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1. 发明专利

JP2007277249A Neutrokine-alpha and neutrokine-alpha splice variant 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：JP2007277249A
公开(公告)日：2007-10-25
申请号：JP2007111070
申请日：2007-04-19
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： ROSEN CRAIG A , NI JIAN , EBNER REINHARD , YU GUO-LIANG
IPC分类号： C07K14/52 , C12N15/09 , A61K38/00 , A61K38/19 , A61P31/00 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/06 , C07K14/715 , C07K16/24 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/19 , C12P21/02
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/24 , C07K2317/34
摘要： PROBLEM TO BE SOLVED: To provide a cytokine similar to TNF involved in a pathological state. SOLUTION: The above protein is an isolated protein containing a Neutrokine-α protein fused to a toxin protein, wherein the Neutrokine-alpha protein contains an amino acid sequence chosen from the group consisting of (a) the amino acid sequence of particular amino acid residues, (b) an amino acid sequence that is at least 90% identical to the particular amino acid residues and (c) the amino acid sequence of a portion of the particular polypeptide, wherein the portion is at least 30 amino acids in length and is capable of stimulating B cell proliferation. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供与参与病理状态的TNF相似的细胞因子。解决方案：上述蛋白质是含有与毒素蛋白质融合的中和蛋白α蛋白质的分离蛋白质，其中中性粒细胞-β蛋白质含有选自（a）特定氨基酸序列的氨基酸序列氨基酸残基，（b）与特定氨基酸残基至少90％相同的氨基酸序列和（c）特定多肽的一部分的氨基酸序列，其中该部分至少具有30个氨基酸，长度，能够刺激B细胞增殖。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2005218453A 87 human secreted proteins 审中-公开
标题翻译： 87人类分泌蛋白
公开(公告)号：JP2005218453A
公开(公告)日：2005-08-18
申请号：JP2005082833
申请日：2005-03-22
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YOUNG PAUL , GREENE JOHN M , FERRIE ANN M , RUBEN STEVEN M , ROSEN CRAIG A , DUAN ROXANNE D , HU JING-SHAN , FLORENCE KIMBERLY A , OLSEN HENRIK S , EBNER REINHARD , BREWER LAUIE A , PAUL A MOORE , SHI YANGGU , LAFLEUR DAVID W , NI JIAN
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P7/02 , A61P7/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P15/08 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/28 , A61P25/30 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/04 , A61P37/06 , A61P37/08 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/68
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/6893
摘要： PROBLEM TO BE SOLVED: To identify and characterize a novel human secreted protein and a gene encoding thereof in expanded roles of secreted proteins in human physiology, and to provide methods for detecting, treating and preventing a medical disorder by using the secreted protein or the gene encoding thereof. SOLUTION: There are provided a novel polynucleotide and a polypeptide encoded thereby, and a vector, host cell, antibody and recombinant method for producing the polypeptide and the polynucleotide; a diagnostic method for detecting disorders related to the polypeptide; a therapeutic method for treating such disorders; and a screening method for identifying a binding partner of the polypeptide. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：鉴定和表征新型人分泌蛋白及其在人体生理学中分泌蛋白质扩展作用中编码的基因，并提供通过使用分泌蛋白质来检测，治疗和预防医学病症的方法或其编码基因。提供了一种新型多核苷酸和由此编码的多肽，以及用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法; 用于检测与该多肽有关的疾病的诊断方法; 治疗这种疾病的治疗方法; 以及鉴定多肽结合配偶体的筛选方法。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2009136294A NEUTROKINE α 审中-公开
标题翻译： NEUTROKINE alpha
公开(公告)号：JP2009136294A
公开(公告)日：2009-06-25
申请号：JP2009012969
申请日：2009-01-23
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-RIAN , EBNER REINHARD , NI JIAN
IPC分类号： C12N15/09 , C07K14/52
CPC分类号： Y02A50/412
摘要： PROBLEM TO BE SOLVED: To provide an isolated nucleic acid molecule containing polynucleotide at least 95% homology with a new cytokine comprising a specific sequence. SOLUTION: The specific sequences are; (a) a sequence encoding neutrokine α polypeptide having a complete amino acid sequence, (b) a sequence encoding neutrokine α having a complete amino acid sequence encoded by cDNA clone included in deposition to the ATCC on 22nd October 1996, (c) a sequence encoding neutrokine α polypeptide extracellular domain, (d) a sequence encoding neutrokine α polypeptide transmembrane domain, (e) a sequence encoding neutrokine α polypeptide intracellular domain, (f) a sequence encoding soluble neutrokine α polypeptide deleted of transmembrane domain, and (g) a sequence complementary to optional sequence of (a), (b), (c), (d), (e) or (f). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供含有与包含特定序列的新细胞因子至少95％同源性的分离的核酸分子。解决方案：具体序列为（a）编码具有完整氨基酸序列的中性粒细胞α多肽的序列，（b）编码具有由1996年10月22日向ATCC沉积的cDNA克隆编码的完整氨基酸序列的中性粒细胞α的序列，（c）编码中性粒细胞α多肽细胞外结构域，（d）编码中性粒细胞α多肽跨膜结构域的序列，（e）编码中性粒细胞α多肽细胞内结构域的序列，（f）编码跨膜结构域缺失的可溶性中性粒细胞α多肽的序列，（g）与（a），（b），（c），（d），（e）或（f）的任选序列互补的序列。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2012044999A NEUTROKINE α 审中-公开
标题翻译： NEUTROKINEα
公开(公告)号：JP2012044999A
公开(公告)日：2012-03-08
申请号：JP2011242255
申请日：2011-11-04
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-RIAN , EBNER REINHARD , NI JIAN
IPC分类号： C12N15/09 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a TNF-like cytokine involved in a pathological state.SOLUTION: An isolated nucleic acid molecule containing polynucleotide with a sequence at least 95% homology with the following sequences is provided: (a) a sequence encoding neutrokine α polypeptide having a complete amino acid sequence in Fig.1; (b) a sequence encoding neutrokine α having a complete amino acid sequence encoded by cDNA clone included in deposition to ATCC on October 22nd 1996; (c) a sequence encoding neutrokine α polypeptide extracellular domain; (d) a sequence encoding neutrokine α polypeptide transmembrane domain; (e) a sequence encoding neutrokine α polypeptide intracellular domain; (f) a sequence encoding soluble neutrokine α polypeptide deleted of transmembrane domain; and (g) a sequence complementary to optional sequence of (a), (b), (c), (d), (e) or (f).
摘要翻译：待解决的问题：提供涉及病理状态的TNF样细胞因子。提供了一种分离的核酸分子，其含有与以下序列具有至少95％同源性的序列的多核苷酸：（a）编码具有图1中完整氨基酸序列的中性粒细胞α多肽的序列; （b）1996年10月22日向ATCC提供的具有由cDNA克隆编码的完整氨基酸序列的中性粒细胞α的序列; （c）编码中性粒细胞α多肽细胞外结构域的序列; （d）编码中性粒细胞α多肽跨膜结构域的序列; （e）编码中性粒细胞α多肽细胞内结构域的序列; （f）编码跨膜结构域缺失的可溶性中性粒细胞α多肽的序列; 和（g）与（a），（b），（c），（d），（e）或（f）的任选序列互补的序列。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2010279364A 207 human secreted proteins 审中-公开
标题翻译： 207人类分泌蛋白
公开(公告)号：JP2010279364A
公开(公告)日：2010-12-16
申请号：JP2010152548
申请日：2010-07-02
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： PAUL YOUNG , JOHN M GREEN , FERRIE ANN M , RUBEN STEVEN M , ROSEN CRAIG A , HU JING-SHAN , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , SHI YANGGU , FLORENCE CHARLES , FLORENCE KIMBERLY , LAFLEUR DAVID W , NI JIAN , FAN PIN , WEI IN-FEI , FISCHER CARRIE L , DANIEL R SOPETTO , LI YI , ZENG ZHIZHEN , KYAW HLA , YU GUO-LIANG , FENG PING , DILLON PATRICK J , ENDRESS GREGORY A , CARTER KENNETH C
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12P21/08 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide secreted proteins or genes encoding such proteins, and methods for detecting, treating and preventing medical disorders using the proteins or genes. SOLUTION: There are disclosed 207 human secreted proteins and isolated nucleic acids comprising the coding regions of the genes encoding such proteins. There are also disclosed vectors, host cells, antibodies, and recombinant methods for producing the human secreted proteins. There are further disclosed diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these human secreted proteins. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供编码这种蛋白质的分泌蛋白质或基因，以及使用蛋白质或基因检测，治疗和预防医学病症的方法。解决方案：公开了207种人分泌蛋白质和分离的核酸，其包含编码这种蛋白质的基因的编码区。还公开了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。进一步公开了用于诊断和治疗与这些人分泌蛋白相关的疾病的诊断和治疗方法。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2009131263A 50 human secreted proteins 审中-公开
标题翻译： 50人类分泌蛋白
公开(公告)号：JP2009131263A
公开(公告)日：2009-06-18
申请号：JP2008321654
申请日：2008-12-17
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： PAUL A MOORE , RUBEN STEVEN M , LAFLEUR DAVID W , SHI YANG-GU , ROSEN CRAIG A , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A
IPC分类号： C12N15/09 , G01N33/53 , A61K38/00 , A61K48/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , C07K14/435 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： PROBLEM TO BE SOLVED: To provide new human secreted proteins, and to provide isolated nucleic acids containing coding regions of genes encoding the proteins. SOLUTION: The problems are solved by the new human secreted proteins, and the isolated nucleic acids containing the coding regions of the genes encoding the proteins, and vectors, host cells, antibodies, and recombinant methods for producing the human secreted proteins described in the specification. Furthermore, diagnostic and therapeutic methods useful for diagnosing and treating disorders related to the new human secreted proteins are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供新的人分泌蛋白质，并提供含有编码蛋白质的基因的编码区的分离的核酸。解决方案：通过新的人分泌蛋白质和包含编码蛋白质的基因的编码区域的分离的核酸以及用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法来解决问题在规范中。此外，提供了用于诊断和治疗与新的人分泌蛋白相关的疾病的诊断和治疗方法。版权所有（C）2009，JPO＆INPIT

7. 发明申请

WO02057420A3 50 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 50人分泌蛋白
公开(公告)号：WO02057420A3
公开(公告)日：2002-11-07
申请号：PCT/US0201109
申请日：2002-01-17
申请人： HUMAN GENOME SCIENCES INC , MOORE PAUL A , RUBEN STEVEN M , LAFLEUR DAVID W , SHI YANGGU , ROSEN CRAIG A , OLSEN HENRIK , EBNER REINHARD , BREWER LAURIE A
发明人： MOORE PAUL A , RUBEN STEVEN M , LAFLEUR DAVID W , SHI YANGGU , ROSEN CRAIG A , OLSEN HENRIK , EBNER REINHARD , BREWER LAURIE A
IPC分类号： A61K38/00 , C07K14/47 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及新的人分泌蛋白和含有编码这些蛋白的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白的载体，宿主细胞，抗体和重组方法。本发明进一步涉及诊断和治疗方法，用于诊断和治疗与这些新的人类分泌蛋白相关的疾病，病症和/或病症。

8. 发明申请

WO9830693A9 TUMOR NECROSIS FACTOR RECEPTOR 5 审中-公开
标题翻译：肿瘤坏死因子受体5
公开(公告)号：WO9830693A9
公开(公告)日：1999-09-02
申请号：PCT/US9800152
申请日：1998-01-13
申请人： HUMAN GENOME SCIENCES INC , WEI YING FEI , NI JIAN , EBNER REINHARD , YU GUO LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
发明人： WEI YING-FEI , NI JIAN , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P7/00 , A61P9/10 , A61P19/08 , A61P25/16 , A61P25/28 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , A61K38/17 , C12N15/70 , C12N15/85 , C12N15/86
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as "TNFR-5" or "TR5", and now referred to hereinafter as "TRAIL receptor without intracellular domain" or "TRID". TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

9. 发明申请

WO9830693A2 TUMOR NECROSIS FACTOR RECEPTOR 5 审中-公开
标题翻译：肿瘤坏死因子受体5
公开(公告)号：WO9830693A2
公开(公告)日：1998-07-16
申请号：PCT/US9800152
申请日：1998-01-13
申请人： HUMAN GENOME SCIENCES INC , WEI YING FEI , NI JIAN , EBNER REINHARD , YU GUO LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
发明人： WEI YING-FEI , NI JIAN , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P7/00 , A61P9/10 , A61P19/08 , A61P25/16 , A61P25/28 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , A61K38/17 , C12N15/70 , C12N15/85 , C12N15/86
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as "TNFR-5" or "TR5", and now referred to hereinafter as "TRAIL receptor without intracellular domain" or "TRID". TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

10. 发明申请

WO9807862A2 CHEMOKINE BETA-16 审中-公开
公开(公告)号：WO9807862A2
公开(公告)日：1998-02-26
申请号：PCT/US9714787
申请日：1997-08-22
申请人： HUMAN GENOME SCIENCES INC , EBNER REINHARD , KREIDER BRENT L , RUBEN STEVEN M
发明人： EBNER REINHARD , KREIDER BRENT L , RUBEN STEVEN M
IPC分类号： A61K38/00 , C07K14/52 , C12N1/21 , C12N15/19 , A61K38/19 , C07K16/24 , C12N5/10 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/523 , A61K38/00 , C12N2799/026
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the Chemokine Beta-16 protein. Chemokine Beta-16 polypeptides are also provided. The invention further concerns diagnostic methods for detecting immune system disorders and therapeutic methods for modulating immune system cell proliferation, differentiation and function.
摘要翻译：本发明涉及人趋化因子CC蛋白家族的成员。特别地，提供编码趋化因子β-16蛋白的分离的核酸分子。还提供趋化因子β-16多肽。本发明还涉及用于检测免疫系统疾病的诊断方法和用于调节免疫系统细胞增殖，分化和功能的治疗方法。

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