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1. 发明授权

US5570182A Method for detection of dental caries and periodontal disease using optical imaging 失效
标题翻译：使用光学成像检测龋齿和牙周病的方法
公开(公告)号：US5570182A
公开(公告)日：1996-10-29
申请号：US250492
申请日：1994-05-27
申请人： Howard Nathel , John H. Kinney , Linda L. Otis
发明人： Howard Nathel , John H. Kinney , Linda L. Otis
IPC分类号： A61B5/00 , G01D9/02
CPC分类号： A61B5/0066 , A61B5/0088
摘要： A method for detecting the presence of active and inactive caries in teeth and diagnosing periodontal disease uses non-ionizing radiation with techniques for reducing interference from scattered light. A beam of non-ionizing radiation is divided into sample and reference beams. The region to be examined is illuminated by the sample beam, and reflected or transmitted radiation from the sample is recombined with the reference beam to form an interference pattern on a detector. The length of the reference beam path is adjustable, allowing the operator to select the reflected or transmitted sample photons that recombine with the reference photons. Thus radiation scattered by the dental or periodontal tissue can be prevented from obscuring the interference pattern. A series of interference patterns may be generated and interpreted to locate dental caries and periodontal tissue interfaces.
摘要翻译：用于检测牙齿中活性和非活动性龋齿的存在并诊断牙周病的方法使用非电离辐射来减少来自散射光的干扰的技术。非电离辐射束被分为采样和参考光束。要检查的区域被样品束照射，并且来自样品的反射或透射辐射与参考光束重新结合，以在检测器上形成干涉图案。参考光束路径的长度是可调节的，允许操作者选择与参考光子重组的反射或透射的样品光子。因此，可以防止由牙齿或牙周组织散射的辐射遮蔽干涉图案。可以产生和解释一系列干涉图案以定位龋齿和牙周组织界面。

2. 发明授权

US6015969A Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media 失效
标题翻译：散射介质中光吸收物质的多波长光谱定量
公开(公告)号：US6015969A
公开(公告)日：2000-01-18
申请号：US8234
申请日：1998-01-16
申请人： Howard Nathel , Harry E. Cartland , Billy W. Colston, Jr. , Matthew J. Everett , Jeffery N. Roe
发明人： Howard Nathel , Harry E. Cartland , Billy W. Colston, Jr. , Matthew J. Everett , Jeffery N. Roe
IPC分类号： G01N21/31 , G01B9/02
CPC分类号： G01N21/314
摘要： An oxygen concentration measurement system for blood hemoglobin comprises a multiple-wavelength low-coherence optical light source that is coupled by single mode fibers through a splitter and combiner and focused on both a target tissue sample and a reference mirror. Reflections from both the reference mirror and from the depths of the target tissue sample are carried back and mixed to produce interference fringes in the splitter and combiner. The reference mirror is set such that the distance traversed in the reference path is the same as the distance traversed into and back from the target tissue sample at some depth in the sample that will provide light attenuation information that is dependent on the oxygen in blood hemoglobin in the target tissue sample. Two wavelengths of light are used to obtain concentrations. The method can be used to measure total hemoglobin concentration [Hb.sub.deoxy +Hb.sub.oxy ] or total blood volume in tissue and in conjunction with oxygen saturation measurements from pulse oximetry can be used to absolutely quantify oxyhemoglobin [HbO.sub.2 ] in tissue. The apparatus and method provide a general means for absolute quantitation of an absorber dispersed in a highly scattering medium.
摘要翻译：用于血液血红蛋白的氧浓度测量系统包括多波长低相干光学光源，其由单模光纤通过分离器和组合器耦合并聚焦在目标组织样本和参考反射镜两者上。来自参考镜和来自目标组织样本的深度的反射被携带并混合以在分离器和组合器中产生干涉条纹。参考镜被设置为使得在参考路径中穿过的距离与在样本中的某个深度处从目标组织样本穿过的距离相同，其将提供取决于血液血红蛋白中的氧的光衰减信息在目标组织样本中。使用两个波长的光来获得浓度。该方法可用于测量组织中总血红蛋白浓度[Hbdeoxy + Hboxy]或总体积，并结合脉搏血氧饱和度测量结果，可用于绝对量化组织中的氧合血红蛋白[HbO2]。该装置和方法提供了用于绝对定量分散在高度散射介质中的吸收体的一般手段。

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