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1. 发明申请

US20110114549A1 MICROFLUIDIC DEVICE COMPRISING SEPARATION COLUMNS 审中-公开
标题翻译：包含分离柱的微流体装置
公开(公告)号：US20110114549A1
公开(公告)日：2011-05-19
申请号：US12617926
申请日：2009-11-13
申请人： Hongfeng Yin , Kevin Killeen , Karsten Kraiczek
发明人： Hongfeng Yin , Kevin Killeen , Karsten Kraiczek
IPC分类号： B01D15/22
CPC分类号： G01N30/6004 , B01L3/502753 , B01L2300/0816 , B01L2300/0838 , B01L2300/0883 , G01N30/6095
摘要： A microfluidic chip comprises a first substantially linear separation column having a first length, the first separation column comprising a first stationary phase particle density distribution along the first length; and a second substantially linear separation column having a second length connected in series with the first separation column, the second separation column comprising a second stationary phase particle density distribution along the second length.
摘要翻译：微流体芯片包括具有第一长度的第一基本线性分离柱，所述第一分离柱包括沿着所述第一长度的第一固定相颗粒密度分布; 以及具有与所述第一分离柱串联连接的第二长度的第二基本线性分离柱，所述第二分离塔包括沿所述第二长度的第二固定相颗粒密度分布。

2. 发明申请

US20080190840A1 Microfluidic Device with at Least One Retaining Device 审中-公开
标题翻译：具有至少一个固定装置的微流体装置
公开(公告)号：US20080190840A1
公开(公告)日：2008-08-14
申请号：US11547696
申请日：2005-02-03
申请人： Jan Eickhoff , Patrick Mueller , Jose Angel Mora-Fillat , Karsten Kraiczek , Kevin Killeen , Hongfeng Yin
发明人： Jan Eickhoff , Patrick Mueller , Jose Angel Mora-Fillat , Karsten Kraiczek , Kevin Killeen , Hongfeng Yin
IPC分类号： B01D35/00 , B32B37/00 , B01J19/12 , B29C39/02
CPC分类号： B01L3/502753 , Y10T156/10
摘要： A microfluidic device comprising at least one inlet port, at least one flow path coupled to the inlet port, and at least one fluid separation element coupled to the flow path, wherein the fluid separation element comprises a packing material and is adapted for separating different components of a fluid, wherein the microfluidic device comprises at least one retaining device for keeping the packing material of the fluid separation element fixed in place and protecting the microfluidic device from debris polluting the analyte.
摘要翻译：一种微流体装置，包括至少一个入口端口，连接到入口端口的至少一个流动路径，以及耦合到流动路径的至少一个流体分离元件，其中流体分离元件包括填充材料，并且适于分离不同的部件的流体，其中所述微流体装置包括至少一个保持装置，用于将所述流体分离元件的包装材料固定就位并保护所述微流体装置免受污染所述分析物的碎屑。

3. 发明申请

US20060219637A1 Devices, systems and methods for liquid chromatography 审中-公开
标题翻译：液相色谱仪的设备，系统和方法
公开(公告)号：US20060219637A1
公开(公告)日：2006-10-05
申请号：US11093605
申请日：2005-03-29
申请人： Kevin Killeen , Hongfeng Yin , Karsten Kraiczek
发明人： Kevin Killeen , Hongfeng Yin , Karsten Kraiczek
IPC分类号： B01D15/08
CPC分类号： G01N30/10 , G01N30/20 , G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/385
摘要： Devices comprising a mechanism for selectively diverting a portion of a mobile phase flowing through a mobile-phase transporting conduit to a fluid-transporting conduit comprising a stationary phase for separating sample components are disclosed, as well as systems and methods for using the same.
摘要翻译：公开了一种用于选择性地将流过流动相输送管道的流动相的一部分转移到包括用于分离样品组分的固定相的流体输送导管的机构的装置，以及用于分离样品组分的系统和方法。

4. 发明申请

US20110132077A1 MULTI-WAVELENGTH LIGHT SOURCE 审中-公开
标题翻译：多波长光源
公开(公告)号：US20110132077A1
公开(公告)日：2011-06-09
申请号：US12737693
申请日：2009-07-22
申请人： Kevin P. Killeen , Karsten Kraiczek , Hubert Kuderer
发明人： Kevin P. Killeen , Karsten Kraiczek , Hubert Kuderer
IPC分类号： G01N30/00 , G01N30/74 , F21V11/00
CPC分类号： G01N30/74 , G01J2003/102 , G01N21/05 , G01N21/31 , G01N2021/0346 , G01N2021/3129 , G01N2021/3133 , G01N2021/3148 , G01N2021/317 , G01N2030/027 , G01N2201/06153 , G01N2201/0627 , G01N2201/0638
摘要： A fluid separation system (10) for separating compounds of a sample fluid in a mobile phase comprises a detector (50) adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal to the optical stimulus signal. The detector (50) comprises a light source (100) adapted to provide an output light beam (230) as the optical stimulus signal. The light source (100) comprises a plurality of light emitting elements (200, 200A, 200Z) each adapted to emit a light beam (210, 210A1, 210A2, 210Z1, 210Z2) having a respective wavelength, and a diffracting element (220). The plurality of light emitting elements (200, 200A, 200Z) are arranged that emitted light beams (210, 210A1, 210A2, 210Z1, 210Z2) impinging, on the diffracting element (220) are diffracted by the diffracting element (220) to form the output light beam (230).
摘要翻译：用于分离流动相中的样品流体的化合物的流体分离系统（10）包括适于通过向样品流体提供光学刺激信号并且接收对光学刺激信号的响应信号来检测分离的化合物的检测器（50）。检测器（50）包括适于提供输出光束（230）作为光学刺激信号的光源（100）。光源（100）包括多个发光元件（200,200A，200Z），每个发光元件适于发射具有相应波长的光束（210,210A1,210A2,210Z1,210Z2）和衍射元件（220），。多个发光元件（200,200A，200Z）被布置成入射到衍射元件（220）上的发射光束（210,210A1,210A2,210Z1,210Z2）被衍射元件（220）衍射以形成输出光束（230）。

5. 发明授权

US5615010A Diode array spectrophotometer 失效
标题翻译：二极管阵列分光光度计
公开(公告)号：US5615010A
公开(公告)日：1997-03-25
申请号：US589075
申请日：1996-01-23
申请人： Karsten Kraiczek , Bernhard Dehmer
发明人： Karsten Kraiczek , Bernhard Dehmer
IPC分类号： G01J3/28 , G02B7/00 , G01J3/02 , G01J3/18
CPC分类号： G02B7/00 , G01J3/2803
摘要： A diode array spectrophotometer has an entrance slit apparatus, a diffraction grating, a diode array and a casing to define the relative positions of these elements. The casing and the holder for accepting the diffraction grating are made of a ceramic whose coefficient of thermal expansion is adapted to that of the diode array. The grating holder has a cylindrical outer surface and is situated within a conic-frustum-shaped opening of the casing. Between the grating holder and the conic-frustum-shaped opening, there are a plurality of filler elements which are made of ceramic or glass.
摘要翻译：二极管阵列分光光度计具有入口狭缝装置，衍射光栅，二极管阵列和壳体，以限定这些元件的相对位置。用于接受衍射光栅的壳体和保持器由其热膨胀系数适应于二极管阵列的系数的陶瓷制成。光栅保持器具有圆柱形外表面并且位于壳体的锥形截头锥形开口内。在光栅保持器和锥形截头锥形开口之间，存在多个由陶瓷或玻璃制成的填充元件。

6. 发明授权

US5513031A Adjustable optical component 失效
标题翻译：可调光学元件
公开(公告)号：US5513031A
公开(公告)日：1996-04-30
申请号：US245243
申请日：1994-05-17
申请人： Raymond Vuilleumier , Karsten Kraiczek , Axel Wiese
发明人： Raymond Vuilleumier , Karsten Kraiczek , Axel Wiese
IPC分类号： G01J3/04 , G02B26/02
CPC分类号： G01J3/04
摘要： An adjustable optical component, for example an optical slit having adjustable slit width, comprises a movable member for providing an optical function, for example a slit and/or a shutter, and resilient suspension elements for connecting the movable member to a frame. The essential parts of the movable member, of the resilient suspension elements and of the frame consist of microstructures which are made of a common base material. Preferably, these parts are manufactured from a silicon chip by a micromechanical technique comprising, for example, anisotropic etching. In the case of an optical slit, the movable member comprises a plurality of openings of different widths which constitute a step slit. In order to adjust different slit widths, the member is moved along a line parallel to the center line of the step slit, with the force for moving the member being applied at an opening. When the member is moved by an external force, the resilient silicon beams are bending and the bars are moving. The movable member has an integrated shutter position. A high reproducibility of the adjustment of the center positions of the openings constituting the step slit during repeated movement of the member is ensured.
摘要翻译：可调节光学部件，例如具有可调狭缝宽度的光学狭缝，包括用于提供光学功能的可移动部件，例如狭缝和/或快门，以及用于将可移动部件连接到框架的弹性悬挂元件。弹性悬挂元件和框架的可动构件的主要部件由由共同的基底材料制成的微结构构成。优选地，这些部件通过包括例如各向异性蚀刻的微机械技术由硅芯片制造。在光学狭缝的情况下，可移动部件包括构成台阶狭缝的不同宽度的多个开口。为了调整不同的狭缝宽度，构件沿着平行于台阶狭缝的中心线的线移动，其中用于使构件移动的力被施加在开口处。当构件通过外力移动时，弹性硅梁弯曲并且杆移动。可动构件具有一体的快门位置。确保了在构件的重复移动期间构成台阶狭缝的开口的中心位置的调整的高再现性。

7. 发明申请

US20070132230A1 Coupling for conduits sealed in a recess of a housing 有权
标题翻译：用于密封在壳体的凹部中的管道的联接
公开(公告)号：US20070132230A1
公开(公告)日：2007-06-14
申请号：US11302873
申请日：2005-12-14
申请人： Jochen Mueller , Karsten Kraiczek , Bertram Beigel
发明人： Jochen Mueller , Karsten Kraiczek , Bertram Beigel
IPC分类号： F16L39/00
CPC分类号： G01N21/05 , B01L3/502715 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , G01N21/85 , G01N2021/0346
摘要： A coupling for bringing a first conduit in communication with a second conduit. Each of the conduits comprises an end to be coupled and each of the conduits is adapted for conducting a medium. The coupling has a housing and at least one aperture in said housing. The housing is adapted for introducing said first and second conduits into the housing. Furthermore, the coupling comprises a recess in the housing. The recess is adapted for partly receiving the ends of the first and second conduits. The coupling has a seal adapted for sealing the first and second conduits within the recess.
摘要翻译：用于使第一导管与第二导管连通的联接器。每个导管包括要连接的端部，并且每个导管适于传导介质。联轴器具有壳体和所述壳体中的至少一个孔。壳体适于将所述第一和第二导管引入壳体。此外，联接器包括在壳体中的凹部。凹部适于部分地接收第一和第二导管的端部。联接器具有适于密封凹部内的第一和第二导管的密封件。

8. 发明申请

US20070071638A1 Parallel processing microfluidic chip 审中-公开
标题翻译：并行处理微流控芯片
公开(公告)号：US20070071638A1
公开(公告)日：2007-03-29
申请号：US11603404
申请日：2006-11-22
申请人： Karsten Kraiczek , Bernd Glatz , Patrick Mueller , Jan Eickhoff , Martin Baeuerle , Herbert Anderer
发明人： Karsten Kraiczek , Bernd Glatz , Patrick Mueller , Jan Eickhoff , Martin Baeuerle , Herbert Anderer
IPC分类号： G01N21/00
CPC分类号： G01N30/466 , B01L3/5025 , B01L3/502738 , B01L2400/0622 , G01N30/20 , G01N30/6095 , G01N30/724 , G01N2030/085 , G01N2030/201 , G01N2030/202 , H01J41/04 , H01J49/04
摘要： A microfluidic chip with at least one inlet port, with at least one microfluidic flow path coupled to the inlet port, and with at least one analytical element adapted for analyzing and/or separating components of a liquid within the flow path which is arranged within or adjacent to, and/or is coupled to the microfluidic flow path. The microfluidic chip is adapted to execute at least two processes in parallel.
摘要翻译：具有至少一个入口端口的微流体芯片，其具有耦合到入口端口的至少一个微流体流动路径，以及适于分析和/或分离流路内部的液体的组分的至少一个分析元件，邻近和/或耦合到微流体流动路径。微流控芯片适于并行执行至少两个过程。

9. 发明授权

US09752978B2 Micromachined flow cell with freestanding fluidic tube 有权
公开(公告)号：US09752978B2
公开(公告)日：2017-09-05
申请号：US14376430
申请日：2012-02-03
申请人： Karsten Kraiczek , John Mannion , Kevin P. Killeen
发明人： Karsten Kraiczek , John Mannion , Kevin P. Killeen
IPC分类号： G01N21/05 , B01L3/00 , G01N30/74 , G01N33/543 , B32B37/18 , B32B38/10 , G01N21/03 , G01N30/02
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0838 , B32B37/18 , B32B38/10 , B32B2551/00 , G01N30/74 , G01N33/54373 , G01N2021/0346 , G01N2021/052 , G01N2021/056 , G01N2030/027 , G01N2030/746 , G01N2201/08 , Y10T156/10
摘要： A micromachined flow cell includes a substrate and a freestanding tube, delimiting a fluidic conduit therein and being integrally formed from material of the substrate.

10. 发明授权

US07651280B2 Coupling for conduits sealed in a recess of a housing 有权
标题翻译：用于密封在壳体的凹部中的管道的联接
公开(公告)号：US07651280B2
公开(公告)日：2010-01-26
申请号：US11302873
申请日：2005-12-14
申请人： Jochen Mueller , Karsten Kraiczek , Bertram Beigel
发明人： Jochen Mueller , Karsten Kraiczek , Bertram Beigel
IPC分类号： G02B6/36 , G02B6/00 , G01N1/10
CPC分类号： G01N21/05 , B01L3/502715 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , G01N21/85 , G01N2021/0346
摘要： A coupling for bringing a first conduit in communication with a second conduit. Each of the conduits comprises an end to be coupled and each of the conduits is adapted for conducting a medium. The coupling has a housing and at least one aperture in said housing. The housing is adapted for introducing said first and second conduits into the housing. Furthermore, the coupling comprises a recess in the housing. The recess is adapted for partly receiving the ends of the first and second conduits. The coupling has a seal adapted for sealing the first and second conduits within the recess.
摘要翻译：用于使第一导管与第二导管连通的联接器。每个导管包括要连接的端部，并且每个导管适于传导介质。联轴器具有壳体和所述壳体中的至少一个孔。壳体适于将所述第一和第二导管引入壳体。此外，联接器包括在壳体中的凹部。凹部适于部分地接收第一和第二导管的端部。联接器具有适于密封凹部内的第一和第二导管的密封件。

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