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1. 发明授权

US5766919A Replication of hepatitis C virus genome and identification of virus having high infectivity 失效
标题翻译：复制丙型肝炎病毒基因组和识别感染性高的病毒
公开(公告)号：US5766919A
公开(公告)日：1998-06-16
申请号：US654128
申请日：1996-05-28
申请人： Hiroshi Yoshikura , Yohko Shimizu , Aikichi Iwamoto , Minako Hijikata
发明人： Hiroshi Yoshikura , Yohko Shimizu , Aikichi Iwamoto , Minako Hijikata
IPC分类号： C12N7/00 , C12Q1/04 , G01N33/50 , G01N33/576 , C12N7/01
CPC分类号： G01N33/5767 , C12N7/00 , C12Q1/04 , G01N33/5091 , C12N2770/24221 , C12N2770/24251 , G01N2333/18
摘要： A method for replication of hepatitis C virus genome comprising infecting animal cells that have been infected with mouse retrovirus, with hepatitis C virus, and then culturing those cells. The present invention further provides a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising centrifugating a sample comprising a virus to be tested in a liquid medium to determine the density of the virus, and assigning the virus to a hepatitis C virus with high infectivity it the density thereof is up to about 1.06 g/ml, and assigning the virus to a hepatitis C virus with less infectivity if the density thereof is at least 1.13 g/ml; a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising bringing a virus to be tested into contact with an anti-human immunoglobulin, and assigning the virus to hepatitis C virus with high infectivity if the virus does not form an immunocomplex and assigning the virus to a hepatitis C virus with less infectivity if it does form an immunocomplex; and a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising inoculating a virus to be tested to cells infected with murine retrovirus, culturing the cells, and assigning the virus to a hepatitis C virus with high infectivity if the virus replicates in the cells, or assigning the virus to a hepatitis C virus with less infectivity if the virus does not replicate in the cells.
摘要翻译：一种用于复制丙型肝炎病毒基因组的方法，包括用丙型肝炎病毒感染已被小鼠逆转录病毒感染的动物细胞，然后培养这些细胞。本发明还提供了一种鉴别具有较高感染性的丙型肝炎病毒和感染性较差的丙型肝炎病毒的方法，包括在液体培养基中离心包含待测试病毒的样品以确定病毒的密度，病毒感染性高的丙型肝炎病毒，其密度高达约1.06μg/ ml，并且如果其密度至少为1.13μg/ ml，则将该病毒分配给感染性较差的丙型肝炎病毒; 一种区分具有高感染性的丙型肝炎病毒和较少感染性的丙型肝炎病毒的方法，包括使待测试的病毒与抗人免疫球蛋白接触，并将病毒分配给感染性高的丙型肝炎病毒，如果病毒如果它形成免疫复合物，则不形成免疫复合物并将病毒分配给具有较少感染性的丙型肝炎病毒; 以及用于区分具有高感染性的丙型肝炎病毒和感染性较差的丙型肝炎病毒的方法，包括将待测试的病毒接种到用鼠逆转录病毒感染的细胞，培养细胞，并将病毒分配给具有高度感染性的丙型肝炎病毒如果病毒在细胞中复制，或者如果病毒不在细胞中复制，则将病毒分配给具有较少感染性的丙型肝炎病毒的感染性。

2. 发明授权

US5552310A Replication of hepatitis C virus genome and identification of virus having high infectivity 失效
标题翻译：复制丙型肝炎病毒基因组和识别感染性高的病毒
公开(公告)号：US5552310A
公开(公告)日：1996-09-03
申请号：US963490
申请日：1992-10-20
申请人： Hiroshi Yoshikura , Yohko Shimizu , Aikichi Iwamoto , Minako Hijikata
发明人： Hiroshi Yoshikura , Yohko Shimizu , Aikichi Iwamoto , Minako Hijikata
IPC分类号： C12N7/00 , C12Q1/04 , G01N33/50 , G01N33/576 , C12Q1/70 , C12N7/01 , C12N7/02
CPC分类号： G01N33/5767 , C12N7/00 , C12Q1/04 , G01N33/5091 , C12N2770/24221 , C12N2770/24251 , G01N2333/18
摘要： A method for replication of hepatitis C virus genome comprising infecting animal cells that have been infected with mouse retrovirus, with hepatitis C virus, and then culturing those cells. The present invention further provides a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising centrifugating a sample comprising a virus to be tested in a liquid medium to determine the density of the virus, and assigning the virus to a hepatitis C virus with high infectivity if the density thereof is up to about 1.06 g/ml, and assigning the virus to a hepatitis C virus with less infectivity if the density thereof is at least 1.13 g/ml; a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising brining a virus to be tested into contact with an anti-human immunoglobulin, and assigning the virus to hepatitis C virus with high infectivity if it does not form an immunocomplex and assigning the virus to a hepatitis C virus with less infectivity if it does form an immunocomplex; and a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising inoculating a virus to be tested to cells infected with murine retrovirus, culturing the cells, and assigning the virus to a hepatitis C virus with high infectivity if the virus replicates in the cells, or assigning the virus to a hepatitis C virus with less infectivity if the virus does not replicate in the cells.
摘要翻译：一种用于复制丙型肝炎病毒基因组的方法，包括用丙型肝炎病毒感染已被小鼠逆转录病毒感染的动物细胞，然后培养这些细胞。本发明还提供了一种鉴别具有较高感染性的丙型肝炎病毒和感染性较差的丙型肝炎病毒的方法，包括在液体培养基中离心包含待测试病毒的样品以确定病毒的密度，如果其密度高达约1.06μg/ ml，则具有高感染性的丙型肝炎病毒，如果其密度至少为1.13μg/ ml，则将病毒分配给具有较低感染性的丙型肝炎病毒; 一种区分具有高感染性的丙型肝炎病毒和较少感染性的丙型肝炎病毒的方法，包括将待测试的病毒与抗人免疫球蛋白接触，并将该病毒分配给感染性高的丙型肝炎病毒不形成免疫复合物，如果确实形成免疫复合物，则将病毒分配给感染性较差的丙型肝炎病毒; 以及用于区分具有高感染性的丙型肝炎病毒和感染性较差的丙型肝炎病毒的方法，包括将待测试的病毒接种到用鼠逆转录病毒感染的细胞，培养细胞，并将病毒分配给具有高度感染性的丙型肝炎病毒如果病毒在细胞中复制，或者如果病毒不在细胞中复制，则将病毒分配给具有较少感染性的丙型肝炎病毒的感染性。

3. 发明授权

US06667155B2 Carrier for gene detection and its use for detecting validity of interferon therapy 失效
公开(公告)号：US06667155B2
公开(公告)日：2003-12-23
申请号：US09813031
申请日：2001-03-21
申请人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
发明人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
IPC分类号： C12Q168
CPC分类号： B82Y30/00 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00677 , B01J2219/00707 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q1/707 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B40/10 , C40B60/14 , C12Q2565/607
摘要： A carrier for gene detection as a means for prediction before treatment whether interferon therapy is valid or not for a patient, a method for detection of interferon therapy for an individual, an apparatus for gene detection, and a kit for detection of validity of interferon therapy.

4. 发明授权

US07659068B1 Carrier for gene detection and its use for detecting validity of interferon therapy 失效
标题翻译：用于基因检测的载体及其用于检测干扰素治疗有效性的用途
公开(公告)号：US07659068B1
公开(公告)日：2010-02-09
申请号：US11502556
申请日：2006-08-11
申请人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
发明人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2565/607
摘要： A carrier for gene detection as a means for prediction before treatment whether interferon therapy is valid or not for a patient, a method for detection of interferon therapy for an individual, an apparatus for gene detection, and a kit for detection of validity of interferon therapy.
摘要翻译：用于基因检测的载体作为治疗前预测的手段，干扰素治疗对于患者是否有效，用于检测个体的干扰素治疗的方法，用于基因检测的装置和用于检测干扰素治疗有效性的试剂盒。

5. 发明授权

US06783935B2 Genetic polymorphism of MxA protein and use thereof 失效
标题翻译： MxA蛋白的遗传多态性及其用途
公开(公告)号：US06783935B2
公开(公告)日：2004-08-31
申请号：US09813990
申请日：2001-03-22
申请人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
发明人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/6886 , C12Q1/707 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides polynucleotides having base sequences of sequence Nos. 1 to 4, as polynucleotides having polymorphism sites capable of being useful indicators for prediction of validity of interferon therapy.
摘要翻译：本发明提供了具有序列号1〜4的碱基序列的多核苷酸，作为能够作为预测干扰素治疗有效性的有用指标的多态性位点的多核苷酸。

6. 发明申请

US20050100909A1 Carrier for gene detection and its use for detecting validity of interferon therapy 审中-公开
标题翻译：用于基因检测的载体及其用于检测干扰素治疗有效性的用途
公开(公告)号：US20050100909A1
公开(公告)日：2005-05-12
申请号：US10633659
申请日：2003-08-05
申请人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
发明人： Minako Hijikata , Shunji Mishiro , Yasuhiko Oota , Koji Hashimoto
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C12Q1/70 , C40B40/06 , C40B40/10 , C40B60/14 , G01N37/00
CPC分类号： B82Y30/00 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00677 , B01J2219/00707 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q1/707 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B40/10 , C40B60/14 , C12Q2565/607
摘要： A carrier for gene detection as a means for prediction before treatment whether interferon therapy is valid or not for a patient, a method for detection of interferon therapy for an individual, an apparatus for gene detection, and a kit for detection of validity of interferon therapy.
摘要翻译：用于基因检测的载体作为治疗前预测的手段，干扰素治疗对于患者是否有效，用于检测个体的干扰素治疗的方法，用于基因检测的装置和用于检测干扰素治疗有效性的试剂盒。

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