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1. 发明申请

US20100196370A1 FUSION PROTEIN OF IMMUNOGLOBULIN FC AND HUMAN APOLIPOPROTEIN(A) KRINGLE FRAGMENT 审中-公开
标题翻译：免疫球蛋白FC和人APOLIPOPROTEIN的融合蛋白（A）KRINGLE FRAGMENT
公开(公告)号：US20100196370A1
公开(公告)日：2010-08-05
申请号：US12519653
申请日：2007-11-16
申请人： Hyun-Kyung Yu , Yeup Yoon , Jin-Hyung Ahn , In-Hwan Lim , Ho-Jeong Lee , Jang-Seong Kim , Doo-Hong Park
发明人： Hyun-Kyung Yu , Yeup Yoon , Jin-Hyung Ahn , In-Hwan Lim , Ho-Jeong Lee , Jang-Seong Kim , Doo-Hong Park
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , A61P35/04
CPC分类号： C07K14/775 , C07K2319/31
摘要： The present invention relates to an LK8-Fc fusion protein, which has increased angiogenesis inhibitory activity and in vivo stability. More specifically, relates to an LK8-Fc fusion protein in which an LK8 protein having angiogenesis inhibitory activity is fused with the Fc region of human immunoglobulin IgG1, as well as a composition for treating cancer, which contains the fusion protein. The LK8-Fc fusion protein has not only angiogenesis inhibitory activity leading to anticancer and metastasis inhibitory activities, but also a very long in vivo half-life, and thus can be used as a more efficient and economic cancer therapeutic agent or cancer inhibitor.
摘要翻译：本发明涉及具有增加的血管发生抑制活性和体内稳定性的LK8-Fc融合蛋白。更具体地，涉及其中具有血管生成抑制活性的LK8蛋白与人免疫球蛋白IgG1的Fc区融合的LK8-Fc融合蛋白以及含有融合蛋白的用于治疗癌症的组合物。 LK8-Fc融合蛋白不仅具有导致抗癌和转移抑制活性的血管发生抑制活性，而且具有非常长的体内半衰期，因此可用作更有效和经济的癌症治疗剂或癌症抑制剂。

2. 发明授权

US07285277B2 Anticancer agent 失效
标题翻译：抗癌剂
公开(公告)号：US07285277B2
公开(公告)日：2007-10-23
申请号：US11162817
申请日：2005-09-23
申请人： Jang-Seong Kim , Jin-Hyung Ahn , Hyun-Kyung Yu , Ho-Jeong Lee , Doo-Hong Park , Yeup Yoon
发明人： Jang-Seong Kim , Jin-Hyung Ahn , Hyun-Kyung Yu , Ho-Jeong Lee , Doo-Hong Park , Yeup Yoon
IPC分类号： A61K39/00 , A61K38/03
CPC分类号： A61K38/1709
摘要： The present application discloses a method of reducing tumor growth that includes contacting the tumor with a tumor growth reducing effective amount of a composition comprising LK8 or LK68 protein or a functionally equivalent amino acid variant thereof and a pharmaceutically acceptable carrier thereof to a subject having tumor.
摘要翻译：本申请公开了一种减少肿瘤生长的方法，其包括使肿瘤与具有肿瘤生长的有效量的包含LK8或LK68蛋白或其功能等同的氨基酸变体和其药学上可接受的载体的组合物接触肿瘤。

3. 发明申请

US20070031379A1 Therapeutic agent for treatment of cancer comprising human apolipoprotein (a) kringles lk68 or lk8 genes as effective ingredient, and method for treating cancer using the same 审中-公开
标题翻译：用于治疗包含人载脂蛋白（a）三叉八酮或lk8基因作为有效成分的癌症的治疗剂，以及使用其的癌症治疗方法
公开(公告)号：US20070031379A1
公开(公告)日：2007-02-08
申请号：US10584383
申请日：2005-01-10
申请人： Kyu Lee , Hyunkyung Yu , Ho-Jeong Lee , Jin-Hyung Ahn , Jang-Seong Kim , Eui-Cheol Jo , Yeup Yoon , Doo-Hong Park , Seong-Tae Yun
发明人： Kyu Lee , Hyunkyung Yu , Ho-Jeong Lee , Jin-Hyung Ahn , Jang-Seong Kim , Eui-Cheol Jo , Yeup Yoon , Doo-Hong Park , Seong-Tae Yun
IPC分类号： A61K48/00
CPC分类号： A61K48/005 , A61K48/00 , C07K14/775 , C12N15/86 , C12N2740/13043 , C12N2750/14143
摘要： The present invention relates to an anticancer or an anti-metastatic agent for gene therapy, more precisely, an anticancer or an anti-metastatic agent for gene therapy containing a gene carrier or cells harboring human apolipoprotein (a) kringle KIV9-KIV10-KV (LK68) or KV (LK8) gene as an effective ingredient, and a treatment method for cancer using the same. The agent for gene therapy of the present invention has an inhibiting effect on the growth and the metastasis of a tumor, so it can be effectively used for the prevention and the treatment of various solid tumors as a metastasis inhibitor or a therapeutic agent for primary tumors.
摘要翻译：本发明涉及用于基因治疗的抗癌剂或抗转移剂，更准确地说，涉及含有携带人载脂蛋白的基因载体或细胞的基因治疗用抗癌剂或抗转移剂（a）kringle KIV9-KIV10-KV（ LK68）或KV（LK8）基因作为有效成分，以及使用其的癌症治疗方法。本发明的基因治疗剂对肿瘤的生长和转移具有抑制作用，因此可有效地用于预防和治疗各种实体瘤作为转移抑制剂或原发性肿瘤的治疗剂。

4. 发明授权

US08516252B2 Method and apparatus for authenticating a sensor node in a sensor network 有权
标题翻译：用于认证传感器网络中的传感器节点的方法和装置
公开(公告)号：US08516252B2
公开(公告)日：2013-08-20
申请号：US12823694
申请日：2010-06-25
申请人： Tae-Shik Shon , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
发明人： Tae-Shik Shon , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
IPC分类号： H04L29/06
CPC分类号： H04L9/0833 , H04L9/3213 , H04L2209/805
摘要： A method and apparatus for authenticating a sensor node in a sensor network. The method for authenticating a sensor node by a first sink node in a sensor network includes receiving an authentication request using an authentication ticket from the sensor node, identifying a second sink node which has issued the authentication ticket, decoding the authentication ticket using a group key, which is previously stored in correspondence to the second sink node to confirm the validity of the authentication ticket, when the second sink node is included in a neighboring node list, normally processing authentication for the sensor node, generating an authentication ticket using a group key of the first sink node, and transmitting the generated authentication ticket to the sensor node.
摘要翻译：一种用于认证传感器网络中的传感器节点的方法和装置。用于通过传感器网络中的第一汇点认证传感器节点的方法包括使用来自传感器节点的认证券接收认证请求，识别发出认证券的第二接收节点，使用组密钥解码认证券，当第二宿节点被包括在相邻节点列表中时，通常对传感器节点进行处理认证，使用组密钥生成认证券并且将所生成的认证券发送到所述传感器节点。

5. 发明授权

US08412939B2 System and method for mutual authentication between node and sink in sensor network 有权
标题翻译：传感器网络中节点和接收器之间的相互认证的系统和方法
公开(公告)号：US08412939B2
公开(公告)日：2013-04-02
申请号：US12821577
申请日：2010-06-23
申请人： Tae-Shik Shon , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
发明人： Tae-Shik Shon , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
IPC分类号： H04L29/06
CPC分类号： H04L9/3273 , H04L63/0869 , H04L2209/805
摘要： Disclosed a system and method for mutual authentication between a node and a sink in a sensor network. At least one sink periodically creates a neighboring sink list including information on at least one adjacent sink, and the sink requests node authentication to a base station when receiving an authentication request from the node and transmits its own neighboring sink list to the node when the node authentication has been completed. When the node moves and requests authentication to another sink, the another sink stores a neighboring sink list received from the node, determines if a node-authenticable sink exists in its own neighboring sink list according to the authentication request, and requests re-authentication of the node to the node-authenticable sink when the node-authenticable sink exists, so that re-authentication between the node and the sink is easily performed.
摘要翻译：公开了用于在传感器网络中的节点和汇点之间的相互认证的系统和方法。至少一个接收器周期性地创建包括关于至少一个相邻接收器的信息的相邻接收器列表，并且当从所述节点接收到认证请求时，所述接收器向基站请求节点认证，并且当所述节点认证已经完成。当节点移动并请求对另一个宿的认证时，另一宿存储从节点接收的相邻宿列表，根据认证请求确定节点可认证的宿是否存在于其本身的相邻宿列表中，并请求重新认证当节点可认证接收器存在时，节点到节点可认证的接收器，从而容易地执行节点和接收器之间的重新认证。

6. 发明申请

US20100332830A1 SYSTEM AND METHOD FOR MUTUAL AUTHENTICATION BETWEEN NODE AND SINK IN SENSOR NETWORK 有权
标题翻译：传感器网络中的节点和网络之间的互相认证的系统和方法
公开(公告)号：US20100332830A1
公开(公告)日：2010-12-30
申请号：US12821577
申请日：2010-06-23
申请人： Tae-Shik Shon , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
发明人： Tae-Shik Shon , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
IPC分类号： G06F21/00 , H04L9/32
CPC分类号： H04L9/3273 , H04L63/0869 , H04L2209/805
摘要： Disclosed a system and method for mutual authentication between a node and a sink in a sensor network. At least one sink periodically creates a neighboring sink list including information on at least one adjacent sink, and the sink requests node authentication to a base station when receiving an authentication request from the node and transmits its own neighboring sink list to the node when the node authentication has been completed. When the node moves and requests authentication to another sink, the another sink stores a neighboring sink list received from the node, determines if a node-authenticable sink exists in its own neighboring sink list according to the authentication request, and requests re-authentication of the node to the node-authenticable sink when the node-authenticable sink exists, so that re-authentication between the node and the sink is easily performed.
摘要翻译：公开了用于在传感器网络中的节点和汇点之间的相互认证的系统和方法。至少一个接收器周期性地创建包括关于至少一个相邻接收器的信息的相邻接收器列表，并且当从所述节点接收到认证请求时，所述接收器向基站请求节点认证，并且当所述节点认证已经完成。当节点移动并请求对另一个宿的认证时，另一宿存储从节点接收的相邻宿列表，根据认证请求确定节点可认证的宿是否存在于其本身的相邻宿列表中，并请求重新认证当节点可认证接收器存在时，节点到节点可认证的接收器，从而容易地执行节点和接收器之间的重新认证。

7. 发明申请

US20110126015A1 SINK AUTHENTICATION SYSTEM AND METHOD USING MOBILE COMMUNICATION NETWORK 审中-公开
标题翻译： SINK认证系统和使用移动通信网络的方法
公开(公告)号：US20110126015A1
公开(公告)日：2011-05-26
申请号：US12954279
申请日：2010-11-24
申请人： Tae-Shik SHON , Yong-Suk Park , Kyu-Suk Han , Kwang-Jo Kim , Jang-Seong Kim
发明人： Tae-Shik SHON , Yong-Suk Park , Kyu-Suk Han , Kwang-Jo Kim , Jang-Seong Kim
IPC分类号： H04K1/00 , H04L9/00
CPC分类号： H04W12/06 , H04L63/0884
摘要： A system is provided for authentication between a mobile device (MD) and a sink using a mobile communication network. If a sink authentication request for the sink is received from the MD, a base station (BS) sends a sink authentication response including sink authentication information for the sink, to the MD. The MD forwards the sink authentication request for the sink to the BS, and if a sink authentication response is received from the BS, authenticates the sink using the received sink authentication information. The sink performs authentication with the MD.
摘要翻译：提供了一种用于使用移动通信网络在移动设备（MD）和接收机之间进行认证的系统。如果从MD接收到宿的接收器认证请求，则基站（BS）向MD发送包括宿的接收认证信息的接收认证响应。 MD将宿的接收认证请求转发给BS，并且如果从BS接收到接收器认证响应，则使用接收的接收认证信息来认证接收器。接收端用MD执行认证。

8. 发明申请

US20100332831A1 METHOD AND APPARATUS FOR AUTHENTICATING A SENSOR NODE IN A SENSOR NETWORK 有权
标题翻译：传感器网络中传感器节点识别的方法和装置
公开(公告)号：US20100332831A1
公开(公告)日：2010-12-30
申请号：US12823694
申请日：2010-06-25
申请人： Tae-Shik SHON , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
发明人： Tae-Shik SHON , Yong-Suk Park , Soon-Seob Han , Kwang-Jo Kim , Kyu-Suk Han , Jang-Seong Kim
IPC分类号： H04L9/32
CPC分类号： H04L9/0833 , H04L9/3213 , H04L2209/805
摘要： A method and apparatus for authenticating a sensor node in a sensor network. The method for authenticating a sensor node by a first sink node in a sensor network includes receiving an authentication request using an authentication ticket from the sensor node, identifying a second sink node which has issued the authentication ticket, decoding the authentication ticket using a group key, which is previously stored in correspondence to the second sink node to confirm the validity of the authentication ticket, when the second sink node is included in a neighboring node list, normally processing authentication for the sensor node, generating an authentication ticket using a group key of the first sink node, and transmitting the generated authentication ticket to the sensor node.
摘要翻译：一种用于认证传感器网络中的传感器节点的方法和装置。用于通过传感器网络中的第一汇点认证传感器节点的方法包括使用来自传感器节点的认证券接收认证请求，识别发出认证券的第二接收节点，使用组密钥解码认证券，当第二宿节点被包括在相邻节点列表中时，通常对传感器节点进行处理认证，使用组密钥生成认证券并且将所生成的认证券发送到所述传感器节点。

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