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1. 发明专利

JP2006000015A Method for evaluating stress 审中-公开
标题翻译：评估应力的方法
公开(公告)号：JP2006000015A
公开(公告)日：2006-01-05
申请号：JP2004177147
申请日：2004-06-15
申请人： Hitachi Ltd , Kazuhito Rokutan , 一仁六反 , 株式会社日立製作所
发明人： ROKUTAN KAZUHITO , MORITA KYOKO , KANBARA KUMIKO , SAITO TOSHIRO
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09
CPC分类号： C12Q1/6876 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a simple method for objectively evaluating a stress of a healthy person with high accuracy.
SOLUTION: An expression profile of a specific gene group to be an evaluation marker of the stress is analyzed in a messenger RNA derived from peripheral blood of a subject. The stress of the subject is evaluated on the basis of the analytical results thereof.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种以高精度客观评价健康人的压力的简单方法。解决方案：在来自受试者的外周血的信使RNA中分析作为应激评价标记物的特定基因组的表达谱。基于其分析结果评价受试者的压力。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005312435A Method for evaluating depression 审中-公开
标题翻译：评估渗漏的方法
公开(公告)号：JP2005312435A
公开(公告)日：2005-11-10
申请号：JP2005042534
申请日：2005-02-18
申请人： Hitachi Ltd , Tetsuo Omori , Kazuhito Rokutan , 一仁六反 , 哲郎大森 , 株式会社日立製作所
发明人： ROKUTAN KAZUHITO , OMORI TETSUO , MORITA KYOKO , OTA MASAYUKI , SAITO TOSHIRO
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N37/00
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , Y02A90/24 , Y02A90/26
摘要： PROBLEM TO BE SOLVED: To provide a new method for evaluating the conditions of depression of a subject in a simple, objective and accurate manner. SOLUTION: This method for evaluating the depression is characterized as follows. Gene expression is analyzed using a messenger RNA derived from peripheral blood of the subject. Based on the results, whether or not the subject is afflicted with the depression is discriminated. The type of the depression in the subject discriminated to be afflicted with the depression is then identified to evaluate the conditions of the depression for the each type. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种以简单，客观和准确的方式评估受试者的抑郁状况的新方法。解决方案：用于评估抑郁症的方法的特征如下。使用衍生自受试者的外周血的信使RNA分析基因表达。根据结果，判断受试者是否患有抑郁症。然后鉴别被抑郁症患者的抑郁症类型，以评估每种类型的抑郁症状况。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2004208547A Method for evaluating depression 审中-公开
标题翻译：评估渗漏的方法
公开(公告)号：JP2004208547A
公开(公告)日：2004-07-29
申请号：JP2002380614
申请日：2002-12-27
申请人： Hitachi Ltd , Tetsuo Omori , Kazuhito Rokutan , 一仁六反 , 哲郎大森 , 株式会社日立製作所
发明人： ROKUTAN KAZUHITO , OMORI TETSUO , SAITO TOSHIRO , TOMITA HIROYUKI , KATO KOICHI , NARAHARA MASATOSHI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating depression by measuring the expression amount of a specific gene group in the peripheral blood leukocyte of a testee, by which the depression can simply and accurately be evaluated.
SOLUTION: This method for evaluating the depression is characterized by analyzing the expression amount of at least one gene selected from apoptosis-related gene, ATPase-related gene, cell cycle-related gene, cytokine-related gene, heat shock protein-related gene, polymerase-related gene, GTP-bound protein-related gene, protein kinase C-related gene, and mitochondria cytochrome C oxidase-related gene from a messenger RNA originating from the peripheral blood leukocyte of the testee and then evaluating the depression state of the testee on the basis of the analysis result.
COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过测量受试者的外周血白细胞中特定基因组的表达量来评估抑郁症的方法，由此可以简单且准确地评价抑郁症。解决方案：该方法用于分析从凋亡相关基因，ATP酶相关基因，细胞周期相关基因，细胞因子相关基因，热休克蛋白相关基因中选出的至少一种基因的表达量，相关基因，聚合酶相关基因，GTP结合蛋白相关基因，蛋白激酶C相关基因和源自受试者外周血白细胞的信使RNA的线粒体细胞色素C氧化酶相关基因，然后评估抑郁状态的受试者在分析结果的基础上。版权所有（C）2004，JPO＆NCIPI

4. 发明专利

JP2007228878A Method for diagnosis of chronic fatigue syndrome 审中-公开
标题翻译：慢性疲劳综合征诊断方法
公开(公告)号：JP2007228878A
公开(公告)日：2007-09-13
申请号：JP2006054414
申请日：2006-03-01
申请人： Hitachi Ltd , Univ Nagoya , Univ Of Tokushima , 国立大学法人名古屋大学 , 国立大学法人徳島大学 , 株式会社日立製作所
发明人： ROKUTAN KAZUHITO , MORITA KYOKO , BAN SHINTARO , SAIJO TAKUYA , SUGIYAMA HISASHI , SAITO TOSHIRO
IPC分类号： C12Q1/68 , C12N15/09 , G01N37/00
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a new method for easy, objective and accurate estimation of the contraction of a subject to chronic fatigue syndrome.
SOLUTION: The contraction of a subject to chronic fatigue syndrome is diagnosed by using a messenger RNA derived from the peripheral blood of the subject and judging the contraction based on the expression analysis result of either one of selected marker genes. The diagnosis of chronic fatigue syndrome is easily performed by the use of a small amount of peripheral blood. The vital functions can be multilaterally grasped from multiple RNA expression levels.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种容易，客观和准确地估计受试者对慢性疲劳综合征的收缩的新方法。解决方案：通过使用源自受试者的外周血的信使RNA来诊断受试者对慢性疲劳综合征的收缩，并且基于选择的标记基因中的任一个的表达分析结果判断收缩。慢性疲劳综合征的诊断很容易通过使用少量外周血进行。重要功能可以从多个RNA表达水平上多次掌握。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006141210A Method for detecting chimera gene 审中-公开
标题翻译：检测CHIMERA基因的方法
公开(公告)号：JP2006141210A
公开(公告)日：2006-06-08
申请号：JP2004331808
申请日：2004-11-16
申请人： Hitachi High-Technologies Corp , Hitachi Ltd , 株式会社日立ハイテクノロジーズ , 株式会社日立製作所
发明人： NARAHARA MASATOSHI , SAITO TOSHIRO , OBARA TAKAYUKI , YASUDA KENJI
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6806 , C12Q1/6827 , C12Q1/6834 , C12Q1/6886 , C12Q2600/158 , C12Q2525/143 , C12Q2521/119 , C12Q2525/149
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting chimera genes produced from chromosomal translocations, with which a great number of existing chimera genes are detected at once in a high throughput.
SOLUTION: The method for detecting chimera genes comprises hybridizing a sample containing a nucleic acid derived from a chimera gene with at least two or more kinds of probes including a partial base sequence in an exon sequence across a translocation point of a chimera gene immobilized on a substrate in-between or a base sequence complementary thereto.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于检测由染色体易位产生的嵌合基因的方法，利用该方法在高通量中立即检测到大量现有嵌合基因。解决方案：检测嵌合基因的方法包括将含有源自嵌合基因的核酸的样品与包含嵌合基因的易位位置的外显子序列中的部分碱基序列的至少两种或更多种探针杂交固定在其上的底物或与其互补的碱基序列之间。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005160440A Method for determining expression of gene relating to multiple sclerosis, chip for determining expression of gene relating to multiple sclerosis, gene group for identifying affection of multiple sclerosis and method for estimation of multiple sclerosis 审中-公开
标题翻译：用于确定与多发性硬化相关的基因表达的方法，用于确定与多发性硬化相关的基因的表达的芯片，用于鉴定多发性硬化症的影响的基因组和多发性硬化症的估计方法
公开(公告)号：JP2005160440A
公开(公告)日：2005-06-23
申请号：JP2003406750
申请日：2003-12-05
申请人： Hitachi Ltd , Kokuritsu Seishin Shinkei Center , 国立精神・神経センター総長 , 株式会社日立製作所
发明人： SAITO TOSHIRO , YAMAMURA TAKASHI , SATO JUNICHI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a method for easily estimating the affection of multiple sclerosis in high reliability without increasing the load on an examinee.
SOLUTION: A disease marker varying its expression quantity according to the affection of multiple sclerosis is specified by comparing the expression quantity of the gene groups of the peripheral blood lymphocyte of a patient with multiple sclerosis and a healthy person by a DNA chip. The affection of multiple sclerosis is easily estimated in high accuracy by the use of the estimation method.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于在不增加受检者的负担的情况下容易地估计多发性硬化的可靠性高的可靠性的方法。解决方案：根据多发性硬化的影响改变其表达量的疾病标志物是通过用DNA芯片比较患者多发性硬化的外周血淋巴细胞的基因组与健康人的表达量来确定的。通过使用估计方法，可以高精度地容易地估计多发性硬化的影响。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2004028926A Method for predicting effectiveness of interferon beta medicine treatment to multiple sclerosis 有权
公开(公告)号：JP2004028926A
公开(公告)日：2004-01-29
申请号：JP2002188932
申请日：2002-06-28
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： YAMAMURA TAKASHI , SATO JUNICHI , SAITO TOSHIRO , TOMITA HIROYUKI , NARAHARA MASATOSHI , KATO KOICHI
IPC分类号： G01N33/53 , A61K38/21 , A61P25/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/48 , G01N37/00
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting the presence of medicinal efficacy simply and with high reliability without increasing a load on the patient when a patient of multiple sclerosis is treated by medicine due to interferon beta.
SOLUTION: A database which records the correlation between the presence of the medicinal efficacy of the interferon beta administration, and an interferon inducing protein, interferon regulatory factor and the expression level of the gene of a chemokine is used. The presence of the medicinal efficacy of the interferon administration is predicted by measuring the expression level of the gene thereof from mRNA derived from peripheral blood leukocyte of a subject.
COPYRIGHT: (C)2004,JPO

8. 发明专利

JP2004016070A Oligonucleotide array for measuring ortholog gene expression distribution 审中-公开
公开(公告)号：JP2004016070A
公开(公告)日：2004-01-22
申请号：JP2002174208
申请日：2002-06-14
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： TOMITA HIROYUKI , SAITO TOSHIRO , NARAHARA MASATOSHI , KATO KOICHI
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an oligonucleotide array which enables the extrapolation of data for predicting toxicity and medicinal actions in an experimental animal (for example, rat or mouse) to man with a DNA chip having excellent performance for predicting the toxicity and the medicinal actions, and to provide a method using the same.
SOLUTION: This array in which a plurality of oligonucleotides having different base sequences are immobilized at different positions on a support is characterized in that the partial sequences of the ortholog genes of species A and B are used as probes and cross hybridization is reduced in an extent which can substantially be ignored.
COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2010187694A Dna alley, method for analyzing gene expression and method for investigating useful gene using the same 审中-公开
标题翻译： DNA ALLEY，用于分析基因表达的方法和使用该方法调查有用基因的方法
公开(公告)号：JP2010187694A
公开(公告)日：2010-09-02
申请号：JP2010101603
申请日：2010-04-27
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： YOKOI TAKAHIDE , MINOWA TAKASHI , SAITO TOSHIRO , KAKO YOSHIKO
IPC分类号： C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive and efficient method for comprehensively analyzing gene expression and method for investigating useful genes using a DNA alley with targeting organisms lacked in base sequence information. SOLUTION: The comprehensive gene expression analysis can be performed without receiving any restriction in the amount of gene sequence information by directly immobilizing a genomic library to a substrate, wherein the genomic library is prepared from randomly cleaved genom DNA fragments and the substrate is able to individually discriminate the genomic library and match the same. Furthermore, useful genes are investigated by preparing a sub-DNA alley immobilized on a substrate by fragmenting a plasmid detected by the prepared random DNA alley into shorter DNAs and analyzing the gene expression. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于综合分析基因表达的廉价和有效的方法以及使用DNA碱基对基因序列信息中缺乏的靶向生物进行研究的有用基因的方法。解决方案：通过将基因组文库直接固定在底物上，可以不对基因序列信息量产生任何限制，进行综合基因表达分析，其中基因组文库由随机切割的基因组DNA片段制备，底物为能够单独区分基因组文库并进行匹配。此外，通过制备通过将由所制备的随机DNA小区检测的质粒断裂成更短的DNA并分析基因表达来制备固定在底物上的亚DNA小巷来研究有用的基因。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2007185140A Method for measuring slight amount of sample 审中-公开
标题翻译：测量样品量的方法
公开(公告)号：JP2007185140A
公开(公告)日：2007-07-26
申请号：JP2006006169
申请日：2006-01-13
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KATO KOICHI , SAITO TOSHIRO , NARAHARA MASATOSHI
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/53 , G01N33/566 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To reduce the amount of a sample required for one time measurement in a gene expression analysis by using a DNA chip for reduction of the cost and labor for the same.
SOLUTION: This method for performing the gene expression analysis of a sample containing ≤15 μg total RNA is performed by using a DNA-immobilized sample having ≤100 mm
2 area and used in the hybridization with the sample.
COPYRIGHT: (C)2007,JPO&INPIT

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