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    • 3. 发明授权
    • Diabody-type bispecific antibody
    • 双抗体型双特异性抗体
    • US07635475B2
    • 2009-12-22
    • US10642284
    • 2003-08-18
    • Izumi KumagaiToshio KudoKouhei TsumotoRyutaro Asano
    • Izumi KumagaiToshio KudoKouhei TsumotoRyutaro Asano
    • A61K39/395C12P21/08
    • C07K16/2863A61K2039/505C07K16/2809C07K2317/24C07K2317/56C07K2317/626
    • The purpose of the present invention is to provide a diabody-type bispecific antibody, which is characterized by having low immunogenicity and high infiltrating activity into tumor tissues, and by being easily mass-produced at a low cost with use of microorganisms, and by being easily altered in function by means of genetic engineering. The diabody-type bispecific antibody shows a more remarkable effect than the conventional diabody-type bispecific antibodies and chemically synthesized bispecific antibodies even in a very low concentration and in the absence of the super antigen. The present invention is related to a diabody-type bispecific antibody, having a first specificity to a human epidermal growth factor (EGF) receptor and a second specificity to a surface antigen expressed by a cell having phagocytosis or cytotoxic activity, a single-chain polypeptide constituting the antibody or each region contained therein, a nucleic acid encoding the polypeptide, a replicable cloning vector or expression vector comprising the nucleic acid, a host cell transformed with the vector, and a pharmaceutical preparation comprising thereof.
    • 本发明的目的是提供一种双抗体型双特异性抗体,其特征在于对肿瘤组织具有低的免疫原性和高的渗透活性,并且通过使用微生物容易地以低成本批量生产,并且通过 通过遗传工程容易地改变功能。 双抗体双特异性抗体比常规的双抗体型双特异性抗体和化学合成的双特异性抗体甚至在非常低的浓度和不存在超抗原的情况下显示出更显着的效果。 本发明涉及对人表皮生长因子(EGF)受体具有第一特异性的双抗体型双特异性抗体和由具有吞噬作用或细胞毒活性的细胞表达的表面抗原的第二特异性,单链多肽 构成抗体或其中包含的每个区域,编码多肽的核酸,可复制的克隆载体或包含该核酸的表达载体,用该载体转化的宿主细胞及其包含的药物制剂。
    • 4. 发明申请
    • Novel diabody-type bispecific antibody
    • 新型双抗体型双特异性抗体
    • US20060210564A1
    • 2006-09-21
    • US10642284
    • 2003-08-18
    • Izumi KumagaiToshio KudoKouhei TsumotoRyutaro Asano
    • Izumi KumagaiToshio KudoKouhei TsumotoRyutaro Asano
    • A61K39/395C07H21/04C12P21/06C12N15/74C12N1/21C07K16/24
    • C07K16/2863A61K2039/505C07K16/2809C07K2317/24C07K2317/56C07K2317/626
    • The purpose of the present invention is to provide a diabody-type bispecific antibody, which is characterized by having low immunogenicity and high infiltrating activity into tumor tissues, and by being easily mass-produced at a low cost with use of microorganisms, and by being easily altered in function by means of genetic engineering. The diabody-type bispecific antibody shows a more remarkable effect than the conventional diabody-type bispecific antibodies and chemically synthesized bispecific antibodies even in a very low concentration and in the absence of the super antigen. The present invention is related to a diabody-type bispecific antibody, having a first specificity to a human epidermal growth factor (EGF) receptor and a second specificity to a surface antigen expressed by a cell having phagocytosis or cytotoxic activity, a single-chain polypeptide constituting the antibody or each region contained therein, a nucleic acid encoding the polypeptide, a replicable cloning vector or expression vector comprising the nucleic acid, a host cell transformed with the vector, and a pharmaceutical preparation comprising thereof.
    • 本发明的目的是提供一种双抗体型双特异性抗体,其特征在于对肿瘤组织具有低的免疫原性和高的渗透活性,并且通过使用微生物容易地以低成本批量生产,并且通过 通过遗传工程容易地改变功能。 双抗体双特异性抗体比常规的双抗体型双特异性抗体和化学合成的双特异性抗体甚至在非常低的浓度和不存在超抗原的情况下显示出更显着的效果。 本发明涉及对人表皮生长因子(EGF)受体具有第一特异性的双抗体型双特异性抗体和由具有吞噬作用或细胞毒活性的细胞表达的表面抗原的第二特异性,单链多肽 构成抗体或其中包含的每个区域,编码多肽的核酸,可复制的克隆载体或包含该核酸的表达载体,用该载体转化的宿主细胞及其包含的药物制剂。