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1. 发明授权

US07087149B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07087149B1
公开(公告)日：2006-08-08
申请号：US09958671
申请日：2000-04-13
申请人： Hitoshi Muguruma , Atsunori Hiratsuka , Isao Karube
发明人： Hitoshi Muguruma , Atsunori Hiratsuka , Isao Karube
IPC分类号： G01N27/327 , C08F2/46 , C12Q1/00
CPC分类号： C12Q1/002
摘要： A novel biosensor was accomplished using a plasma-polymerized membrane. The biosensor of the present invention is a high-performance biosensor produced by a simpler method and applicable to a wide range of fields.
摘要翻译：使用等离子体聚合膜完成了新颖的生物传感器。本发明的生物传感器是通过更简单的方法制造并适用于广泛领域的高性能生物传感器。

2. 发明申请

US20070045118A1 Automated two-dimensional electrophoresis apparatus and instrument constituting the apparatus 有权
标题翻译：构成装置的自动二维电泳装置和仪器
公开(公告)号：US20070045118A1
公开(公告)日：2007-03-01
申请号：US11510838
申请日：2006-08-28
申请人： Yuji Maruo , Katsuyoshi Takahashi , Yutaka Unuma , Keisuke Usui , Hideki Kinoshita , Kisho Shiseki , Yoshio Suzuki , Atsunori Hiratsuka , Hiroyuki Fukui , Kenji Yokoyama , Ichiji Namatame , Kouhei Yodoya , Yasuhiro Ogawa , Koji Sakairi , Chie Hayashida , Satonari Akutsu , Kazuyoshi Yano , Isao Karube
发明人： Yuji Maruo , Katsuyoshi Takahashi , Yutaka Unuma , Keisuke Usui , Hideki Kinoshita , Kisho Shiseki , Yoshio Suzuki , Atsunori Hiratsuka , Hiroyuki Fukui , Kenji Yokoyama , Ichiji Namatame , Kouhei Yodoya , Yasuhiro Ogawa , Koji Sakairi , Chie Hayashida , Satonari Akutsu , Kazuyoshi Yano , Isao Karube
IPC分类号： G01N27/00
CPC分类号： G01N27/44778
摘要： The present invention is to provide a sample separation instrument used in a sample separation apparatus which includes: holding means for holding a first medium supporter which supports a first medium; and driving means for moving fixing means or the holding means in a direction parallel or perpendicular to a plane whose sides extend in the first direction and in the second directions. The sample separation instrument includes an insulator for storing a second medium which allows a sample separated in the first medium in the first direction to be further separated in the second direction different from the first direction, wherein: the insulator includes a first opening and a second opening each of which defines the second direction in which the second medium is electrified, and the second opening has a shape which allows the first medium containing the separated sample to be attached to the second medium along the first direction. The present invention realizes automation of the two-dimensional electrophoresis to enhance the convenience of the two-dimensional electrophoresis, to less depend on the operator's skill, and to enhance the reproducibility of the electrophoresis result.
摘要翻译：本发明提供一种在样品分离装置中使用的样品分离装置，其包括：保持装置，用于保持支撑第一介质的第一介质支持体; 以及用于在平行或垂直于其侧面沿第一方向和第二方向延伸的平面的方向上移动固定装置或保持装置的驱动装置。样品分离装置包括用于存储第二介质的绝缘体，其允许在第一方向上在第一介质中分离的样品在与第一方向不同的第二方向上进一步分离，其中：绝缘体包括第一开口和第二开口其中每个开口限定第二介质带电的第二方向，第二开口具有允许包含分离样品的第一介质沿着第一方向附着到第二介质的形状。本发明实现了二维电泳的自动化，以增强二维电泳的便利性，较少依赖于操作者的技能，并提高电泳结果的再现性。

3. 发明授权

US08221604B2 Method for controlling substance transfer 有权
标题翻译：物质转移控制方法
公开(公告)号：US08221604B2
公开(公告)日：2012-07-17
申请号：US10533015
申请日：2003-10-28
申请人： Kazuyoshi Yano , Isao Karube , Atsunori Hiratsuka , Shuo-Wen Tsai
发明人： Kazuyoshi Yano , Isao Karube , Atsunori Hiratsuka , Shuo-Wen Tsai
IPC分类号： G01N27/447
CPC分类号： B01D57/02 , G01N27/44773 , G01N27/44791
摘要： Transfer of fluid substances, and/or substances comprised in fluid substances, is controlled by introducing a separation medium, which prevents transfer of the fluid substances, and/or the substances comprised in the fluid substances, to an intermediate cavity connecting a first cavity and a second cavity; and introducing a connection medium to replace the separation medium and thereby start substance transfer to the second cavity. Substance transfer may be readily controlled without relying on mechanical means. Based on the present invention, two-dimensional electrophoretic analysis can be readily implemented on a chip.
摘要翻译：通过引入分离介质来控制流体物质和/或包含在流体物质中的物质，该分离介质防止流体物质和/或包含在流体物质中的物质转移到连接第一空腔和第二腔; 并引入连接介质以更换分离介质，从而开始物质转移到第二腔。可以容易地控制物质转移，而不依赖于机械装置。基于本发明，可以容易地在芯片上实现二维电泳分析。

4. 发明授权

US07964077B2 Automated two-dimensional electrophoresis apparatus and instrument constituting the apparatus 有权
标题翻译：构成装置的自动二维电泳装置和仪器
公开(公告)号：US07964077B2
公开(公告)日：2011-06-21
申请号：US11510838
申请日：2006-08-28
申请人： Yuji Maruo , Katsuyoshi Takahashi , Yutaka Unuma , Keisuke Usui , Hideki Kinoshita , Kisho Shiseki , Yoshio Suzuki , Atsunori Hiratsuka , Hiroyuki Fukui , Kenji Yokoyama , Ichiji Namatame , Kouhei Yodoya , Yasuhiro Ogawa , Koji Sakairi , Chie Hayashida , Satonari Akutsu , Kazuyoshi Yano , Isao Karube
发明人： Yuji Maruo , Katsuyoshi Takahashi , Yutaka Unuma , Keisuke Usui , Hideki Kinoshita , Kisho Shiseki , Yoshio Suzuki , Atsunori Hiratsuka , Hiroyuki Fukui , Kenji Yokoyama , Ichiji Namatame , Kouhei Yodoya , Yasuhiro Ogawa , Koji Sakairi , Chie Hayashida , Satonari Akutsu , Kazuyoshi Yano , Isao Karube
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44778
摘要： The present invention is to provide a sample separation instrument used in a sample separation apparatus which includes: holding means for holding a first medium supporter which supports a first medium; and driving means for moving fixing means or the holding means in a direction parallel or perpendicular to a plane whose sides extend in the first direction and in the second directions. The sample separation instrument includes an insulator for storing a second medium which allows a sample separated in the first medium in the first direction to be further separated in the second direction different from the first direction, wherein: the insulator includes a first opening and a second opening each of which defines the second direction in which the second medium is electrified, and the second opening has a shape which allows the first medium containing the separated sample to be attached to the second medium along the first direction. The present invention realizes automation of the two-dimensional electrophoresis to enhance the convenience of the two-dimensional electrophoresis, to less depend on the operator's skill, and to enhance the reproducibility of the electrophoresis result.
摘要翻译：本发明提供一种在样品分离装置中使用的样品分离装置，其包括：保持装置，用于保持支撑第一介质的第一介质支持体; 以及用于在平行或垂直于其侧面沿第一方向和第二方向延伸的平面的方向上移动固定装置或保持装置的驱动装置。样品分离装置包括用于存储第二介质的绝缘体，其允许在第一方向上在第一介质中分离的样品在与第一方向不同的第二方向上进一步分离，其中：绝缘体包括第一开口和第二开口其中每个开口限定第二介质带电的第二方向，第二开口具有允许包含分离样品的第一介质沿着第一方向附着到第二介质的形状。本发明实现了二维电泳的自动化，以增强二维电泳的便利性，较少依赖于操作者的技能，并提高电泳结果的再现性。

5. 发明申请

US20060137983A1 Method of controlling migration of substance 有权
标题翻译：控制物质迁移的方法
公开(公告)号：US20060137983A1
公开(公告)日：2006-06-29
申请号：US10533015
申请日：2003-10-28
申请人： Kazuyoshi Yano , Isao Karube , Atsunori Hiratsuka , Shuo-Wen Tsai
发明人： Kazuyoshi Yano , Isao Karube , Atsunori Hiratsuka , Shuo-Wen Tsai
IPC分类号： C07K1/26 , B01D57/02 , G01N27/447
CPC分类号： B01D57/02 , G01N27/44773 , G01N27/44791
摘要： Transfer of fluid substances, and/or substances comprised in fluid substances, is controlled by introducing a separation medium, which prevents transfer of the fluid substances, and/or the substances comprised in the fluid substances, to an intermediate cavity connecting a first cavity and a second cavity; and introducing a connection medium to replace the separation medium and thereby start substance transfer to the second cavity. Substance transfer may be readily controlled without relying on mechanical means. Based on the present invention, two-dimensional electrophoretic analysis can be readily implemented on a chip.
摘要翻译：通过引入分离介质来控制流体物质和/或包含在流体物质中的物质，该分离介质防止流体物质和/或包含在流体物质中的物质转移到连接第一空腔和第二腔; 并引入连接介质以更换分离介质，从而开始物质转移到第二腔。可以容易地控制物质转移，而不依赖于机械装置。基于本发明，可以容易地在芯片上实现二维电泳分析。

6. 发明申请

US20060113189A1 Method for separating substances 审中-公开
标题翻译：分离物质的方法
公开(公告)号：US20060113189A1
公开(公告)日：2006-06-01
申请号：US10526213
申请日：2003-09-05
申请人： Atsunori Hiratsuka , Kazuyoshi Yano , Isao Karube , Shuo-Wen Tsai , Kenji Yokoyama , Satoshi Koide , Takuo Akimoto
发明人： Atsunori Hiratsuka , Kazuyoshi Yano , Isao Karube , Shuo-Wen Tsai , Kenji Yokoyama , Satoshi Koide , Takuo Akimoto
IPC分类号： C07K1/26 , G01N27/447
CPC分类号： B82Y30/00 , G01N27/447 , G01N27/44752
摘要： An objective of the present invention is to provide electrophoretic separation methods and devices that enable the various features of a substrate surface that comes in contact with an electrophoresis medium to be controlled. The present invention provides methods for electrophoresing substances, which comprises the steps of: (a) adding a substance to be analyzed to an electrophoresis medium retained in a substrate, whose surface that has come in contact with the electrophoresis medium has been coated with a polymer membrane; and (b) adding electrophoretic pressure to the electrophoresis medium. For example, the use of a plasma-polymerized membrane allows the formation of a membrane with homogeneous quality and thickness on the surface of an arbitrary shape. In addition, desired characteristics can be conferred on the surface through selection of monomeric substances. Protein adsorption onto micro-chips can be effectively prevented as well.
摘要翻译：本发明的目的是提供一种电泳分离方法和装置，其使得能够控制与电泳介质接触的基底表面的各种特征。本发明提供了用于电泳物质的方法，其包括以下步骤：（a）将待分析的物质加入保留在基质中的电泳介质中，其中与电泳介质接触的表面已经涂覆有聚合物膜; 和（b）向电泳介质中加入电泳压力。例如，使用等离子体聚合膜允许在任意形状的表面上形成均匀质量和厚度的膜。此外，通过选择单体物质可以赋予表面所需的特性。可以有效地防止蛋白质在微芯片上的吸附。

7. 发明授权

US08419916B2 Biological molecule separation apparatus 失效
标题翻译：生物分子分离装置
公开(公告)号：US08419916B2
公开(公告)日：2013-04-16
申请号：US13073835
申请日：2011-03-28
申请人： Koji Sakairi , Satonari Akutsu , Atsunori Hiratsuka , Kenji Yokoyama , Yuji Maruo , Hiroshi Ohki
发明人： Koji Sakairi , Satonari Akutsu , Atsunori Hiratsuka , Kenji Yokoyama , Yuji Maruo , Hiroshi Ohki
IPC分类号： G01N27/26
CPC分类号： G01N27/44769
摘要： A biological molecule separation apparatus for separating a biological molecule of one embodiment of the present invention has a buffer solution chamber receiving a buffer solution, a separation electrode arranged in the buffer solution chamber, a biological molecule separation medium for separating a biological molecule, a biological molecule adsorption film for adsorbing a biological molecule, a pair of transfer electrodes having a plurality of line shaped conductors extending in a direction perpendicular to a first direction, the conductors being arranged in the direction perpendicular to the first direction, and a separation part which holds the transfer electrode, the biological molecule adsorption film, the medium and the transfer electrode, wherein the transfer electrode, the biological molecule adsorption film, the medium and the transfer electrode are stacked in this order.
摘要翻译：本发明的一个实施方案的分离生物分子的生物分子分离装置具有接收缓冲溶液的缓冲溶液室，配置在缓冲溶液室中的分离电极，分离生物分子的生物分子分离介质，生物分子分离装置用于吸附生物分子的分子吸附膜，具有沿与第一方向垂直的方向延伸的多个线状导体的一对转移电极，导体沿垂直于第一方向的方向排列，分离部保持转移电极，生物分子吸附膜，介质和转移电极，其中转移电极，生物分子吸附膜，介质和转移电极按此顺序堆叠。

8. 发明申请

US20120273360A1 INSTRUMENT FOR ELECTROPHORESIS AND ELECTROPHORESIS APPARATUS 审中-公开
标题翻译：电泳和电泳装置仪器
公开(公告)号：US20120273360A1
公开(公告)日：2012-11-01
申请号：US13518686
申请日：2010-12-21
申请人： Hideki Kinoshita , Yuji Maruo , Yutaka Unuma , Atsunori Hiratsuka , Koji Sakairi , Satonari Akutsu
发明人： Hideki Kinoshita , Yuji Maruo , Yutaka Unuma , Atsunori Hiratsuka , Koji Sakairi , Satonari Akutsu
IPC分类号： C25B9/00 , G01N27/447
CPC分类号： G01N27/44756 , G01N27/44743
摘要： An instrument for electrophoresis includes a sample-separating portion in which a slab sample-separating medium that separates a sample is provided. The instrument for electrophoresis includes a sample-transporting portion that transports a sample-containing medium containing the sample to the sample-separating portion. The instrument for electrophoresis includes a positioning portion that is provided to the sample-separating portion and/or the sample-transporting portion and used for connecting the sample-transporting portion to a predetermined position of the sample-separating portion.
摘要翻译：电子仪器包括样品分离部分，其中提供分离样品的板坯样品分离介质。用于电泳的仪器包括将含有样品的含样本培养基输送到样品分离部分的样品输送部分。电泳仪包括设置在样品分离部分和/或样品输送部分上的定位部分，用于将样品输送部分连接到样品分离部分的预定位置。

9. 发明申请

US20050273032A1 Filter and biosensor having the same 审中-公开
标题翻译：过滤器和生物传感器具有相同的功能
公开(公告)号：US20050273032A1
公开(公告)日：2005-12-08
申请号：US10529483
申请日：2004-04-26
申请人： Atsunori Hiratsuka , Fumiaki Emoto , Toshiaki Miyaji
发明人： Atsunori Hiratsuka , Fumiaki Emoto , Toshiaki Miyaji
IPC分类号： G01N33/49 , A61B19/00
CPC分类号： G01N33/491
摘要： The present invention relates to a filter for filtering a blood sample containing a blood cell component, which comprises a main body which defines a channel for causing the blood sample to flow, an opening for introducing the blood sample, the opening being located at one end of the channel, and an opening for discharging the blood sample filtered through the channel, the opening being located at the other end of the channel. A plurality of structures are disposed in the channel to prevent the blood cell component from passing through the channel. The structures are disposed at intervals such that a slit through which the blood cell component cannot pass is formed between each structure and an adjacent inner wall of the channel and between adjacent structures. The plurality of structures and the inner wall of the channel define at least one cavity functioning as a blood cell reservoir for accommodating the blood cell component in the channel.
摘要翻译：本发明涉及一种用于过滤含有血细胞成分的血液样本的过滤器，该过滤器包括限定用于使血液样品流动的通道的主体，用于引入血液样品的开口，该开口位于一端以及用于排出通过通道过滤的血液样本的开口，该开口位于通道的另一端。多个结构设置在通道中以防止血细胞成分通过通道。这些结构以间隔设置，使得在每个结构和通道的相邻内壁之间以及相邻结构之间形成有不能通过血细胞组分的狭缝。多个结构和通道的内壁限定用作血细胞储存器的至少一个空腔，用于容纳通道中的血球成分。

10. 发明授权

US08500981B2 Electrophoresis apparatus and electrophoresis method 有权
标题翻译：电泳仪和电泳法
公开(公告)号：US08500981B2
公开(公告)日：2013-08-06
申请号：US13054271
申请日：2009-07-15
申请人： Koji Sakairi , Satonari Akutsu , Yuji Maruo , Takateru Matsunaga , Yutaka Unuma , Atsunori Hiratsuka , Hideki Kinoshita , Nao Sakaguchi , Kenji Yokoyama
发明人： Koji Sakairi , Satonari Akutsu , Yuji Maruo , Takateru Matsunaga , Yutaka Unuma , Atsunori Hiratsuka , Hideki Kinoshita , Nao Sakaguchi , Kenji Yokoyama
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44773
摘要： An electrophoresis apparatus includes a sample separating section for containing a sample separating medium for separating a sample in a horizontal direction, the sample separating section containing the sample separating medium in such a manner that the sample separating medium has an exposed portion at least one end of a surface of the sample separating medium, the surface being in parallel with the horizontal direction; and medium connecting means for connecting a sample containing medium to the sample separating medium at a connecting region, the sample containing medium containing a sample, and the connecting region satisfying a particular equation. By this, an electrophoresis technique with better accuracy than conventional arts can be provided.
摘要翻译：电泳装置包括样品分离部分，用于容纳用于在水平方向上分离样品的样品分离介质，样品分离部分包含样品分离介质，使得样品分离介质具有暴露部分，至少一端所述样品分离介质的表面与所述水平方向平行; 以及介质连接装置，用于在连接区域连接包含样品的介质到样品分离介质，所述样品包含含有样品的介质和满足特定等式的连接区域。由此，可以提供比现有技术更好的精度的电泳技术。

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