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1. 发明授权

US5928258A Method and apparatus for loading a stent or stent-graft into a delivery sheath 失效
标题翻译：将支架或支架移植物装载到输送鞘中的方法和装置
公开(公告)号：US5928258A
公开(公告)日：1999-07-27
申请号：US947450
申请日：1997-09-26
申请人： I. John Khan , Leonard Pinchuk , John B. Martin, Jr.
发明人： I. John Khan , Leonard Pinchuk , John B. Martin, Jr.
IPC分类号： A61F2/06 , A61F2/84 , A61B17/00
CPC分类号： A61F2/95 , A61F2002/9517 , A61F2002/9522
摘要： An apparatus for loading a self-expanding prosthesis into a delivery sheath includes a substantially cylindrical cartridge for receiving the prosthesis and a cartridge un-loading device for removing the prosthesis from the cartridge and loading it into a delivery sheath. The cartridge is provided with an exterior radial key at one end. The unloading device includes a substantially cylindrical member having an interior stationary coaxial piston extending substantially its entire length and an exterior sliding ring. The cylindrical member is provided with a radial slot which restricts movement of the sliding ring, and a stepped internal stop at one end. The stepped internal stop has a radial keyway which is dimensioned to receive the key on the cartridge. The sliding ring is provided with a radial pin which resides in the radial slot in the cylindrical member and which couples the sliding ring to an interior key engaging member with a locking keyway dimensioned to engage the key on the cartridge. The method of the invention includes loading the prosthesis into the cartridge, attaching the cartridge to the unloading device, placing the delivery sheath over the cartridge, and pulling the cartridge into the unloading device leaving the prosthesis inside the delivery sheath.
摘要翻译：用于将自扩张假体装载到输送护套中的装置包括用于接收假体的基本上圆柱形的药筒和用于从药筒移除假体并将其装载到输送护套中的药筒卸载装置。盒的一端设有外径向键。卸载装置包括基本上圆柱形的构件，其具有基本上延伸其整个长度延伸的内部固定同轴活塞和外部滑动环。圆柱形构件设置有限制滑环的移动的径向狭槽和一端的阶梯式内部止动件。台阶式内部止动件具有径向键槽，其尺寸适于接收盒上的钥匙。滑动环设置有位于圆柱形构件中的径向槽中的径向销，并且将滑动环连接到具有锁定键槽的内部键接合构件，锁定键槽的尺寸适于接合盒上的键。本发明的方法包括将假体装载到药筒中，将药筒附接到卸载装置，将输送护套放置在药筒上，以及将药筒牵引到卸载装置中，使假体离开输送护套。

2. 发明授权

US07431709B2 Glaucoma implant device 有权
标题翻译：青光眼植入装置
公开(公告)号：US07431709B2
公开(公告)日：2008-10-07
申请号：US11004539
申请日：2004-12-03
申请人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes , Saul Gottlieb , John B. Martin, Jr. , Yasushi Pedro Kato
发明人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes , Saul Gottlieb , John B. Martin, Jr. , Yasushi Pedro Kato
IPC分类号： A61M5/00 , A61K9/22 , A61M31/00
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： A surgical implant device for treating glaucoma includes an elongate duct structure formed from a material comprising polyisobutylene and a glassy segment. The material of the elongate duct structure preferably has a general block structure with a central elastomeric polyolefinic block and thermoplastic end blocks (e.g., a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The elongate duct structure provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. Preferably, the elongate duct structure defines a lumen channel having an inside diameter between 0.05 mm and 0.3 mm. The material of the elongate duct structure is biocompatible and biostable. Moreover, the material will not encapsulate in the eye and thus provides an unobstructed flowpath that diverts aqueous humor from the anterior chamber. Different embodiments of the implant device divert the aqueous humor to different parts of the eye (e.g., a space between the conjuctiva and sclera, Schlemm's canal, or a fluid reservoir formed on a posterior surface of the eye).
摘要翻译：用于治疗青光眼的手术植入装置包括由包含聚异丁烯和玻璃状段的材料形成的细长管道结构。细长管道结构的材料优选具有中央弹性聚烯烃嵌段和热塑性端嵌段（例如，包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）的通用嵌段结构。细长的管道结构提供用于将房水从眼睛的前房转向的流体通道。优选地，细长管道结构限定了具有在0.05mm和0.3mm之间的内径的管腔通道。细长管道结构的材料是生物相容性和生物稳定性。此外，该材料将不会包封在眼睛中，从而提供将房水从前房转移的畅通的流路。植入装置的不同实施例将房水转移到眼睛的不同部分（例如，结膜和巩膜之间的空间，施莱姆氏管或形成在眼后表面上的流体储存器）。

3. 发明授权

US06254633B1 Delivery device for a medical device having a constricted region 失效
标题翻译：具有收缩区域的医疗装置的输送装置
公开(公告)号：US06254633B1
公开(公告)日：2001-07-03
申请号：US08989119
申请日：1997-12-11
申请人： Leonard Pinchuk , John B. Martin, Jr.
发明人： Leonard Pinchuk , John B. Martin, Jr.
IPC分类号： A61F200
CPC分类号： A61B17/12109 , A61B17/12022 , A61B17/12172 , A61B2017/00557 , A61B2017/1205
摘要： A delivery device for delivering an implantable, radially expandable medical device having a constricted region for occluding fluid flow to a desired location in a body lumen. The delivery device includes an outer sleeve, an inner tube terminating at its distal end in a plunger, and a tapered guide member. In one embodiment, the tapered guide member is attached to and extends away from the constricted region of the occlusion device, and is thus implanted in the body lumen along with the occlusion device upon deployment of the occlusion device at the desired treatment location. In a second embodiment, the tapered guide member is integrated into the constricted region of the occlusion device. In a third embodiment, an inflatable balloon is positioned distally of the medical device, and when inflated provides a tapered guide surface that eases the navigation of the delivery device through the body lumen. Upon deployment of the medical device at the desired location, the balloon is deflated to such a size as to be able to be withdrawn through the constricted region of the occlusion device, and is thus removed from the body lumen.
摘要翻译：一种递送装置，用于递送具有收缩区域的可植入的可径向扩张的医疗装置，用于将流体流阻塞到体腔内的期望位置。输送装置包括一个外套管，一个在其远端终止于柱塞的内管，以及一锥形导向件。在一个实施例中，锥形引导构件附接到闭塞装置的收缩区域并且远离咬合装置的收缩区域，并且因此在将闭塞装置展开在期望的治疗位置时与闭塞装置一起植入体腔内。在第二实施例中，锥形引导构件集成到闭塞装置的收缩区域中。在第三实施例中，可充气气囊位于医疗装置的远侧，并且当充气时提供锥形的引导表面，其减轻了输送装置通过体腔的导航。在将医疗装置部署在期望的位置时，气囊被放气到能够通过闭塞装置的收缩区域取出的尺寸，并且因此被从身体腔排出。

4. 发明授权

US4872455A Anastomosis trimming device and method of using the same 失效
标题翻译：吻合修剪装置及其使用方法
公开(公告)号：US4872455A
公开(公告)日：1989-10-10
申请号：US292643
申请日：1988-12-30
申请人： Leonard Pinchuk , John B. Martin, Jr.
发明人： Leonard Pinchuk , John B. Martin, Jr.
IPC分类号： A61B17/11 , A61B17/125 , A61B17/32
CPC分类号： A61B17/3201 , A61B17/11
摘要： The anastomosis trimming device is used for trimming one end section of a tubular structure, such as a blood vessel or vascular graft, which is to be anastomosed, to provide the anastomotic end with a smooth, reproducible shape. The end is trimmed in such a manner as to mate with a similarly trimmed end of a second tubular structure or with an incision in the side of a second tubular structure. The device comprises first and second arms pivotably connected to each other at one end, with the first arm mounting a cutting die including a cutting element on a free end thereof. The cutting element faces toward the second arm, and the free end of the second arm mounts a mating element facing toward the first arm which, upon pivoting of the free ends of the first and second arm, mates with the cutting element on the first arm.
摘要翻译：吻合修剪装置用于修整将被吻合的管状结构（例如血管或血管移植物）的一个端部，以为吻合端提供平滑，可重现的形状。该端部以与第二管状结构的类似修剪端部或与第二管状结构侧面的切口配合的方式修剪。该装置包括在一端可枢转地彼此连接的第一臂和第二臂，第一臂在其自由端上安装包括切割元件的切割模。所述切割元件朝向所述第二臂，并且所述第二臂的自由端安装面向所述第一臂的配合元件，所述配合元件在所述第一臂和所述第二臂的自由端枢转时与所述第一臂上的所述切割元件配合。

5. 发明授权

US4743252A Composite grafts 失效
标题翻译：复合移植物
公开(公告)号：US4743252A
公开(公告)日：1988-05-10
申请号：US818483
申请日：1986-01-13
申请人： John B. Martin, Jr. , David C. MacGregor , Leonard Pinchuk
发明人： John B. Martin, Jr. , David C. MacGregor , Leonard Pinchuk
IPC分类号： A61F2/06
CPC分类号： D01F6/76 , A61F2/06
摘要： Composite grafts are provided that have a porous wall structure to permit ingrowth thereinto under in vivo conditions but which include a generally non-porous membrane in the wall to prevent substantial fluid passage therethrough so as to provide an implantable porous graft that does not require preclotting prior to implantation. One or more of such membranes are formed in place by applying a polymeric membrane-forming composition during the formation of a graft body by winding elongated extruded fibers on a mandrel.
摘要翻译：提供具有多孔壁结构以在体内条件下向内生长的复合移植物，但在壁中包括通常无孔的膜，以防止实质上流体通过其中，从而提供不需要先前预先插入的可植入多孔移植物植入。通过在细长的挤出纤维上缠绕在形成移植体的过程中，通过施加聚合物成膜组合物来形成一个或多个这样的膜。

6. 发明授权

US5376117A Breast prostheses 失效
标题翻译：乳房假肢
公开(公告)号：US5376117A
公开(公告)日：1994-12-27
申请号：US975979
申请日：1992-11-13
申请人： Leonard Pinchuk , John B. Martin, Jr. , Anne A. Maurin
发明人： Leonard Pinchuk , John B. Martin, Jr. , Anne A. Maurin
IPC分类号： A61F2/00 , A61F2/12 , A61L27/34 , B29C41/08 , B29C41/20
CPC分类号： B29C41/20 , A61F2/0077 , A61F2/12 , A61L27/34 , B29C41/06 , B29C41/08 , B29K2083/00 , B29L2031/7532
摘要： Breast prostheses for subcutaneous implantation for breast augmentation. The prostheses include an outer shell having a smooth non-porous outer envelope and a non-woven porous outer layer affixed to the envelope. The outer layer is preferably manufactured by an electrostatic spinning process to deposit biocompatible polymeric fibers on the smooth outer envelope of the prosthesis to build up a porous surface which promotes tissue ingrowth therein. In a preferred embodiment, the biocompatible porous outer layer and the non-porous outer envelope are manufactured with a polyurethane polymer material. Most preferably, a polycarbonate urethane polymer is used to manufacture the outer layer. The outer envelope and the porous outer layer may be further treated with an acetoxy-terminated siloxane to render them more crack-resistant under in vivo use.
摘要翻译：乳房假体为皮下植入用于隆胸。假体包括具有光滑无孔外壳的外壳和固定到外壳的无纺多孔外层。外层优选通过静电纺丝工艺制造，以将生物相容的聚合物纤维沉积在假体的光滑的外包络上，以建立促进组织向内生长的多孔表面。在一个优选的实施方案中，生物相容性多孔外层和无孔外壳用聚氨酯聚合物材料制造。最优选使用聚碳酸酯聚氨酯聚合物制造外层。外包膜和多孔外层可以进一步用乙酰氧基封端的硅氧烷处理，使其在体内使用中更具抗裂性。

7. 发明授权

US5163951A Mesh composite graft 失效
标题翻译：网复合移植
公开(公告)号：US5163951A
公开(公告)日：1992-11-17
申请号：US859132
申请日：1992-03-27
申请人： Leonard Pinchuk , John B. Martin, Jr. , Bruce A. Weber
发明人： Leonard Pinchuk , John B. Martin, Jr. , Bruce A. Weber
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , Y10S623/921
摘要： A mesh composite graft including an inner component, an outer component formed from strands of durable material, such as polyethylene terephthalate, and an intermediate component made from strands of biocompatible synthetic material having a melting point less than that of the durable material from which the outer component is formed and less than that of the biocompatible synthetic material from which the inner component of the graft is formed. By heating the graft to a temperature greater than the melting point of the material from which the intermediate component is formed but less than the melting point of the outer component material and less than the melting point of the material from which the inner component is formed, the components are bound by the melted intermediate component to provide a totally porous, compliant composite graft reinforced by the outer component.
摘要翻译：一种网状复合材料移植物，其包括内部组分，由耐用材料线形成的外部组分，例如聚对苯二甲酸乙二醇酯，以及由生物相容性合成材料的链制成的中间组分，其熔点小于耐久材料的熔点形成组分并且小于形成移植物的内部组分的生物相容性合成材料的组分。通过将移植物加热到高于形成中间成分的材料的熔点但小于外部组分材料的熔点并低于形成内部组分的材料的熔点的温度，组分被熔融的中间组分结合，以提供由外部组分增强的完全多孔的柔顺复合接枝。

8. 发明授权

US5116360A Mesh composite graft 失效
标题翻译： MESH复合材料
公开(公告)号：US5116360A
公开(公告)日：1992-05-26
申请号：US634425
申请日：1990-12-27
申请人： Leonard Pinchuk , John B. Martin, Jr. , Bruce A. Weber
发明人： Leonard Pinchuk , John B. Martin, Jr. , Bruce A. Weber
IPC分类号： A61F2/06
CPC分类号： A61F2/06
摘要： A mesh composite graft including an inner component, an outer component formed from strands of durable material, such as polyethylene terephthalate, and an intermediate component made from strands of bicompatible synthetic material having a melting point less than that of the durable material from which the outer component is formed and less than that of the biocompatible synthetic material from which the inner component of the graft is formed. By heating the graft to a temperature grater than the melting point of the material from which the intermediate component is formed but less than the melting point of the outer component material and less than the melting point of the material from which the inner component is formed, the components are bound by the melted intermediate component to provide a totally porous, compliant composite graft reinforced by the outer component.

9. 发明授权

US4738740A Method of forming implantable vascular grafts 失效
标题翻译：形成可植入血管移植物的方法
公开(公告)号：US4738740A
公开(公告)日：1988-04-19
申请号：US800524
申请日：1985-11-21
申请人： Leonard Pinchuk , John B. Martin, Jr.
发明人： Leonard Pinchuk , John B. Martin, Jr.
IPC分类号： A61F2/06 , B29C37/00 , B29C53/58 , B29D23/00 , B65H81/00 , A61F1/02
CPC分类号： D01D5/0076 , A61F2/06 , B29C53/587 , B29D23/001 , D01F6/70 , B29C37/0017 , B29K2105/04 , B29K2995/0056 , B29K2995/0068 , B29L2031/7534
摘要： Vascular grafts are provided that have an external surface which has a porous structure that is conducive to tissue ingrowth thereinto after the vascular graft has been implanted. The vascular graft is prepared by winding an extruded fiber onto a mandrel in the presence of intermittently applied electrostatic forces. Such vascular graft may include an internal surface that was formed under the influence of the electrostatic charge, which internal surface has a porosity that is substantially less than that of said porous external surface.
摘要翻译：提供了具有外表面的血管移植物，其具有在植入血管移植物之后有助于组织向内生长的多孔结构。通过在间歇施加的静电力的存在下将挤出的纤维卷绕到心轴上来制备血管移植物。这种血管移植物可以包括在静电荷的影响下形成的内表面，该内表面具有基本上小于所述多孔外表面的孔隙率。

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