标记的寡核苷酸包括已知的核苷酸序列和分子纳代码。然后使用SPM检测与核酸结合的分离的标记寡核苷酸的纳代码。在某些方面，本发明的纳代码包括超过编码关于条形码对象的信息的标签布置的可检测特征，其有助于检测编码关于条形码对象的信息的标签。可检测特征包括用于错误校验/纠错，加密和数据缩减/压缩的纳代码或与纳代码相关联的结构，这里称为可检测特征标签。

5. 发明申请

WO2005066635A1 BIOSENSOR UTILIZING A RESONATOR HAVING A FUNCTIONALIZED SURFACE 审中-公开
标题翻译：生物传感器利用具有功能化表面的共振器
公开(公告)号：WO2005066635A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043363
申请日：2004-12-24
申请人： INTEL CORPORATION , RAO, Valluri , MA, Qing , YAMAKAWA, Mineo , BERLIN, Andrew , WANG, Li-Peng , ZHANG, Yuegang
发明人： RAO, Valluri , MA, Qing , YAMAKAWA, Mineo , BERLIN, Andrew , WANG, Li-Peng , ZHANG, Yuegang
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N27/126 , G01N29/022 , G01N29/036 , G01N29/2437 , G01N29/348 , G01N33/0031 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , Y10T436/11 , Y10T436/143333 , Y10T436/144444 , Y10T436/25375
摘要： Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator’s frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator’s frequency response.
摘要翻译：使用包含具有功能化表面以与靶生物分子反应的共振器的生物传感器来检测样品中存在生物分子的系统和方法。在一个实施例中，器件包括压电谐振器，其具有被配置为与靶分子反应的官能化表面，从而改变谐振器的质量和/或电荷，从而改变谐振器的频率响应。将曝光后的谐振器频率响应与参考值进行比较，例如在暴露于采样之前的频率响应，存储的基准频率响应或控制谐振器的频率响应。

6. 发明申请

WO2005066366A2 NUCLEIC ACID SEQUENCING BY RAMAN MONITORING OF UPTAKE OF NUCLEOTIDES DURING MOLECULAR REPLICATION 审中-公开
标题翻译：在分子复制期间通过拉曼监测核酸摄取的核酸序列
公开(公告)号：WO2005066366A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043091
申请日：2004-12-24
申请人： INTEL CORPORATION , RAO, Valluri , NEUBAUER, Gabi , KIRCH, Steven , YAMAKAWA, Mineo , BERLIN, Andrew
发明人： RAO, Valluri , NEUBAUER, Gabi , KIRCH, Steven , YAMAKAWA, Mineo , BERLIN, Andrew
IPC分类号： C12Q1/68
CPC分类号： G01N21/05 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2300/0896 , B01L2400/0454 , B01L2400/0463 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C12Q1/6869 , G01N21/658 , G01N2021/0346 , G01N2021/651 , G01N2021/653 , G01N2021/655 , G01N2021/656 , C12Q2565/628
摘要： The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction.
摘要翻译：本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。该方法涉及使用表面增强拉曼光谱（SERS）检测核苷酸，核苷或碱基。检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。

7. 发明申请

WO2006069366A1 METHODS OF PROTEIN PROFILING BY THIOLATION 审中-公开
标题翻译：通过断裂进行蛋白质分析的方法
公开(公告)号：WO2006069366A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/046993
申请日：2005-12-21
申请人： INTEL CORPORATION , YAMAKAWA, Mineo
发明人： YAMAKAWA, Mineo
IPC分类号： G01N33/68
CPC分类号： G01N33/6842 , B82Y5/00 , B82Y10/00 , G01N33/6803
摘要： Methods for analyzing a protein are provided, including isolating the protein having original reactive functional groups from a biological sample, and converting substantially all original reactive functional groups into thiol groups, followed by attaching tags to the protein via the thiol groups.
摘要翻译：提供了用于分析蛋白质的方法，包括从生物样品中分离具有原始反应性官能团的蛋白质，并将基本上所有的原始反应性官能团转化成硫醇基团，然后通过硫醇基团将标签附着到蛋白质上。

8. 发明申请

WO2014021862A1 APPARATUS FOR PERFORMING SPECTROSCOPY HAVING A PARABOLIC REFLECTOR AND SERS ELEMENTS 审中-公开
标题翻译：用于执行具有抛物面反射器和元件元件的光谱的装置
公开(公告)号：WO2014021862A1
公开(公告)日：2014-02-06
申请号：PCT/US2012/049031
申请日：2012-07-31
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , WANG, Shih-Yuan , GIBSON, Gary , LI, Zhiyong , BRATKOVSKI, Alexandre M. , BARCELO, Steven J. , KIM, Ansoon , YAMAKAWA, Mineo , ZHOU, Zhang-Lin , KUO, Huei Pei
发明人： WANG, Shih-Yuan , GIBSON, Gary , LI, Zhiyong , BRATKOVSKI, Alexandre M. , BARCELO, Steven J. , KIM, Ansoon , YAMAKAWA, Mineo , ZHOU, Zhang-Lin , KUO, Huei Pei
IPC分类号： G01N21/65 , G02B5/10
CPC分类号： G01N21/658 , A61F2/02 , A61F2/82 , G01N2201/068 , G02B5/10 , Y10T29/49826
摘要： According to an example, an apparatus for performing spectroscopy includes a parabolic reflector and a plurality of surface-enhanced Raman spectroscopy (SERS) elements spaced from the parabolic reflector and positioned substantially at a focal point of the parabolic reflector. The parabolic reflector is to reflect Raman scattered light emitted from molecules in a near field generated by the plurality of SERS elements to substantially increase the flux of the Raman scattered light emitted out of the apparatus.
摘要翻译：根据一个实例，用于执行光谱学的装置包括抛物面反射器和与抛物面反射器间隔开并且基本上位于抛物面反射器的焦点的多个表面增强拉曼光谱（SERS）元件。抛物面反射器是反射由多个SERS元件产生的近场中的分子发射的拉曼散射光，以大大增加从该装置发出的拉曼散射光的通量。

9. 发明申请

WO2004065635A2 LASER EXPOSURE OF PHOTOSENSITIVE MASKS FOR DNA MICROARRAY FABRICATION 审中-公开
标题翻译：激光曝光用于DNA微量制备的光敏掩模
公开(公告)号：WO2004065635A2
公开(公告)日：2004-08-05
申请号：PCT/US2003/037839
申请日：2003-11-26
申请人： INTEL CORPORATION
发明人： RAO, Valluri , YAMAKAWA, Mineo , BERLIN, Andrew
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00441 , B01J2219/00527 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722
摘要： A method and apparatus for forming a polymer array on a substrate suitable for synthesizing polymer sequences. This includes forming an array, each location of the array having at least one strand end, forming photosensitive protection on the strand ends, and selectively scanning and modulating at least one energy beam to expose a pattern on the photosensitive protection. In some embodiments, the method further includes removing a protective group from selected strand ends based on the exposed pattern. The method then includes adding a predetermined one or more polymeric subunits to the deprotected strand ends. In some embodiments the photosensitive protection includes a layer of photoresist to cover the strand ends. Some embodiments use an ultra-violet laser.
摘要翻译：一种在适于合成聚合物序列的基材上形成聚合物阵列的方法和装置。这包括形成阵列，阵列的每个位置具有至少一个绞合端，在绞合端上形成感光保护，并且选择性地扫描和调制至少一个能量束以暴露感光保护上的图案。在一些实施方案中，该方法还包括基于暴露图案从选定的链末端去除保护基团。该方法然后包括将预定的一个或多个聚合物亚单位加入去保护的末端。在一些实施例中，感光保护包括一层光致抗蚀剂以覆盖绞合端。一些实施例使用紫外激光。

10. 发明申请

WO2003078649A2 METHODS TO INCREASE NUCLEOTIDE SIGNALS BY RAMAN SCATTERING 审中-公开
标题翻译：通过拉曼散射增加核苷酸信号的方法
公开(公告)号：WO2003078649A2
公开(公告)日：2003-09-25
申请号：PCT/US2003/007641
申请日：2003-03-11
申请人： INTEL CORPORATION
发明人： SU, Xing , BERLIN, Andrew , KOO, Tae-Woong , CHAN, Selena , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo
IPC分类号： C12Q
CPC分类号： C12Q1/6869 , C12Q1/6816 , C12Q1/6825 , C12Q1/6872 , C12Q2565/632 , C12Q2563/155 , C12Q2521/319
摘要： The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid (13). Exonuclease (15) treatment of the labeled nucleic acid (13) results in the release of labeled nucleotides (16, 130), which are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides (16, 130) released from a nucleic acid (13) by exonuclease (15) treatment are covalently cross-linked to silver or gold nanoparticles (140) and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus (10, 100, 210) for nucleic acid sequencing.
摘要翻译：本文公开的方法和装置涉及通过增强拉曼光谱进行的核酸测序。在本发明的某些实施方案中，核苷酸在掺入核酸（13）之前共价连接到拉曼标记上。标记核酸（13）的外切核酸酶（15）处理导致标记的核苷酸（16,130）的释放，其通过拉曼光谱法检测。在本发明的替代实施方案中，通过核酸外切酶（15）处理从核酸（13）释放的核苷酸（16,130）与银或金纳米颗粒（140）共价交联并通过表面增强拉曼光谱（SERS）检测，，表面增强共振拉曼光谱（SERRS）和/或相干反斯托克斯拉曼光谱（CARS）。本发明的其它实施方案涉及用于核酸测序的装置（10,100,210）。

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