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1. 发明授权

US6424866B2 Apparatus and method for timing the delivery of non-excitatory ETC signals to a heart 有权
标题翻译：用于定时将非兴奋性ETC信号传递给心脏的装置和方法
公开(公告)号：US6424866B2
公开(公告)日：2002-07-23
申请号：US84189101
申请日：2001-04-25
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart are disclosed. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrilation signals to the heart.
摘要翻译：公开了用于定时递送用于改善心脏部分心肌收缩力的非兴奋性信号的方法和装置。该方法包括以下步骤：将电极施加到多个心脏部位，通过第一电极感测第一心脏位点中的电活动，以检测搏动周期内的第一电去极化事件，通过第二电极感测第二心脏位点中的电活动电极，用于检测所述拍摄周期内的第二电去极化事件，以及响应于检测到所述第二电去极化事件中的至少一个所述电极中的至少第二心脏位点处或附近的心脏施加非兴奋性信号警报窗口期间。警报窗口期间从检测到第一电去极化事件的时间开始，并且具有第一持续时间。从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。该方法可以包括用于降低由于电噪声和/或异位搏动而递送不正确定时的非兴奋性信号的可能性的步骤，并且还可以包括用于防止在第一心脏位点处或附近传递多个非兴奋性信号的步骤单心跳搏动循环。优选地，第一心脏位点位于心脏的右心室或右心房周围，并且第二心脏部位位于心脏的左心室周围。所述装置还可适于起搏心脏和/或用于将心脏除颤信号输送。

2. 发明申请

WO0130436A3 DEVICE FOR CARDIAC THERAPY 审中-公开
标题翻译：心脏治疗设备
公开(公告)号：WO0130436A3
公开(公告)日：2002-01-17
申请号：PCT/IL0000682
申请日：2000-10-25
申请人： IMPULSE DYNAMICS NV , PRUTCHI DAVID , DARVISH NISSIM , ROUTH ANDRE G , HALUSKA EDWARD , BELSKY ZIV
发明人： PRUTCHI DAVID , DARVISH NISSIM , ROUTH ANDRE G , HALUSKA EDWARD , BELSKY ZIV
IPC分类号： A61N1/362 , A61N1/39 , A61N1/365
CPC分类号： A61N1/39 , A61N1/3621 , A61N1/3627 , A61N1/3956
摘要： A multi-modal cardiotherapy device (100) includes an anti-arrhythmic unit (118) for delivering multiple types of anti-arrhythmic therapy to a heart, a cardiac contractility modulating unit (108) for delivering cardiac contractility modulating signals to the heart, and for applying anti-arrhythmic cardiac contractility modulating signal therapy to the heart, one or more sensing units (112) for sensing electrical signals related to electrical activity of the heart to provide an output signal, one or more detecting units (116) operatively connected to the sensing unit(s) (112) for detecting in the output signal cardiac events of the heart, a controller unit (106) operatively connected to the anti-arrhythmic unit (118), the cardiac contractility modulating unit (108) and the detecting unit(s) (116). The controller unit (106) processes the output of the detecting unit(s) (116) to detect a cardiac arrhythmia or indications of a possible arrhythmia in the heart and controls the application of anti-arrhythmic therapy, anti-arrhythmic cardiac contractility modulating signal therapy, and cardiac contractility modulating therapy to the heart. The device may be an implantable device or a non-implantable device. The device (100) may also include a pacing unit (102). Methods are disclosed for using the device for delivering multi-modal cardiotherapy to the heart.
摘要翻译：多模式心脏治疗装置（100）包括用于向心脏递送多种类型的抗心律失常治疗的抗心律不齐装置（118），用于将心脏收缩调节信号输送到心脏的心脏收缩力调节单元（108），以及用于向心脏施加抗心律失常心脏收缩调节信号治疗，一个或多个感测单元（112），用于感测与心脏的电活动相关的电信号以提供输出信号;一个或多个检测单元（116），其可操作地连接到用于在输出信号中检测心脏心脏事件的感测单元（112），可操作地连接到抗心律失调单元（118）的心脏收缩力调节单元（108）和检测器单位（116）。控制器单元（106）处理检测单元（116）的输出以检测心脏心律失常或心脏中可能的心律不齐的指示，并控制抗心律不齐治疗，抗心律失常心脏收缩调节信号的应用治疗和心脏收缩力调节治疗心脏。该装置可以是可植入装置或非植入装置。设备（100）还可以包括起搏单元（102）。公开了使用用于向心脏递送多模式心脏治疗的装置的方法。

3. 发明申请

WO0187134A3 APPARATUS AND METHOD FOR CONTROLLING THE DELIVERY OF NON-EXCITATORY CARDIAC CONTRACTILITY MODULATING SIGNALS TO A HEART 审中-公开
标题翻译：用于控制向心脏递送非激活性心脏病合并调节信号的装置和方法
公开(公告)号：WO0187134A3
公开(公告)日：2002-05-02
申请号：PCT/IL0100417
申请日：2001-05-10
申请人： IMPULSE DYNAMICS NV , BELSKY ZIV , MIKA YUVAL
发明人： BELSKY ZIV , MIKA YUVAL
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/7217 , A61B5/7264 , A61N1/3627 , A61N1/365 , A61N1/368
摘要： A method and device for controlling the delivery of cardiac contractility modulating signals to the heart. The method includes applying electrodes to a heart, sensing electrical activity in a first cardiac chamber and in at least a second cardiac chamber to detect events within a cardiac beat cycle and applying a cardiac contractility modulating signal to the heart at or about the first cardiac chamber in response to detecting an event within an alert window time interval. The applying of the cardiac contractility modulating signal is inhibited in response to detecting one or more inhibitory events occurring within specific time intervals defined within a current beat cycle.
摘要翻译：用于控制心脏收缩力调节信号传递给心脏的方法和装置。该方法包括将电极施加到心脏，感测第一心室和第二心室中的电活动，以检测心搏周期内的事件，并将心脏收缩调节信号施加于第一心室或其周围的心脏响应于检测到警报窗口时间间隔内的事件。响应于检测在当前搏动周期内定义的特定时间间隔内发生的一个或多个抑制事件，抑制心肌收缩调节信号的应用。

4. 发明申请

WO0130139A3 ANTI-ARRHYTHMIC DEVICE AND A METHOD OF DELIVERING ANTI-ARRHYTHMIC CARDIAC THERAPY 审中-公开
标题翻译：抗精神病药物和递送抗心律失常药物治疗方法
公开(公告)号：WO0130139A3
公开(公告)日：2002-02-14
申请号：PCT/IL0000681
申请日：2000-10-25
申请人： IMPULSE DYNAMICS NV , SHEMER ITZHAK , POLICKER SHAY , BELSKY ZIV , HALUSKA EDWARD
发明人： SHEMER ITZHAK , POLICKER SHAY , BELSKY ZIV , HALUSKA EDWARD
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/39 , A61N1/3621 , A61N1/3627 , A61N1/3956
摘要： A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device (30) includes a power source (165). The device may be an implantable device or a non-implantable device. A method for delivering anti-arrhythmic therapy to a heart. The method includes applying one or more non-excitatory cardiac contractility modulating electrical signals to said heart.
摘要翻译：心脏收缩力调节（CCM）装置（30）包括抗心律失常治疗单元（38），用于基于处理与心脏感测的心脏活动相关的电信号来检测患者的心脏（2）中的心律不齐，以及用于向心脏递送抗心律失常药物。该装置包括能够向心脏递送心脏收缩调节（CCM）信号以调节一部分心脏的收缩力的心脏收缩力调节（CCM）单元（40）。设备（30）包括电源（165）。该装置可以是可植入装置或非植入装置。一种向心脏递送抗心律失常药物的方法。该方法包括将一个或多个非兴奋性心脏收缩调节电信号应用于所述心脏。

5. 发明公开

EP1284786A4 APPARATUS AND METHOD FOR CONTROLLING THE DELIVERY OF NON-EXCITATORY CARDIAC CONTRACTILITY MODULATING SIGNALS TO A HEART 有权
标题翻译：设备及其控制方法NICHTEXCITATORISCHEN，心脏，KONTRAKTIONSMODULIERENDEN信号的管理心脏病
公开(公告)号：EP1284786A4
公开(公告)日：2004-12-15
申请号：EP01929956
申请日：2001-05-10
申请人： IMPULSE DYNAMICS NV
发明人： BELSKY ZIV , MIKA YUVAL
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/39 , A61N1/36 , A61B5/0245
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/7217 , A61B5/7264 , A61N1/3627 , A61N1/365 , A61N1/368
摘要： A method and device for controlling the delivery of cardiac contractility modulating signals to the heart. The method includes applying electrodes to a heart, sensing electrical activity in a first cardiac chamber and in at least a second cardiac chamber to detect events within a cardiac beat cycle and applying a cardiac contractility modulating signal to the heart at or about the first cardiac chamber in response to detecting an event within an alert window time interval. The applying of the cardiac contractility modulating signal is inhibited in response to detecting one or more inhibitory events occurring within specific time intervals defined within a current beat cycle.

6. 发明申请

WO0074552A3 METHOD FOR DETERMINIG ALERT WINDOW PARAMETERS FOR ETC SIGNAL DELIVERY 审中-公开
标题翻译：用于确定用于ETC信号传递的窗口参数的方法
公开(公告)号：WO0074552A3
公开(公告)日：2003-03-13
申请号：PCT/IL0000310
申请日：2000-05-30
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
IPC分类号： A61B5/0402 , A61N1/362 , A61N1/37 , A61N1/39 , H01L21/68 , H01L23/31
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00
摘要： A method for obtaining data (76) from a patient's heart useful for on-line setting of parameters (80) of a detection window in an excitable tissue control device.
摘要翻译：一种用于从患者心脏获取数据（76）的方法，其可用于可兴奋组织控制装置中检测窗口的参数（80）的在线设置。

7. 发明申请

WO0057952A8 APPARATUS AND METHOD FOR TIMING THE DELIVERY OF NON-EXCITATORY ETC SIGNALS TO A HEART 审中-公开
标题翻译：用于定时向非心脏输送非特异性ETC信号的装置和方法
公开(公告)号：WO0057952A8
公开(公告)日：2001-05-25
申请号：PCT/IL0000126
申请日：2000-03-01
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method, and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of the heart includes applying electrodes to a plurality of cardiac sites (RA, RV, LV), using a first electrode (2A, 4A) at a first cardiac site (RV, RA) to detect a first electrical depolarization event within a beat cycle, using a second electrode (6A) at a second cardiac site (LV) to detect a second electrical depolarization event within a beat cycle, and applying a non-excitatory signal to the heart near at least the second cardiac site (LV) through at least one of the electrodes (6A) in response to detecting the second electrical depolarization event within an alert window period. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The devices may also be adapted for pacing the heart, and/or for delivering de-defibrillation signals to the heart.
摘要翻译：方法和用于定时递送用于改善心脏心脏收缩力的非兴奋性信号的装置包括使用第一电极（2A，4A）将电极施加到多个心脏部位（RA，RV，LV）心脏位点（RV，RA），以在搏动周期内检测第一电去极化事件，使用第二心脏位点（LV）处的第二电极（6A）来检测搏动周期内的第二电去极化事件，响应于检测到警报窗口周期内的第二电去极化事件，至少通过至少一个电极（6A）向心脏附近的至少第二心脏位点（LV）的心脏信号。从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。所述装置还可适于起搏心脏和/或用于将去除颤颤信号递送至心脏。

8. 发明公开

EP2139553A4 APPARATUS AND METHOD FOR SETTING THE PARAMETERS OF AN ALERT WINDOW USED FOR TIMING THE DELIVERY OF ETC SIGNALS TO A HEART UNDER VARYING CARDIAC CONDITIONS 有权
标题翻译：装置和方法进入一个“警告窗口”工艺参数的ETC信号准投票的时间为心脏病变工况心脏病
公开(公告)号：EP2139553A4
公开(公告)日：2010-01-06
申请号：EP00939018
申请日：2000-06-04
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
IPC分类号： A61N1/362 , A61B5/0402 , A61N1/37 , A61N1/39 , H01L21/68 , H01L23/31
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3622 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00

9. 发明公开

EP1171199A4 APPARATUS AND METHOD FOR TIMING THE DELIVERY OF NON-EXCITATORY ETC SIGNALS TO A HEART 有权
标题翻译：装置和方法用于同步当局为何不EXZITATONISCHER ETC信号到HEART
公开(公告)号：EP1171199A4
公开(公告)日：2009-04-08
申请号：EP00907911
申请日：2000-03-01
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method, and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of the heart includes applying electrodes to a plurality of cardiac sites (RA, RV, LV), using a first electrode (2A, 4A) to at a first cardiac site (RV, RA) to detect a first electrical depolarization event within a beat cycle, using a second electrode (6A) at a second cardiac site (LV) to detect a second electrical depolarization event within a beat cycle, and applying a non-excitatory signal to the heart near at least the second cardiac site (LV) through at least one of the electrodes (6A) in response to detecting the second electrical depolarization event within an alert window period. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The devices may also be adapted for pacing the heart, and/or for delivering de-defibrillation signals to the heart.

10. 发明公开

EP1311190A4 APPARATUS AND METHOD FOR COLLECTING DATA USEFUL FOR DETERMINING THE PARAMETERS OF AN ALERT WINDOW FOR TIMING DELIVERY OF ETC SIGNALS TO A HEART UNDER VARYING CARDIAC CONDITIONS 有权
标题翻译：设备和方法用于收集有用数据以测定窗口的参数的投票时间等信号的注意力心在变化的心脏状况
公开(公告)号：EP1311190A4
公开(公告)日：2005-06-22
申请号：EP00929767
申请日：2000-05-30
申请人： IMPULSE DYNAMICS NV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
IPC分类号： A61B5/0402 , A61N1/362 , A61N1/37 , A61N1/39 , H01L21/68 , H01L23/31
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00
摘要： A method for obtaining data (76) from a patient's heart useful for on-line setting of parameters (80) of a detection window in an excitable tissue control device.

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