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1. 发明专利

IL289295D0 Nanoparticle with single site for template polynucleotide attachment 未知
公开(公告)号：IL289295D0
公开(公告)日：2022-02-01
申请号：IL28929521
申请日：2021-12-22
申请人： ILLUMINA CAMBRIDGE LTD , ILLUMINA SINGAPORE PTE LTD , ILLUMINA INC , YANG XIANGYUAN , GEORGE WAYNE N , LAFRANCONI PIETRO GATTI , TEO YIN NAH , BROWN ANDREW A , ROGERT BACIGALUPO MARIA CANDELARIA , BRUSTAD ERIC , BOHRA HASSAN , WANG CLIFFORD
发明人： YANG XIANGYUAN , GEORGE WAYNE N , LAFRANCONI PIETRO GATTI , TEO YIN NAH , BROWN ANDREW A , ROGERT BACIGALUPO MARIA CANDELARIA , BRUSTAD ERIC , BOHRA HASSAN , WANG CLIFFORD
IPC分类号： B01J19/00 , B82Y30/00
摘要： Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

2. 发明专利

IL289230D0 Nanoparticle with single site for template polynucleotide attachment 未知
公开(公告)号：IL289230D0
公开(公告)日：2022-02-01
申请号：IL28923021
申请日：2021-12-21
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , ILLUMINA SINGAPORE PTE LTD , GEORGE WAYNE N , BOUTELL JONATHAN MARK , LESSARD VIGER MATHIEU , NIRANTAR SAURABH , LAFRANCONI PIETRO GATTI , MCDONALD SETH , TEO YIN NAH , ROGERT BACIGALUPO MARIA CANDELARIA , PEISAJOVICH SERGIO , BRUSTAD ERIC , HOWARD MICHAEL , YANG XIANGYUAN , BOWEN M SHANE , NEMIROSKI ALEX , BRODIN JEFFREY , VINCENT LUDOVIC , BERTI LORENZO , BROWN ANDREW A , SHEN FEI , STORMS LENA , BENICE OLIVIA
发明人： GEORGE WAYNE N , BOUTELL JONATHAN MARK , LESSARD-VIGER MATHIEU , NIRANTAR SAURABH , LAFRANCONI PIETRO GATTI , MCDONALD SETH , TEO YIN NAH , ROGERT BACIGALUPO MARIA CANDELARIA , PEISAJOVICH SERGIO , BRUSTAD ERIC , HOWARD MICHAEL , YANG XIANGYUAN , BOWEN M SHANE , NEMIROSKI ALEX , BRODIN JEFFREY , VINCENT LUDOVIC , BERTI LORENZO , BROWN ANDREW A , SHEN FEI , STORMS LENA , BENICE OLIVIA
IPC分类号： B01J19/00 , B82Y30/00
摘要： Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

3. 发明专利

AU2020412619A1 Nanoparticle with single site for template polynucleotide attachment 未知
公开(公告)号：AU2020412619A1
公开(公告)日：2022-01-06
申请号：AU2020412619
申请日：2020-12-22
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , ILLUMINA SINGAPORE PTE LTD
发明人： YANG XIANGYUAN , GEORGE WAYNE N , GATTI LAFRANCONI PIETRO , TEO YIN NAH , BROWN ANDREW A , BACIGALUPO MARIA ROGERT , BRUSTAD ERIC , BOHRA HASSAN , WANG CLIFFORD
IPC分类号： C12Q1/6806 , C12Q1/6869
摘要： Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from an asymmetrical acrylamide polymer one or a dendrimer including lysyl constitutional repeating units, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

4. 发明专利

AU2020414692A1 Nanoparticle with single site for template polynucleotide attachment 未知
公开(公告)号：AU2020414692A1
公开(公告)日：2022-01-06
申请号：AU2020414692
申请日：2020-12-22
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , ILLUMINA SINGAPORE PTE LTD
发明人： GEORGE WAYNE N , BOUTELL JONATHAN MARK , LESSARD-VIGER MATHIEU , NIRANTAR SAURABH , GATTI LAFRANCONI PIETRO , MCDONALD SETH , TEO YIN NAH , BACIGALUPO MARIA ROGERT , PEISAJOVICH SERGIO , BRUSTAD ERIC , HOWARD MICHAEL , YANG XIANGYUAN , BOWEN SHANE M , NEMIROSKI ALEX , BRODIN JEFFREY , VINCENT LUDOVIC , BERTI LORENZO , BROWN ANDREW A , SHEN FEI , STORMS LENA , BENICE OLIVIA
IPC分类号： C12Q1/6869
摘要： Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle, in particular in sequencing by synthesis.

5. 发明专利

CA3144531A1 NANOPARTICLE WITH SINGLE SITE FOR TEMPLATE POLYNUCLEOTIDE ATTACHMENT 未知
公开(公告)号：CA3144531A1
公开(公告)日：2021-07-01
申请号：CA3144531
申请日：2020-12-22
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , ILLUMINA SINGAPORE PTE LTD
发明人： YANG XIANGYUAN , GEORGE WAYNE N , GATTI LAFRANCONI PIETRO , TEO YIN NAH , BROWN ANDREW A , BACIGALUPO MARIA ROGERT , BRUSTAD ERIC , BOHRA HASSAN , WANG CLIFFORD
IPC分类号： C12N15/10 , C12Q1/6806 , C12Q1/6869 , C40B50/14
摘要： Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from an asymmetrical acrylamide polymer one or a dendrimer including lysyl constitutional repeating units, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

6. 发明专利

CA3144528A1 NANOPARTICLE WITH SINGLE SITE FOR TEMPLATE POLYNUCLEOTIDE ATTACHMENT 未知
公开(公告)号：CA3144528A1
公开(公告)日：2021-07-01
申请号：CA3144528
申请日：2020-12-22
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , ILLUMINA SINGAPORE PTE LTD
发明人： GEORGE WAYNE N , BOUTELL JONATHAN MARK , LESSARD-VIGER MATHIEU , NIRANTAR SAURABH , GATTI LAFRANCONI PIETRO , MCDONALD SETH , TEO YIN NAH , BACIGALUPO MARIA ROGERT , PEISAJOVICH SERGIO , BRUSTAD ERIC , HOWARD MICHAEL , YANG XIANGYUAN , BOWEN M SHANE , NEMIROSKI ALEX , BRODIN JEFFREY , VINCENT LUDOVIC , BERTI LORENZO , BROWN ANDREW A , SHEN FEI , STORMS LENA , BENICE OLIVIA
IPC分类号： C12N15/10 , C12Q1/6806 , C12Q1/6869 , C40B50/14
摘要： Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle, in particular in sequencing by synthesis.

7. 发明专利

AU2021271637A1 Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase 未知
公开(公告)号：AU2021271637A1
公开(公告)日：2022-12-08
申请号：AU2021271637
申请日：2021-05-11
申请人： ILLUMINA INC , ILLUMINA SINGAPORE PTE LTD
发明人： NIRANTAR SAURABH RAJENDRA , PEISAJOVICH SERGIO , BRUSTAD ERIC
IPC分类号： C12N9/12
摘要： Disclosed herein include methods of generating a single stranded deoxyribonucleic acid (ssDNA) scaffold comprising nucleotides with modified bases using a recombinant terminal deoxynucleotidyl transferase (TdT). The recombinant TdT can comprise an amino acid sequence that is at least 80% identical to a Bos taurus TdT, or a fragment thereof, and for example comprise one or more amino acid substitution mutations at one or more positions functionally equivalent to Glu191, Lys193, Glu194, Asp242, Lys287, Phe296, Met299, Thr342, and His420 in the Bos taurus TdT.

8. 发明专利

AU2022240477A1 Detecting methylcytosine and its derivatives using S-adenosyl-L-methionine analogs (xSAMs) 未知
公开(公告)号：AU2022240477A1
公开(公告)日：2022-11-10
申请号：AU2022240477
申请日：2022-03-14
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： SHULTZABERGER SARAH , WU XIAOLIN , BRUSTAD ERIC , GORMLEY NIALL
IPC分类号： C12P19/34 , C12N9/10 , C12N9/78 , C12Q1/6806 , C12Q1/6869
摘要： Examples provided herein are related to detecting methylcytosine and its derivatives using S- adenosyl-L-methionine analogs (xSAMs). Compositions and methods for performing such detection are disclosed. A target polynucleotide may include cytosine (C) and methylcytosine (mC). The method may include (a) protecting the C in the target polynucleotide from deamination; and (b) after step (a), deaminating the mC in the target polynucleotide to form thymine (T). Protecting the C from deamination may include adding a protective group to the 5 position of the C, e.g., using a methyltransferase enzyme that adds the first protective group from an xSAM.

9. 发明专利

CA3180183A1 DETECTING METHYLCYTOSINE AND ITS DERIVATIVES USING S-ADENOSYL-L-METHIONINE ANALOGS (XSAMS) 未知
公开(公告)号：CA3180183A1
公开(公告)日：2022-09-22
申请号：CA3180183
申请日：2022-03-14
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： SHULTZABERGER SARAH , WU XIAOLIN , BRUSTAD ERIC , GORMLEY NIALL
IPC分类号： C12P19/34 , C12N9/10 , C12N9/78 , C12Q1/6806 , C12Q1/6869
摘要： Examples provided herein are related to detecting methylcytosine and its derivatives using S- adenosyl-L-methionine analogs (xSAMs). Compositions and methods for performing such detection are disclosed. A target polynucleotide may include cytosine (C) and methylcytosine (mC). The method may include (a) protecting the C in the target polynucleotide from deamination; and (b) after step (a), deaminating the mC in the target polynucleotide to form thymine (T). Protecting the C from deamination may include adding a protective group to the 5 position of the C, e.g., using a methyltransferase enzyme that adds the first protective group from an xSAM.

10. 发明申请

WO2009059056A3 A GENETICALLY ENCODED BORONATE AMINO ACID 审中-公开
标题翻译：一种基因编码的二硼酸氨基酸
公开(公告)号：WO2009059056A3
公开(公告)日：2009-08-20
申请号：PCT/US2008081868
申请日：2008-10-30
申请人： SCRIPPS RESEARCH INST , BRUSTAD ERIC , BUSHEY MARK L , SCHULTZ PETER G
发明人： BRUSTAD ERIC , BUSHEY MARK L , SCHULTZ PETER G
IPC分类号： C12N9/00
CPC分类号： C12P13/222 , C07K17/06 , C12N9/93 , C12N15/67 , C12P21/02
摘要： Provided are compositions comprising an aminoacyl tRNA synthetase that selectively recognizes a boronic amino acid. Methods of incorporating a boronic amino acid into a target polypeptides and target polypeptides produced by the methods are also provided. Methods of producing a protein, which methods comprise site-specifically encoding a boronic amino acid residue into a mutant protein and selectively converting the boronic amino acid residue into a natural amino acid residue are provided. Also provided are compositions comprising a solid phase matrix covalently bound to a polypeptide through a boronic amino acid residue. In addition, compositions comprising a purified population of polypeptide molecules that each comprise a borono amino acid at a selected site are provided.
摘要翻译：提供了包含选择性识别硼酸氨基酸的氨酰基tRNA合成酶的组合物。还提供了将硼酸氨基酸掺入靶多肽和通过该方法产生的靶多肽的方法。提供了产生蛋白质的方法，该方法包括将硼酸氨基酸残基特异性编码到突变蛋白中并选择性地将硼酸氨基酸残基转化成天然氨基酸残基。还提供了包含通过硼酸氨基酸残基与多肽共价结合的固相基质的组合物。此外，提供了包含纯化的多肽分子群的组合物，其各自包含选定位点的硼氢氨基酸。

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