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1. 发明授权

US08299049B2 Compositions comprising an extract of Tiarella polyphylla or compounds isolated therefrom for preventing and treating cancer diseases 有权
标题翻译：组合物，其包含提取物，其中从其中分离出的化合物，用于预防和治疗癌症疾病
公开(公告)号：US08299049B2
公开(公告)日：2012-10-30
申请号：US12626553
申请日：2009-11-25
申请人： Hyeong-Kyu Lee , Sei-Ryang Oh , Kyungseop Ahn , Joongku Lee , Sangku Lee , Ho-Jae Lee , Doo-Young Kim , Jung-Hee Kim , Eun-Ah Kim , Soon-Ja Choi , Soo Hyun Kim , Jung Weon Lee , Su-Yong Choi
发明人： Hyeong-Kyu Lee , Sei-Ryang Oh , Kyungseop Ahn , Joongku Lee , Sangku Lee , Ho-Jae Lee , Doo-Young Kim , Jung-Hee Kim , Eun-Ah Kim , Soon-Ja Choi , Soo Hyun Kim , Jung Weon Lee , Su-Yong Choi
IPC分类号： A61K31/56
CPC分类号： A61K36/185 , A23L33/105
摘要： The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.
摘要翻译：本发明涉及一种脱氧诱导剂，其包含与其分离的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐，其对表达肿瘤相关抗原L6的癌细胞或其同源物是特异性的。本发明的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐导致细胞粘附丧失，以减少癌细胞增殖，并表现出在表达肿瘤相关抗原L6的癌细胞中诱导细胞死亡的作用其同系物，因此用于预防和治疗由于肿瘤相关抗原L6或其同源物引起的癌症。

2. 发明申请

US20100081638A1 COMPOSITIONS COMPRISING AN EXTRACT OF TIARELLA POLYPHYLLA OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTING AND TREATING CANCER DISEASES 有权
标题翻译：包含TIARELLA POLYPHYLLA或其化合物提取物的组合物，用于预防和治疗癌症疾病
公开(公告)号：US20100081638A1
公开(公告)日：2010-04-01
申请号：US12626553
申请日：2009-11-25
申请人： Hyeong-Kyu Lee , Sei-Ryang Oh , Kyungseop Ahn , Joongku Lee , Sangku Lee , Ho-Jae Lee , Doo-Young Kim , Jung-Hee Kim , Eun-Ah Kim , Soon-Ja Choi , Soo Hyun Kim , Jung Weon Lee , Su-Yong Choi
发明人： Hyeong-Kyu Lee , Sei-Ryang Oh , Kyungseop Ahn , Joongku Lee , Sangku Lee , Ho-Jae Lee , Doo-Young Kim , Jung-Hee Kim , Eun-Ah Kim , Soon-Ja Choi , Soo Hyun Kim , Jung Weon Lee , Su-Yong Choi
IPC分类号： A61K31/56 , C07J53/00
CPC分类号： A61K36/185 , A23L33/105
摘要： The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.
摘要翻译：本发明涉及一种脱氧诱导剂，其包含与其分离的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐，其对表达肿瘤相关抗原L6的癌细胞或其同源物是特异性的。本发明的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐导致细胞粘附丧失，以减少癌细胞增殖，并表现出在表达肿瘤相关抗原L6的癌细胞中诱导细胞死亡的作用其同系物，因此用于预防和治疗由于肿瘤相关抗原L6或其同源物引起的癌症。

3. 发明授权

US08980846B2 Composition containing styraxlignolide A or the aglycone thereof as an active ingredient for preventing or treating asthma 有权
标题翻译：含有苯乙烯利洛尔A或其糖苷配基作为预防或治疗哮喘的活性成分的组合物
公开(公告)号：US08980846B2
公开(公告)日：2015-03-17
申请号：US13885986
申请日：2011-11-17
申请人： Kyung Seop Ahn , Ha Young Jang , Sei Ryang Oh , Hyeong Kyu Lee , Ok-Kyoung Kwon , Semi Kim , Jung Hee Kim , Doo-Young Kim
发明人： Kyung Seop Ahn , Ha Young Jang , Sei Ryang Oh , Hyeong Kyu Lee , Ok-Kyoung Kwon , Semi Kim , Jung Hee Kim , Doo-Young Kim
IPC分类号： A61K31/70 , A61K31/34 , A61K31/7048 , A61K31/343 , A61K36/185 , A23L1/30
CPC分类号： A61K31/7048 , A23L33/105 , A23V2002/00 , A61K31/343 , A61K36/185 , A23V2200/314 , A23V2250/21 , A23V2250/2116
摘要： The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of Styrax japonica, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-β1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.
摘要翻译：本发明涉及一种用于预防或治疗哮喘的药物组合物，该组合物含有作为活性成分的苯达洛尔苷A或其糖苷配基。更特别的是，辛伐利精A化合物是从Styrax japonica的茎和吠声中分离出来的化合物，作为styraxlignolide A的糖苷配基的辛伐利汀A或homoegonol，具有改善的安全性，具有减轻体重减轻和气道高反应性的作用，的气道中的活性氧，抑制血清和支气管肺泡灌洗液中IgE，TGF-β1和IL-17的产生，抑制支气管炎性细胞浸润，抑制哮喘中粘膜和上皮下纤维化的形成诱导的鼠标模型。因此，可以有效地使用辛伐利汀或同型异黄酮作为预防或治疗气道重塑进行的支气管哮喘的药物组合物的活性成分。

4. 发明申请

US20140228427A1 PHARMACEUTICAL COMPOSITION CONTAINING WOGONIN AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING ASTHMA 审中-公开
标题翻译：含有WOGONIN的药物组合物作为预防或治疗哮喘的主要成分
公开(公告)号：US20140228427A1
公开(公告)日：2014-08-14
申请号：US14122789
申请日：2012-05-24
申请人： Sei Ryang Oh , Kyung Seop Ahn , Hyeong Kyu Lee , Ha Young Jang , Ok-Kyoung Kwon , Jung Hee Kim , Ji Won Park , Doo-Young Kim
发明人： Sei Ryang Oh , Kyung Seop Ahn , Hyeong Kyu Lee , Ha Young Jang , Ok-Kyoung Kwon , Jung Hee Kim , Ji Won Park , Doo-Young Kim
IPC分类号： A61K31/352
CPC分类号： A61K31/352
摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of asthma comprising Wogonin as an active ingredient. The Wogonin of the present invention is excellent not only in relieving airway hypersensitivity that causes asthma in vivo, in inhibiting reactive oxygen species generation in the airway, and in inhibiting the infiltration of inflammatory cells in the bronchus, but also in inhibiting the generation of IgE in serum and bronchoalveolar lavage fluid, and in inhibiting the expressions of Th2 cytokines in the lung. Therefore, the Wogonin of the present invention can be effectively used as a composition for the prevention, treatment, or improvement of asthma.
摘要翻译：本发明涉及一种用于预防或治疗哮喘的药物组合物，其包含沃可素作为活性成分。本发明的Wogonin不仅能缓解气道在体内引起哮喘，抑制气道中的活性氧产生，抑制炎症细胞在支气管中的浸润，而且抑制IgE的产生，在血清和支气管肺泡灌洗液中，并抑制肺中Th2细胞因子的表达。因此，本发明的沃可素可以有效地用作预防，治疗或改善哮喘的组合物。

5. 发明申请

US20130244959A1 Composition Containing Styraxlignolide A or the Aglycone Thereof as an Active Ingredient for Preventing or Treating Asthma 有权
标题翻译：含有苯丙氨ide内酯A或其糖苷配基作为预防或治疗哮喘的有效成分的组合物
公开(公告)号：US20130244959A1
公开(公告)日：2013-09-19
申请号：US13885986
申请日：2011-11-17
申请人： Kyung Seop Ahn , Ha Young Jang , Sei Ryang Oh , Hyeong Kyu Lee , Ok-Kyoung Kwon , Semi Kim , Jung Hee Kim , Doo-Young Kim
发明人： Kyung Seop Ahn , Ha Young Jang , Sei Ryang Oh , Hyeong Kyu Lee , Ok-Kyoung Kwon , Semi Kim , Jung Hee Kim , Doo-Young Kim
IPC分类号： A61K31/7048 , A61K31/343
CPC分类号： A61K31/7048 , A23L33/105 , A23V2002/00 , A61K31/343 , A61K36/185 , A23V2200/314 , A23V2250/21 , A23V2250/2116
摘要： The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of Styrax japonica, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-β1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.
摘要翻译：本发明涉及一种用于预防或治疗哮喘的药物组合物，该组合物含有作为活性成分的苯达洛尔苷A或其糖苷配基。更特别的是，辛伐利精A化合物是从Styrax japonica的茎和吠声分离出来的化合物，作为styraxlignolide A的糖苷配基的styraxlignolide A或homoegonol，具有改善的安全性，具有减轻体重减轻和气道高反应性的作用，的气道中的活性氧，抑制血清和支气管肺泡灌洗液中IgE，TGF-β1和IL-17的产生，抑制支气管炎性细胞浸润，抑制哮喘诱发的粘液栓塞和上皮下纤维化形成鼠标模型。因此，可以有效地使用辛伐利汀或同型异黄酮作为预防或治疗气道重塑进行的支气管哮喘的药物组合物的活性成分。

6. 发明申请

US20090207674A1 DEVICE AND METHOD GENERATING INTERNAL VOLTAGE IN SEMICONDUCTOR MEMORY DEVICE 有权
标题翻译：在半导体存储器件中产生内部电压的器件和方法
公开(公告)号：US20090207674A1
公开(公告)日：2009-08-20
申请号：US12372290
申请日：2009-02-17
申请人： Soo-Bong Chang , Doo-Young Kim , Jung-Im Huh
发明人： Soo-Bong Chang , Doo-Young Kim , Jung-Im Huh
IPC分类号： G11C7/00 , G11C5/14
CPC分类号： G11C5/147
摘要： A semiconductor memory device and a method of generating an internal voltage in the semiconductor memory device are provided. The semiconductor memory device includes a controller configured to activate a sensing enable signal when an active command is applied from outside, inactivate the sensing enable signal when a precharge command is applied, and output the sensing enable signal, and an array internal voltage generator configured to output an active array power supply voltage as an array power supply voltage when the sensing enable signal is activated, output an external array power supply voltage and a standby array power supply voltage as the array power supply voltage when the sensing enable signal is inactivated, and output the standby array power supply voltage alone as the array power supply voltage when the sensing enable signal is inactivated for at least a specific period.
摘要翻译：提供半导体存储器件和在半导体存储器件中产生内部电压的方法。半导体存储器件包括：控制器，被配置为当从外部施加有效命令时激活感测使能信号，当施加预充电命令时使感测使能信号失效，并输出感测使能信号;以及阵列内部电压发生器，被配置为当感测使能信号被激活时，输出有源阵列电源电压作为阵列电源电压，当感测使能信号被去激活时，输出外部阵列电源电压和备用阵列电源电压作为阵列电源电压;以及当感测使能信号在至少特定的时间段内被去激活时，单独输出备用阵列电源电压作为阵列电源电压。

7. 发明授权

US07206252B2 Circuit and method for generating word line control signals and semiconductor memory device having the same 失效
标题翻译：用于产生字线控制信号的电路和方法以及具有该字线控制信号的半导体存储器件
公开(公告)号：US07206252B2
公开(公告)日：2007-04-17
申请号：US11141783
申请日：2005-05-31
申请人： Doo-Young Kim
发明人： Doo-Young Kim
IPC分类号： G11C8/00
CPC分类号： G11C8/10
摘要： A circuit for generating word line control signals that have a stable boosting margin of the sub-word line driver: The circuit includes a first address buffer, a pre-decoder unit, a second address buffer, a main decoder and a circuit for generating a word-line boosting signal. The second address buffer delays a refresh count signal for a predetermined time and generates an enable signal having a predetermined pulse width in response to a row address setup signal and the delayed refresh count signal, and receives and latches a pre-decoded row address signals to output decoded row address signals in response to the enable signal. Accordingly, the circuit for generating word line control signals is capable of obtaining a stable self-boosting margin when the semiconductor memory device operates in a refresh mode.
摘要翻译：一种用于产生具有所述子字线驱动器的稳定升压裕度的字线控制信号的电路：所述电路包括第一地址缓冲器，预解码器单元，第二地址缓冲器，主解码器和用于产生字线升压信号。第二地址缓冲器将刷新计数信号延迟预定时间，并且响应于行地址建立信号和延迟刷新计数信号产生具有预定脉冲宽度的使能信号，并且接收并锁存预解码的行地址信号响应于使能信号输出解码的行地址信号。因此，当半导体存储器件以刷新模式工作时，用于产生字线控制信号的电路能够获得稳定的自增益裕度。

8. 发明授权

US06775199B2 Semiconductor memory device having an array voltage control circuit constructed with a plurality of feedback loops 有权
标题翻译：具有由多个反馈回路构成的阵列电压控制电路的半导体存储器件
公开(公告)号：US06775199B2
公开(公告)日：2004-08-10
申请号：US10405770
申请日：2003-04-01
申请人： Doo-Young Kim , Byung-Chul Kim
发明人： Doo-Young Kim , Byung-Chul Kim
IPC分类号： G11C700
CPC分类号： G11C5/147 , G11C5/14
摘要： The invention discloses a semiconductor memory device having an array voltage control circuit constructed with a plurality of feedback loops. In order to maintain constant the array voltage used for a single memory cell array region the plurality of feedback loops dividedly connect to a power line structure covering the memory cell array region, resulting in a reduction in the load to be taken by the output of feedback amplifiers to thereby achieve stable array voltage control operations.
摘要翻译：本发明公开了一种具有由多个反馈回路构成的阵列电压控制电路的半导体存储器件。为了保持用于单个存储单元阵列区域的阵列电压恒定，多个反馈回路分别连接到覆盖存储单元阵列区域的电力线结构，导致由反馈的输出采取的负载减小放大器，从而实现稳定的阵列电压控制操作。

9. 发明授权

US08547763B2 Memory cell, methods of manufacturing memory cell, and memory device having the same 有权
标题翻译：存储单元，存储单元的制造方法以及具有该单元的存储器件
公开(公告)号：US08547763B2
公开(公告)日：2013-10-01
申请号：US13219998
申请日：2011-08-29
申请人： Jong-Pil Son , Seong-Jin Jang , Byung-Sik Moon , Doo-Young Kim , Ju-Seop Park
发明人： Jong-Pil Son , Seong-Jin Jang , Byung-Sik Moon , Doo-Young Kim , Ju-Seop Park
IPC分类号： G11C7/00 , G11C11/405
CPC分类号： G11C11/405 , G11C17/16 , G11C17/165 , H01L27/101 , H01L29/1045 , H01L29/1083 , H01L29/66537 , H01L29/7835
摘要： A memory cell includes a selection transistor on a substrate and an antifuse on the substrate. The selection transistor includes a first gate connected to a read word line, a first gate insulation layer that insulates the first gate from the substrate, a first source region connected to a bit line, and a first drain region, an impurity concentration of the first drain region being lower than an impurity concentration of the first source region. The antifuse includes a first electrode connected to a program word line and a second electrode connected to the selection transistor.
摘要翻译：存储单元包括衬底上的选择晶体管和衬底上的反熔丝。选择晶体管包括连接到读字线的第一栅极，将第一栅极与衬底绝缘的第一栅极绝缘层，连接到位线的第一源极区域和第一漏极区域，第一漏极区域的杂质浓度漏极区域低于第一源极区域的杂质浓度。反熔丝包括连接到编程字线的第一电极和连接到选择晶体管的第二电极。

10. 发明申请

US20120213018A1 DEVICE AND METHOD GENERATING INTERNAL VOLTAGE IN SEMICONDUCTOR MEMORY DEVICE 审中-公开
标题翻译：在半导体存储器件中产生内部电压的器件和方法
公开(公告)号：US20120213018A1
公开(公告)日：2012-08-23
申请号：US13462915
申请日：2012-05-03
申请人： Soo-Bong Chang , Doo-Young Kim , Jung-Im Huh
发明人： Soo-Bong Chang , Doo-Young Kim , Jung-Im Huh
IPC分类号： G11C7/00
CPC分类号： G11C5/147
摘要： A semiconductor memory device and a method of generating an internal voltage in the semiconductor memory device are provided. The semiconductor memory device includes a controller configured to activate a sensing enable signal when an active command is applied from outside, inactivate the sensing enable signal when a precharge command is applied, and output the sensing enable signal, and an array internal voltage generator configured to output an active array power supply voltage as an array power supply voltage when the sensing enable signal is activated, output an external array power supply voltage and a standby array power supply voltage as the array power supply voltage when the sensing enable signal is inactivated, and output the standby array power supply voltage alone as the array power supply voltage when the sensing enable signal is inactivated for at least a specific period.
摘要翻译：提供半导体存储器件和在半导体存储器件中产生内部电压的方法。半导体存储器件包括：控制器，被配置为当从外部施加有效命令时激活感测使能信号，当施加预充电命令时使感测使能信号失效，并输出感测使能信号;以及阵列内部电压发生器，被配置为当感测使能信号被激活时，输出有源阵列电源电压作为阵列电源电压，当感测使能信号被去激活时，输出外部阵列电源电压和备用阵列电源电压作为阵列电源电压;以及当感测使能信号在至少特定的时间段内被去激活时，单独输出备用阵列电源电压作为阵列电源电压。

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