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1. 发明授权

US08460285B2 Ablation catheter electrode having multiple thermal sensors and method of use 有权
公开(公告)号：US08460285B2
公开(公告)日：2013-06-11
申请号：US11647282
申请日：2006-12-29
申请人： Huisun Wang , Hong Cao , Jeremy D. Dando
发明人： Huisun Wang , Hong Cao , Jeremy D. Dando
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/14 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , Y10T29/49117
摘要： The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.

2. 发明申请

US20080161794A1 Irrigated ablation catheter having a pressure sensor to detect tissue contact 有权
标题翻译：灌注消融导管具有检测组织接触的压力传感器
公开(公告)号：US20080161794A1
公开(公告)日：2008-07-03
申请号：US11646270
申请日：2006-12-28
申请人： Huisun Wang , Hong Cao
发明人： Huisun Wang , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2090/065 , A61B2218/002
摘要： The invention relates to an irrigated ablation catheter that has a pressure sensor to determine tissue contact as well as methods of using the same. The irrigated ablation catheter contains fluid tubing, an electrode with passages and a lumen and a pressure sensor located inside the lumen of the electrode. In some embodiments, a cooling fluid, such as saline, is passed through the catheter.
摘要翻译：本发明涉及一种具有确定组织接触的压力传感器的灌洗消融导管及其使用方法。灌注消融导管包含流体管，具有通道的电极和内腔，位于电极内腔内的压力传感器。在一些实施例中，诸如盐水的冷却流体通过导管。

3. 发明申请

US20080161797A1 Ablation catheter electrode having multiple thermal sensors and method of use 有权
标题翻译：消融导管电极具有多个热传感器和使用方法
公开(公告)号：US20080161797A1
公开(公告)日：2008-07-03
申请号：US11647282
申请日：2006-12-29
申请人： Huisun Wang , Hong Cao , Jeremy D. Dando
发明人： Huisun Wang , Hong Cao , Jeremy D. Dando
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/14 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , Y10T29/49117
摘要： The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.
摘要翻译：本发明涉及消融导管装置中使用的电极，其中电极在电极内的不同位置包含能够检测沿着电极外表面的温度差的两个或多个热传感器。在优选实施例中，热传感器被一个或多个绝热构件隔开，并且热传感器位于与电极端部大约相同距离处的电极的外表面附近，使得温度测量可以指示位置电极相对于希望烧蚀的组织。

4. 发明授权

US08690870B2 Irrigated ablation catheter system with pulsatile flow to prevent thrombus 有权
标题翻译：灌注式消融导管系统具有脉动流量，可预防血栓
公开(公告)号：US08690870B2
公开(公告)日：2014-04-08
申请号：US11646275
申请日：2006-12-28
申请人： Huisun Wang , Jeremy D. Dando , Hong Cao
发明人： Huisun Wang , Jeremy D. Dando , Hong Cao
IPC分类号： A61B18/04 , A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00577 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow saline flow out of an inner cavity of the electrode. This fluid flow is pulsatile to increase turbulence, reducing areas of stagnant flow, and produces a desired cooling effect.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管电极上生物流体的凝结，防止与电极接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。电极包括定位成允许盐水从电极的内腔流出的通道。这种流体流动是脉动的，以增加湍流，减少滞留流动的面积，并产生所需的冷却效果。

5. 发明授权

US07591816B2 Irrigated ablation catheter having a pressure sensor to detect tissue contact 有权
标题翻译：灌注消融导管具有检测组织接触的压力传感器
公开(公告)号：US07591816B2
公开(公告)日：2009-09-22
申请号：US11646270
申请日：2006-12-28
申请人： Huisun Wang , Hong Cao
发明人： Huisun Wang , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2090/065 , A61B2218/002
摘要： The invention relates to an irrigated ablation catheter that has a pressure sensor to determine tissue contact as well as methods of using the same. The irrigated ablation catheter contains fluid tubing, an electrode with passages and a lumen and a pressure sensor located inside the lumen of the electrode. In some embodiments, a cooling fluid, such as saline, is passed through the catheter.
摘要翻译：本发明涉及一种具有确定组织接触的压力传感器的灌洗消融导管及其使用方法。灌注消融导管包含流体管，具有通道的电极和内腔，位于电极内腔内的压力传感器。在一些实施例中，诸如盐水的冷却流体通过导管。

6. 发明授权

US08221409B2 Thermally insulated irrigation catheter assembly 有权
标题翻译：绝热冲洗导管组件
公开(公告)号：US08221409B2
公开(公告)日：2012-07-17
申请号：US11962600
申请日：2007-12-21
申请人： Hong Cao , Huisun Wang
发明人： Hong Cao , Huisun Wang
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00083 , A61B2018/00101 , A61B2218/002
摘要： The present invention relates to ablation electrode assemblies. The present invention further relates to an insulated irrigated ablation electrode assembly. The insulated irrigated ablation electrode assembly of the present invention includes a proximal member, a distal member and an intermediate thermally insulating member. The proximal member includes a body portion defined by an outer surface, an inner cavity defined within the outer body portion, and at least one passageway that extends from the inner cavity to the outer surface of the body portion. The distal member of the electrode assembly includes a distal end. Moreover, the intermediate member of the electrode assembly is disposed between the proximal member and the distal member thereby thermally insulating the proximal member from the distal member.
摘要翻译：本发明涉及消融电极组件。本发明还涉及绝缘灌溉消融电极组件。本发明的绝缘灌溉消融电极组件包括近端构件，远侧构件和中间隔热构件。近端构件包括由外表面限定的主体部分，限定在外主体部分内的内腔以及从内腔延伸到主体部分的外表面的至少一个通道。电极组件的远端构件包括远端。此外，电极组件的中间构件设置在近端构件和远端构件之间，从而使近端构件与远端构件热绝缘。

7. 发明申请

US20080161795A1 Irrigated ablation catheter system with pulsatile flow to prevent thrombus 有权
标题翻译：灌注式消融导管系统具有脉动流量，可预防血栓
公开(公告)号：US20080161795A1
公开(公告)日：2008-07-03
申请号：US11646275
申请日：2006-12-28
申请人： Huisun Wang , Jeremy D. Dando , Hong Cao
发明人： Huisun Wang , Jeremy D. Dando , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00577 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow saline flow out of an inner cavity of the electrode. This fluid flow is pulsatile to increase turbulence, reducing areas of stagnant flow, and produces a desired cooling effect.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管电极上生物流体的凝结，防止与电极接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。电极包括定位成允许盐水从电极的内腔流出的通道。这种流体流动是脉动的，以增加湍流，减少滞留流动的面积，并产生所需的冷却效果。

8. 发明授权

US11079000B2 Differential capable of automatically restricting differential ratio and increasing torque 有权
公开(公告)号：US11079000B2
公开(公告)日：2021-08-03
申请号：US17264803
申请日：2018-09-25
申请人： Hong Cao
发明人： Hong Cao
IPC分类号： F16H48/20 , F16H48/08 , F16H48/10 , F16H48/24
摘要： A differential capable of automatically restricting a differential ratio and increasing torque comprises a container. A differential housing is provided in the container. The differential housing is internally provided with a planetary gear, a planetary shaft, a left half axle gear, and a right half axle gear. The planetary gear is provided on the planetary shaft, and the planetary gear engages with the left half axle gear and the right half axle gear, respectively. The differential housing comprises a left housing and a right housing engaging with each other. A ring gear is provided at the outer circumference of an end of the left housing engaging with the right housing, and a bevel ring gear is provided at the outer circumference of an end of the right housing engaging with the left housing.

9. 发明授权

US09487570B2 Glucagon like peptide analogs, composition, and method of use 有权
标题翻译：胰高血糖素样肽类似物，组合物和使用方法
公开(公告)号：US09487570B2
公开(公告)日：2016-11-08
申请号：US13698819
申请日：2010-05-17
申请人： Shaojing Hu , Fenlai Tan , Yanping Wang , Cunbo Ma , Yunyan Hu , Hong Cao , Xiangdong Zhao , Wei Long , Yinxiang Wang , Lieming Ding
发明人： Shaojing Hu , Fenlai Tan , Yanping Wang , Cunbo Ma , Yunyan Hu , Hong Cao , Xiangdong Zhao , Wei Long , Yinxiang Wang , Lieming Ding
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K9/00
CPC分类号： C07K14/605 , A61K9/0019 , A61K38/00
摘要： The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels.
摘要翻译：本发明涉及胰高血糖素样肽的新型类似物和可用于上调哺乳动物胰岛素表达和治疗糖尿病的组合物。特别地，这些肽衍生物具有肽模拟接头并且提供用于治疗糖尿病和其它促胰岛素肽相关疾病，胃肠功能和与胰高血糖素水平相关的活性的长期作用。

10. 发明授权

US09283026B2 Assessment of electrode coupling for tissue ablation 有权
标题翻译：组织消融电极耦合评估
公开(公告)号：US09283026B2
公开(公告)日：2016-03-15
申请号：US12096070
申请日：2006-12-06
申请人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe
发明人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe
IPC分类号： A61B18/04 , A61B5/053 , A61B18/12 , A61B18/14 , A61B19/00 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter (14) and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter (14) comprises an electrode (20) adapted to apply electrical energy. A measurement circuit (42) is adapted to measure impedance between the electrode (20) and ground as the electrode approaches a target tissue (24). A processor (50) determines a contact and coupling condition for the target tissue (24) based at least in part on reactance of the impedance measured by the measurement circuit (42). In another exemplary embodiment, the electrode catheter (14) determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了一种电极导管（14）和用于评估电极组织接触和耦合的方法。示例性电极导管（14）包括适于施加电能的电极（20）。测量电路（42）适于在电极接近目标组织（24）时测量电极（20）和地面之间的阻抗。处理器（50）至少部分地基于由测量电路（42）测量的阻抗的电抗来确定目标组织（24）的接触和耦合条件。在另一示例性实施例中，电极导管（14）至少部分地基于阻抗的相位角来确定接触和耦合条件。

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