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1. 发明申请

US20100048762A1 COMPOSITION AND DENTAL MATERIAL 审中-公开
标题翻译：组合物和牙科材料
公开(公告)号：US20100048762A1
公开(公告)日：2010-02-25
申请号：US12523591
申请日：2008-01-16
申请人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Naoki Nishigaki , Ai Hinamoto , Mariko Sugiura
发明人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Naoki Nishigaki , Ai Hinamoto , Mariko Sugiura
IPC分类号： A61K6/087
CPC分类号： A61K6/0023 , A61K6/083 , C08F20/10 , C08F20/28 , C08F220/26 , C08L33/04 , C08L33/26
摘要： The present invention provides a composition that exhibits excellent adhesive properties to tooth structure (particularly dentin) when applied as a dental material. The present invention is a composition containing a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups, and a bisacylphosphine oxide (B) represented by the following formula (1): where the respective symbols are as defined in the specification.
摘要翻译：本发明提供当作为牙科材料使用时，对牙齿结构（特别是牙本质）具有优异的粘合性的组合物。本发明是含有具有至少四个连续键合的碳原子的非共轭碳链，至少两个可聚合基团和至少两个羟基的可聚合单体（A）和由下式表示的双酰基氧化膦（B）的组合物以下公式（1）：其中各符号如说明书中所定义。

2. 发明申请

US20100036075A1 POLYMERIZABLE MONOMER-CONTAINING COMPOSITION 有权
标题翻译：含聚合物的单体组合物
公开(公告)号：US20100036075A1
公开(公告)日：2010-02-11
申请号：US12523538
申请日：2008-01-16
申请人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Naoki Nishigaki
发明人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Naoki Nishigaki
IPC分类号： C08F220/26
CPC分类号： A61K6/0023 , A61K6/083 , C08F20/10 , C08F20/28 , C08F220/26 , C08L33/04 , C08L33/26
摘要： The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups; and a polymerizable monomer (B) having one polymerizable group and at least one hydroxyl group. When a suitable component is added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.
摘要翻译：本发明提供了适用于牙科用组合物的组合物。本发明是一种组合物，其含有：具有连接有至少四个碳原子的非共轭碳链，至少两个可聚合基团和至少两个羟基的可聚合单体（A）和具有一个可聚合基团和至少一个羟基的可聚合单体（B）。当将合适的组分加入到该组合物中时，所得组合物可适用于底漆，粘合材料，复合树脂和水泥等牙科用材料。

3. 发明授权

US07977405B2 Polymerizable monomer-containing composition 有权
标题翻译：含可聚合单体的组合物
公开(公告)号：US07977405B2
公开(公告)日：2011-07-12
申请号：US12523538
申请日：2008-01-16
申请人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Naoki Nishigaki
发明人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Naoki Nishigaki
IPC分类号： C08F118/02 , C08L33/02 , A61K6/083
CPC分类号： A61K6/0023 , A61K6/083 , C08F20/10 , C08F20/28 , C08F220/26 , C08L33/04 , C08L33/26
摘要： The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups; and a polymerizable monomer (B) having one polymerizable group and at least one hydroxyl group. When a suitable component is added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.
摘要翻译：本发明提供了适用于牙科用组合物的组合物。本发明是一种组合物，其含有：具有连接有至少四个碳原子的非共轭碳链，至少两个可聚合基团和至少两个羟基的可聚合单体（A）和具有一个可聚合基团和至少一个羟基的可聚合单体（B）。当将合适的组分加入到该组合物中时，所得组合物可适用于底漆，粘合材料，复合树脂和水泥等牙科用材料。

4. 发明申请

US20100130682A1 POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION, AND DENTAL MATERIAL 审中-公开
标题翻译：可聚合单体，可聚合组合物和牙科材料
公开(公告)号：US20100130682A1
公开(公告)日：2010-05-27
申请号：US12523554
申请日：2008-01-16
申请人： Ai Hinamoto , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Mitsuru Takei , Naoki Nishigaki
发明人： Ai Hinamoto , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada , Mitsuru Takei , Naoki Nishigaki
IPC分类号： C08L33/10 , C07C69/73 , C08F230/02
CPC分类号： A61K6/0023 , A61K6/083 , C08F20/10 , C08F20/28 , C08F220/26 , C08L33/04 , C08L33/26
摘要： The present invention provides a polymerizable composition that exhibits excellent adhesive properties to a tooth structure (particularly dentin) when applied as a dental material, and a polymerizable monomer that is used as a component of the polymerizable composition. The present invention is a polymerizable monomer (A) that is a compound having at least two polymerizable groups. The polymerizable monomer (A) has a retention time of 7 minutes to 30 minutes in a high-performance liquid chromatography (HPLC) measurement conducted under a condition in which a column with an inner diameter of 3.9 mm and a length of 300 mm, packed with a C18 packing material having been crushed to have an average particle size of 10 μm and a pore size of 125 angstroms, is used, an eluent is a mixed solvent of methanol and water contained at a ratio of 3:7, a flow rate is 1.0 mL/minute, a measurement temperature is 50° C., a sample injection volume is 10 μL, and a dead volume from a sample inlet to a detection point excluding the column is 87 μL. The present invention also is a composition containing the polymerizable monomer (A).
摘要翻译：本发明提供了当作为牙科材料使用时，对牙齿结构（特别是牙本质）表现出优异的粘合性的可聚合组合物和用作可聚合组合物的组分的可聚合单体。本发明是具有至少两个可聚合基团的化合物的可聚合单体（A）。可聚合单体（A）在内径为3.9mm，长度为300mm的柱的条件下进行的高效液相色谱（HPLC）测定中的保留时间为7分钟〜30分钟，包装使用已经粉碎至平均粒径为10μm，孔径为125埃的C18填充材料，洗脱液为甲醇与水的比例为3:7的混合溶剂，流速为1.0mL /分钟，测定温度为50℃，样品注入体积为10μL，从样品入口到除柱外的检测点的死体积为87μL。本发明也是含有聚合性单体（A）的组合物。

5. 发明申请

US20100330005A1 DENTAL ORAL COMPOSITION 有权
标题翻译：牙科口服组合物
公开(公告)号：US20100330005A1
公开(公告)日：2010-12-30
申请号：US12863330
申请日：2009-01-15
申请人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Shogo Takashiba , Kazuomi Suzuki , Yamato Nojiri , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
发明人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Shogo Takashiba , Kazuomi Suzuki , Yamato Nojiri , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61K8/60 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/416 , A61K8/55 , A61K8/60 , A61K8/602 , A61K8/73 , A61K8/732
摘要： A dental composition for oral use, containing a phosphorylated saccharide (a), a polyphosphoric acid and/or a salt thereof (b), and a cationic bactericidal agent (c), wherein a ratio of a total amount of the phosphorylated saccharide (a) and the polyphosphoric acid and/or a salt thereof (b) contained to an amount of the cationic bactericidal agent (c) contained, i.e. {(a)+(b)}/(c), is from 0.05 to 20 in a weight ratio. The dental composition for oral use of the present invention can be suitably used for an oral cavity cleaning agent, including dentifrice agents such as a paste dentifrice agent, a powder dentifrice agent, and a liquid dentifrice agent, a mouse-wash agent, a troche, a tablet, a cream, an ointment, a bonding agent, a mouth spray, a coating agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, wet tissue for oral cavity care, an oral refreshing agent, chewing gum, or a gargling agent, or the like.
摘要翻译：含有磷酸化糖（a），多磷酸和/或其盐（b）和阳离子性杀菌剂（c）的口服用牙科用组合物，其中，所述磷酸化糖类（a ）和与（a）+（b）} /（c）所含的一定量的阳离子性杀菌剂（c）的多磷酸和/或其盐（b）的比例为0.05〜20 重量比。本发明的口腔用牙科用组合物可适用于口腔清洁剂，包括洁牙剂，例如糊剂洁牙剂，粉末洁牙剂和液体洁齿剂，小鼠洗涤剂，锭剂，片剂，霜剂，软膏剂，粘合剂，口腔喷雾剂，牙齿表面的涂布剂或牙齿修复剂，过敏性抑制剂，牙周病的治疗剂，施用于牙周袋，湿纸巾用于口腔护理，口腔清爽剂，口香糖或漱口剂等。

6. 发明授权

US08999298B2 Dental oral composition 有权
标题翻译：口腔成分
公开(公告)号：US08999298B2
公开(公告)日：2015-04-07
申请号：US12863330
申请日：2009-01-15
申请人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Shogo Takashiba , Kazuomi Suzuki , Yamato Nojiri , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
发明人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Shogo Takashiba , Kazuomi Suzuki , Yamato Nojiri , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61K8/46 , A61Q11/00 , A61K8/24 , A61K8/55 , A61K8/60 , A61K8/41 , A61K8/73
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/416 , A61K8/55 , A61K8/60 , A61K8/602 , A61K8/73 , A61K8/732
摘要： A dental composition for oral use, containing a phosphorylated saccharide (a), a polyphosphoric acid and/or a salt thereof (b), and a cationic bactericidal agent (c), wherein a ratio of a total amount of the phosphorylated saccharide (a) and the polyphosphoric acid and/or a salt thereof (b) contained to an amount of the cationic bactericidal agent (c) contained, i.e. {(a)+(b)}/(c), is from 0.05 to 20 in a weight ratio. The dental composition for oral use of the present invention can be suitably used for an oral cavity cleaning agent, including dentifrice agents such as a paste dentifrice agent, a powder dentifrice agent, and a liquid dentifrice agent, a mouse-wash agent, a troche, a tablet, a cream, an ointment, a bonding agent, a mouth spray, a coating agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, wet tissue for oral cavity care, an oral refreshing agent, chewing gum, or a gargling agent, or the like.
摘要翻译：含有磷酸化糖（a），多磷酸和/或其盐（b）和阳离子性杀菌剂（c）的口服用牙科用组合物，其中，所述磷酸化糖类（a ）和与（a）+（b）} /（c）所含的一定量的阳离子性杀菌剂（c）的多磷酸和/或其盐（b）的比例为0.05〜20 重量比。本发明的口腔用牙科用组合物可以适用于口腔清洁剂，包括洁牙剂，例如糊剂洁牙剂，粉末洁牙剂和液体洁齿剂，小鼠洗涤剂，锭剂，片剂，霜剂，软膏剂，粘合剂，口腔喷雾剂，牙齿表面的涂布剂或牙齿修复剂，过敏性抑制剂，牙周病的治疗剂，施用于牙周袋，湿纸巾用于口腔护理，口腔清爽剂，口香糖或漱口剂等。

7. 发明申请

US20100240714A1 ORAL COMPOSITION FOR DENTAL PURPOSES 有权
标题翻译：口腔组合物用于牙科用途
公开(公告)号：US20100240714A1
公开(公告)日：2010-09-23
申请号：US12374215
申请日：2007-07-18
申请人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Kaori Yoshimoto , Shogo Takashiba , Kazuomi Suzuki , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
发明人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Kaori Yoshimoto , Shogo Takashiba , Kazuomi Suzuki , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61K31/4425 , A61P1/02
CPC分类号： A61K8/73 , A61Q11/00 , A61Q11/02 , A61Q17/005
摘要： A dental composition for oral use, containing a phosphorylated saccharide (a), a cationic bactericidal agent (b) and a solvent (c). By using the dental composition for oral use of the present invention, the adhesion of the bacteria in the oral cavity to the surfaces of the teeth can be suppressed for a long period of time; therefore, the dental composition for oral use can be suitably used for, for example, a mouse-wash agent, a dentifrice agent, a gargling agent, a mouse spray, a coating agent or a bonding agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, or the like.
摘要翻译：含有磷酸化糖（a），阳离子性杀菌剂（b）和溶剂（c））的口腔用牙科用组合物。通过使用本发明的口腔用牙科用组合物，能够长时间地抑制口腔内的细菌与牙齿表面的粘附，因此，口腔用牙科用组合物可以适当地用于例如小鼠洗涤剂，洁牙剂，漱口剂，小鼠喷雾剂，涂布剂或与牙齿表面的粘合剂或牙齿修补剂，过敏性抑制剂，牙周病的治疗剂，应用于牙周袋等。

8. 发明授权

US08147807B2 Oral composition for dental purposes 有权
标题翻译：用于牙科用途的口服成分
公开(公告)号：US08147807B2
公开(公告)日：2012-04-03
申请号：US12374215
申请日：2007-07-18
申请人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Kaori Yoshimoto , Shogo Takashiba , Kazuomi Suzuki , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
发明人： Yasuhiro Yoshida , Naoko Namba , Noriyuki Nagaoka , Kaori Yoshimoto , Shogo Takashiba , Kazuomi Suzuki , Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61K8/00
CPC分类号： A61K8/73 , A61Q11/00 , A61Q11/02 , A61Q17/005
摘要： A dental composition for oral use, containing a phosphorylated saccharide (a), a cationic bactericidal agent (b) and a solvent (c). By using the dental composition for oral use of the present invention, the adhesion of the bacteria in the oral cavity to the surfaces of the teeth can be suppressed for a long period of time; therefore, the dental composition for oral use can be suitably used for, for example, a mouse-wash agent, a dentifrice agent, a gargling agent, a mouse spray, a coating agent or a bonding agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, or the like.
摘要翻译：含有磷酸化糖（a），阳离子性杀菌剂（b）和溶剂（c））的口腔用牙科用组合物。通过使用本发明的口腔用牙科用组合物，能够长时间地抑制口腔内的细菌与牙齿表面的粘附，因此，口腔用牙科用组合物可以适当地用于例如小鼠洗涤剂，洁牙剂，漱口剂，小鼠喷雾剂，涂布剂或与牙齿表面的粘合剂或牙齿修补剂，过敏性抑制剂，牙周病的治疗剂，应用于牙周袋等。

9. 发明申请

US20100048761A1 POLYMERIZABLE MONOMER-CONTAINING COMPOSITION 审中-公开
标题翻译：含聚合物的单体组合物
公开(公告)号：US20100048761A1
公开(公告)日：2010-02-25
申请号：US12523546
申请日：2008-01-16
申请人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
发明人： Hiroshige Ishino , Takahiro Sekiguchi , Koichi Okada
IPC分类号： C08F118/02 , C08L33/02 , A61K6/083
CPC分类号： A61K6/0023 , A61K6/083 , C08F20/10 , C08F20/28 , C08F220/26 , C08L33/04 , C08L33/26
摘要： The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups; and a water (B). The composition contains 6 to 2000 parts by weight of the water (B) with respect to 100 parts by weight of the whole amount of polymerizable monomer components. When suitable components are added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.
摘要翻译：本发明提供了适用于牙科用组合物的组合物。本发明是一种组合物，其含有：具有连接有至少四个碳原子的非共轭碳链，至少两个可聚合基团和至少两个羟基的可聚合单体（A）和水（B）。该组合物相对于100重量份的全部量的可聚合单体组分含有6至2000重量份的水（B）。当将合适的组分加入到该组合物中时，所得组合物可适用于底漆，粘合材料，复合树脂和水泥等牙科材料。

10. 发明授权

US08906151B2 Calcium phosphate composition and process for producing the same 有权
标题翻译：磷酸钙组合物及其制备方法
公开(公告)号：US08906151B2
公开(公告)日：2014-12-09
申请号：US12160971
申请日：2007-01-15
申请人： Tadashi Hashimoto , Takahiro Sekiguchi , Koichi Okada
发明人： Tadashi Hashimoto , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61L24/02 , A61L27/42 , A61K6/033 , A61L24/00 , C04B28/34 , A61K6/00 , A61K6/02 , A61K6/06 , C04B111/00
CPC分类号： A61L27/425 , A61K6/0008 , A61K6/0067 , A61K6/0215 , A61K6/024 , A61K6/0245 , A61K6/025 , A61K6/0255 , A61K6/033 , A61K6/0643 , A61L24/0063 , C04B28/344 , C04B2111/00836 , C04B14/06 , C04B14/305 , C04B22/064 , A61K6/0038 , C08L1/286 , C08L1/284 , C08L1/28 , C08L71/02 , C08L89/00 , C08L29/04 , C08L33/08 , A61K6/097 , A61K6/087 , A61K6/083
摘要： A calcium phosphate composition comprising tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B) and at least one kind of inorganic particles (C) selected from silica particles or titania particles, wherein the mixing ratio (A/B) of (A) to (B) is from 45/55 to 55/45 in molar ratio, the inorganic particles (C) have an average particle diameter of from 0.002 to 0.5 μm, and the inorganic particles (C) are contained in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of (A) and (B) in total. Thereby provided is a calcium phosphate composition such that when it is used as a material for bone repair, a formed bone has high mechanical strength and a high bone replacement rate is achieved.
摘要翻译：一种磷酸钙组合物，其包含磷酸二氢钙颗粒（A），磷酸氢钙颗粒（B）和至少一种选自二氧化硅颗粒或二氧化钛颗粒的无机颗粒（C），其中（A / B））至（B）的摩尔比为45/55〜55/45，无机粒子（C）的平均粒径为0.002〜0.5μm，无机粒子（C）的含量为0.1 相对于100重量份的（A）和（B）总计为20重量份。由此，提供了一种磷酸钙组合物，当其用作骨修复材料时，形成的骨骼具有高的机械强度，并且实现了高的骨置换率。

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