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1. 发明专利

JP2007167407A Diagnostic agent administration type iontophoresis apparatus 审中-公开
标题翻译：诊断代理管理类型IOPOPHORESIS设备
公开(公告)号：JP2007167407A
公开(公告)日：2007-07-05
申请号：JP2005370130
申请日：2005-12-22
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KAWAKAMI HIROYOSHI , AKIYAMA HIDEO , SAITO AKIYOSHI , KANEMURA KIYOSHI
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus being non-invasive to a living body and efficiently and simply administering a diagnostic agent.
SOLUTION: This iontophoresis apparatus is provided with an electric power unit, a working electrode structure connected to the electric power unit, releasing the diagnostic agent by iontophoresis and percutaneously administering it to the living body, and a non-working electrode structure as a counter electrode of the working electrode structure.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供对生物体无侵入性的离子电渗疗法装置，并有效且简单地施用诊断剂。该离子电渗疗法装置具备：电力单元，与电力单元连接的工作电极结构，通过离子电渗法将诊断剂离子化并将其经皮施用于生物体;以及非工作电极结构工作电极结构的对电极。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2007097689A Iontophoresis apparatus and photodynamic therapy system using iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备和使用IOPOPHORESIS设备的光电治疗系统
公开(公告)号：JP2007097689A
公开(公告)日：2007-04-19
申请号：JP2005288811
申请日：2005-09-30
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KAWAKAMI HIROYOSHI , SHIBATA TSUTOMU , AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61K31/409 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus which can administer photosensitive matter to only a malignant tumor cell. SOLUTION: The iontophoresis apparatus is equipped with an electrode 22A connected to a power source 12, an electrolyte holding section 26A which is arranged in the front of the electrode 22A and holds an electrolyte, an anion exchange membrane 28A which is arranged in the front of the electrolyte holding section 26A and passes an anion selectively, a liquid medicine holding section 30A which is arranged in the front of the anion exchange membrane 28A and holds a photosensitization reactant, a cation exchange membrane 32A which is arranged in the front of the liquid medicine holding section 30A and passes a cation selectively, a working side electrode structure 20A which is arranged in a part on the front side of the cation exchange membrane 32A and has at least a release-inhibiting layer 40 to control the release of the photosensitization reactant, and a position index which is formed in the working side electrode structure 20A and can specify the position of a pasting face 60A to a living body. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种可以将光敏物质仅施用于恶性肿瘤细胞的离子电渗疗法。解决方案：离子电渗仪装置配备有连接到电源12的电极22A，布置在电极22A的前面并保持电解质的电解质保持部26A，阴离子交换膜28A 电解质保持部26A的前方，通过阴离子选择性地配置在阴离子交换膜28A的前方并保持有光敏性反应物的液体药剂保持部30A，配置在阴离子交换膜28A的前方的阳离子交换膜32A 液体药剂保持部30A选择性地通过阳离子，设置在阳离子交换膜32A的前侧的一部分中的工作侧电极结构20A，并具有至少一个释放抑制层40，以控制阳离子交换膜32A的释放。光敏反应物和在工作侧电极结构20A中形成的位置指数，并且可以将粘贴面60A的位置指定为活体。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2007089911A PERCUTANEOUS INTRODUCTION METHOD FOR siRNA 审中-公开
标题翻译：用于siRNA的PERCUTANEOUS引言方法
公开(公告)号：JP2007089911A
公开(公告)日：2007-04-12
申请号：JP2005285427
申请日：2005-09-29
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KAWAKAMI HIROYOSHI , AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61K48/00 , A61N1/04 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To percutaneously introduce a siRNA (small interfering RNA) to an introduction part without imposing a large load on a patient concerning a method for allowing the siRNA to electrically penetrate skin. SOLUTION: The chemical holding part 240 of an iontophoresis apparatus 10 holds the siRNA dissociated into ions. The siRNA held in the chemical holding part 240 are allowed to electrically penetrate the skin by energizing the iontophoresis apparatus 10 and the skin of a living body. An ion-exchange membrane may be used in the iontophoresis apparatus 10. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了经皮地将siRNA（小干扰RNA）引入引入部分，而不会对患者施加大的负荷，涉及允许siRNA电穿透皮肤的方法。解决方案：离子电渗疗法装置10的化学保持部分240保持被离解成离子的siRNA。通过使离子电渗透装置10和生物体的皮肤通电，使被保持在化学保持部240中的siRNA能够电穿透皮肤。离子电渗装置10中可以使用离子交换膜。（C）2007，JPO＆INPIT

4. 发明专利

JP2007089426A Gene introduction device and gene introduction method 审中-公开
标题翻译：基因引言设备和基因引言方法
公开(公告)号：JP2007089426A
公开(公告)日：2007-04-12
申请号：JP2005280541
申请日：2005-09-27
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KAWAKAMI HIROYOSHI , AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： C12M1/00 , C12N15/09
CPC分类号： C12M35/02
摘要： PROBLEM TO BE SOLVED: To surely introduce genes prepared for transformation, transduction, or the like into target cells in a large amount in simple processes.
SOLUTION: This gene introduction device for introducing genes into target cells comprises at least the first electrode 142 connected to the cathode of an electric source 112, the first buffer solution-holding portion 143 disposed on the front side of the first electrode 142 and holding a buffer solution, the first cation exchange membrane 144 disposed on the further front side of the first buffer solution-holding portion 143, a gene-holding portion 145 disposed on the further front side of the first cation exchange membrane 144 and holding the genes, and the first anion exchange membrane 146 disposed on the further front side of the gene-holding portion 145.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：在简单的过程中，大量引入用于转化，转导等准备用于靶细胞的基因。解决方案：用于将基因导入靶细胞的基因导入装置至少包括连接到电源112的阴极的第一电极142，设置在第一电极142的前侧的第一缓冲溶液保持部143 并且保持缓冲溶液，设置在第一缓冲溶液保持部分143的另一前侧上的第一阳离子交换膜144，设置在第一阳离子交换膜144的另一前侧上的基因保持部分145，基因和设置在基因保持部分145的另一前侧上的第一阴离子交换膜146。（C）2007，JPO和INPIT

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