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1. 发明申请

WO2011064403A1 INTEGRATED CIRCUIT FOR SPECTRAL IMAGING SYSTEM 审中-公开
标题翻译：用于光谱成像系统的集成电路
公开(公告)号：WO2011064403A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/068575
申请日：2010-11-30
申请人： IMEC , TACK, Klaas , LAMBRECHTS, Andy , HASPESLAGH, Luc
发明人： TACK, Klaas , LAMBRECHTS, Andy , HASPESLAGH, Luc
IPC分类号： G01J3/26 , G01J3/28 , G01J3/12
CPC分类号： G01J3/2823 , G01J3/12 , G01J3/26 , G01J3/2803 , G01J2003/1226 , G01J2003/265 , G01J2003/2806 , G01J2003/2826 , H04N5/332 , H04N5/378
摘要： An integrated circuit for an imaging system has an array of optical sensors (40), and an array of optical filters (10) each configured to pass a band of wavelengths onto one or more of the sensors, the array of optical filters being integrated with the array of sensors, and the integrated circuit also having read out circuitry (30) to read out pixel values from the array of sensors to represent an image, different ones of the optical filters being configured to have a different thickness, to pass different bands of wavelengths by means of interference, to allow detection of a spectrum of wavelengths. The read out circuitry can enable multiple pixels under one optical filter to be read out in parallel. The thicknesses may vary non monotonically across the array. The read out, or later image processing, may involve selection or interpolation between wavelengths, to carry out spectral sampling or shifting, to compensate for thickness errors.
摘要翻译：一种用于成像系统的集成电路具有光学传感器阵列（40）和每个被配置成将波长带传递到一个或多个传感器上的滤光器阵列（10），所述滤光器阵列与所述传感器阵列和所述集成电路还具有读出电路（30），以从所述传感器阵列中读出像素值以表示图像，所述不同的所述滤光器被配置为具有不同的厚度以通过不同的带的波长，以允许检测波长的光谱。读出电路可以使一个光学滤波器下的多个像素平行读出。厚度可以在整个阵列上单调变化。读出或稍后的图像处理可能涉及波长之间的选择或插值，以进行频谱采样或移位，以补偿厚度误差。

2. 发明申请

WO2015082476A1 APPARATUS AND METHOD FOR PERFORMING IN-LINE LENS-FREE DIGITAL HOLOGRAPHY OF AN OBJECT 审中-公开
标题翻译：用于执行对象的在线无数字数字全息扫描的装置和方法
公开(公告)号：WO2015082476A1
公开(公告)日：2015-06-11
申请号：PCT/EP2014/076270
申请日：2014-12-02
申请人： IMEC VZW
发明人： STAHL, Richard , VANMEERBEECK, Geert , JAPALAYA, Murali , LAMBRECHTS, Andy
IPC分类号： G03H1/04 , H04N9/04
CPC分类号： G03H1/0443 , G01N15/1429 , G01N15/1434 , G01N15/147 , G01N2015/1454 , G03H1/0404 , G03H1/0465 , G03H1/0486 , G03H1/0493 , G03H1/0866 , G03H2001/0212 , G03H2001/0428 , G03H2001/0447 , G03H2001/0452 , G03H2001/0497 , G03H2001/266 , G03H2210/12 , G03H2210/13 , G03H2222/14 , G03H2226/11 , G03H2240/62 , H04N5/332 , H04N9/045
摘要： An apparatus for performing in-line lens-free digital holography of an object, comprising: • - a single point light source (2) adapted for emitting coherent light; • - an image sensing device (5) adapted and arranged for recording interference patterns wherein • - the point light source comprises a broad wavelength spectrum light source and a pinhole structure, • - the image sensing device is adapted for receiving and recording, at the same moment in time, a plurality of interference patterns by a respective plurality of disjoint subsets of pixels (I, II, III, IV); • - the image sensing device comprises for each of the disjoint subsets of pixels, a respective narrow band wavelength filter positioned above each of the pixels of the disjoint subset of pixels, wherein a wavelength range of each narrow band wavelength filter falls within the broad wavelength spectrum of the point light source, these wavelength ranges of the narrow band wavelength filters being non-overlapping;
摘要翻译：一种用于执行物体的无镜头数字全息术的设备，包括： - 适于发射相干光的单点光源（2）; • - 适于和布置用于记录干涉图案的图像感测装置（5），其中•点光源包括宽波长光谱光源和针孔结构， - 图像感测装置适于接收和记录在相同的时刻，通过相应的多个不相交的像素子集（I，II，III，IV）的多个干涉图案; •图像感测装置包括用于每个不相似像素的子集，位于像素不相交子像素的每个像素上方的相应窄带波长滤波器，其中每个窄带波长滤波器的波长范围落在宽波长范围内点光源的光谱，窄带波长滤波器的这些波长范围是不重叠的;

3. 发明申请

WO2013064510A1 SPECTRAL CAMERA WITH MOSAIC OF FILTERS FOR EACH IMAGE PIXEL 审中-公开
标题翻译：与每个图像像素的滤波器的光谱相机
公开(公告)号：WO2013064510A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071509
申请日：2012-10-30
申请人： IMEC
发明人： GEELEN, Bert , LAMBRECHTS, Andy , TACK, Klaas
IPC分类号： G01J3/28 , G01J3/02
CPC分类号： G01J3/26 , G01J3/02 , G01J3/0208 , G01J3/0235 , G01J3/0256 , G01J3/0259 , G01J3/2823 , G01J2003/2826
摘要： A spectral camera for producing a spectral output has an objective lens (10) for producing an image, a mosaic of filters (30) for passing different bands of the optical spectrum, and a sensor array (40) arranged to detect pixels of the image at the different bands passed by the filters, wherein for each of the pixels, the sensor array has a cluster of sensor elements for detecting the different bands, and the mosaic has a corresponding cluster of filters of different bands, integrated on the sensor element so that the image can be detected simultaneously at the different bands. The filters are first order Fabry-Perot filters, which can give any desired passband to give high spectral definition. Cross talk can be reduced since there is no longer a parasitic cavity.
摘要翻译：用于产生光谱输出的光谱相机具有用于产生图像的物镜（10），用于通过光谱的不同带的滤光器（30）的马赛克;以及布置成检测图像的像素的传感器阵列（40）在滤波器通过的不同频带处，其中对于每个像素，传感器阵列具有用于检测不同频带的传感器元件群，并且马赛克具有集成在传感器元件上的不同频带的相应的滤波器簇，因此可以在不同的频带同时检测图像。滤波器是一阶法布里 - 珀罗滤波器，可以给出任何所需的通带，以提供高的频谱分辨率。可以减少串扰，因为不再有寄生腔。

4. 发明申请

WO2015150589A1 METHOD AND DEVICE FOR DRUG SCREENING 审中-公开
标题翻译：用于药物筛选的方法和装置
公开(公告)号：WO2015150589A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/097017
申请日：2015-04-03
申请人： IMEC VZW
发明人： REUMERS, Veerle , BRAEKEN, Dries , VANMEERBEECK, Geert , STAHL, Richard , LAMBRECHTS, Andy
IPC分类号： G01N21/45 , G01N21/47 , G01N33/50 , G01N21/17 , G03H1/26 , G03H1/00 , G03H1/04
CPC分类号： G01N15/1031 , G01N15/1434 , G01N15/1468 , G01N21/1717 , G01N21/45 , G01N21/453 , G01N21/4788 , G01N33/5044 , G01N2015/0065 , G01N2015/1006 , G01N2015/1454 , G01N2021/1721 , G01N2021/1738 , G01N2021/1765 , G01N2201/06113 , G01N2201/062 , G01N2500/10 , G03H1/0005 , G03H1/0402 , G03H1/0443 , G03H1/0465 , G03H2001/0033 , G03H2001/005 , G03H2001/0447 , G03H2001/0469 , G03H2001/0471 , G03H2222/22 , G03H2226/11
摘要： A lens-free device (100) for performing drug screening on cells (103) comprises a substrate (101) having a surface (102); a light source (104) positioned to illuminate the cells (103), when present, on the substrate surface (104) with a light wave; a sensor (105) positioned to detect an optical signal caused by illuminating the cells (103). The substrate surface (102) furthermore comprises a microelectrode array for sensing electrophysiological signals from the cells (103). Further, a method for performing drug screening on cells is presented.
摘要翻译：用于对细胞（103）进行药物筛选的无镜头装置（100）包括具有表面（102）的基底（101）; 定位成当光电池（103）存在时用光波照射在衬底表面（104）上的光源（104）定位成检测通过照亮单元（103）而引起的光信号的传感器（105）。衬底表面（102）还包括用于感测来自电池（103）的电生理信号的微电极阵列。此外，提出了在细胞上进行药物筛选的方法。

5. 发明申请

WO2013064511A1 SPECTRAL CAMERA WITH INTEGRATED FILTERS AND MULTIPLE ADJACENT IMAGE COPIES PROJECTED ONTO SENSOR ARRAY 审中-公开
标题翻译：具有集成滤波器的光谱摄像机和投影到传感器阵列的多个相邻图像复制
公开(公告)号：WO2013064511A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071510
申请日：2012-10-30
申请人： IMEC
发明人： GEELEN, Bert , LAMBRECHTS, Andy , TACK, Klaas
IPC分类号： G01J3/28 , G01J3/02
CPC分类号： G01J3/2823 , G01J3/0208 , G01J3/0256 , G01J3/0259 , G01J2003/2826 , H04N9/045
摘要： A spectral camera for producing a spectral output has an objective lens (10) for producing an image, an optical duplicator (20), an array of filters (30) and a sensor arrays (40) arranged to detect the filtered image copies simultaneously on different parts of the sensor array. A field stop (50) defines an outline of the image copies projected on the sensor array. The filters are integrated on the sensor array, which has a planar structure without perpendicular physical barriers for preventing cross talk between each of the adjacent optical channels. The field stop enables adjacent image copies to fit together without gaps for such barriers. The integrated filters mean there is no parasitic cavity causing crosstalk between the adjacent image copies. This means there is no longer a need for barriers between adjacent projected image copies, and thus sensor area can be better utilised.
摘要翻译：用于产生光谱输出的光谱相机具有用于产生图像的物镜（10），光学复制器（20），滤光器阵列（30）和传感器阵列（40），其布置成同时检测滤波的图像拷贝传感器阵列的不同部分。场停止（50）定义投影在传感器阵列上的图像副本的轮廓。滤波器集成在传感器阵列上，该传感器阵列具有平面结构，而没有垂直的物理屏障，用于防止每个相邻光通道之间的串扰。现场停止功能使相邻的图像副本可以组合在一起，无间隙地用于这种屏障。集成滤波器意味着没有引起相邻图像副本之间串扰的寄生腔。这意味着不再需要相邻投影图像副本之间的屏障，因此可以更好地利用传感器区域。

6. 发明申请

WO2016124677A1 LARGE AREA LENS-FREE IMAGING DEVICE 审中-公开
标题翻译：大面积无镜头成像设备
公开(公告)号：WO2016124677A1
公开(公告)日：2016-08-11
申请号：PCT/EP2016/052355
申请日：2016-02-04
申请人： IMEC VZW
发明人： STAHL, Richard , CLAES, Tom , ROTTENBERG, Xavier , VANMEERBEECK, Geert , LAMBRECHTS, Andy
IPC分类号： G02B21/00 , G02B27/00 , G03H1/04
CPC分类号： G03H1/0465 , G01N15/1434 , G01N15/147 , G01N15/1484 , G01N2015/1454 , G02B6/122 , G02B21/0008 , G02B27/0087 , G02B2006/12061 , G03H1/0443 , G03H2001/0447 , G03H2222/34 , G03H2222/35 , G03H2222/53 , H04N5/2256 , H04N5/374
摘要： A lens-free device (100) for imaging one or more objects (106), the lens-free device comprising: a light source (102) positioned for illuminating at least one object (106); a detector (103) positioned for recording interference patterns of the illuminated at least one object (106); wherein the light source (102) comprises a plurality of light emitters (104) that are positioned and configured to create a controlled light wavefront (105) for performing lens-free imaging.
摘要翻译：一种用于对一个或多个物体（106）进行成像的无镜头装置（100），所述无镜头装置包括：定位用于照射至少一个物体（106）的光源（102）; 定位成用于记录被照亮的至少一个物体（106）的干涉图案的检测器（103）; 其中所述光源（102）包括多个发光器（104），所述多个发光器被定位和配置成产生用于进行无镜头成像的受控光波前（105）。

7. 发明申请

WO2013064512A1 SPECTRAL CAMERA WITH MIRRORS FOR PROJECTING MULTIPLE ADJACENT IMAGE COPIES ONTO SENSOR ARRAY 审中-公开
标题翻译：用于将多个相邻图像复制投影到传感器阵列的光学相机
公开(公告)号：WO2013064512A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071511
申请日：2012-10-30
申请人： IMEC
发明人： GEELEN, Bert , LAMBRECHTS, Andy , TACK, Klaas
IPC分类号： G01J3/28 , G01J3/02
CPC分类号： H04N5/332 , G01J3/0208 , G01J3/0256 , G01J3/0259 , G01J3/2823 , G01J2003/2826 , H04N5/265 , H04N17/002
摘要： A spectral camera for producing a spectral output has an objective lens (10) for producing an image, an array of mirrors (20), an array of filters (30) for passing a different passband of the optical spectrum for different ones of the optical channels arranged so as to project multiple of the optical channels onto different parts of the same focal plane, and a sensor array (40) at the focal plane o detect the filtered image copies simultaneously. By using mirrors, there may be less optical degradation and the trade off of cost with optical quality can be better. By projecting the optical channels onto different parts of the same focal plane a single sensor or coplanar multiple sensors can to be used to detect the different optical channels simultaneously which promotes simpler alignment and manufacturing.
摘要翻译：用于产生光谱输出的光谱相机具有用于产生图像的物镜（10），反射镜阵列（20），用于通过光谱不同通带的滤光器阵列（30），用于不同的光学通道布置成将多个光通道投影到同一焦平面的不同部分上，并且在焦平面处的传感器阵列（40）同时检测滤波的图像副本。通过使用镜子，可能会有较少的光学劣化，并且与光学质量的成本的折衷可以更好。通过将光通道投影到相同焦平面的不同部分上，可以使用单个传感器或共面多个传感器来同时检测不同的光学通道，从而促进更简单的对准和制造。

8. 发明申请

WO2013064507A1 SPECTRAL CAMERA WITH OVERLAPPING SEGMENTS OF IMAGE COPIES INTERLEAVED ONTO SENSOR ARRAY 审中-公开
标题翻译：与传感器阵列交错的图像复制的重叠部分的光谱相机
公开(公告)号：WO2013064507A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071506
申请日：2012-10-30
申请人： IMEC
发明人： GEELEN, Bert , LAMBRECHTS, Andy , TACK, Klaas
IPC分类号： G01J3/28 , G01J3/51 , G01J3/02 , H01L27/146
CPC分类号： G01J3/2803 , G01J3/0208 , G01J3/0229 , G01J3/0235 , G01J3/0264 , G01J3/2823 , G01J3/513 , Y10T29/49826
摘要： A spectral camera has an objective lens (10), an array of lenses (25) for producing optical copies of segments of the image, an array of filters (30) for the different optical channels and having an interleaved spatial pattern and a sensor array to detect the copies of the image segments. Detected segment copies of spatially adjacent optical channels have different passbands and represent overlapping segments of the image, and detected segment copies of the same passband on spatially non-adjacent optical channels represent adjacent segments of the image which fit together. Having segments of the image copied can help enable better optical quality for a given cost. Having an interleaved pattern of the filter bands with overlapping segments enables each point of the image to be sensed at different bands to obtain the spectral output for many bands simultaneously to provide better temporal resolution.
摘要翻译：光谱相机具有物镜（10），用于产生图像的段的光学副本的透镜阵列（25），用于不同光学通道的滤光器阵列（30），并且具有交错的空间图案和传感器阵列以检测图像片段的副本。空间相邻光通道的检测段副本具有不同的通带并且表示图像的重叠段，并且在空间上不相邻的光通道上检测到相同通带的段副本表示装配在一起的图像的相邻段。复制图像的片段有助于为给定成本提供更好的光学质量。具有重叠片段的滤波器带的交错图案使得能够在不同频带处感测图像的每个点，以同时获得许多频带的频谱输出以提供更好的时间分辨率。

9. 发明公开

EP3184975A1 A SPECTROMETER MODULE 有权转让
标题翻译：一个SPECTROMETER模块
公开(公告)号：EP3184975A1
公开(公告)日：2017-06-28
申请号：EP15202374.3
申请日：2015-12-23
申请人： IMEC VZW
发明人： BORREMANS, Jonathan , LAMBRECHTS, Andy , BARON, Jerome
IPC分类号： G01J3/02 , G01J3/28 , G01J3/12
CPC分类号： G01J3/0264 , G01J3/0262 , G01J3/0291 , G01J3/12 , G01J3/28 , G01J3/2803 , G01J2003/1213 , G01J2003/2806 , G01J2003/2826 , G01J2003/2866
摘要： The present invention relates to a spectrometer module (10), comprising: a plurality of separate electronic circuit modules (20), each comprising an integrated sensor circuit including a light sensitive area (22) occupying part of an area of the integrated sensor circuit, the integrated sensor circuit being arranged to detect incident light, wherein the plurality of separate electronic circuit modules (20) include a group of adjacent electronic circuit modules (20) and the light sensitive areas (22) of the electronic circuit modules (20) are so arranged on the respective integrated sensor circuits that the group is mounted so that the light sensitive areas (22) thereof are arranged in vicinity to each other, and an optical module (10), which is common to said plurality of separate electronic circuit modules (20) and arranged to direct incident light towards the light sensitive areas (22) of each of said electronic circuit modules (20).
摘要翻译：本发明涉及一种光谱仪模块（10），包括：多个独立的电子电路模块（20），每个电子电路模块包括集成传感器电路，集成传感器电路包括占据集成传感器电路的一部分区域的光敏区域（22）所述集成传感器电路被布置为检测入射光，其中所述多个单独电子电路模块（20）包括一组相邻电子电路模块（20）和所述电子电路模块（20）的所述光敏区域（22）是如此布置在相应的集成传感器电路上，使得该组被安装成使得其光敏区域（22）彼此邻近地布置，以及光学模块（10），其对于所述多个分离的电子电路模块（20）并且布置成将入射光导向每个所述电子电路模块（20）的光敏区域（22）。

10. 发明公开

EP3126818A1 METHOD AND DEVICE FOR DRUG SCREENING 有权
标题翻译： VERFAHREN UND VORRICHTUNGENFÜRARZNEIMITTELSCREENING
公开(公告)号：EP3126818A1
公开(公告)日：2017-02-08
申请号：EP15713796.9
申请日：2015-04-03
申请人： IMEC vzw
发明人： REUMERS, Veerle , BRAEKEN, Dries , VANMEERBEECK, Geert , STAHL, Richard , LAMBRECHTS, Andy
IPC分类号： G01N21/45 , G01N21/47 , G01N33/50 , G01N21/17 , G03H1/26 , G03H1/00 , G03H1/04
CPC分类号： G01N15/1031 , G01N15/1434 , G01N15/1468 , G01N21/1717 , G01N21/45 , G01N21/453 , G01N21/4788 , G01N33/5044 , G01N2015/0065 , G01N2015/1006 , G01N2015/1454 , G01N2021/1721 , G01N2021/1738 , G01N2021/1765 , G01N2201/06113 , G01N2201/062 , G01N2500/10 , G03H1/0005 , G03H1/0402 , G03H1/0443 , G03H1/0465 , G03H2001/0033 , G03H2001/005 , G03H2001/0447 , G03H2001/0469 , G03H2001/0471 , G03H2222/22 , G03H2226/11
摘要： The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.
摘要翻译：本公开涉及被配置为在细胞上进行药物筛选的装置和方法。至少一个实施方案涉及用于在细胞上进行药物筛选的无镜头装置。无透镜装置包括具有表面的基板。无镜头的装置还包括一个光源，该光源定位成用光照照在基板表面上。无镜头装置还包括传感器，其被定位成检测通过照亮细胞而引起的光信号。衬底表面包括用于感测细胞的电生理信号的微电极阵列。

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