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1. 发明专利

JP2007097641A Electrode structure for iontophoresis used to administer drug enclosed in liposome and iontophoresis device making use of the same 审中-公开
标题翻译：用于用脂质体包裹的管理药物的静电结构的电极结构和使用其的异源装置
公开(公告)号：JP2007097641A
公开(公告)日：2007-04-19
申请号：JP2005288167
申请日：2005-09-30
申请人： Hokkaido Univ , Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社 , 国立大学法人北海道大学
发明人： AKIYAMA HIDEO , KOGURE KENTARO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide an electrode structure for iontophoresis which enables iontophoresis administration of drugs even those administered without ionization or those insoluble or hardly soluble in water and confers disirable functions in drug delivery to such drugs or drugs administered after ionization. SOLUTION: The electrode structure for iontophoresis holds a drug enclosed in ionic liposomes. The electrode structure at least comprises an electrode connected to a power source having the same polarity as the ionic liposomes held within the electrode structure, an electrolyte holding section arranged adjacent to the electrode for impregnating and holding an electrolyte, an ion exchange membrane arranged adjacent to the electrolyte holding section for selecting ions having a polarity opposite to the ionic liposomes, a drug solution holding section arranged adjacent to the ion exchange membrane for impregnating and holding the ionic liposomes, and an ion exchange membrane for selecting ions having the same polarity as the ionic liposomes. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于离子电渗疗法的电极结构，其即使是没有电离的药物也能够进行离子电渗治疗，或者不溶于或几乎不溶于水的药物的离子电渗给药，并且在药物递送中赋予药物或电离后施用的药物的令人不快的功能。解决方案：用于离子电渗疗法的电极结构保持封闭在离子脂质体中的药物。电极结构至少包括连接到具有与保持在电极结构内的离子脂质体相同极性的电源的电极，与电极相邻设置的用于浸渍和保持电解质的电解质保持部分，邻近设置的离子交换膜用于选择具有与离子脂质体相反的极性的离子的电解质保持部分，与用于浸渍和保持离子性脂质体的离子交换膜相邻设置的药物溶液保持部分，以及用于选择具有相同极性的离子的离子交换膜离子脂质体。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2007135893A Iontophoresis apparatus and working-side electrode unit 审中-公开
标题翻译：电子装置和工作电极单元
公开(公告)号：JP2007135893A
公开(公告)日：2007-06-07
申请号：JP2005334314
申请日：2005-11-18
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： YAMAMOTO AKIRA , MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To promote transdermal administration of medicines in an iontophoresis apparatus administering drug ions to a living body.
SOLUTION: This iontophoresis apparatus 10 administering the drug ions to the living body is provided with a first electrode member 210 electrically connected to a first conductivity type terminal 62, a same conductivity type to the drug ions in a main power supply 60, a working-side electrode structure 200 having a medicinal solution retaining section 240 retaining the medicine and disposed in an electric field formed by the first electrode member 210, a non-working-side electrode structure 300 electrically connected to a second conductivity type terminal 64, or the opposite conductivity type to the first conductivity type in the main power supply 60, an ultrasonic oscillator oscillating ultrasonic waves, and a vibration section 400 having an ultrasonic vibrator 420 vibrating by ultrasonic waves fed from the ultrasonic oscillator 410. The ultrasonic vibrator 420 is disposed close to the working-side electrode structure 200.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：在向生物体施用药物离子的离子电渗疗法中促进药物的透皮给药。该离子电渗疗法装置10向生物体施用药物离子，设置有与第一导电型端子62电连接的第一电极部件210，与主电源60中的药物离子相同的导电型，工作侧电极结构200，其具有保持药物并设置在由第一电极部件210形成的电场中的药液保持部240;电连接到第二导电型端子64的非工作侧电极结构体300，或与主电源60中的第一导电类型相反的导电类型，超声波振荡器振荡超声波，以及具有由超声波振荡器410提供的超声波振动的超声波振动器420的振动部400.超声波振动器420 设置在工作侧电极结构200附近。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2007075536A Transcutaneous extraction apparatus and iontophoresis system 审中-公开
标题翻译： TRANSCUTANEOUS EXTRACTION APPARATUS AND IONTOPHORESIS SYSTEM
公开(公告)号：JP2007075536A
公开(公告)日：2007-03-29
申请号：JP2005270969
申请日：2005-09-16
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： UCHIYAMA KAZUMI , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , AKIYAMA HIDEO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide a transcutaneous extraction apparatus where a speed and efficiency for extracting internal components are raised. SOLUTION: The shift of anion to a living body side in an internal component storage part 14a is blocked by a cation exchange film 15a in the transcutaneous extraction apparatus having an extraction side electrode structure body 10a, so that most part of amount of an electric current applied to an electrode 11a contribute to the shift of the cation to the internal component storage part 14a from a living body. An anion exchange film 13b blocks or limits the passage of cation and also permits the passage of anion. Consequently, the flow-in amount of the cation from the living body to the internal component storage part 14a is increased and the migration flow of the cation allows the flow-in amount of internal neutral molecules and the anion to the internal component storage part 14a to be increased. Thus, the various kinds of internal components including: the internal cation; the neutral molecules; and the anion, are extracted at higher speed or with higher efficiency. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种提取用于提取内部部件的速度和效率的经皮提取装置。解决方案：在具有提取侧电极结构体10a的经皮提取装置中，阳离子交换膜15a阻止内部组分存储部分14a中的阴离子向活体侧的移动，使得大部分量的施加到电极11a的电流有助于阳离子从活体向内部部件收容部14a的移动。阴离子交换膜13b阻挡或限制阳离子的通过并且还允许阴离子通过。因此，阳离子从生物体向内部成分保持部14a的流入量增加，阳离子的迁移流量允许内部中性分子和阴离子流入内部部件收纳部14a的流入量增加。因此，各种内部组件包括：内部阳离子; 中性分子; 并以较高的速度或更高的效率提取阴离子。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007075504A Iontophoresis device administering same medical agent with moving on regions to be administered over time 审中-公开
标题翻译： IOPOPHORESIS DEVICE ADMINISTERING SAME MEDICAL AGENT WITH MOVING ON REGIONS待管理时间
公开(公告)号：JP2007075504A
公开(公告)日：2007-03-29
申请号：JP2005270357
申请日：2005-09-16
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： TSUJI KAZUYUKI , SHIBATA TSUTOMU , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , AKIYAMA HIDEO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis device capable of administering an identical medical agent with moving on regions to be administered over time.
SOLUTION: The iontophoresis device comprises an electric power unit, a medical agent administering means at least including at least three electrode structures connected to the electric power unit, and a current control means to respectively control currents passing through the electrode structures. The medical agent administering means includes at least two first electrode structures to keep the identical ionic medical agent, and at least a second electrode structure as a counter electrode of the first electrode structures not to keep the ionic medical agent. The iontophoresis device can administer the identical medical agent with moving on the regions to be administered over time when the first electrode structures respectively discharge and administer a predetermined amount of the ionic medical agent to a living body in response to the current amount passing from the current control means.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供能够在随时间施用的区域上移动相同的药剂的离子电渗疗法装置。离子电渗疗法装置包括电力单元，至少包括连接到电力单元的至少三个电极结构的药剂施用装置和分别控制通过电极结构的电流的电流控制装置。药剂施用装置包括至少两个第一电极结构以保持相同的离子药剂，并且至少第二电极结构作为第一电极结构的对电极不能保持离子药剂。离子电渗装置可以在第一电极结构分别放电并将预定量的离子药剂施用于生物体以响应于从电流流过的电流量而在随时间施用的区域上移动时施用相同的药剂控制手段。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2007075374A Iontophoresis device and power supply device for iontophoresis device 审中-公开
标题翻译： IOPOPHORESIS设备和用于静电放电装置的电源装置
公开(公告)号：JP2007075374A
公开(公告)日：2007-03-29
申请号：JP2005267587
申请日：2005-09-14
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： NAKAYAMA HATOO , KANEMURA KIYOSHI , MATSUMURA TAKEHIKO , AKIYAMA HIDEO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To limit the dose to an allowable value or lower even if an iontophoresis device is stuck to the skin for a long period of time by mistake. SOLUTION: The iontophoresis device comprises a power supply device with a battery 46 and a constant current power supply circuit 47 including a booster circuit, and a medicament dosing means connected to the power supply device and including at least electrode structures 12 and 14 for holding an ionic medicament. The ionic medicament is released from the electrode structures according to the current fed to the electrode structures to be percutaneously applied to a living body. The discharge time is controlled to a prescribed value or lower by taking out a larger volume of electric currents than normal and by the design of the battery, so that dosing of the medicament can be automatically stopped. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：即使离子电渗疗法装置被误认为长时间粘在皮肤上，也可将剂量限制在允许值以下。离子电渗装置包括具有电池46的电源装置和包括升压电路的恒流电源电路47以及连接到电源装置并且至少包括电极结构12和14的药剂计量装置用于保持离子药物。离子药物根据馈送到电极结构的电流从电极结构释放，以经皮施加到生物体上。通过取出比正常电流和电池设计更大的电流来将放电时间控制在规定值以下，从而可以自动停止药物的给药。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2007037868A Transdermal administration device and its controlling method 审中-公开
标题翻译：超导管理装置及其控制方法
公开(公告)号：JP2007037868A
公开(公告)日：2007-02-15
申请号：JP2005227377
申请日：2005-08-05
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO , MATSUMURA AKIHIKO , KANEMURA KIYOSHI , TANIOKA AKIHIKO
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0428 , A61N1/0436 , A61N1/0448
摘要： PROBLEM TO BE SOLVED: To provide a transdermal administration device which increases a transfer speed of a medical substance into a skin and the transferring amount of the medical substance.
SOLUTION: An action side structure body A1 is equipped with an electrode member 11 connected to the positive pole of a power source C, an electrolytic solution retaining part 12 which retains an electrolytic solution and makes contact with the electrode member 11, and a bipolar membrane 13 which is disposed on the front side (on the side of a skin) of the electrolytic solution retaining part 12 and comprises an anion exchange membrane 13A and a cation exchange membrane 13C, and is housed in a container 14. A non-action side structure body B is equipped with an electrode member 21 connected to the negative pole of the power source C and an electrolytic solution retaining part 22 which retains an electrolytic solution and makes contact with the electrode member 21, and is housed in a container 24. Consequently, H
+ ions generated by the electrolysis of water in the bipolar membrane 13 are supplied to the front side of the bipolar membrane 13 and are transferred in the skin S by the action of a positive voltage V1. Then a pH value of the skin S is reduced. Not only the molecules of the medical substance but also negative medical ions in a medical solution layer 15 are transferred in the skin S.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种将药物转移到皮肤中的转移速度和药物的转移量的透皮给药装置。解决方案：动作侧结构体A1配备有连接到电源C的正极的电极构件11，保持电解液并与电极构件11接触的电解液保持部12，以及设置在电解液保持部12的前侧（皮肤侧）的双极性膜13，其包含阴离子交换膜13A和阳离子交换膜13C，容纳在容器14中。配置侧结构体B配备有与电源C的负极连接的电极部件21和电解液保持部22，电解液保持部22保持电解液并与电极部件21接触，容纳在容器因此，通过双极膜13中的水的电解产生的H

7. 发明专利

JP2006212194A Iontophoresis device 有权
标题翻译： IONTOPHORESIS设备
公开(公告)号：JP2006212194A
公开(公告)日：2006-08-17
申请号：JP2005027748
申请日：2005-02-03
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： TANIOKA AKIHIKO , MINAGAWA YOSHIE , KANEMURA KIYOSHI , MATSUMURA AKIHIKO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , AKIYAMA HIDEO
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis device having high administration efficiency of medicines.
SOLUTION: The iontophoresis device is provided with an action pole structure comprising: an electrode to which a positive voltage is applied; a medicine holding part arranged on the front surface side of the electrode for holding a liquid medicine containing medicine ions charged to be positive; and a cellulose based resin membrane arranged on the front surface side of the medicine holding part or a composite membrane arranged on the front surface side of the medicine holding part, which is the composite membrane composed of a cation exchange membrane and the cellulose based resin membrane arranged on the front surface side of the cation exchange membrane. The medicine ions are administered through the cellulose based resin membrane.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有高药物施用效率的离子电渗疗法装置。解决方案：离子电渗装置设置有动作极结构，包括：施加正电压的电极; 药剂保持部，其配置在所述电极的前表面侧，用于保持含有药物离子的液体药剂，以及布置在药物保持部的前表面侧的纤维素系树脂膜或配置在由阳离子交换膜和纤维素系树脂膜构成的复合膜的药剂保持部的前表面侧的复合膜布置在阳离子交换膜的前表面侧。药物离子通过纤维素基树脂膜施用。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2008043266A Method for introducing aroma substance 审中-公开
标题翻译： AROMA物质介绍方法
公开(公告)号：JP2008043266A
公开(公告)日：2008-02-28
申请号：JP2006222522
申请日：2006-08-17
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： AKIYAMA HIDEO , TSUJI KAZUYUKI
IPC分类号： A01G7/00 , A01G7/06 , A01M29/00 , A01M29/12
摘要： PROBLEM TO BE SOLVED: To provide a method for introducing aroma substance by which the concentration and the components each of aroma substance dispersed from a plant 500 can be regulated into desired ones. SOLUTION: The method for introducing aroma substance introduces aroma substance to the plant 500 so as to make the aroma substance disperse from the plant 500, and is provided with the following: a preparation procedure for preparing an iontophoresis device 10 having an acting-side electrode structure 200 where the flavor substance is ionized to be held, and an acted-side electrode structure 300 holding electrolysis solution; a contact procedure for making at least part of the acting-side electrode structure 200 and the acted-side electrode structure 300 come into contact with the plant 500; and a power supply procedure for supplying power to the midway between the acting-side electrode structure 200 and the acted-side electrode structure 300. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种引入芳香物质的方法，通过该方法，可以将从植物500分散的各种香味物质的浓度和组分调节到期望的浓度。解决方案：引入芳香物质的方法将芳香物质引入植物500，以使香料物质从植物500分散，并具有以下：制备离子电渗疗装置10的制备方法，其具有作用其中香味物质被离子化以保持的电极结构200和保持电解溶液的作用侧电极结构300; 用于使作用侧电极结构200和作用侧电极结构300的至少一部分与工厂500接触的接触步骤; 以及用于向作用侧电极结构200和作用侧电极结构300之间的中途供电的电源程序。（C）2008，JPO＆INPIT

9. 发明专利

JP2007097689A Iontophoresis apparatus and photodynamic therapy system using iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备和使用IOPOPHORESIS设备的光电治疗系统
公开(公告)号：JP2007097689A
公开(公告)日：2007-04-19
申请号：JP2005288811
申请日：2005-09-30
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KAWAKAMI HIROYOSHI , SHIBATA TSUTOMU , AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61K31/409 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus which can administer photosensitive matter to only a malignant tumor cell. SOLUTION: The iontophoresis apparatus is equipped with an electrode 22A connected to a power source 12, an electrolyte holding section 26A which is arranged in the front of the electrode 22A and holds an electrolyte, an anion exchange membrane 28A which is arranged in the front of the electrolyte holding section 26A and passes an anion selectively, a liquid medicine holding section 30A which is arranged in the front of the anion exchange membrane 28A and holds a photosensitization reactant, a cation exchange membrane 32A which is arranged in the front of the liquid medicine holding section 30A and passes a cation selectively, a working side electrode structure 20A which is arranged in a part on the front side of the cation exchange membrane 32A and has at least a release-inhibiting layer 40 to control the release of the photosensitization reactant, and a position index which is formed in the working side electrode structure 20A and can specify the position of a pasting face 60A to a living body. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种可以将光敏物质仅施用于恶性肿瘤细胞的离子电渗疗法。解决方案：离子电渗仪装置配备有连接到电源12的电极22A，布置在电极22A的前面并保持电解质的电解质保持部26A，阴离子交换膜28A 电解质保持部26A的前方，通过阴离子选择性地配置在阴离子交换膜28A的前方并保持有光敏性反应物的液体药剂保持部30A，配置在阴离子交换膜28A的前方的阳离子交换膜32A 液体药剂保持部30A选择性地通过阳离子，设置在阳离子交换膜32A的前侧的一部分中的工作侧电极结构20A，并具有至少一个释放抑制层40，以控制阳离子交换膜32A的释放。光敏反应物和在工作侧电极结构20A中形成的位置指数，并且可以将粘贴面60A的位置指定为活体。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2007089821A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007089821A
公开(公告)日：2007-04-12
申请号：JP2005283112
申请日：2005-09-28
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA TAKEHIKO , KANEMURA KIYOSHI , NAKAYAMA HATOO , AKIYAMA HIDEO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus capable of receiving a procedural advantage for granting an approval and a registration on the safety and the efficacy executed by government organizations. SOLUTION: This iontophoresis apparatus is provided with a first conductivity type ion exchange membrane doped with first conductivity type medicine ions, and a voltage impressing member for impressing a voltage to the first ion exchange membrane; and the voltage impressing member includes an electrode, an electrolyte retaining section retaining electrolyte coming into contact with the electrode and a detachable impermeable separator disposed in the front face side of the electrolyte retaining section. This iontophoresis apparatus is constituted to dose the medicine ions in such a state that the separator is detached and the first ion exchange membrane is disposed in the front face side of the electrolyte retaining section. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种离子电渗仪器，能够获得批准和注册政府机构执行的安全性和效力的程序优势。解决方案：该离子电渗仪设置有掺杂有第一导电型药物离子的第一导电型离子交换膜和用于向第一离子交换膜施加电压的电压施加构件; 并且电压施加构件包括电极，与电极接触的保持电解质的电解质保留部分和设置在电解质保持部的正面侧的可拆卸的不可渗透隔板。该离子电渗疗法装置构成为以分离器分离的状态剂量药物离子，第一离子交换膜设置在电解质保持部的正面侧。版权所有（C）2007，JPO＆INPIT

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