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1. 发明申请

US20070078151A1 Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds 失效
标题翻译：结晶和无定形嘧啶化合物及制备嘧啶化合物的方法
公开(公告)号：US20070078151A1
公开(公告)日：2007-04-05
申请号：US11378307
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： A61K31/506 , C07D405/14
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

2. 发明授权

US07767812B2 Crystals of pyrimidine compound and process for producing the same 失效
标题翻译：嘧啶化合物的晶体及其制备方法
公开(公告)号：US07767812B2
公开(公告)日：2010-08-03
申请号：US12346544
申请日：2008-12-30
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ;±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体 °和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

3. 发明申请

US20090111986A1 NOVEL CRYSTALS OF PYRIMIDINE COMPOUND AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译：吡啶化合物的新型结晶及其制造方法
公开(公告)号：US20090111986A1
公开(公告)日：2009-04-30
申请号：US12346544
申请日：2008-12-30
申请人： Hitoshi HARADA , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi HARADA , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： C07D405/14 , C07D405/02
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

4. 发明授权

US07396928B2 Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same 失效
标题翻译： 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体及其制备方法
公开(公告)号：US07396928B2
公开(公告)日：2008-07-08
申请号：US11378315
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
IPC分类号： C07D401/04
CPC分类号： C07D405/14
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 12.8°, 18.1° and/or 23.5° in a powder X-ray diffraction are excellent in stability against light, therefore are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为12.8°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体，18.1°和/或23.5°，对于光的稳定性优异，因此适用于诸如便秘的疾病的预防和治疗剂的活性成分。

5. 发明申请

US20060235225A1 Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same 失效
标题翻译： 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体及其制备方法
公开(公告)号：US20060235225A1
公开(公告)日：2006-10-19
申请号：US11378315
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 12.8°, 18.1° and/or 23.5° in a powder X-ray diffraction are excellent in stability against light, therefore are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为12.8°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体，18.1°和/或23.5°，对于光的稳定性优异，因此适用于诸如便秘的疾病的预防和治疗剂的活性成分。

6. 发明申请

US20090182149A1 SALT OF SULFINYLBENZIMIDAZOLE COMPOUND, AND CRYSTAL AND AMORPHOUS FORM THEREOF 审中-公开
标题翻译：磺酰苯胺唑化合物的盐，以及其晶体和非晶形式
公开(公告)号：US20090182149A1
公开(公告)日：2009-07-16
申请号：US12296902
申请日：2006-10-13
申请人： Tetsuya Kawahara , Hitoshi Harada , Hiroki Terauchi , Nobuhisa Watanabe , Masato Ueda , Atsushi Kamada , Sachiko Kikuchi , Hiroshi Ishihara , Koichi Koyama
发明人： Tetsuya Kawahara , Hitoshi Harada , Hiroki Terauchi , Nobuhisa Watanabe , Masato Ueda , Atsushi Kamada , Sachiko Kikuchi , Hiroshi Ishihara , Koichi Koyama
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Salts of 2-[({4-[(2,2-dimethyl-1,3-dioxan-5-yl)methoxy]-3,5-dimethylpyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole and their crystalline and amorphous forms.
摘要翻译： 2 - [（{4 - [（2,2-二甲基-1,3-二恶烷-5-基）甲氧基] -3,5-二甲基吡啶-2-基}甲基）亚磺酰基] -1H-苯并咪唑的盐及其晶体和无定形形式。

7. 发明申请

US20100179321A1 SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF 审中-公开
标题翻译： 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮及其结晶的盐
公开(公告)号：US20100179321A1
公开(公告)日：2010-07-15
申请号：US12440407
申请日：2007-09-06
申请人： Hiroshi Ishihara , Yoshiaki Sato
发明人： Hiroshi Ishihara , Yoshiaki Sato
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： The present invention provides a salt of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and a crystal thereof.
摘要翻译：本发明提供5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮及其晶体的盐。

8. 发明授权

US09968583B2 Method of manufacture of liposome composition 有权
公开(公告)号：US09968583B2
公开(公告)日：2018-05-15
申请号：US13260864
申请日：2010-03-30
申请人： Hiroshi Kikuchi , Kenji Hyodo , Hiroshi Ishihara
发明人： Hiroshi Kikuchi , Kenji Hyodo , Hiroshi Ishihara
IPC分类号： A61K9/127 , A61K31/724 , A61K31/337 , A61K31/704 , A61K31/7048
CPC分类号： A61K31/337 , A61K9/1271 , A61K9/1278 , A61K31/704 , A61K31/7048
摘要： The present invention provides a method of manufacture of a liposome composition including a step in which: a liposome dispersion liquid containing a liposome, and further containing cyclodextrin in the liposome internal phase is provided and a step in which an active compound is introduced into said liposome internal phase, and the liposome composition.

9. 发明授权

US07727843B2 Semiconductor element, semiconductor storage device using the same, data writing method thereof, data reading method thereof, and manufacturing method of those 有权
标题翻译：半导体元件，使用其的半导体存储装置，其数据写入方法，数据读取方法及其制造方法
公开(公告)号：US07727843B2
公开(公告)日：2010-06-01
申请号：US11651108
申请日：2007-01-09
申请人： Hiroshi Ishihara , Kenji Maruyama , Tetsuro Tamura , Hiromasa Hoko
发明人： Hiroshi Ishihara , Kenji Maruyama , Tetsuro Tamura , Hiromasa Hoko
IPC分类号： H01L21/336
CPC分类号： G11C11/22 , H01L21/28291 , H01L27/11585 , H01L27/1159 , H01L29/78391
摘要： The invention relates to a semiconductor element used for a nonvolatile semiconductor storage device or the like, a semiconductor storage device using the same, a data writing method thereof, a data reading method thereof and a manufacturing method of those, and has an object to provide a semiconductor element in which scaling and integration of cells are possible, storage characteristics of data are excellent, and reduction in power consumption is possible, a semiconductor storage device using the same, a data writing method thereof, a data reading method thereof, and a manufacturing method of those. A pn junction diode GD with a ferroelectric gate as the semiconductor element includes a gate electrode formed on a ferroelectric film, an inversion layer formation region in which an inversion layer is formed in a semiconductor substrate below the ferroelectric film according to a polarization direction of the ferroelectric film, a cathode region formed on one of both sides of the inversion layer formation region, and an anode region formed on the other of both the sides.
摘要翻译：本发明涉及用于非易失性半导体存储器件等的半导体元件，使用该半导体存储器件的半导体存储器件，其数据写入方法，数据读取方法及其制造方法，其目的是提供可以进行单元的缩放和积分的半导体元件，数据的存储特性优异，功耗的降低成为可能，使用该半导体元件的半导体存储装置，其数据写入方法，数据读取方法以及制造方法。具有铁电栅极作为半导体元件的pn结二极管GD包括形成在铁电体膜上的栅极电极，根据所述铁电体的极化方向在所述铁电体的下方的半导体基板中形成有反型层的反型层形成区域铁电体膜，形成在反型层形成区域的两侧之一上的阴极区域和形成在两侧的另一侧的阳极区域。

10. 发明申请

US20070126246A1 Vehicle door opening/closing device 审中-公开
标题翻译：车门打开/关闭装置
公开(公告)号：US20070126246A1
公开(公告)日：2007-06-07
申请号：US11600088
申请日：2006-11-16
申请人： Shintaro Suzuki , Hiroshi Ishihara
发明人： Shintaro Suzuki , Hiroshi Ishihara
IPC分类号： E05B3/00
CPC分类号： B60R25/246 , E05B81/78 , G07C9/00309 , G07C2009/00388 , G07C2209/65 , Y10T292/57
摘要： A vehicle door opening/closing device includes a door handle provided at the exterior of a vehicle door and by which the vehicle door is opened and closed, control device executing a vehicle door opening process for the vehicle door on the basis of a user's door handle operation to open the vehicle door, input device provided at the door handle and inputting the user's door handle operation to open the vehicle door, wherein on the basis of the user's door handle operation to open the vehicle door, the control device executes the vehicle door opening process for one of vehicle doors, to which the door handle is not provided.
摘要翻译：车门打开/关闭装置包括设置在车门外部的门把手，车门打开和关闭，通过使用者门把手执行车门的车门打开处理的控制装置操作以打开车门，设置在门把手处的输入装置和输入用户的门把手操作以打开车门，其中，基于用户的门把手操作来打开车门，控制装置执行车门不提供门把手的车门之一的打开过程。

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