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1. 发明授权

US6424866B2 Apparatus and method for timing the delivery of non-excitatory ETC signals to a heart 有权
标题翻译：用于定时将非兴奋性ETC信号传递给心脏的装置和方法
公开(公告)号：US6424866B2
公开(公告)日：2002-07-23
申请号：US84189101
申请日：2001-04-25
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart are disclosed. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrilation signals to the heart.
摘要翻译：公开了用于定时递送用于改善心脏部分心肌收缩力的非兴奋性信号的方法和装置。该方法包括以下步骤：将电极施加到多个心脏部位，通过第一电极感测第一心脏位点中的电活动，以检测搏动周期内的第一电去极化事件，通过第二电极感测第二心脏位点中的电活动电极，用于检测所述拍摄周期内的第二电去极化事件，以及响应于检测到所述第二电去极化事件中的至少一个所述电极中的至少第二心脏位点处或附近的心脏施加非兴奋性信号警报窗口期间。警报窗口期间从检测到第一电去极化事件的时间开始，并且具有第一持续时间。从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。该方法可以包括用于降低由于电噪声和/或异位搏动而递送不正确定时的非兴奋性信号的可能性的步骤，并且还可以包括用于防止在第一心脏位点处或附近传递多个非兴奋性信号的步骤单心跳搏动循环。优选地，第一心脏位点位于心脏的右心室或右心房周围，并且第二心脏部位位于心脏的左心室周围。所述装置还可适于起搏心脏和/或用于将心脏除颤信号输送。

2. 发明申请

WO0130436A3 DEVICE FOR CARDIAC THERAPY 审中-公开
标题翻译：心脏治疗设备
公开(公告)号：WO0130436A3
公开(公告)日：2002-01-17
申请号：PCT/IL0000682
申请日：2000-10-25
申请人： IMPULSE DYNAMICS NV , PRUTCHI DAVID , DARVISH NISSIM , ROUTH ANDRE G , HALUSKA EDWARD , BELSKY ZIV
发明人： PRUTCHI DAVID , DARVISH NISSIM , ROUTH ANDRE G , HALUSKA EDWARD , BELSKY ZIV
IPC分类号： A61N1/362 , A61N1/39 , A61N1/365
CPC分类号： A61N1/39 , A61N1/3621 , A61N1/3627 , A61N1/3956
摘要： A multi-modal cardiotherapy device (100) includes an anti-arrhythmic unit (118) for delivering multiple types of anti-arrhythmic therapy to a heart, a cardiac contractility modulating unit (108) for delivering cardiac contractility modulating signals to the heart, and for applying anti-arrhythmic cardiac contractility modulating signal therapy to the heart, one or more sensing units (112) for sensing electrical signals related to electrical activity of the heart to provide an output signal, one or more detecting units (116) operatively connected to the sensing unit(s) (112) for detecting in the output signal cardiac events of the heart, a controller unit (106) operatively connected to the anti-arrhythmic unit (118), the cardiac contractility modulating unit (108) and the detecting unit(s) (116). The controller unit (106) processes the output of the detecting unit(s) (116) to detect a cardiac arrhythmia or indications of a possible arrhythmia in the heart and controls the application of anti-arrhythmic therapy, anti-arrhythmic cardiac contractility modulating signal therapy, and cardiac contractility modulating therapy to the heart. The device may be an implantable device or a non-implantable device. The device (100) may also include a pacing unit (102). Methods are disclosed for using the device for delivering multi-modal cardiotherapy to the heart.
摘要翻译：多模式心脏治疗装置（100）包括用于向心脏递送多种类型的抗心律失常治疗的抗心律不齐装置（118），用于将心脏收缩调节信号输送到心脏的心脏收缩力调节单元（108），以及用于向心脏施加抗心律失常心脏收缩调节信号治疗，一个或多个感测单元（112），用于感测与心脏的电活动相关的电信号以提供输出信号;一个或多个检测单元（116），其可操作地连接到用于在输出信号中检测心脏心脏事件的感测单元（112），可操作地连接到抗心律失调单元（118）的心脏收缩力调节单元（108）和检测器单位（116）。控制器单元（106）处理检测单元（116）的输出以检测心脏心律失常或心脏中可能的心律不齐的指示，并控制抗心律不齐治疗，抗心律失常心脏收缩调节信号的应用治疗和心脏收缩力调节治疗心脏。该装置可以是可植入装置或非植入装置。设备（100）还可以包括起搏单元（102）。公开了使用用于向心脏递送多模式心脏治疗的装置的方法。

3. 发明公开

EP1171199A4 APPARATUS AND METHOD FOR TIMING THE DELIVERY OF NON-EXCITATORY ETC SIGNALS TO A HEART 有权
标题翻译：装置和方法用于同步当局为何不EXZITATONISCHER ETC信号到HEART
公开(公告)号：EP1171199A4
公开(公告)日：2009-04-08
申请号：EP00907911
申请日：2000-03-01
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method, and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of the heart includes applying electrodes to a plurality of cardiac sites (RA, RV, LV), using a first electrode (2A, 4A) to at a first cardiac site (RV, RA) to detect a first electrical depolarization event within a beat cycle, using a second electrode (6A) at a second cardiac site (LV) to detect a second electrical depolarization event within a beat cycle, and applying a non-excitatory signal to the heart near at least the second cardiac site (LV) through at least one of the electrodes (6A) in response to detecting the second electrical depolarization event within an alert window period. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The devices may also be adapted for pacing the heart, and/or for delivering de-defibrillation signals to the heart.

4. 发明申请

WO2007029254A3 APPARATUS AND METHOD FOR DELIVERING ELECTRICAL SIGNALS TO A HEART 审中-公开
标题翻译：用于向心脏输送电信号的装置和方法
公开(公告)号：WO2007029254A3
公开(公告)日：2007-07-05
申请号：PCT/IL2006001042
申请日：2006-09-06
申请人： IMPULSE DYNAMICS NV , ROUSSO BENNY , EIZENBERG NETANEL , PRUTCHI DAVID , MIKA YUVAL , SNIR YEHUDA
发明人： ROUSSO BENNY , EIZENBERG NETANEL , PRUTCHI DAVID , MIKA YUVAL , SNIR YEHUDA
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/0464 , A61B5/7217 , A61N1/3622 , A61N1/36585 , A61N1/368 , A61N1/3684 , A61N1/3702
摘要： Devices, systems and methods for controlling (inhibiting or enabling) the delivery of electrotherapeutic signals to a heart using sensing of local and/or global ECG signals to detect ventricular arrhythmia or indication of possible ventricular arrhythmia in the heart. The devices, systems and methods process the sensed signals and are capable of delivering electroptherapeutic signals to the heart in the presence of a supra-ventricular arrhythmia such as atrial fibrillation and atrial flutter, while inhibiting the delivering electroptherapeutic signals in the presence of PVCs and/or extopic beats, and/or ventricular arrhythmia. The electrotherapeutic signals may include, among others, pacing signals and cardiac contractility modulating signals.
摘要翻译：使用局部和/或全局ECG信号的感测来检测心室心律失常或指示心脏中可能的室性心律失常的装置，系统和方法，用于控制（抑制或启用）向心脏递送电疗信号。该装置，系统和方法处理感测到的信号，并且能够在存在室上性心律失常如心房颤动和心房扑动的情况下将电治疗信号传递至心脏，同时抑制在存在PVC和/或心房扑动的情况下递送电疗信号，或外感节拍，和/或室性心律失常。电疗信号可以包括起搏信号和心脏收缩性调节信号等等。

5. 发明申请

WO0074552A3 METHOD FOR DETERMINIG ALERT WINDOW PARAMETERS FOR ETC SIGNAL DELIVERY 审中-公开
标题翻译：用于确定用于ETC信号传递的窗口参数的方法
公开(公告)号：WO0074552A3
公开(公告)日：2003-03-13
申请号：PCT/IL0000310
申请日：2000-05-30
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
IPC分类号： A61B5/0402 , A61N1/362 , A61N1/37 , A61N1/39 , H01L21/68 , H01L23/31
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00
摘要： A method for obtaining data (76) from a patient's heart useful for on-line setting of parameters (80) of a detection window in an excitable tissue control device.
摘要翻译：一种用于从患者心脏获取数据（76）的方法，其可用于可兴奋组织控制装置中检测窗口的参数（80）的在线设置。

6. 发明申请

WO0057947A3 BIPOLAR SENSOR FOR MUSCLE TISSUE ACTION POTENTIAL DURATION ESTIMATION 审中-公开
标题翻译：用于肌肉组织行动的双极传感器潜在的持续时间估计
公开(公告)号：WO0057947A3
公开(公告)日：2002-05-02
申请号：PCT/IL0000190
申请日：2000-03-28
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID
发明人： MIKA YUVAL , PRUTCHI DAVID
IPC分类号： A61B5/0492 , A61B5/04
CPC分类号： A61B5/0492
摘要： A bipolar sensor for muscle tissue action potential duration estimation, in accordance with a preferred embodiment of the present invention, comprising two electrodes (4, 5) exposed at the distal end of an electrode lead (2). The electrodes at said distal end are kept at a very close poximity, and the sensor is electically connected to a processing means for processing the signal detected by the sensor. Another prefered embodiment of the bipolar sensor for muscle tissue action potential duration estimation comprises two electrodes (23, 24) positioned at a side wall of an electrode lead, wherein said electrodes are kept at a very close promixity, and wherein said sensor is electrically connected to a processing means for processing the signal detected by the sensor.
摘要翻译：根据本发明的优选实施例的用于肌肉组织动作电位持续时间估计的双极传感器，包括在电极引线（2）的远端处暴露的两个电极（4,5）。所述远端处的电极保持非常接近的距离，并且传感器电连接到用于处理由传感器检测到的信号的处理装置。用于肌肉组织动作电位持续时间估计的双极传感器的另一优选实施例包括位于电极引线的侧壁处的两个电极（23,24），其中所述电极保持非常接近的允许性，并且其中所述传感器电连接涉及用于处理由传感器检测到的信号的处理装置。

7. 发明申请

WO0057952A8 APPARATUS AND METHOD FOR TIMING THE DELIVERY OF NON-EXCITATORY ETC SIGNALS TO A HEART 审中-公开
标题翻译：用于定时向非心脏输送非特异性ETC信号的装置和方法
公开(公告)号：WO0057952A8
公开(公告)日：2001-05-25
申请号：PCT/IL0000126
申请日：2000-03-01
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method, and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of the heart includes applying electrodes to a plurality of cardiac sites (RA, RV, LV), using a first electrode (2A, 4A) at a first cardiac site (RV, RA) to detect a first electrical depolarization event within a beat cycle, using a second electrode (6A) at a second cardiac site (LV) to detect a second electrical depolarization event within a beat cycle, and applying a non-excitatory signal to the heart near at least the second cardiac site (LV) through at least one of the electrodes (6A) in response to detecting the second electrical depolarization event within an alert window period. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The devices may also be adapted for pacing the heart, and/or for delivering de-defibrillation signals to the heart.
摘要翻译：方法和用于定时递送用于改善心脏心脏收缩力的非兴奋性信号的装置包括使用第一电极（2A，4A）将电极施加到多个心脏部位（RA，RV，LV）心脏位点（RV，RA），以在搏动周期内检测第一电去极化事件，使用第二心脏位点（LV）处的第二电极（6A）来检测搏动周期内的第二电去极化事件，响应于检测到警报窗口周期内的第二电去极化事件，至少通过至少一个电极（6A）向心脏附近的至少第二心脏位点（LV）的心脏信号。从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。所述装置还可适于起搏心脏和/或用于将去除颤颤信号递送至心脏。

8. 发明公开

EP2139553A4 APPARATUS AND METHOD FOR SETTING THE PARAMETERS OF AN ALERT WINDOW USED FOR TIMING THE DELIVERY OF ETC SIGNALS TO A HEART UNDER VARYING CARDIAC CONDITIONS 有权
标题翻译：装置和方法进入一个“警告窗口”工艺参数的ETC信号准投票的时间为心脏病变工况心脏病
公开(公告)号：EP2139553A4
公开(公告)日：2010-01-06
申请号：EP00939018
申请日：2000-06-04
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
IPC分类号： A61N1/362 , A61B5/0402 , A61N1/37 , A61N1/39 , H01L21/68 , H01L23/31
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3622 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00

9. 发明公开

EP1937357A4 APPARATUS AND METHOD FOR DELIVERING ELECTRICAL SIGNALS TO A HEART 有权转让
标题翻译： GERÄTUND VERFAHREN ZUR ABGABE VON ELEKTRISCHEN SIGNALEN AN EIN HERZ
公开(公告)号：EP1937357A4
公开(公告)日：2012-02-29
申请号：EP06780471
申请日：2006-09-06
申请人： IMPULSE DYNAMICS NV
发明人： ROUSSO BENNY , EIZENBERG NETANEL , PRUTCHI DAVID , MIKA YUVAL , SNIR YEHUDA
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/0464 , A61B5/7217 , A61N1/3622 , A61N1/36585 , A61N1/368 , A61N1/3684 , A61N1/3702
摘要： Devices, systems and methods for controlling (inhibiting or enabling) the delivery of electrotherapeutic signals to a heart using sensing of local and/or global ECG signals to detect ventricular arrhythmia or indication of possible ventricular arrhythmia in the heart. The devices, systems and methods process the sensed signals and are capable of delivering electroptherapeutic signals to the heart in the presence of a supra-ventricular arrhythmia such as atrial fibrillation and atrial flutter, while inhibiting the delivering electroptherapeutic signals in the presence of PVCs and/or extopic beats, and/or ventricular arrhythmia. The electrotherapeutic signals may include, among others, pacing signals and cardiac contractility modulating signals.
摘要翻译：用于通过感测局部和/或全局心电图信号来检测心脏心律失常或心脏心律失常的指示来控制（抑制或使能）向心脏递送电治疗信号的装置，系统和方法。装置，系统和方法处理感测到的信号，并且能够在心室颤动和心房扑动等超心律失常的情况下向心脏递送电治疗信号，同时在存在PVC的情况下抑制递送电治疗信号和/ 或过度搏动，和/或室性心律失常。电疗信号可以包括起搏信号和心脏收缩调节信号。

10. 发明公开

EP1218059A4 APPARATUS AND METHOD FOR CONTROLLING THE DELIVERY OF CONTRACTILITY MODULATING NON-EXCITATORY SIGNALS TO THE HEART 审中-公开
标题翻译：设备及其控制方法KONTRAKTIONSMODULIERENDEN，NON-RISE信号管理的心
公开(公告)号：EP1218059A4
公开(公告)日：2009-04-15
申请号：EP00953414
申请日：2000-08-15
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365
CPC分类号： A61N1/368
摘要： Apparatus (340) for automatically controlling the delivery of excitable tissue control signals to a heart (349). The apparatus (340) includes an excitable tissue control unit (346) for delivering excitable tissue control signals to the heart (349), an action potential duration (APD) determining unit (350) for receiving sensed cardiac action potential related signals. The APD determining unit (350) determines an estimated action potential duration value from one or more action potential related signals, computes one or more excitable tissue control signal parameters, and controls the delivery of excitable tissue control signals based on the computed signal parameter(s). The cardiac action potential related signals may be cardiac close bipolar electrogram signals and cardiac monophasic action potential signals. Methods are disclosed for use with the apparatus to control the delivery of excitable tissue control signals to the heart.

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