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1. 发明申请

WO03037083A9 SYSTEMS AND METHODS FOR FREEZING AND STORING BIOPHARMACUETICAL MATERIAL 审中-公开
标题翻译：用于冷冻和储存生物材料的系统和方法
公开(公告)号：WO03037083A9
公开(公告)日：2004-01-15
申请号：PCT/US0235137
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LOK MAXIME , LEONARD LEONIDAS CARTWRIGHT , HUGHES TIMOTHY GERARD , WISNIEWSKI RICHARD
发明人： VOUTE NICOLAS , LOK MAXIME , LEONARD LEONIDAS CARTWRIGHT , HUGHES TIMOTHY GERARD , WISNIEWSKI RICHARD
IPC分类号： A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00 , A01N1/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein for freezing, thawing, and storing. The container is formed of a first substantially flat sheet of flexible material joined together by a seam with a second substantially flat sheet of flexible material so as to lie substantially flat when empty. The container fully encloses an interior portion for receiving the biopharmaceutical material. Also, the container is configured to form a three dimensional shape when filled with the biopharmaceutical material, wherein the three dimensional shape has a first side and a second side opposite the first side. The conduit is connected to the flexible container with the outside of the container being in fluid communication with the interior portion via the conduit. The temperature control unit includes a first surface and a second surface facing the first surface and the temperature control unit is configured to receive the flexible container therein, when the container is filled with the biopharmaceutical material. The container conforms to the shape of the interior of the temperature control unit and the first side and the second side of the container contact the first surface and the second surface of the temperature control unit. The first surface and/or the second surface of temperature control unit include heat transfer surface(s).
摘要翻译：本发明提供一种用于冷冻，解冻和储存包括柔性容器，导管和温度控制单元的生物药物材料的系统。柔性容器适于在其中容纳生物药物用于冷冻，解冻和储存。容器由具有第二基本平坦的柔性材料片的接缝连接在一起的第一基本平坦的柔性材料片形成，以便在空的时基本平坦。容器完全包围用于接收生物药物材料的内部部分。此外，容器被配置为当填充有生物药物材料时形成三维形状，其中三维形状具有与第一侧相对的第一侧和第二侧。导管连接到柔性容器，容器的外部通过导管与内部部分流体连通。温度控制单元包括面向第一表面的第一表面和第二表面，并且温度控制单元构造成当容器填充有生物药物材料时将柔性容器接纳在其中。容器符合温度控制单元的内部形状，并且容器的第一侧和第二侧接触温度控制单元的第一表面和第二表面。温度控制单元的第一表面和/或第二表面包括传热表面。

2. 发明申请

WO03037082A9 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIAL 审中-公开
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO03037082A9
公开(公告)日：2004-01-15
申请号：PCT/US0235135
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , GEISELHART EDWARD
发明人： VOUTE NICOLAS , LOK MAXIME N , BROWN DAVID C , KENDALL JAMES W , GEISELHART EDWARD
IPC分类号： A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00 , A01N1/00 , B65D81/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： A system for controlled freezing, storing and thawing a biopharmaceutical material includes a flexible container and a supporting structure. The flexible container is adapted to receive the biopharmaceutical material therein for freezing, storing and thawing. The container further includes a flange and the supporting structure is engageable with the flange to receive the container. The supporting structure may position the container for freezing and may protect it during transport and storage.
摘要翻译：用于控制冷冻，储存和解冻生物药物材料的系统包括柔性容器和支撑结构。柔性容器适于容纳其中的生物药物用于冷冻，储存和解冻。容器还包括凸缘，并且支撑结构可与凸缘接合以容纳容器。支撑结构可以将容器定位成冷冻并且可以在运输和储存期间保护它。

3. 发明申请

WO2007103917A2 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO2007103917A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063381
申请日：2007-03-06
申请人： INTEGRATED BIOSYSTEMS INC , VOUTE NICOLAS , LEE ERIC K , YAKOUSHKIN DIMITRY
发明人： VOUTE NICOLAS , LEE ERIC K , YAKOUSHKIN DIMITRY
CPC分类号： F25D25/005 , A61J1/165 , F25D2331/809
摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.
摘要翻译：用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。保持器固定地连接到容器装置。保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

4. 发明申请

WO2009086136A3 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO2009086136A3
公开(公告)日：2010-04-15
申请号：PCT/US2008087728
申请日：2008-12-19
申请人： SARTORIUS STEDIM NORTH AMERICA , CUTTING JONATHAN , GAY ISABELLE , LEE ERIC K , VOUTE NICOLAS
发明人： CUTTING JONATHAN , GAY ISABELLE , LEE ERIC K , VOUTE NICOLAS
IPC分类号： A01N1/02 , A61J1/05 , B65D81/38 , F25D3/00
CPC分类号： A01N1/02 , A01N1/0263
摘要： A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.
摘要翻译：一种用于使用冷冻，储存和解冻生物药物材料的系统，其包括用于在其中保持生物药物材料的保持器和容器。保持器具有空腔并且容器容纳在空腔中。保持器包括第一部分和第二部分。容器容纳在第一部分和第二部分之间，以将容器连接到保持器。保持器包括具有底部的内部支架和从底部延伸的边缘。摇篮限定了空腔。外缘连接到支架并与空腔分离。底部包括面向容纳容器的空腔的内表面和外表面。底部的外表面相对于外缘的外表面凹陷。

5. 发明申请

WO2010036552A3 SYSTEMS AND METHODS FOR STORING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于储存生物材料的系统和方法
公开(公告)号：WO2010036552A3
公开(公告)日：2010-06-17
申请号：PCT/US2009057241
申请日：2009-09-17
申请人： SARTORIUS STEDIM NORTH AMERICA , VOUTE NICOLAS , CUTTING JONATHAN , GAY ISABELLE
发明人： VOUTE NICOLAS , CUTTING JONATHAN , GAY ISABELLE
IPC分类号： A61J1/05 , A61J1/16
CPC分类号： A01N1/0263
摘要： A system for use in storing biopharmaceutical materials includes a holder and a container for holding biopharmaceutical materials therein. The container includes a storage portion and a sampling portion connected to each other by a connecting portion. The holder has a storage cavity receiving the storage portion and a sampling cavity receiving the sampling portion. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior storage cradle bounding the storage cavity of the holder. The holder includes an interior sampling cradle bounding the sampling cavity. The sampling cradle is separated from the storage cradle and connected to the storage cradle by a passage receiving the connecting portion connecting the storage portion to the sampling portion. An outer rim of the holder is connected to the cradle and separated from the cavity.
摘要翻译：用于储存生物药物材料的系统包括保持器和用于在其中保持生物药物材料的容器。容器包括通过连接部分彼此连接的存储部分和采样部分。保持器具有容纳存储部的存储空间和接收采样部的采样腔。保持器包括第一部分和第二部分。容器容纳在第一部分和第二部分之间，以将容器连接到保持器。保持器包括限定保持器的存储腔的内部存储支架。支架包括一个限定采样腔的内部采样支架。采样托架与存储托架分离，并通过接收将存储部分连接到采样部分的连接部分的通道连接到存储支架。保持器的外缘连接到支架并与空腔分离。

6. 发明申请

WO2004027331B1 SYSTEMS AND METHODS FOR FREEZING, MIXING AND THAWING BIOPHARMACEUTICAL MATERIAL 审中-公开
标题翻译：用于冷冻，混合和解冻生物医药材料的系统和方法
公开(公告)号：WO2004027331B1
公开(公告)日：2004-08-19
申请号：PCT/US0329727
申请日：2003-09-23
申请人： INTEGRATED BIOSYSTEMS INC
发明人： BROWN DAVID C , CUTTING JONATHAN , LEE ERIC K , VOUTE NICOLAS , WOODARD BRIAN J
IPC分类号： A01N1/00 , A01N1/02 , F25D25/00 , F25D31/00 , F25D16/00
CPC分类号： F25D25/005 , A01N1/00 , A01N1/02 , A01N1/0257 , A01N1/0263 , A01N1/0273 , F25B2600/07 , F25D25/00 , F25D2331/801 , F25D2400/20
摘要： A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity (26) for receiving a container (10) for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces (28) facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable-contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable-contacting surface contacts the container. Also, the cavity may be configured to receive a frame (15) for supporting the container holding the biopharmaceutical material. Further, the system may include a driver (500) to move the frame holding the container inside the cavity.
摘要翻译：用于生物制药材料的受控冷冻，储存和融化的系统包括用于接收容纳生物制药材料的容器（10）的空腔（26）。还包括至少一对面对生物制药材料保持容器的相对表面（28）。所述相对表面中的至少一个包括可移动接触表面，所述可移动接触表面构造成接触所述容器以阻止所述容器与所述可移动接触表面之间的间隙。还包括至少一个热传递表面，当可移动接触表面接触容器时，热传递表面热耦合到生物制药材料容纳容器。而且，空腔可以构造成接收用于支撑容纳生物制药材料的容器的框架（15）。此外，该系统可以包括驱动器（500），以将容纳容器的框架移动到腔内。

7. 发明专利

DE60212680T2 未知
公开(公告)号：DE60212680T2
公开(公告)日：2007-06-28
申请号：DE60212680
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC
发明人： VOUTE NICOLAS , LOK MAXIME , LEONARD CARTWRIGHT , HUGHES GERARD , WISNIEWSKI RICHARD
IPC分类号： A01N1/00 , A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00

8. 发明专利

DK1542894T3 未知
公开(公告)号：DK1542894T3
公开(公告)日：2006-10-09
申请号：DK03759407
申请日：2003-09-23
申请人： INTEGRATED BIOSYSTEMS INC
发明人： VOUTE NICOLAS , LEE ERIC K , DEBEERS JAMES EDWARD , WOODARD BRIAN J , LEE NGEE JENN
IPC分类号： B62B3/10 , A01N1/00 , A01N1/02 , B65D19/44 , F25D25/00

9. 发明专利

DK1441586T3 未知
公开(公告)号：DK1441586T3
公开(公告)日：2006-10-23
申请号：DK02778703
申请日：2002-11-01
申请人： INTEGRATED BIOSYSTEMS INC
发明人： LOK MAXIME , LEONARD LEONIDAS CARTWRIGHT , HUGHES TIMOTHY GERARD , VOUTE NICOLAS , WISNIEWSKI RICHARD
IPC分类号： A01N1/00 , A61J3/00 , A01N1/02 , A23L3/36 , A23L3/365 , A61J1/10 , A61M1/02 , B65D81/18 , F25D25/00 , F25D31/00

10. 发明申请

WO2004027331A2 SYSTEMS AND METHODS FOR FREEZING, MIXING AND THAWING BIOPHARMACEUTICAL MATERIAL 审中-公开
标题翻译：冷冻，混合和治疗生物材料的系统和方法
公开(公告)号：WO2004027331A2
公开(公告)日：2004-04-01
申请号：PCT/US0329727
申请日：2003-09-23
申请人： INTEGRATED BIOSYSTEMS INC
发明人： BROWN DAVID C , CUTTING JONATHAN , LEE ERIC K , VOUTE NICOLAS , WOODARD BRIAN J
IPC分类号： A01N1/00 , A01N1/02 , F25D25/00 , F25D31/00 , F25D16/00
CPC分类号： F25D25/005 , A01N1/00 , A01N1/02 , A01N1/0257 , A01N1/0263 , A01N1/0273 , F25B2600/07 , F25D25/00 , F25D2331/801 , F25D2400/20
摘要： A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.
摘要翻译：用于受控冷冻，储存和解冻生物药物材料的系统包括用于容纳用于保持生物药物材料的容器的空腔。还包括面向生物药物材料保持容器的至少一对相对表面。相对表面中的至少一个包括可移动的接触表面，其构造成接触容器以阻止容器和可动接触表面之间的间隙。还包括至少一个热传递表面，当可移动接触表面接触容器时，热传递表面热耦合到生物药物材料保持容器。此外，空腔可以被配置为容纳用于支撑容纳生物药物材料的容器的框架。此外，系统可以包括驱动器，以将保持容器的框架移动到腔体内。

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