专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110319385A1 QUINOXALINE COMPOUND 有权
标题翻译：喹啉化合物
公开(公告)号：US20110319385A1
公开(公告)日：2011-12-29
申请号：US13254368
申请日：2010-03-04
申请人： Hiroyuki Kaizawa , Mari Sugita , Hidenori Azami , Ryushi Seo , Takaho Nomura , Satoshi Yamamoto , Hirofumi Yamamoto , Kazuyuki Tsuchiya , Hideki Kubota , Kazunori Kamijo
发明人： Hiroyuki Kaizawa , Mari Sugita , Hidenori Azami , Ryushi Seo , Takaho Nomura , Satoshi Yamamoto , Hirofumi Yamamoto , Kazuyuki Tsuchiya , Hideki Kubota , Kazunori Kamijo
IPC分类号： A61K31/4985 , C07D413/14 , A61P13/00 , A61K31/5377 , A61K31/55 , C07D487/04 , C07D403/14
CPC分类号： C07D498/04 , C07D487/04 , C07D491/107 , C07D519/00
摘要： [Problem]Provided is a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.[Means for Solution]The present inventors have investigated a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like, and thus, have found that an imidazoquinoxaline compound or a triazoloquinoxaline compound has a PDE9-inhibiting action, thereby completing the present invention. The imidazoquinoxaline compound or the triazoloquinoxaline compound of the present invention has a PDE9-inhibiting action and can be used as an agent for preventing and/or treating storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.
摘要翻译： [问题]提供具有PDE9抑制作用并可用作治疗和/或预防储存功能障碍，排尿功能障碍和膀胱/尿道疾病的药剂的活性成分的化合物等。 [解决方案]本发明人已经研究了具有PDE9抑制作用并可用作治疗和/或预防储存功能障碍，排尿功能障碍和膀胱/尿道疾病等的活性成分的化合物，因此已经发现咪唑并喹喔啉化合物或三唑并喹喔啉化合物具有抑制PDE9的作用，从而完成了本发明。本发明的咪唑并喹喔啉化合物或三唑并喹喔啉化合物具有PDE9抑制作用，可用作预防和/或治疗储存功能障碍，排尿功能障碍和膀胱/尿道疾病等的药剂。

2. 发明授权

US08357688B2 Substituted imidazo[1,5-a]quinoxalin-4(5H)-ones as PDE9 inhibitors 有权
标题翻译：取代的咪唑并[1,5-a]喹喔啉-4（5H） - 酮作为PDE9抑制剂
公开(公告)号：US08357688B2
公开(公告)日：2013-01-22
申请号：US13254368
申请日：2010-03-04
申请人： Hiroyuki Kaizawa , Mari Sugita , Hidenori Azami , Ryushi Seo , Takaho Nomura , Satoshi Yamamoto , Hirofumi Yamamoto , Kazuyuki Tsuchiya , Hideki Kubota , Kazunori Kamijo
发明人： Hiroyuki Kaizawa , Mari Sugita , Hidenori Azami , Ryushi Seo , Takaho Nomura , Satoshi Yamamoto , Hirofumi Yamamoto , Kazuyuki Tsuchiya , Hideki Kubota , Kazunori Kamijo
IPC分类号： A61K31/495
CPC分类号： C07D498/04 , C07D487/04 , C07D491/107 , C07D519/00
摘要： Substituted imidazo[1,5-a]quinoxalin-4(5H)-ones are useful as PDE9 inhibitors.
摘要翻译：取代的咪唑并[1,5-a]喹喔啉-4（5H） - 酮可用作PDE9抑制剂。

3. 发明授权

US10150966B2 RNA sequence having anti-tumour activity 有权
公开(公告)号：US10150966B2
公开(公告)日：2018-12-11
申请号：US15123623
申请日：2015-03-04
申请人： Hirofumi Yamamoto , Masaki Mori
发明人： Hirofumi Yamamoto , Masaki Mori , Yuichiro Doki
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , A61K47/02 , A61K9/00 , A61K9/51
摘要： Provided is a novel useful microRNA having improved anti-tumor activity, obtained by introducing a variation in a microRNA which is present in-vivo and which exhibits an anti-tumor effect. This microRNA containing a base sequence (SEQ ID NO: 1) obtained by varying a predetermined region of the base sequence of miR-29b is able to exhibit a particularly outstanding anti-tumor effect.

4. 发明授权

US09889155B2 Enhancer of anti-tumor effect of anti-cancer agent 有权
公开(公告)号：US09889155B2
公开(公告)日：2018-02-13
申请号：US15119862
申请日：2015-02-20
申请人： Hirofumi Yamamoto , Masaki Mori
发明人： Hirofumi Yamamoto , Masaki Mori , Yuichiro Doki , Xin Wu
IPC分类号： A61K33/06 , A61K31/513 , A61K33/24 , A61K31/555 , A61K31/337 , A61K31/704
CPC分类号： A61K33/06 , A61K31/337 , A61K31/513 , A61K31/555 , A61K31/704 , A61K33/24 , A61K2300/00
摘要： An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.

5. 发明申请

US20140075458A1 DEVICE SPECIFIC DATA IN A UNIFIED POINTER MESSAGE 有权
标题翻译：设备特定数据在统一的点消息
公开(公告)号：US20140075458A1
公开(公告)日：2014-03-13
申请号：US13609258
申请日：2012-09-11
申请人： Stephen Wright , Hirofumi Yamamoto , Pak Kiu Chung , Raju Ramanathan , Krishnan Menon , Lawrence Osterman , Alan Stephenson , Reed Townsend , Jacob Rossi
发明人： Stephen Wright , Hirofumi Yamamoto , Pak Kiu Chung , Raju Ramanathan , Krishnan Menon , Lawrence Osterman , Alan Stephenson , Reed Townsend , Jacob Rossi
IPC分类号： G06F3/00
CPC分类号： G06F3/038 , G06F9/4411 , G06F9/451
摘要： In one embodiment, a unified pointer message 300 may describe in a single type of pointer message a coordinate input from a user via multiple types of pointer devices. An input device interface 150 may receive a coordinate input 350 from an input device. A processor 120 may execute an application programming interface layer 430 that creates a unified pointer message 300 for the coordinate input 350. The processor 120 may send the unified pointer message 300 to an application. The processor 120 may process a device specific data set 244 unhandled by the application.
摘要翻译：在一个实施例中，统一指针消息300可以以单一类型的指针消息描述来自用户经由多种类型的指针设备的坐标输入。输入设备接口150可以从输入设备接收坐标输入350。处理器120可以执行应用编程接口层430，其创建用于坐标输入350的统一指针消息300.处理器120可以将统一指针消息300发送到应用。处理器120可以处理由应用程序未处理的设备特定数据集244。

6. 发明授权

US08398010B2 Polyester monofilament package 有权
标题翻译：聚酯单丝包装
公开(公告)号：US08398010B2
公开(公告)日：2013-03-19
申请号：US13521380
申请日：2011-01-05
申请人： Shinnosuke Tomita , Hirofumi Yamamoto , Kiyoshi Akazawa , Takayuki Yoshimiya
发明人： Shinnosuke Tomita , Hirofumi Yamamoto , Kiyoshi Akazawa , Takayuki Yoshimiya
IPC分类号： B65H55/04
CPC分类号： B65H55/04 , B65H2701/313
摘要： A polyester monofilament package is formed by reeling a polyester monofilament comprising polyethylene terephthalate and satisfies all of the following requirements (a) to (d): (a) the coefficient of dynamic friction between yarns of the polyester monofilament being 0.13 μd or less; (b) the package end being in a tapered shape with a taper angle (0) of 75° or less; (c) the variation gradient in unreeling tension (AT) being 0.02 cN/dtex-m or less; and (d) in a part of a reeling thickness of 1 mm in the inner layer of the package, the variation in contraction stress of the polyester monofilament being 3.0 cN/dtex or less.
摘要翻译：通过缠绕包含聚对苯二甲酸乙二醇酯的聚酯单丝来形成聚酯单丝包装，并且满足以下所有要求（a）至（d）：（a）聚酯单丝的纱线之间的动摩擦系数为0.13μd以下; （b）封装端部呈锥形（0）为75°以下的锥形，（c）未拉伸张力（AT）的变化梯度为0.02cN / dtex-m以下; 和（d）在包装的内层中的卷取厚度为1mm的一部分中，聚酯单丝的收缩应力的变化为3.0cN / dtex以下。

7. 发明申请

US20120159363A1 Z-ORDER BANDS 审中-公开
公开(公告)号：US20120159363A1
公开(公告)日：2012-06-21
申请号：US12970904
申请日：2010-12-16
申请人： Gabriel DeBacker , Alex Snitkovskiv , Chris Guzak , John Stephens , Thomas Olsen , Mohamed Sadek , Hirofumi Yamamoto , Robert Jarrett , David Abzarian , Alice Tang , Jennifer Nan , Adrian Ford , Chaitanya Sareen
发明人： Gabriel DeBacker , Alex Snitkovskiv , Chris Guzak , John Stephens , Thomas Olsen , Mohamed Sadek , Hirofumi Yamamoto , Robert Jarrett , David Abzarian , Alice Tang , Jennifer Nan , Adrian Ford , Chaitanya Sareen
IPC分类号： G06F3/048
CPC分类号： G06F9/451
摘要： The subject disclosure relates to managing z-dimensional ordering of elements within a computing system display through the use of z-order bands. As described herein, z-order bands are utilized to arrange windows and other graphics corresponding to respective application types. A policy engine controls which windows and/or other graphical elements can enter and exit each band. Graphical elements within a given band can additionally be subject to per-band properties corresponding to the band and/or user preferences. As additionally described herein, z-order bands and/or other suitable mechanisms are utilized to facilitate registration watermarking for a computing environment by rendering a registration watermark display upon determining that one or more licensed elements of a computing system have not been registered. The registration watermark display is assigned a z-order band that enables its display over all other graphical elements associated with the computing system and prevents other graphical elements from interfering with its display.
摘要翻译：本公开涉及通过使用z阶频带来管理计算系统显示器内的元件的z维排序。如本文所述，z阶频带用于布置对应于各个应用类型的窗口和其他图形。策略引擎控制哪些窗口和/或其他图形元素可以进入和退出每个频带。给定频带内的图形元素可另外经受对应于频带和/或用户偏好的每频段特性。如本文另外描述的，使用z阶频带和/或其他合适的机制来通过在确定计算系统的一个或多个许可元件尚未被注册之后呈现注册水印显示来促进计算环境的注册水印。注册水印显示被分配一个z阶带，使其能够显示在与计算系统相关联的所有其它图形元素上，并防止其他图形元素干扰其显示。

8. 发明申请

US20070028294A1 Desktop security 有权
标题翻译：桌面安全
公开(公告)号：US20070028294A1
公开(公告)日：2007-02-01
申请号：US11193312
申请日：2005-07-30
申请人： Hirofumi Yamamoto , Mohamed Fathalla , Yashabh Sethi , Richard Ward
发明人： Hirofumi Yamamoto , Mohamed Fathalla , Yashabh Sethi , Richard Ward
IPC分类号： H04L9/32
CPC分类号： H04L63/101 , G06F21/6218 , G06F2221/2105 , G06F2221/2141 , H04L63/1441
摘要： In aspects, interactions between processes of a desktop are allowed or denied based on security data. The security data may comprise a first bitmap that indicates whether a requesting process is allowed to cause an action to occur, a second bitmap that indicates whether a process is protected from having an action occur, and a third bitmap that indicates whether the requesting process may override protection, if any, in causing the action to occur.
摘要翻译：在一些方面，基于安全性数据允许或拒绝桌面进程之间的交互。安全数据可以包括指示请求进程是否允许发生动作的第一位图，指示进程是否被保护以防止发生动作的第二位图，以及指示请求进程是否可以超越保护（如果有的话）导致动作发生。

9. 发明授权

US06468995B1 Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US06468995B1
公开(公告)日：2002-10-22
申请号：US08781924
申请日：1996-12-30
申请人： Kohji Kawabata , Takeshi Terasawa , Ayako Ohki , Fumiyuki Shirai , Hirofumi Yamamoto
发明人： Kohji Kawabata , Takeshi Terasawa , Ayako Ohki , Fumiyuki Shirai , Hirofumi Yamamoto
IPC分类号： C07D50134
CPC分类号： C07D501/00 , Y02P20/55
摘要： A compound of the formula: wherein R1 is amino or protected amino; R2 is hydrogen, lower alkyl or hydroxy protective group; R3 is carboxy or protected carboxy; R4 is an unsubstituted 5, 6 or 7-membered heteromonocyclic group containing two nitrogen atoms as heteroatoms, and which optionally further contains one oxygen or sulfur atom; or R4 is said 5, 6 or 7-membered heteromonocyclic group substituted by 1 to 4 groups selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyclo(lower)alkyl, cyclo(lower)alkenyl, halogen, amino, protected amino, protected hydroxy, cyano, nitro, carboxy, hydroxy(lower)alkyl, amino(lower)alkyl, and carbamoyloxy; and n is 1 or 2.
摘要翻译：下式的化合物：其中R 1是氨基或被保护的氨基; R 2是氢，低级烷基或羟基保护基; R 3是羧基或被保护的羧基; R 4是未取代的5,6或7元杂单环基，杂原子，并且任选地还含有一个氧或硫原子; 或R4是由1-4个选自低级烷基，低级烷氧基，低级烷硫基，低级烷基氨基，环（低级）烷基，环（低级）烯基，卤素，氨基，保护的氨基，保护的羟基，氰基，硝基，羧基，羟基（低级）烷基，氨基（低级）烷基和氨基甲酰氧基; andn是1或2。

10. 发明授权

US06387180B1 Coating apparatus 有权
标题翻译：涂装设备
公开(公告)号：US06387180B1
公开(公告)日：2002-05-14
申请号：US09469787
申请日：1999-12-22
申请人： Susumu Takahashi , Haruhiro Iida , Hirofumi Yamamoto
发明人： Susumu Takahashi , Haruhiro Iida , Hirofumi Yamamoto
IPC分类号： B05C100
CPC分类号： B05C11/025 , B05C5/0254 , B05C11/023
摘要： A coating apparatus has compact coating assembly modules which require less storage space and are easier to handle and which through the common use of parts and accessory tools provide a reduced manufacturing cost of the apparatus as a whole. A coating assembly which rotates during coating and a coating assembly which does not rotate during coating can be interchangeably installed to a support frame. Two bearing cases are mounted on the support frame, and the coating assemblies each have two shaft parts which can be removably set in the bearing cases. The shaft parts of the rotating coating assembly can be rotatably set in the bearing cases, and a shaft part of the non-rotating coating assembly can, when set in its corresponding bearing case, be anchored to a fixed part so that it cannot rotate. Another coating assembly which does not rotate during coating has left and right mounting parts which can be removably fixed to bearing cradle parts of the bearing cases.
摘要翻译：涂覆装置具有紧凑的涂层组件模块，其需要较少的存储空间并且更易于处理，并且通过部件和辅助工具的常见使用提供整体上的装置的制造成本降低。在涂覆期间旋转的涂层组件和在涂覆期间不旋转的涂层组件可以互换地安装到支撑框架。两个轴承箱安装在支撑框架上，涂层组件各有两个轴部分，可以可拆卸地设置在轴承箱中。旋转涂层组件的轴部分可以可旋转地设置在轴承箱中，并且非旋转涂层组件的轴部分可以在其相应的轴承箱中设置时被锚固到固定部分，使得其不能旋转。在涂覆期间不旋转的另一个涂层组件具有可拆卸地固定到轴承箱的轴承支架部分的左和右安装部件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式