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1. 发明专利

JP2008247916A Polycyclic pyrimidine as potassium ion channel controller 审中-公开
标题翻译：多环磷酰胺作为钾离子通道控制器
公开(公告)号：JP2008247916A
公开(公告)日：2008-10-16
申请号：JP2008113282
申请日：2008-04-24
申请人： Astellas Pharma Inc , Icagen Inc , アステラス製薬株式会社 , イカジェンインコーポレイテッド
发明人： WANG XIADONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO
IPC分类号： C07D401/14 , A61K31/506 , A61K31/517 , A61K31/555 , A61P1/02 , A61P1/04 , A61P1/10 , A61P3/10 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/10 , A61P13/12 , A61P15/06 , A61P15/08 , A61P17/14 , A61P21/04 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P35/00 , A61P37/06 , A61P43/00 , C07D405/14 , C07D409/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： PROBLEM TO BE SOLVED: To provide polycyclic pyrimidines useful as a potassium ion channel controller. SOLUTION: The ion channel is a cellular protein that controls inflow into and outflow from a cell of ions containing calcium, potassium, sodium and chlorine. All of these channels exist in a human cell and exert influences on physiological processes such as nerve conduction, muscle contraction, cell secretion, control of heartbeat and artery extension. The potassium channel exists most widely and is diverse to be found in nerves, muscles, glands, immune systems and the like. A complex of a compound containing pyrimidine is provided as the channel controller. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可用作钾离子通道控制剂的多环嘧啶。解决方案：离子通道是控制从钙，钾，钠和氯离子的细胞流入和流出的细胞蛋白质。所有这些通道存在于人类细胞中，并对生理过程（如神经传导，肌肉收缩，细胞分泌，心跳和动脉延伸的控制）产生影响。钾通道存在最广泛，并且在神经，肌肉，腺体，免疫系统等中存在多种多样性。提供含有嘧啶化合物的络合物作为通道控制剂。版权所有（C）2009，JPO＆INPIT

2. 发明申请

WO2005100349A3 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多环吡啶作为钾离子通道调节剂
公开(公告)号：WO2005100349A3
公开(公告)日：2006-03-16
申请号：PCT/US2005012837
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC , WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
发明人： WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
IPC分类号： A61K31/4427 , A61P9/10 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C07D419/14 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶属。本发明的调节剂在治疗和诊断方法中都有用。

3. 发明专利

AU2005252160A1 Polycyclic pyrazines as potassium ion channel modulators 未知
公开(公告)号：AU2005252160A1
公开(公告)日：2005-12-22
申请号：AU2005252160
申请日：2005-04-13
申请人： ASTELLAS PHARMA INC , ICAGEN INC
发明人： FULP ALAN BRADLEY , SECONI DARRICK , ISHII TAKAHIRO , WANG XIAODONG , SUZUKI TAKESHI , SPEAR KERRY LEIGH , MORITOMO AYAKO
IPC分类号： C07D401/12 , A61K31/497 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14

4. 发明专利

AU2005233642A1 Polycyclic pyridines as potassium ion channel modulators 未知
公开(公告)号：AU2005233642A1
公开(公告)日：2005-10-27
申请号：AU2005233642
申请日：2005-04-13
申请人： ASTELLAS PHARMA INC , ICAGEN INC
发明人： SECONI DARRICK , FULP ALAN BRADLEY , SPEAR KERRY LEIGH , KUBOTA HIDEKI , ISHII TAKAHIRO , KAZAMI JUN-ICHI , MORITOMO AYAKO , SUZUKI TAKESHI , WANG XIAODONG
IPC分类号： A61K31/4427 , A61P9/10 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

5. 发明专利

AU2005232745A1 Polycyclic pyrimidines as potassium ion channel modulators 未知
公开(公告)号：AU2005232745A1
公开(公告)日：2005-10-27
申请号：AU2005232745
申请日：2005-04-13
申请人： ASTELLAS PHARMA INC , ICAGEN INC
发明人： SUZUKI TAKESHI , WANG XIADONG , MORITOMO AYAKO , KUBOTA HIDEKI , ISHII TAKAHIRO , SECONI DARRICK , KAZAMI JUN-ICHI , FULP ALAN BRADLEY , SPEAR KERRY LEIGH
IPC分类号： A61K31/506 , A61K31/555 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

6. 发明专利

BRPI0509844A 未知
公开(公告)号：BRPI0509844A
公开(公告)日：2007-10-09
申请号：BRPI0509844
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC
发明人： WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
IPC分类号： C07D419/14 , A61K31/4439 , A61P25/00

7. 发明专利

CA2561831A1 POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS 未知
公开(公告)号：CA2561831A1
公开(公告)日：2005-12-22
申请号：CA2561831
申请日：2005-04-13
申请人： ASTELLAS PHARMA INC , ICAGEN INC
发明人： SUZUKI TAKESHI , ISHII TAKAHIRO , SECONI DARRICK , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , WANG XIAODONG , MORITOMO AYAKO
IPC分类号： C07D401/12 , A61K31/497 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a genus of polycyclic pyrazines of formula I (I) that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods; wherein A and B are independently substituted or unsubstituted 5- or 6-membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 is formula II (II); W2 is -CH=, -NH-, -N=, -S-, or -O-; Z1 is formula III (III) or formula IV (IV); Z2 is -CH=, -NH-, -N=, -S-, or -O-; Y is a bond, -CH=N-NH-, -NH-CH2-, or -NR5-; s and t are independently integers fr om 1 to 4; R1, R2A, R2B and R3 are independently or unsubstituted alkyle, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl , substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstitute d aryl, or substituted or unsubstituted heteroaryl; and R5 is H, substituted o r unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted o r unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein if s is greater than one, then each R1 is optionally different; wherein if t is greater than on, then each R3 is optionally different; wherein two R1 groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted ring; and wherein two R3 groups are optionally joined together with the atoms to which they are attached to form a susbtituted or unsubstituted ring.

8. 发明专利

CA2560346A1 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 未知
公开(公告)号：CA2560346A1
公开(公告)日：2005-10-27
申请号：CA2560346
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC
发明人： SPEAR KERRY LEIGH , WANG XIAODONG , SUZUKI TAKESHI , SECONI DARRICK , FULP ALAN BRADLEY , KAZAMI JUN-ICHI , MORITOMO AYAKO , KUBOTA HIDEKI , ISHII TAKAHIRO
IPC分类号： C07D419/14 , A61K31/4427 , A61K31/4439 , A61P9/10 , A61P25/00 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04
摘要： The present invention provides a genus of polycyclic pyridines that are usef ul as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

9. 发明专利

DE602005024382D1 POLYCYCLISCHE PYRIMIDINE ALS KALIUMIONENKANAL-MODULATOREN 未知
公开(公告)号：DE602005024382D1
公开(公告)日：2010-12-09
申请号：DE602005024382
申请日：2005-04-13
申请人： ASTELLAS PHARMA INC , ICAGEN INC
发明人： WANG XIADONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO
IPC分类号： A61K31/506 , A61K31/555 , A61P25/00 , C07D401/14 , C07D405/14 , C07D409/14

10. 发明专利

AT458730T 未知
公开(公告)号：AT458730T
公开(公告)日：2010-03-15
申请号：AT05779464
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC
发明人： WANG XIAODONG , SPEAR KERRY , FULP ALAN , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO
IPC分类号： C07D401/12 , A61K31/497 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14

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