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1. 发明授权

US5695583A Light diffuser and process for the manufacturing of a light diffuser 失效
标题翻译：光扩散器和制造光扩散器的工艺
公开(公告)号：US5695583A
公开(公告)日：1997-12-09
申请号：US593312
申请日：1996-01-31
申请人： Hubert van den Bergh , Jerome Mizeret
发明人： Hubert van den Bergh , Jerome Mizeret
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , F21V8/00 , G02B5/02 , G02B6/24 , G02B6/245 , G02B6/36 , G02B23/26 , B32B31/00 , B05D5/06
CPC分类号： A61B18/22 , A61N5/0601 , A61N5/062 , G02B5/0221 , G02B5/0242 , G02B6/0008 , G02B6/241 , G02B6/245 , A61B2018/2261 , G02B6/3624
摘要： A light diffuser for the radial emission of light, which has been fed into the diffuser in axial direction, comprises an optical waveguide, which itself comprises a core and a cladding. The core of the waveguide is exposed at an active region at the distal end. The exposed active region of the core is optically separated from a substance containing scattering particles. In a preferred embodiment, the core is roughened and is embedded in a first layer of an elastic substance, which has a refractive index similar to the refractive index of the cladding and which does not contain any scattering particles. This first layer is embedded in at least one further, second layer of an elastic substance comprising the scattering particles. This substance is surrounded by the outer tube.
摘要翻译：用于径向发射光的漫射器，其已经沿轴向馈送到扩散器中，包括光波导，其自身包括芯和包层。波导的核心在远端的有源区域露出。核心的暴露的活性区域与含有散射颗粒的物质光学分离。在优选实施例中，芯被粗糙化并且嵌入弹性物质的第一层中，其具有与包层的折射率相似的折射率，并且不包含任何散射颗粒。该第一层嵌入至少一个另外的第二层包含散射颗粒的弹性物质中。该物质被外管包围。

2. 发明授权

US5536265A Light diffuser and process for the manufacturing of a light diffuser 失效
标题翻译：光扩散器和制造光扩散器的工艺
公开(公告)号：US5536265A
公开(公告)日：1996-07-16
申请号：US413815
申请日：1995-03-17
申请人： Hubert van den Bergh , Jerome Mizeret
发明人： Hubert van den Bergh , Jerome Mizeret
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , F21V8/00 , G02B5/02 , G02B6/24 , G02B6/245 , G02B6/36 , G02B23/26 , A61B17/36
CPC分类号： A61B18/22 , A61N5/0601 , A61N5/062 , G02B5/0221 , G02B5/0242 , G02B6/0008 , G02B6/241 , G02B6/245 , A61B2018/2261 , G02B6/3624
摘要： A light diffuser for the radial emission of light, which has been fed into the diffuser in axial direction, comprises an optical waveguide, which itself comprises a core and a cladding. The core of the waveguide is exposed at an active region at the distal end. The exposed active region of the core is optically separated from a substance containing scattering particles. In a preferred embodiment, the core is roughened and is embedded in a first layer of an elastic substance, which has a refractive index similar to the refractive index of the cladding and which does not contain any scattering particles. This first layer is embedded in at least one further, second layer of an elastic substance comprising the scattering particles. This substance is surrounded by the outer tube.
摘要翻译：用于径向发射光的漫射器，其已经沿轴向馈送到扩散器中，包括光波导，其自身包括芯和包层。波导的核心在远端的有源区域露出。核心的暴露的活性区域与含有散射颗粒的物质光学分离。在优选实施例中，芯被粗糙化并且嵌入弹性物质的第一层中，其具有与包层的折射率相似的折射率，并且不包含任何散射颗粒。该第一层嵌入至少一个另外的第二层包含散射颗粒的弹性物质中。该物质被外管包围。

3. 发明授权

US4998797A Optical waveguide plug connection 失效
标题翻译：光波导插头连接
公开(公告)号：US4998797A
公开(公告)日：1991-03-12
申请号：US563771
申请日：1990-08-07
申请人： Hubert van den Bergh , Georges Wagnieres
发明人： Hubert van den Bergh , Georges Wagnieres
IPC分类号： G02B6/36 , G02B6/26 , G02B6/38
CPC分类号： G02B6/3825 , G02B6/262 , G02B6/3813 , G02B6/3814
摘要： An optical waveguide plug connection for the transmission of high continuous wave light powers from an incoming optical waveguide into an outgoing optical waveguide comprises a metallic plug housing equipped with a metallic centering element. The incoming optical waveguide and the outgoing optical waveguide project into the centering element, the end faces of the two optical waveguides being arranged opposite each other. The width of the gap is approximately in the range of from 5 to 30 micrometres. The core diameter of the outgoing optical waveguide is approximately one third larger than the core diameter of the incoming optical waveguide. The gap is filled with gas. The plug housing is connected to a housing of large surface area which dissipates heat. Using this plug connection, continuous wave powers of up to some 100's of watts in the case of visible to infrared laser light can be transmitted with a high degree of coupling without danger to the end faces of the coupling connection.
摘要翻译：用于将高连续波光功率从入射光波导传输到输出光波导的光波导插头连接器包括配备有金属定心元件的金属插头壳体。入射光波导和出射光波导投影到定心元件中，两个光波导的端面彼此相对布置。间隙的宽度大约在5至30微米的范围内。出射光波导的芯径大约比入射光波导的芯直径大三分之一。间隙充满气体。插头壳体连接到散热的大表面积的壳体。使用这种插头连接，在红外激光可见的情况下，高达100瓦特的连续波功率可以以高度耦合传输，而不会危及耦合连接的端面。

4. 发明授权

US5054867A Apparatus for irradiating the bronchi of a patient for the purpose of photodynamic therapy 失效
标题翻译：用于照射患者的支气管以用于光动力疗法的装置
公开(公告)号：US5054867A
公开(公告)日：1991-10-08
申请号：US638254
申请日：1991-01-04
申请人： Georges Wagnieres , Hubert van den Bergh , Philippe Monnier
发明人： Georges Wagnieres , Hubert van den Bergh , Philippe Monnier
IPC分类号： A61B18/20 , A61B1/00 , A61B18/22 , A61N5/06
CPC分类号： A61N5/062 , A61N5/0601 , A61B2018/2261 , A61N2005/0604
摘要： An apparatus for irradiating the bronchi of a patient for the purpose of photodynamic therapy has an optical fibre (11) that feeds the light of a laser into a bronchoscope and is surrounded by a light-guide tube (8) and an outer tube (2). The distal end (13) of the optical fibre (11) is embedded in a silicone composition (17) containing 7 parts per thousand of TiO.sub.2 particles having a particle size of 0.2 .mu.m. The silicone composition (17) fills the front end of the light-guide tube (8) as far as the end face (6) of an aluminium cylinder (5) which acts as a mirror. The light dispersed by the TiO.sub.2 particles is emitted radially through the light-guide tube (8) and the front portion of the outer tube (2) and acts on the patient's bronchi.
摘要翻译：用于照射光动力学治疗目的的患者的支气管的装置具有将激光的光进入支气管镜并被导光管（8）和外管（2）包围的光纤（11））。将光纤（11）的前端（13）嵌入含有7个/粒子尺寸为0.2μm的TiO 2粒子的硅氧烷组合物（17）中。有机硅组合物（17）将导光管（8）的前端填充至作为反射镜的铝圆筒（5）的端面（6）。由TiO 2颗粒分散的光径向地通过导光管（8）和外管（2）的前部发射并作用在患者的支气管上。

5. 发明授权

US6148227A Diagnosis apparatus for the picture providing recording of fluorescing biological tissue regions 失效
标题翻译：用于提供荧光生物组织区域记录的图像的诊断装置
公开(公告)号：US6148227A
公开(公告)日：2000-11-14
申请号：US98286
申请日：1998-06-16
申请人： Georges Wagnieres , Matthieu Zellweger , Nicolas Chauvin , Norbert Lange , Ulf Zanger , Andre Studzinski , Hubert van den Bergh
发明人： Georges Wagnieres , Matthieu Zellweger , Nicolas Chauvin , Norbert Lange , Ulf Zanger , Andre Studzinski , Hubert van den Bergh
IPC分类号： H04N5/225 , A61B5/00 , G01J3/443 , G01N21/64 , G02B23/24 , H04N7/18 , H04N9/09
CPC分类号： A61B5/0084 , A61B1/043 , A61B5/0071 , G02B23/2484 , H04N7/18
摘要： The diagnosis apparatus according to the invention for the picture providing recording of fluorescing biological tissue by way of an endoscope contains a stimulation light source which beams spectral components suitable for fluorescence stimulation into the tissue through the endoscope. The fluorescent light reflected by the tissue reaches through the endoscope optics into a head piece where it is split into a green, and spacially separated from this, a red spectral component and falls each on one half of a CCD solid body of a highly sensitive black and white camera. In an electronic and processor component the video signals allocated to the green and to the red spectral component are processed into two separate processing channels in a manner such that the separately processed green-red video signals are simultaneously inputted to a color video monitor and here may be superimposed to a red-green monitor picture, which may show changes of tissue indicating disease, for example dysplasia, carcinomas in situ etc., in all organs which are endoscopically accessible.
摘要翻译：根据本发明的用于通过内窥镜提供荧光生物组织记录的图像的诊断装置包括将通过内窥镜将适合于荧光刺激的光谱成分射入组织的刺激光源。由组织反射的荧光通过内窥镜光学器件进入头部，在其中分割成绿色，并与之空间分开，红色光谱分量，并分别落在高灵敏度黑色的CCD固体的一半上和白色相机。在电子和处理器部件中，分配给绿色和红色光谱分量的视频信号被处理成两个单独的处理通道，使得分开处理的绿色 - 红色视频信号被同时输入到彩色视频监视器，并且这里可以叠加到红绿色监视器图像上，其可以显示在内窥镜可访问的所有器官中指示疾病的组织的变化，例如发育不良，原位癌等。

6. 发明授权

US08019405B2 Device for the picture-providing diagnosis of tissue using one of at least two diagnosis modes 有权
标题翻译：用于使用至少两种诊断模式之一进行组织图像提供诊断的装置
公开(公告)号：US08019405B2
公开(公告)日：2011-09-13
申请号：US10116543
申请日：2002-04-04
申请人： Bernd Claus Weber , Thomas Goll , Olaf Schmidt , Philipp Eidner , Stefan Müller , Hubert van den Bergh , Didier Goujon , Georges Wagnières
发明人： Bernd Claus Weber , Thomas Goll , Olaf Schmidt , Philipp Eidner , Stefan Müller , Hubert van den Bergh , Didier Goujon , Georges Wagnières
IPC分类号： A61B5/05
CPC分类号： A61B1/043 , A61B1/0638 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： A device for picture-providing diagnosis of tissue is selectively operated in a picture-providing white light diagnosis mode and a picture providing auto-fluorescence mode. A color camera having red, green, and blue sensors provides a monitor which picture signals. A light source emits fluorescence excitation light and additionally emits so much red light that the red light remitted by the tissue dominates the red fluorescence light in the picture providing auto-fluorescence mode. The signal from the red sensor of the camera is damped so that normal time appears green and pre-malignant and early malignant tissue appears red.
摘要翻译：在图像提供白光诊断模式和提供自动荧光模式的图像中选择性地操作用于图像提供组织诊断的装置。具有红色，绿色和蓝色传感器的彩色摄像机为监视器提供哪些图像信号。光源发出荧光激发光，另外发出如此多的红光，由组织汇出的红光支配着提供自动荧光模式的图像中的红色荧光。来自相机红色传感器的信号被阻尼，使得正常时间呈现绿色，恶性前期和早期恶性组织呈红色。

7. 发明授权

US5117474A Device for injecting the light energy of a laser beam into a fibre-optic optical waveguide and a method for adjusting and monitoring the position of the end of the fibre-optic optical waveguide 失效
标题翻译：用于将激光束的光能注入光纤光波导的装置和用于调节和监测光纤光波导端的位置的方法
公开(公告)号：US5117474A
公开(公告)日：1992-05-26
申请号：US591536
申请日：1990-10-02
申请人： Hubert van den Bergh , Peter F. Cornaz, deceased , Max M. Cornaz, heir , Jean-Pierre Cornaz, heir , Maria I. Cornaz, heir , Georges Wagnieres
发明人： Hubert van den Bergh , Peter F. Cornaz, deceased , Max M. Cornaz, heir , Jean-Pierre Cornaz, heir , Maria I. Cornaz, heir , Georges Wagnieres
IPC分类号： G02B6/26 , G02B6/32 , G02B6/42 , G02B7/00
CPC分类号： G02B6/4222 , G02B6/4224
摘要： In a device for injecting the light energy of a laser beam into a multimode fibre-optic optical waveguide (2) a small part of the light emerging from the end face of the optical waveguide (2) is projected through a beam splitting cube (7) and a reproducing lens (21) onto a display screen (1), so that an image (24) of the end face of the optical waveguide (2) can be observed on the display screen (1). The arrangement is such that the system is correctly focused only when the distance between the optical waveguide (2) and a focusing point of the laser beam (12) reaches an intended value. The light spot of the laser beam on the end face of the optical waveguide (2) is clearly visible on the display screen (1) so than an optimum positioning and adjustment can be readily effected.
摘要翻译：在用于将激光束的光能注入多模光纤光波导（2）的装置中，从光波导（2）的端面出射的一小部分光通过分束立方体（7）突出）和再现透镜（21）到显示屏（1）上，使得可以在显示屏（1）上观察到光波导（2）的端面的图像（24）。该布置使得只有当光波导（2）和激光束（12）的聚焦点之间的距离达到预期值时，系统才正确地聚焦。激光束在光波导（2）的端面上的光点在显示屏（1）上清晰可见，因此可以容易地实现最佳的定位和调整。

8. 发明授权

US5219346A Light diffuser for the photodynamic therapy of tumors in the oesophagus of a patient 失效
标题翻译：用于患者食欲的肿瘤的光动力治疗的光扩散器
公开(公告)号：US5219346A
公开(公告)日：1993-06-15
申请号：US638249
申请日：1991-01-04
申请人： Georges Wagnieres , Hubert van den Bergh , Philippe Monnier
发明人： Georges Wagnieres , Hubert van den Bergh , Philippe Monnier
IPC分类号： A61B18/20 , A61B18/22 , A61B19/00 , A61N5/06 , H01S3/00
CPC分类号： A61N5/062 , A61N5/0601 , A61B2018/2261 , A61B90/39 , A61N2005/0609
摘要： A light diffuser for simultaneous photodynamic therapy and hyperthermic treatment in the oesophagus has an arrangement (14 to 18) which disperses radially the light (10) fed in by way of an optical fiber (6) and has a tube (12) filled with silicone to which are added concentrations, modulated in the axial direction, of quartz grains having a diameter of approximately 40 .mu.m which bring about a refraction having little dependence on the wavelength.
摘要翻译：用于在食管中同时进行光动力学治疗和热疗治疗的光扩散器具有通过光纤（6）径向分散进入的光（10）的布置（14至18），并且具有填充有硅氧烷的管（12）在轴向方向上调制的直径为约40μm的石英晶粒的浓度增加，这导致对波长几乎没有依赖性的折射。

9. 发明授权

US5146917A Fibre-optic apparatus for the photodynamic treatment of tumors 失效
标题翻译：用于光动力治疗肿瘤的光纤设备
公开(公告)号：US5146917A
公开(公告)日：1992-09-15
申请号：US638248
申请日：1991-01-04
申请人： Georges Wagnieres , Hubert van den Bergh , Philippe Monnier
发明人： Georges Wagnieres , Hubert van den Bergh , Philippe Monnier
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , H01S3/00
CPC分类号： A61N5/062 , A61N5/0601
摘要： A bronchoscope has a fibre-optic apparatus for the photodynamic treatment of tumors in the region of the furcate branches of the bronchi, the divergent pencil of rays (13), which emerges from the end face (9) of an optical fibre, striking a lens arrangement consisting of two microlenses (14,15) which, owing to the spherical aberration, deflect edge rays (23) in the divergent pencil of rays (13) of the optical fibre (8) in such a manner that a homogeneous sharp-edged emerging pencil of rays is formed.
摘要翻译：支气管镜具有光纤装置，用于在支气管的分枝分支区域中的肿瘤的光动力治疗，即从光纤的端面（9）出射的发散的射线（13），撞击到透镜布置由两个微透镜（14,15）组成，其由于球面像差，使得光纤（8）的发射线（13）中的边缘光线（23）偏转，使得均匀的锐利形成了新兴的射线铅笔。

10. 发明授权

US5068515A Apparatus for homogenizing the non-homogeneous light distribution of a laser beam 失效
标题翻译：用于使激光束的非均匀光分布均匀化的装置
公开(公告)号：US5068515A
公开(公告)日：1991-11-26
申请号：US630120
申请日：1990-12-19
申请人： Hubert van den Bergh , Peter F. Cornaz, deceased , Max M. Cornaz, heir , Jean-Pierre Cornaz, heir , Maria I. Cornaz, heir , Georges Wagnieres
发明人： Hubert van den Bergh , Peter F. Cornaz, deceased , Max M. Cornaz, heir , Jean-Pierre Cornaz, heir , Maria I. Cornaz, heir , Georges Wagnieres
IPC分类号： A61B18/20 , A61N5/06 , A61N5/067 , G02B6/00 , G02B6/14 , G02B21/06 , G02B27/09
CPC分类号： A61N5/062 , G02B6/14 , A61N2005/0644
摘要： An apparatus for precise, homogeneous and sharp-edged irradiation of a large area with the light of a laser beam (5), which can be used especially for large-area photodynamic therapy, is provided with a multimode fibre (10), which is illuminated by the laser beam by way of a microscope objective (4) and has a length of approximately 5 meters, and the end face (13) of which is imaged onto an irradiated area (7) of a working surface (6) by means of a microscope (17).
摘要翻译：用于特别用于大面积光动力治疗的激光束（5）的光的大面积精确，均匀和锐利照射的装置设置有多模光纤（10），其是由激光束通过显微镜物镜（4）照射并具有大约5米的长度，其端面（13）通过装置成像到工作表面（6）的照射区域（7）上的显微镜（17）。

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