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1. 发明申请

WO0158517A3 METHOD AND SYSTEM OF AUTOMATED HEMODYNAMICAL DETECTION OF ARRHYTHMIAS 审中-公开
标题翻译：自动血液动力学检测ARRHYTHMIAS的方法与系统
公开(公告)号：WO0158517A3
公开(公告)日：2002-01-17
申请号：PCT/IL0100127
申请日：2001-02-08
申请人： IMPULSE DYNAMICS NV , POLICKER SHAI , SHEMER ITZHAK , MIKA YUVAL , HAREL TAMAR
发明人： POLICKER SHAI , SHEMER ITZHAK , MIKA YUVAL , HAREL TAMAR
IPC分类号： A61B5/0464 , A61N1/39 , A61B5/021
CPC分类号： A61B5/7264 , A61B5/0464 , A61B5/7217 , A61B5/725 , A61N1/3956
摘要： A method for automated detection of arrhythmias in a patient is disclosed, said method comprising: obtaining continuous pressure data from a cardiac chamber of said patient; segmenting said pressure data to correspond to beat segments (1); extracting features from each of said beat segments with respect to a predetermined number of earlier beat segments, said features relating to at least some of the criteria selected from: beat-to-beat change in the duration of said beat segments, beat-to-beat change in the peak-to-peak amplitude of said beat segments (7), beat-to-beat change in heart rate of said patient (7) and change in value and instance in time of max dP/dt, where P is pressure and t is time; and classifying each of said beat segments (10) as ectopic or normal, wherein ectopic beat is determined using a set of predetermined rules aimed at detecting abnormality in features of each of said beat segments with reference to predetermined thresholds (9, 10).
摘要翻译：公开了一种用于自动检测患者心律失常的方法，所述方法包括：从所述患者的心室获取持续的压力数据; 分割所述压力数据以对应于节拍段（1）; 从相对于预定数量的较早的拍子片段中的每个所述拍子片段提取特征，所述特征与选自以下的至少一些标准有关：所述节拍片段的持续时间中的节拍改变，在所述节拍片段（7）的峰 - 峰幅度之间的节拍变化，所述患者（7）的心率的节拍变化和值的变化以及最大dP / dt的时间变化，其中P是压力和t是时间; 并且将每个所述节拍片段（10）分类为异位或正常，其中使用一组预定规则来确定异位搏击，所述预定规则旨在参考预定阈值（9,10）来检测每个所述拍子片段的特征中的异常。

2. 发明申请

WO2005007232A2 GASTROINTESTINAL METHODS AND APPARATUS FOR USE IN TREATING DISORDERS AND CONTROLLING BLOOD SUGAR 审中-公开
标题翻译：用于治疗疾病和控制血糖的胃肠病学方法和装置
公开(公告)号：WO2005007232A2
公开(公告)日：2005-01-27
申请号：PCT/IL2004000664
申请日：2004-07-21
申请人： IMPULSE DYNAMICS NV , BEN HAIM SHLOMO , POLICKER SHAI , BITON OFIR , HAREL TAMAR
发明人： BEN HAIM SHLOMO , POLICKER SHAI , BITON OFIR , HAREL TAMAR
IPC分类号： A61N20060101 , A61N1/05 , A61N1/18 , A61N1/36 , A61N
CPC分类号： A61N1/36007 , A61N1/05
摘要： A method and apparatus are provided for treating a subject. An electrical signal is applied to at least one stomach site of the subject. The electrical signal is configured to reduce a rise in a blood glucose level of the subject, in order to treat the subject.
摘要翻译：提供了一种用于治疗受试者的方法和装置。电信号被施加到受试者的至少一个胃部位置。电信号被配置为减少对象的血糖水平的上升，以便对待受试者。

3. 发明申请

WO2005023081A2 BLOOD GLUCOSE LEVEL CONTROL 审中-公开
标题翻译：血糖水平控制
公开(公告)号：WO2005023081A2
公开(公告)日：2005-03-17
申请号：PCT/IL2004000797
申请日：2004-09-05
申请人： IMPULSE DYNAMICS NV , HAREL TAMI , POLICKER SHAI , KHAWALED RADWAN , MIKA YUVAL , GLASBERG OFFER , GROSSMAN AHARON
发明人： HAREL TAMI , POLICKER SHAI , KHAWALED RADWAN , MIKA YUVAL , GLASBERG OFFER , GROSSMAN AHARON
IPC分类号： A61B20060101 , A61B5/00 , A61N1/05 , A61N1/18 , A61N1/20 , A61N1/36 , A61B
CPC分类号： A61N1/05 , A61B5/14532 , A61B5/425 , A61B2503/40 , A61N1/205 , A61N1/36007
摘要： A method of glucose level control comprising, providing at least one electrode adapted to apply an electric field to a pancreas; and applying an electric field to the pancreas using said at least one electrode such that blood glucose levels are significantly reduced and blood insulin levels are not significantly increased compared to a regular insulin response in a same person.
摘要翻译：一种葡萄糖水平控制的方法，包括：提供适于向胰腺施加电场的至少一个电极; 以及使用所述至少一个电极向胰腺施加电场，使得血糖水平显着降低并且血液胰岛素水平与同一个人中的正常胰岛素响应相比不显着增加。

4. 发明申请

WO2004021858A3 BLOOD GLUCOSE LEVEL CONTROL 审中-公开
标题翻译：血液葡萄糖水平控制
公开(公告)号：WO2004021858A3
公开(公告)日：2004-11-25
申请号：PCT/IL0300736
申请日：2003-09-04
申请人： IMPULSE DYNAMICS NV , HAREL TAMI , POLICKER SHAI , KHAWALED RADWAN , MIKA YUVAL , GLASBERG OFFER , GROSSMAN AHARON
发明人： HAREL TAMI , POLICKER SHAI , KHAWALED RADWAN , MIKA YUVAL , GLASBERG OFFER , GROSSMAN AHARON
IPC分类号： A61B5/145 , A61B20060101 , A61B18/00 , A61N1/05 , A61N1/10 , A61N1/18 , A61N1/36 , A61N1/40
CPC分类号： A61N1/32 , A61N1/05 , A61N1/36007
摘要： A method of glucose level control, comprising providing at least one electrode (110, 112) adapted to apply an electric field to a pancreas (100); and applying an electric field to the pancreas using said at least one electrode such that blood glucose levels are significantly reduced and blood insulin levels are not significantly increased.
摘要翻译：一种葡萄糖水平控制方法，包括提供适于向胰腺（100）施加电场的至少一个电极（110,112）; 以及使用所述至少一个电极向胰腺施加电场，使得血糖水平显着降低，并且血液胰岛素水平不显着增加。

5. 发明申请

WO02053093A3 REGULATION OF EATING HABITS 审中-公开
标题翻译：调节饮食习惯
公开(公告)号：WO02053093A3
公开(公告)日：2002-12-19
申请号：PCT/IL0200007
申请日：2002-01-03
申请人： IMPULSE DYNAMICS NV , POLICKER SHAI , AVIV RICARDO , BITTON OPHIR
发明人： POLICKER SHAI , AVIV RICARDO , BITTON OPHIR
IPC分类号： A61K49/00 , A61N1/36 , A61N1/08
CPC分类号： A61K49/0004 , A61N1/36007
摘要： A method for treating a subject is provided, including receiving a sensor signal responsive to the subject eating, analyzing the sensor signal, and driving a current into tissue of the subject responsive to analyzing the signal. The current is typically driven into muscle tissue of the subject's stomach (20). Preferably, receiving the sensor signal includes sensing electrical potential change generated responsive to contraction of a muscle such as a stomach muscle of the subject. In a preferred embodiment, the sensor signal is analyzed with respect to the timing of ingestion, and a level of compliance of the subject with a desired ingestion schedule is determined. As appropriate, a parameter of the current driven into the tissue may be configured such that the application of the current to the tissue induces in the subject a sensation of satiation, discomfort, nausea, or vertigo.
摘要翻译：提供了一种用于治疗对象的方法，包括接收响应于对象进食的传感器信号，分析传感器信号并且响应于分析信号而将电流驱动到对象的组织中。通常将电流驱入受试者的胃的肌肉组织（20）。优选地，接收传感器信号包括感测响应于受试者的诸如胃肌肉的肌肉的收缩而产生的电势变化。在优选实施例中，关于摄取的时间来分析传感器信号，并且确定对象与期望的摄取时间表的一致性水平。适当地，驱动进入组织的电流的参数可以被配置成使得向组织施加电流引起对象饱食，不适，恶心或眩晕的感觉。

6. 发明申请

WO2006129321A3 GI LEAD IMPLANTATION 审中-公开
标题翻译： GI铅植入
公开(公告)号：WO2006129321A3
公开(公告)日：2007-10-18
申请号：PCT/IL2006000644
申请日：2006-06-04
申请人： METACURE N V , POLICKER SHAI , PRUTCHI DAVID , BITTON OPHIR , ROUSSO BENNY , GLASBERG OFFER , MIKA YUVAL , HAREL TAMI , HADDAD WALID , MILMAN LENA
发明人： POLICKER SHAI , PRUTCHI DAVID , BITTON OPHIR , ROUSSO BENNY , GLASBERG OFFER , MIKA YUVAL , HAREL TAMI , HADDAD WALID , MILMAN LENA
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61B1/00016 , A61B1/00147 , A61B1/2736 , A61B5/073 , A61B5/076 , A61B5/42 , A61B5/6882 , A61B17/3468 , A61B2017/00221 , A61B2017/00292 , A61B2017/00296 , A61B2017/00411 , A61N1/05 , A61N1/0507 , A61N1/37205 , A61N1/37247 , A61N1/37252 , A61N1/375
摘要： A method is provided, including physically contacting a gastric implantation site of a stomach via a transluminal approach, physically contacting the site via a transabdominal approach, stabilizing the site, and implanting an electrode at the site based on the physical contact provided by the transluminal and transabdominal approach. Other embodiments are also described.
摘要翻译：提供了一种方法，包括通过经腔途径物理接触胃的胃注入部位，通过经腹途径物理接触部位，稳定部位，并根据由腔内提供的物理接触在该部位植入电极，以及经腹手术还描述了其它实施例。

7. 发明公开

EP1357971A4 REGULATION OF EATING HABITS 有权
标题翻译：控制饮食习惯
公开(公告)号：EP1357971A4
公开(公告)日：2009-04-01
申请号：EP02727012
申请日：2002-01-03
申请人： IMPULSE DYNAMICS NV
发明人： POLICKER SHAI , AVIV RICARDO , BITTON OPHIR
IPC分类号： A61K49/00 , A61N1/36 , A61N1/08
CPC分类号： A61K49/0004 , A61N1/36007
摘要： A method for treating a subject is provided, including receiving a sensor signal responsive to the subject eating, analyzing the sensor signal, and driving a current into tissue of the subject responsive to analyzing the signal. The current is typically driven into muscle tissue of the subject's stomach (20). Preferably, receiving the sensor signal includes sensing electrical potential change generated responsive to contraction of a muscle such as a stomach muscle of the subject. In a preferred embodiment, the sensor signal is analyzed with respect to the timing of ingestion, and a level of compliance of the subject with a desired ingestion schedule is determined. As appropriate, a parameter of the current driven into the tissue may be configured such that the application of the current to the tissue induces in the subject a sensation of satiation, discomfort, nausea, or vertigo.

8. 发明专利

AU2023201A Field delivery safety system using detection of atypical ecg 未知
公开(公告)号：AU2023201A
公开(公告)日：2001-07-16
申请号：AU2023201
申请日：2000-12-28
申请人： IMPULSE DYNAMICS NV
发明人： POLICKER SHAI , MIKA YUVAL , PRUTCHI DAVID , SHEMER ITZHAK
IPC分类号： A61N1/08 , A61N1/32 , A61N1/362 , A61N1/368 , A61N1/40

9. 发明专利

AU2003259537A1 BLOOD GLUCOSE LEVEL CONTROL 未知
公开(公告)号：AU2003259537A1
公开(公告)日：2004-03-29
申请号：AU2003259537
申请日：2003-09-04
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , GLASBERG OFFER , GROSSMAN AHARON , HAREL TAMI , POLICKER SHAI , KHAWALED RADWAN
IPC分类号： A61B5/145 , A61B20060101 , A61B18/00 , A61N1/05 , A61N1/10 , A61N1/18 , A61N1/36 , A61N1/40
摘要： A pancreatic controller, comprising: at least one electrode adapted for electrifying at least a portion of a pancreas; and a controller programmed to electrify said electrode so as to positively control at least the effect of at least two members of a group consisting of blood glucose level, blood insulin level and blood level of another pancreatic hormone. In one example, the controller controls insulin, glucagon and/or glucose blood levels.

10. 发明专利

AU2003259537A8 Blood glucose level control 未知
公开(公告)号：AU2003259537A8
公开(公告)日：2004-03-29
申请号：AU2003259537
申请日：2003-09-04
申请人： IMPULSE DYNAMICS NV
发明人： GROSSMAN AHARON , POLICKER SHAI , MIKA YUVAL , GLASBERG OFFER , KHAWALED RADWAN , HAREL TAMI
IPC分类号： A61B5/145 , A61B20060101 , A61B18/00 , A61N1/05 , A61N1/10 , A61N1/18 , A61N1/36 , A61N1/40
摘要： A pancreatic controller, comprising: at least one electrode adapted for electrifying at least a portion of a pancreas; and a controller programmed to electrify said electrode so as to positively control at least the effect of at least two members of a group consisting of blood glucose level, blood insulin level and blood level of another pancreatic hormone. In one example, the controller controls insulin, glucagon and/or glucose blood levels.

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