会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS
    • 聚氯乙烯作为钾离子通道调节剂
    • WO2005121126A1
    • 2005-12-22
    • PCT/US2005/012525
    • 2005-04-13
    • ICAGEN, INC.ASTELLAS PHARMA INC.WANG, XiaodongSPEAR, Kerry, LeighFULP, Alan, BradleySECONI, DarrickSUZUKI, TakeshiISHII, TakahiroMORITOMO, Ayako
    • WANG, XiaodongSPEAR, Kerry, LeighFULP, Alan, BradleySECONI, DarrickSUZUKI, TakeshiISHII, TakahiroMORITOMO, Ayako
    • C07D401/12
    • C07D401/14C07D213/73C07D401/04C07D405/04C07D405/14C07D409/04C07D409/14C07D413/14C07D417/14
    • The present invention provides a genus of polycyclic pyrazines of formula I (I) that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods; wherein A and B are independently substituted or unsubstituted 5- or 6-membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W 1 is formula II (II); W 2 is -CH=, -NH-, -N=, -S-, or -O-; Z 1 is formula III (III) or formula IV (IV); Z 2 is -CH=, -NH-, -N=, -S-, or -O-; Y is a bond, -CH=N-NH-, -NH-CH 2 -, or -NR 5 -; s and t are independently integers from 1 to 4; R 1 , R 2A , R 2B and R 3 are independently or unsubstituted alkyle, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 5 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein if s is greater than one, then each R 1 is optionally different; wherein if t is greater than on, then each R 3 is optionally different; wherein two R 1 groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted ring; and wherein two R 3 groups are optionally joined together with the atoms to which they are attached to form a susbtituted or unsubstituted ring.
    • 本发明提供了可用作钾离子通道调节剂的式I(I)的多环吡嗪属。 本发明的调节剂可用于治疗和诊断方法; 其中A和B独立地为取代或未取代的5-或6-元杂环烷基,或取代或未取代的5-或6-元杂芳基,W 1为式II(II); W 2是-CH =,-NH-,-N =,-S-或-O-; Z 1是式III(III)或式IV(IV); Z 2是-CH =,-NH-,-N =,-S-或-O-; Y是键,-CH = N-NH-,-NH-CH 2 - 或-NR 5 - ; s和t独立地为1至4的整数; R 1,R 2A,R 2B和R 3独立地是未取代的烷基,取代或未取代的烷基,取代或未取代的杂烷基,取代或未取代的3-至7-元环烷基,取代或未取代的 5-至7-元杂环烷基,取代或未取代的芳基或取代或未取代的杂芳基; 并且R 5是H,取代或未取代的烷基,取代或未取代的杂烷基,取代或未取代的3-至7-元环烷基,取代或未取代的5-至7-元杂环烷基,取代或未取代的芳基或取代或未取代的杂芳基 ; 其中如果s大于1,则每个R 1任选地不同; 其中如果t大于on,则每个R 3任选地不同; 其中两个R 1基团任选地与它们所连接的原子连接在一起形成取代或未取代的环; 并且其中两个R 3基团任选地与它们所连接的原子连接在一起以形成未取代或未取代的环。